Article
Developmental Biology
Lubomir Haslik, Jiri Vojtech, Petra Hanulikova, Petr Krepelka, Jaroslav Feyereisl, Ladislav Krofta
Summary: The study revealed that single intrauterine fetal death may lead to acute feto-fetal transfusion in monochorionic twins, mainly influenced by arterio-arterial anastomoses. The diameter and length of AA anastomoses play a crucial role in transfusion risk, which is related to the distance of umbilical cords insertions.
Article
Multidisciplinary Sciences
Helia Imany-Shakibai, Ophelia Yin, Matthew R. Russell, Mark Sklansky, Gary Satou, Yalda Afshar
Summary: A study on congenital heart defects in monochorionic twins showed a six-fold increase compared to singleton or dichorionic twins. Among 23 twin pairs with CHD, 5 were concordant and 18 were discordant. Most cases had discordant phenotypes, suggesting possible environmental and epigenetic influences on the development of discordant CHD in monochorionic twins.
Article
Obstetrics & Gynecology
Manasa G. Rao, Luciana Vieira, Elianna Kaplowitz, Jessica R. Overbey, Shaelyn Johnson, Keisha Paul, Robert Lookstein, Andrei Rebarber, Nathan S. Fox, Joanne Stone
Summary: In patients with monochorionic diamniotic twins, elective multifetal pregnancy reduction via radiofrequency ablation led to significantly lower rates of preterm birth at <37 weeks and a lower trend of pre term birth at <36 weeks' gestation without an increased risk of pregnancy loss. The median gestational age at delivery was significantly higher in the elective multifetal pregnancy reduction group (38 weeks) than in the ongoing pregnancy group (35.9 weeks). Further research is needed to clarify if multifetal pregnancy reduction improves long-term outcomes.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2021)
Article
Obstetrics & Gynecology
Fatemeh Rahimi-Sharbaf, Marjan Ghaemi, Ahmed A. Nassr, Alireza A. Shamshirsaz, Mahboobeh Shirazi
Summary: Radiofrequency ablation for fetal reduction in complicated monochorionic twin pregnancies is a reasonable option, with the highest success rate in the sFGR and TRAP groups and the lowest in the anomaly group.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Obstetrics & Gynecology
Yong Hee Park, Young Nam Kim, Do Hwa Im, Da Hyun Kim, Jung Mi Byun, Dae Hoon Jeong, Kyung Bok Lee, Moon Su Sung
Summary: Monochorionic twins have a higher risk of fetal death in utero and intertwin birth weight discordance compared to dichorionic twins. However, there is no significant difference in obstetrical complication, neonatal mortality, and morbidity between the two groups. After excluding fetal death in utero and monochorionic specific complications, there is no difference in obstetrical complication and neonatal mortality and morbidity according to chorionicity in twin pregnancies with intertwin birth weight discordance.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Kenta Obata, Kenji Tanimura, Naohisa Masuko, Hitomi Imafuku, Moritoki Egi, Yoshito Terai
Summary: This case study highlights the development of abdominal compartment syndrome caused by feto-fetal transfusion syndrome in a monochorionic-triamniotic triplet pregnancy, resulting in extremely preterm birth. The patient underwent cesarean section at 23 weeks and 5 days gestation, leading to successful abdominal decompression and discharge without morbidity 13 days post-operation.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Review
Hematology
L. S. A. Tollenaar, F. Slaghekke, J. M. Middeldorp, E. Lopriore
Summary: This review discusses the causes of fetal anemia in complicated monochorionic twins, focusing on twin anemia polycythemia sequence (TAPS), chronic twin-twin transfusion syndrome (TTTS), acute peripartum TTTS, and cotwins after single fetal demise. Diagnosis is based on abnormal Doppler ultrasound measurements and management options include fetoscopic laser surgery, intrauterine blood transfusion, or expectant management. Fetal anemia can have serious consequences, such as perinatal mortality, neonatal morbidity, cerebral injury, and long-term neurodevelopmental impairment.
EXPERT REVIEW OF HEMATOLOGY
(2023)
Article
Medicine, General & Internal
Anxia Xie, Yan Cui, Gang Luo, Xianxia Chen, Xuecheng Zhang, Jie Han, Li Tong, Yanming Ren, Xiaoxing Wei
Summary: This study systematically evaluated the cause of fetal death in a Han Chinese woman with monochorionic twinning following in vitro fertilization/embryo transfer. Discrepant karyotypes were discovered between the twins, with one fetus having an abnormal male karyotype (46, XY) and duplication (9) (p24.3-q13), and the other having a normal female karyotype (46, XX). The male fetus was considered to have died due to chromosome 9 aberration, while the female fetus died due to subsequent acute exsanguination through vascular anastomosis. This study highlights the importance of recognizing monochorionic dizygotic twinning and the challenges of clinical management for twins following IVF/double embryo transfer.
FRONTIERS IN MEDICINE
(2023)
Article
Acoustics
S. G. Groene, L. S. De Vries, F. Slaghekke, M. C. Haak, B. T. Heijmans, C. De Bruin, A. A. W. Roest, E. Lopriore, J. M. M. Van Klink, S. J. Steggerda
Summary: In monochorionic twins with selective FGR, neonatal cerebral ultrasound reveals restricted brain growth in the smaller twin, with smaller cerebral structures and less white/deep gray matter. There is a positive linear relationship between birth-weight discordance and intracranial-volume discordance.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Review
Genetics & Heredity
Cara Buskmiller, Jessian L. Munoz, Magdalena Sanz Cortes, Roopali V. Donepudi, Michael A. Belfort, Ahmed A. Nassr
Summary: Selective fetal growth restriction (sFGR) complicates a significant percentage of monochorionic twins. Laser treatment for sFGR is associated with more fetal deaths of the growth-restricted twin compared to expectant management, but does not impact neonatal deaths or gestational age at delivery. Laser treatment may decrease abnormal neuroimaging in the unaffected twin. More research and randomized trials are needed to assess the long-term neurological outcomes.
PRENATAL DIAGNOSIS
(2023)
Article
Biochemistry & Molecular Biology
Dayuan Shi, Xinyao Zhou, Luyao Cai, Xing Wei, Luye Zhang, Qianqian Sun, Fenhe Zhou, Luming Sun
Summary: Changes in placental DNA methylation patterns in sFGR may have functional implications for differentially methylated genes and regulatory regions. The study validates the presence of abnormally methylated CYP11A1 gene in the placenta of sFGR.
Article
Pediatrics
Angel Chimenea, Lutgardo Garcia-Diaz, Guillermo Antinolo
Summary: This study aimed to evaluate the risk of neurodevelopmental impairment in monochorionic diamniotic twins undergoing fetoscopic laser surgery for twin-twin transfusion syndrome (TTTS) compared to uncomplicated MCDA twin pregnancies. The results showed that the outcome in MCDA twins who underwent surgery for TTTS was comparable to uncomplicated MCDA twins. These findings underscore the importance of long-term neurodevelopmental follow-up in children from monochorionic twin pregnancies.
Article
Biotechnology & Applied Microbiology
Tianjiao Liu, Li Wen, Shuai Huang, Ting-Li Han, Lan Zhang, Huijia Fu, Junnan Li, Chao Tong, Hongbo Qi, Richard Saffery, Philip N. Baker, Mark D. Kilby
Summary: This study investigated the metabolic changes caused by twin-twin transfusion syndrome and the effects of fetoscopic laser coagulation on placental tissue and cord plasma metabolism. The results showed that cord plasma metabolome performed better in differentiating fetuses with varying hemodynamic statuses. Fetoscopic laser coagulation improved the metabolomic alterations and identified potential biomarkers related to neonatal birth weight and cardiac function.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Obstetrics & Gynecology
Xueju Wang, Luyao Li, Pengbo Yuan, Yangyu Zhao, Yuan Wei
Summary: This study found that the earlier onset time of selective fetal growth restriction (sFGR) II and III compared to I may be due to their higher placental territory discordance. The prevalence of thick artery-artery anastomoses is expected to be higher in sFGR III than in I or II.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Neurosciences
Esra Abaci Turk, Hyuk Jin Yun, Henry A. Feldman, Joo Young Lee, Hyun Ju Lee, Carolina Bibbo, Cindy Zhou, Rubii Tamen, Patricia Ellen Grant, Kiho Im
Summary: There is a significant relationship between placental oxygen transport and fetal brain cortical growth and folding in monochorionic twins. Slower placental oxygen delivery is associated with reduced volumetric and surface growth of the cerebral cortex, as well as more divergent sulcal folding patterns.
Meeting Abstract
Developmental Biology
Rebecca Pelekanos, Varda Sardesai, Marloes Dekker Nitert, Leonie Callaway, Nicholas Fisk, Penny Jeffery
Article
Cardiac & Cardiovascular Systems
Jatin Patel, Elke J. Seppanen, Mathieu P. Rodero, Ho Yi Wong, Prudence Donovan, Zoltan Neufeld, Nicholas M. Fisk, Mathias Francois, Kiarash Khosrotehrani
Article
Cell & Tissue Engineering
Jatin Patel, Ho Yi Wong, Weili Wang, Josue Alexis, Abbas Shafiee, Alexander J. Stevenson, Brian Gabrielli, Nicholas M. Fisk, Kiarash Khosrotehrani
Article
Cell & Tissue Engineering
Dafni Moschidou, Michelangelo Corcelli, Kwan-Leong Hau, Victoria J. Ekwalla, Jacques V. Behmoaras, Paolo De Coppi, Anna L. David, George Bou-Gharios, H. Terence Cook, Charles D. Pusey, Nicholas M. Fisk, Pascale V. Guillot
STEM CELLS AND DEVELOPMENT
(2016)
Article
Multidisciplinary Sciences
Florian Rohart, Elizabeth A. Mason, Nicholas Matigian, Rowland Mosbergen, Othmar Korn, Tyrone Chen, Suzanne Butcher, Jatin Patel, Kerry Atkinson, Kiarash Khosrotehrani, Nicholas M. Fisk, Kim-Anh Le Cao, Christine A. Wells
Article
Biochemistry & Molecular Biology
Abbas Shafiee, Jatin Patel, Ho Yi Wong, Prudence Donovan, Dietmar W. Hutmacher, Nicholas M. Fisk, Kiarash Khosrotehrani
Article
Cell & Tissue Engineering
Varda S. Sardesai, Abbas Shafiee, Nicholas M. Fisk, Rebecca A. Pelekanos
STEM CELLS TRANSLATIONAL MEDICINE
(2017)
Article
Biochemical Research Methods
Abbas Shafiee, Jeremy G. Baldwin, Jatin Patel, Boris M. Holzapfel, Nicholas M. Fisk, Kiarash Khosrotehrani, Dietmar W. Hutmacher
BIOTECHNOLOGY JOURNAL
(2017)
Article
Chemistry, Multidisciplinary
Shehzahdi S. Moonshi, Cheng Zhang, Hui Peng, Simon Puttick, Stephen Rose, Nicholas M. Fisk, Kishore Bhakoo, Brett W. Stringer, Greg G. Qiao, Paul A. Gurr, Andrew K. Whittaker
Article
Cell & Tissue Engineering
Abbas Shafiee, Jatin Patel, Dietmar W. Hutmacher, Nicholas M. Fisk, Kiarash Khosrotehrani
Article
Multidisciplinary Sciences
Abbas Shafiee, Jatin Patel, James S. Lee, Dietmar W. Hutmacher, Nicholas M. Fisk, Kiarash Khosrotehrani
SCIENTIFIC REPORTS
(2017)
Article
Medicine, General & Internal
Michael T. Gabbett, Johanna Laporte, Renuka Sekar, Adayapalam Nandini, Pauline McGrath, Yadav Sapkota, Peiyong Jiang, Haiqiang Zhang, Trent Burgess, Grant W. Montgomery, Rossa Chiu, Nicholas M. Fisk
NEW ENGLAND JOURNAL OF MEDICINE
(2019)
Meeting Abstract
Hematology
Jatin Patel, Elke J. Seppanen, Mathieu Rodero, Ho Yi Wong, Prudence Donovan, Nicholas M. Fisk, Mathias Francois, Kiarash Khosrotehrani
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2017)
Meeting Abstract
Obstetrics & Gynecology
J. Dickinson
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2016)
Article
Endocrinology & Metabolism
Rebecca A. Pelekanos, Varda S. Sardesai, Marloes Dekker Nitert, Leonie K. Callaway, Nicholas M. Fisk, Penny L. Jeffery