Article
Veterinary Sciences
Heba A. Sharawy, Abdel Raouf O. Hegab, Engy F. Risha, Mohamed El-Adl, Walid T. Soliman, Mohamed A. Gohar, Reham A. Fahmy, Virginia M. Farag, Kazuhiko Imakawa, Fuller W. Bazer, Daniela James, Adel Zaghloul, Abdelnasser A. Abdalla, Mariam M. Rabie, Mohammed A. Elmetwally
Summary: This study investigated changes in uterine and vaginal blood flow during the Ovsynch program for synchronization of estrus in Holstein cows using noninvasive color Doppler ultrasound. The results showed that vaginal and uterine blood flow were two determinant factors for higher conception rates in Holstein dairy cows.
BMC VETERINARY RESEARCH
(2022)
Article
Pathology
Angela Sim, Mojgan Devouassoux-Shisheboran, Camelia Benmousaly-Rigollot, Tiphanie Picot, Michel Peoc'h, Georgia Karpathiou
Summary: Uterine IMTs, which are rare tumors, have been found to have ALK rearrangements and ALK immunohistochemical expression. They are more commonly found in pregnancy and exhibit different characteristics compared to other uterine IMTs. This study reports a case of uterine IMT discovered during delivery, which is associated with a previously unreported THBS1-INSR fusion.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Lesia O. O. Kurlak, Paula J. J. Scaife, Louise V. V. Briggs, Fiona Broughton Pipkin, David S. S. Gardner, Hiten D. D. Mistry
Summary: This study aimed to investigate the relationship between the concentrations of trace elements and angiogenic markers in women with pre-eclampsia and their fetuses. The results showed that pregnant women with pre-eclampsia had lower levels of selenium, zinc, and manganese, and higher levels of copper. Additionally, maternal plasma zinc concentration was positively correlated with plasma sFlt-1 concentration, suggesting an imbalance in antioxidant status.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Ronald J. Trotta, Manuel A. Vasquez-Hidalgo, Brandon Smith, Sarah A. Reed, Kristen E. Govoni, Kimberly A. Vonnahme, Kendall C. Swanson
Summary: Previous research has shown that maternal nutrient restriction during mid to late gestation affects the uptake of glucose and amino acids in sheep. This study aimed to investigate the impact of the timing and duration of nutrient restriction during mid to late gestation on the flux of glucose and amino acids in the uterus, uteroplacental, and fetal compartments. The findings suggest that the timing of nutrient restriction during mid to late gestation influences the uptake of glucose and amino acids in the fetus, which could have implications for fetal growth and development.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Reproductive Biology
Katie L. Bidne, Alana L. Rister, Andrea R. McCain, Brianna D. Hitt, Eric D. Dodds, Jennifer R. Wood
Summary: At midgestation, lipid profiles are altered in the circulation of obese mouse dams and placentas with specific changes in phosphatidylcholine and lyso-phosphatidylcholine species, lipid storage, and the expression of apolipoproteins.
BIOLOGY OF REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Anna Louise Vestergaard, Signe Justesen, Tabia Volqvartz, Sissel K. Aagaard, Mette F. Andreasen, Iana Lesnikova, Niels Uldbjerg, Agnete Larsen, Pinar Bor
Summary: Despite high compliance with official guidelines regarding vitamin D supplements, vitamin D insufficiency was frequent and may affect placental growth. High BMI was associated with vitamin D insufficiency and increased placental vitamin D turnover, indicating the need for further investigations.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Reproductive Biology
Nirvay Sah, Claire Stenhouse, Katherine M. Halloran, Robyn M. Moses, Heewon Seo, Robert C. Burghardt, Gregory A. Johnson, Guoyao Wu, Fuller W. Bazer
Summary: Creatine and its related enzymes play a role in fetal-placental development in sheep. The creatine-creatine kinase-phosphocreatine system is involved in maintaining ATP levels in the placenta. This study found that gestational age affects the concentrations of creatine and guanidinoacetate, as well as the expression of related mRNAs and proteins in uterine and placental tissues. These findings suggest that the creatine-creatine kinase-phosphocreatine system is important for energy homeostasis during fetal-placental development.
BIOLOGY OF REPRODUCTION
(2023)
Article
Agriculture, Dairy & Animal Science
A. R. Tanner, M. L. Bauer, K. C. Swanson, V. C. Kennedy, J. D. Kirsch, J. Gaspers, N. Negrin-Pereira, A. B. P. Fontoura, G. A. Perry, G. Stokka, A. Rodas-Gonzalez, A. Ward, C. R. Dahlen, B. Neville, P. P. Borowicz, L. P. Reynolds, K. H. Ominski, K. A. Vonnahme
Summary: The purpose of this study was to evaluate the effects of supplementing corn to gestating beef cows fed low-quality forage on uterine and mammary hemodynamics and neonatal performance. The results showed that corn supplementation enhanced uterine and mammary hemodynamics and increased placental microvascularity. Corn can be a good substitute for hay when cost and availability are economically advantageous to the producer.
Article
Obstetrics & Gynecology
Elia Palladino, Tim Van Mieghem, Kristin L. Connor
Summary: Maternal malnutrition can alter the abundance of gut microbes and folate/inositol transporters, potentially impacting maternal micronutrient status and affecting fetal outcomes.
REPRODUCTIVE SCIENCES
(2021)
Article
Peripheral Vascular Disease
J. M. Catov, M. F. Muldoon, R. E. Gandley, J. Brands, A. Hauspurg, C. A. Hubel, M. Tuft, M. Schmella, G. Tang, W. T. Parks
Summary: Women with adverse pregnancy outcomes, such as preeclampsia and preterm birth, may have placental vascular lesions that are associated with an adverse cardiovascular profile a decade after delivery. These lesions are characterized by microvascular rarefaction, higher blood pressure, and more atherogenic lipids.
Review
Medicine, General & Internal
Wenzhi Xu, Zhibao Liu, Qianqian Ren, Chang Dai, Bo Wang, Yangying Peng, Ling Gao
Summary: This case report describes the successful treatment of infected placenta accreta in the uterine horn using transabdominal temporary occlusion of internal iliac arteries. The diagnosis was made using 3-dimensional ultrasound and magnetic resonance imaging, and confirmed during surgery. After the temporary occlusion of both internal iliac arteries, the placenta was removed and the uterine defect repaired. The patient had a good postoperative recovery with normal body temperature, normal menstruation, and no complications observed.
Article
Multidisciplinary Sciences
Piengbulan Yapan, Suphaphon Tachawatcharapunya, Supitchaya Surasereewong, Piyatida Thongkloung, Julaporn Pooliam, Liona C. Poon, Tuangsit Wataganara
Summary: This study aimed to investigate the impact of a history of previous Cesarean delivery (CD) on uterine artery (UtA) Doppler indices throughout pregnancy. The results showed no difference in the measurements and temporal changes of UtA Doppler indices between women with and without CD. The study found that the Delta values of UtA Doppler indices exhibited a biphasic pattern, decreasing until the second trimester and then increasing.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Katsusuke Ozawa, Marcus G. Davey, Zhiyun Tian, Matthew A. Hornick, Ali Y. Mejaddam, Patrick E. McGovern, Alan W. Flake, Jack Rychik
Summary: The study compared and validated umbilical venous flow volume measured with ultrasound to actual flow volume in fetal sheep on the EXTEND system. Results showed a good correlation between the two measurements, indicating stability and accuracy for this method in assessing placental function.
PRENATAL DIAGNOSIS
(2021)
Review
Obstetrics & Gynecology
Larissa M. Coutinho, Wiviane A. Assis, Ananda Spagnuolo-Souza, Fernando M. Reis
Summary: Uterine leiomyoma and pregnancy may impact each other, with evidence suggesting increased risks of adverse pregnancy outcomes such as spontaneous abortion, placenta previa, placental abruption, and fetal malpresentation in the presence of leiomyomas. Multiple and large fibroids may also contribute to higher rates of cesarean section and preterm birth. Future studies should focus on evaluating the growth pattern of leiomyomas and their influence on obstetric outcomes by enrolling women diagnosed with fibroids prior to pregnancy and following them prospectively throughout gestation and puerperium.
REPRODUCTIVE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xilong Li, Gregory A. Johnson, Huaijun Zhou, Robert C. Burghardt, Fuller W. Bazer, Guoyao Wu
Summary: This study found that dietary supplementation with L-arginine can affect gene expression in the placenta, thereby improving placental growth and embryonic/fetal survival in swine. The results indicate that L-arginine plays a regulatory role in various important metabolic and physiological processes.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Endocrinology & Metabolism
Jacqueline M. Wallace, John S. Milne, Raymond P. Aitken, Dale A. Redmer, Lawrence P. Reynolds, Justin S. Luther, Graham W. Horgan, Clare L. Adam
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2015)
Article
Endocrinology & Metabolism
C. L. Adam, P. A. Williams, J. S. Milne, R. P. Aitken, J. M. Wallace
JOURNAL OF NEUROENDOCRINOLOGY
(2015)
Article
Reproductive Biology
David J. Carr, Jacqueline M. Wallace, Raymond P. Aitken, John S. Milne, John F. Martin, Ian C. Zachary, Donald M. Peebles, Anna L. David
BIOLOGY OF REPRODUCTION
(2016)
Article
Developmental Biology
David J. Carr, Anna L. David, Raymond P. Aitken, John S. Milne, Pawel P. Borowicz, Jacqueline M. Wallace, Dale A. Redmer
Article
Multidisciplinary Sciences
Jacqueline M. Wallace, Sohinee Bhattacharya, Doris M. Campbell, Graham W. Horgan
Review
Developmental Biology
K. D. Sinclair, K. M. D. Rutherford, J. M. Wallace, J. M. Brameld, R. Stoger, R. Alberio, D. Sweetman, D. S. Gardner, V. E. A. Perry, C. L. Adam, C. J. Ashworth, J. E. Robinson, C. M. Dwyer
REPRODUCTION FERTILITY AND DEVELOPMENT
(2016)
Article
Multidisciplinary Sciences
Jacqueline M. Wallace, Sohinee Bhattacharya, Graham W. Horgan
Article
Developmental Biology
Jacqueline M. Wallace, John S. Milne, Raymond P. Aitken, Graham W. Horgan, Clare L. Adam
Review
Endocrinology & Metabolism
Jacqueline M. Wallace
JOURNAL OF ENDOCRINOLOGY
(2019)
Article
Public, Environmental & Occupational Health
Jacqueline M. Wallace, Joeleita P. Agard, Graham W. Horgan
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2020)
Article
Multidisciplinary Sciences
Jacqueline M. Wallace, John S. Milne, Beth W. Aitken, Raymond P. Aitken, Clare L. Adam
Article
Developmental Biology
Jacqueline M. Wallace, John S. Milne, Raymond P. Aitken
Summary: The competition for nutrients during pregnancy in biologically immature adolescent girls may increase the risk of preterm delivery and low birthweight. Overfeeding could lead to fetal growth restriction, with overnourished adolescent dams showing leaner and lighter body characteristics at conception and greater gestational weight gain in early pregnancy. Maternal leptin concentrations in overnourished dams were higher and changes in leptin levels throughout pregnancy predicted reduced fetal cotyledon mass and birthweight.
Article
Endocrinology & Metabolism
Dylan Peter McClurg, Mika Gissler, Miriam Gatt, Jacqueline Wallace, Sohinee Bhattacharya
Summary: Changes in interpregnancy BMI have a modest impact on the risk of high birthweight, PE and IUGR in contrasting directions. However, a prior history of PE and IUGR is the dominant predictor of recurrence in the second pregnancy.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Multidisciplinary Sciences
Jacqueline M. Wallace, Paul O. Shepherd, John S. Milne, Raymond P. Aitken
Summary: In overnourished pregnant sheep, there is a risk of premature delivery and prenatal growth restriction, leading to issues with lamb birthweight and health. However, with appropriate feeding and care, these problems can be mitigated, as demonstrated by proactive neonatal care regime in overcoming complications associated with extreme prematurity and low birthweight.
Article
Developmental Biology
Jacqueline M. Wallace, John S. Milne, Clare L. Adam, Raymond P. Aitken