Article
Neurosciences
Yu-Ming Niu, Jie Zhang, Hong Tang, Lu-Hua Cao, Ting-Yun Jiang, Yuan-Yuan Hu
Summary: A meta-analysis was conducted to investigate the correlation between the DRD2/ANKK1 rs1800497 C > T polymorphism and the risk of post-traumatic stress disorder (PTSD). The results suggested that this polymorphism may contribute to susceptibility to PTSD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Ima Trempler, Ellen Binder, Martin Reuter, Thomas Plieger, Isabel Standke, Falko Mecklenbrauck, Susanne Meinert, Andreas J. Forstner, Markus M. Nothen, Marcella Rietschel, Sophie Sturmer, Udo Dannlowski, Marc Tittgemeyer, Rebekka Lencer, Gereon R. Fink, Ricarda Schubotz
Summary: Genetic variations affecting dopaminergic neuromodulation play an important role in the balance between flexibility and stability of goal-directed behavior and learning from surprise. The DRD2/ANKK1 and COMT Val158Met polymorphisms are related to behavioral and neural responses during updating or stabilizing internal models of predictable sequences.
Article
Endocrinology & Metabolism
Serdar Sahin, Tugce Sudutan, Yasin Kavla, Emre Durcan, Yeliz Yagiz Ozogul, Burc Cagri Poyraz, Muge Sayitoglu, Hande Mefkure Ozkaya, Pinar Kadioglu
Summary: This study aims to investigate the genetic component of dopamine agonist-induced impulse control disorder (ICD) in patients with prolactinoma. By evaluating polymorphisms of dopamine receptors and other genes, it is found that there is a significant increase in genetic diversity associated with DA-induced ICD in patients receiving dopamine agonist treatment for prolactinoma.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Jamie A. Mullally, Wendy K. Chung, Charles A. LeDuc, Tirissa J. Reid, Gerardo Febres, Steven Holleran, Rajasekhar Ramakrishnan, Judith Korner
Summary: The study assessed the association between rs1800497 polymorphism near DRD2 and weight loss with NB treatment, showing that individuals with the A1+ genotype had significantly greater weight loss compared to those with the A1- genotype. This suggests that individuals carrying the A1+ allele may respond better to NB treatment than A1- individuals.
DIABETES OBESITY & METABOLISM
(2021)
Article
Neurosciences
Minlan Yuan, Hongru Zhu, Yuchen Li, Fenfen Ge, Su Lui, Qiyong Gong, Changjian Qiu, Huan Song, Wei Zhang
Summary: This study examined whether the dopamine D2 receptor Taq1A polymorphism moderated the association between PTSD symptom severity and hippocampal subfield volumes, finding a significant interaction for the left CA3 volume. The findings suggest a potential genetic mechanism for the relationship between PTSD symptomatology and hippocampal atrophy at the subfield level.
PSYCHOPHARMACOLOGY
(2022)
Article
Genetics & Heredity
Monika Michalowska-Sawczyn, Krzysztof Chmielowiec, Jolanta Chmielowiec, Grzegorz Trybek, Jolanta Masiak, Marta Niewczas, Pawel Cieszczyk, Wojciech Bajorek, Pawel Krol, Anna Grzywacz
Summary: Physical activity levels are influenced by various factors, including personality traits which have a moderate heritable component. Research on genes such as DRD2Tag1B rs1079597 show differences between combat sports practitioners and controls. Further exploration is needed to find clear associations between personality traits and attitudes towards physical effort.
Article
Clinical Neurology
Kenji Ohira, Hajime Yokota, Shigeki Hirano, Motoi Nishimura, Hiroki Mukai, Takuro Horikoshi, Setsu Sawai, Yoshitaka Yamanaka, Tatsuya Yamamoto, Shingo Kakeda, Satoshi Kuwabara, Tomoaki Tanaka, Takashi Uno
Summary: This study found an association between Taq1A polymorphism and brain volume in patients with Parkinson's disease. A2 homo carriers had significantly decreased volume in the left prefrontal cortex compared to A1 carriers, which may explain compensatory mechanisms in cortical function in A1 carriers with Parkinson's disease.
PARKINSONS DISEASE
(2022)
Article
Endocrinology & Metabolism
Hao Tang, Yijun Cheng, Xiaohui Lou, Hong Yao, Jing Xie, Weiting Gu, Xinyun Huang, Yanting Liu, Shaojian Lin, Yuting Dai, Li Xue, Xiaozhu Lin, Zhe Bao Wu
Summary: This study investigates whether the expression of DRD2 based on F-18-fallypride PET/MR can predict the therapeutic effect of dopamine agonists (DA) on prolactinomas. The results show that F-18-fallypride PET/MR can detect DRD2 expression and is able to predict the response of patients to DA treatment. It may serve as a promising technique for predicting DA response in prolactinoma patients.
Article
Neurosciences
Enrica Montalban, Roman Walle, Julien Castel, Anthony Ansoult, Rim Hassouna, Ewout Foppen, Xi Fang, Zach Hutelin, Sophie Mickus, Emily Perszyk, Anna Petitbon, Jeremy Berthelet, Fernando Rodrigues-Lima, Alberto Cebrian-Serrano, Giuseppe Gangarossa, Claire Martin, Pierre Trifilieff, Clementine Bosch-Bouju, Dana M. Small, Serge Luquet
Summary: This study reveals the importance of the TaqIA genetic variant in the development of psychiatric and metabolic conditions. Using transgenic and viral-mediated techniques, the researchers found that the Ankk1 gene plays a crucial role in the regulation of striatal functions, learning, impulsivity, and flexibility. Additionally, Ankk1 has an unexpected role in the regulation of energy metabolism.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Genetics & Heredity
Diana Z. Paderina, Anastasiia S. Boiko, Ivan Pozhidaev, Irina A. Mednova, Anastasia A. Goncharova, Anna Bocharova, Olga Yu Fedorenko, Elena G. Kornetova, Arkadiy Semke, Nikolay A. Bokhan, Anton J. M. Loonen, Svetlana A. Ivanova
Summary: The study found that the functional polymorphism rs1799732 of the DRD2 gene is associated with drug-induced metabolic syndrome in women with schizophrenia.
Article
Genetics & Heredity
Parham Habibzadeh, Azim Nemati, Hassan Dastsooz, Afsaneh Taghipour-Sheshdeh, Prisho Mariam Paul, Ali Sahraian, Mohammad Ali Faghihi
Summary: Genetic factors play a crucial role in the pathogenesis of schizophrenia, with the Taq1A polymorphism showing a protective effect against the development of schizophrenia. This variant may decrease ANKK1 protein stability and lead to gain of modification sites for ubiquitination and methylation.
JOURNAL OF GENETICS
(2021)
Article
Endocrinology & Metabolism
Hao Tang, Yijun Cheng, Jinyan Huang, Jianfeng Li, Benyan Zhang, Zhe Bao Wu
Summary: Therapeutic agents for refractory prolactinomas that are resistant to dopamine agonists are challenging, with surgery often achieving only partial tumor removal. Second-line treatment with temozolomide is effective for about half of patients, but complete remission is rare. This case report discusses a patient with cabergoline-resistant prolactinoma who achieved complete remission with temozolomide therapy after undergoing two transsphenoidal surgeries. Genomic sequencing revealed 16 possible gene mutations, including a missense mutation of the PABPC1 gene.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
Gianna Spitta, Lena E. Fliedner, Tobias Gleich, Tristan Zindler, Miriam Sebold, Ralph Buchert, Andreas Heinz, Juergen Gallinat, Eva Friedel
Summary: This study investigated the relationship between dopamine receptor availability and genetic factors in alcohol use disorder (AUD), but no significant association was found, possibly due to the small sample size. Further research is needed to clarify this relationship.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Hai-Qian Zhou, Liu-Jing Zhuang, Hong-Qiang Bao, Sheng-Ju Li, Feng-Yan Dai, Ping Wang, Qian Li, Dong -Min Yin
Summary: Olfactory behavior is crucial for animal survival, and olfactory dysfunction is commonly seen in various diseases. This study reveals that mature olfactory sensory neurons (OSNs) express high levels of dopamine D2 receptor (Drd2), which can modulate odorant recognition response by inhibiting odor-induced signaling. Furthermore, nasal dopamine and DRD2 receptor are identified as potential peripheral targets for olfactory modulation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Endocrinology & Metabolism
Linjie Wang, Xiaojing Wang, Fengying Gong, Hui Pan, Huijuan Zhu
Summary: This study summarizes the clinical characteristics of 4 male prolactinoma patients with severe obesity. It was found that these patients were obese since childhood and had multiple obesity related complications. Treatment with dopamine agonists effectively improved their obesity and metabolic profiles.
FRONTIERS IN ENDOCRINOLOGY
(2023)