Review
Endocrinology & Metabolism
Stefano Cianfarani
Summary: GH therapy has shown excellent short-term safety, but long-term potential side effects remain a concern. Recent observational studies in different cohorts of young adult patients have yielded conflicting results, focusing on the risks of cancer, cardio and cerebrovascular diseases, and diabetes associated with GH therapy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Graziano Grugni, Alessandro Sartorio, Davide Soranna, Antonella Zambon, Lucia Grugni, Giuseppe Zampino, Antonino Crino
Summary: PWS is a complex disorder caused by the failure of paternal allele expression on chromosome 15. This study found that long-term GH treatment can improve body fat distribution and body composition in PWS patients. However, the increase in glucose values during GH therapy should be considered, and continuous surveillance of glucose metabolism is mandatory during long-term GH therapy, especially in obese patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ling Hou, Ke Huang, Chunxiu Gong, Feihong Luo, Haiyan Wei, Liyang Liang, Hongwei Du, Jianping Zhang, Yan Zhong, Ruimin Chen, Xinran Chen, Jiayan Pan, Xianjiang Jin, Ting Zeng, Wei Liao, Deyun Liu, Dan Lan, Shunye Zhu, Zhiya Dong, Huamei Ma, Yu Yang, Feng Xiong, Ping Lu, Shengquan Cheng, Xuefan Gu, Runming Jin, Yu Liu, Jinzhun Wu, Xu Xu, Linqi Chen, Qin Dong, Hui Pan, Zhe Su, Lijun Liu, Xiaoming Luo, Shining Ni, Zhihong Chen, Yuhua Hu, Chunlin Wang, Jing Liu, Li Liu, Biao Lu, Xinli Wang, Yunfeng Wang, Fan Yang, Manyan Zhang, Lizhi Cao, GeLi Liu, Hui Yao, Yaqin Zhan, Mingjuan Dai, Guimei Li, Li Li, Yanjie Liu, Kan Wang, Yanfeng Xiao, Xingxing Zhang, Junhua Dong, Zaiyan Gu, Lirong Ying, Feng Huang, Yanling Liu, Zheng Liu, Jin Ye, Dongmei Zhao, Xu Hu, Zhihong Jiang, Kan Ye, Hong Zhu, Shaoke Chen, Xiaobo Chen, Naijun Wan, Zhuangjian Xu, Qingjin Yin, Hongxiao Zhang, Xiaodong Huang, Jianying Yin, Huifeng Zhang, Pin Li, Ping Yin, Junfen Fu, XiaoPing Luo
Summary: This study examined the effectiveness and safety of long-term polyethylene glycol recombinant human GH (PEG-rhGH) in pediatric growth hormone deficiency (GHD). The results showed that PEG-rhGH had favorable outcomes and was safe for treating children with GHD. The high-dose subgroup had better treatment outcomes compared to the low-dose subgroup, and a weekly dose of 0.2 mg/kg might have additional benefits.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Lars Savendahl, Tadej Battelino, Michael Hojby Rasmussen, Meryl Brod, Sebastian Rohrich, Paul Saenger, Reiko Horikawa
Summary: This study aimed to assess the efficacy and safety of somapacitan in treating growth hormone deficiency (GHD) in children, as well as the burden of treatment. The results showed that weekly injections of somapacitan could reduce the burden for patients and their parents/guardians compared to daily GH injections.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, General & Internal
Carolina Di Somma, Elisabetta Scarano, Rossana Arianna, Fiammetta Romano, Mariarosaria Lavorgna, Domenico Serpico, Annamaria Colao
Summary: Experimental studies suggest that GH/IGF-1 status may impact neoplastic tissue growth, and epidemiological studies indicate a correlation between GH/IGF-1 status and cancer risk. However, studies on GH replacement in childhood cancer survivors do not show an increased prevalence of new cancers, and reports on GH-treated children and adults do not indicate an elevated cancer risk in these patients. This review aims to provide an overview and the latest updates on the long-term effects of GH replacement on neoplastic risk in adult cancer survivors with growth hormone deficiency and sellar tumors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Michael B. Ranke
Summary: GH deficiency is a rare childhood disease with challenges in clinical diagnosis and treatment. Despite advances in treatment methods, many children still fail to achieve normal adult height.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Li Yang, Qingyun Liu, Xinhui Wang, Nansha Gao, Xiuzhen Li, Hongzhong Chen, Lin Mei, Xiaowei Zeng
Summary: A micro-needle patch based on silk protein has been developed for sustained release of recombinant human growth hormone, providing a new treatment method for growth hormone deficiency.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biochemistry & Molecular Biology
Heraldo Mendes Garmes, Alejandro Rosell Castillo, Sarah Monte Alegre, Aglecio Luiz de Souza, Yeelen Ballesteros Atala, Denise Engelbrecht Zantut-Wittmann
Summary: The pattern of insulin sensitivity in patients with GH deficiency (GHD) is contradictory, and this study assessed the insulin sensitivity and body composition in adults with hypopituitarism. It was found that patients with childhood-onset GHD showed higher insulin sensitivity compared to controls, while patients with adulthood-onset GHD had similar insulin sensitivity as the control group.
Article
Chemistry, Multidisciplinary
Mingxin Wang, Somia Yassin Hussain Abdalkarim, Ruixin Gong, Haibin Ji, Zhiming Chen, Yunfei Shen, Ying Zhou, Jiayuan Shen, Hou-Yong Yu
Summary: Polymer composite microspheres with excellent biodegradable and controlled long-term release characteristics have gained significant attention. However, producing polymer microspheres with controlled properties and customizable drug release is still a major challenge. In this study, dual-responsive cellulose nanocrystals were engineered and incorporated into polylactide composite microspheres to achieve controlled and sustained drug release behavior. The results demonstrated a temperature and pH dual-responsive controlled drug release capability of the composite microspheres, highlighting their potential as multifunctional drug delivery systems for medical applications.
Article
Agriculture, Dairy & Animal Science
Tanner J. Carlisle, Samuel A. Wyffels, Steve D. Stafford, Anna R. Taylor, Megan L. Van Emon, Timothy DelCurto
Summary: Two studies evaluated the efficacy of sustained release mineral boluses as an alternative nutrient delivery method for beef cattle. The first study focused on degradation rates of bolus prototypes and cow age, while the second study compared different degradation targets and diet qualities. Results showed that degradation rates varied based on bolus prototypes and diet quality, with some prototypes meeting target release rates at 90 days.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2021)
Article
Economics
Ce Gao, Xubo He
Summary: This paper explores the theoretical mechanism of social capability in promoting economic growth and analyzes how accountability quality may lead to capability gap, hindering economic growth in low-income countries.
ECONOMIC ANALYSIS AND POLICY
(2023)
Article
Pharmacology & Pharmacy
Yao Yang, Zimu Li, Ping Huang, Jiachan Lin, Jinyuan Li, Kexin Shi, Jiahui Lin, Jingwen Hu, Zhuoxian Zhao, Yongkang Yu, Hongzhong Chen, Xiaowei Zeng, Lin Mei
Summary: Despite the increasing prevalence and incidence of gout, its management remains suboptimal. Patients are reluctant to take medication every day for incurable occasional gout flares, and an alternative drug delivery system is necessary. A chitosan-containing sustained-release microneedle system co-loaded with colchicine and uricase liposomes was developed, which successfully delivered the drugs to the skin and showed therapeutic potency in managing gout.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biotechnology & Applied Microbiology
Chun-Hwei Tai, Ni-Chung Lee, Yin-Hsiu Chien, Barry J. Byrne, Shin-Ichi Muramatsu, Sheng-Hong Tseng, Wuh-Liang Hwu
Summary: Gene therapy with eladocagene exuparvovec in patients with aromatic L-amino acid decarboxylase deficiency leads to sustained and meaningful benefits, including improvements in motor and cognitive function, increased dopamine production, symptom relief, improved growth, and enhanced quality of life for patients and caregivers.
Article
Endocrinology & Metabolism
Frederick Vogel, Leah Braun, German Rubinstein, Stephanie Zopp, Sarina Benedix, Holger Schneider, Katrin Ritzel, Katharina Schilbach, Ralf Schmidmaier, Felix Beuschlein, Martin Bidlingmaier, Martin Reincke
Summary: Lower individual IGF-I concentrations 6 months after curative surgery for Cushing's syndrome are associated with adverse long-term myopathy outcome, suggesting that IGF-I may be essential for muscle regeneration.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Fabio Bioletto, Mirko Parasiliti-Caprino, Alessandro Maria Berton, Nunzia Prencipe, Valeria Cambria, Ezio Ghigo, Silvia Grottoli, Valentina Gasco
Summary: This study proposes a quantitative estimation of GHD probability prior to stimulation tests based on IGF-I values and the presence/absence of other pituitary deficits. The risk class stratification provides a simple tool for a Bayesian interpretation of stimulation test results, potentially reducing the risk of wrong GHD diagnosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)