Review
Multidisciplinary Sciences
Chockalingam Shivashri, Wesley Hannah, Mohan Deepa, Yonas Ghebremichael-Weldeselassie, Ranjit Mohan Anjana, Ram Uma, Viswanathan Mohan, Ponnusamy Saravanan
Summary: The prevalence of prediabetes and type 2 diabetes mellitus (T2DM) is high among women with a history of Gestational Diabetes Mellitus (GDM) in South Asia (SA) and Southeast Asia (SEA). This indicates the need for follow-up of GDM women to identify dysglycemia early and implement interventions to prevent/delay the development of T2DM.
Article
Multidisciplinary Sciences
Khalid Abdul Basit, Asher Fawwad, Nida Mustafa, Thomas Davey, Bilal Tahir, Abdul Basit
Summary: This study aimed to observe trends of diabetes and its associated risk factors in rural areas of Baluchistan-Pakistan through health surveys conducted between 2002-2017. The results showed a continuous increase in the prevalence of early-onset diabetes in the rural population, with central obesity and dyslipidemia being the major risk factors. This poses a major public health challenge.
Article
Multidisciplinary Sciences
Durga Parkhi, Nishanthi Periyathambi, Yonas Ghebremichael-Weldeselassie, Vinod Patel, Nithya Sukumar, Rahul Siddharthan, Leelavati Narlikar, Ponnusamy Saravanan
Summary: This study aims to predict the risk of postpartum prediabetes in women diagnosed with gestational diabetes. By using a sparse logistic regression approach and selecting only two variables as relevant factors, the study achieved a good predictive performance.
Article
Endocrinology & Metabolism
Angarmurun Dayan, Ryenchindorj Erkhembayar, Oyunbileg Luvsandavaajav, Yerkyebulan Mukhtar, Bolormaa Enkhtuvshin, Bayasgalan Tumenbayar
Summary: The burden of diabetes in Mongolia has increased significantly over the past 30 years, and a national registry of diabetes that tracks individuals is lacking. A cross-sectional, nationally representative survey was conducted to investigate the prevalence of diabetes in Mongolia and analyze associated factors. The study found that the prevalence of prediabetes and diabetes in Mongolia is high and has tripled since 1999. Various modifiable risk factors were associated with diabetes.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Review
Medicine, General & Internal
Aoife M. Egan, Elizabeth Ann L. Enninga, Layan Alrahmani, Amy L. Weaver, Michael P. Sarras, Rodrigo Ruano
Summary: Gestational diabetes mellitus (GDM) recurrence rate is 47.6%, with clinical risk factors including maternal age, weight, ethnicity, and requirement for insulin treatment. More research is needed to evaluate strategies for preventing GDM recurrence.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mehrad Nikravesh, Masoud Mahdavinia, Niloofar Neisi, Layasadat Khorsandi, Mohammad Javad Khodayar
Summary: The study examined the protective effects of citicoline against arsenic-induced hepatotoxicity and glucose intolerance. Citicoline improved glucose tolerance, increased antioxidant enzyme activity, and reduced oxidative stress and inflammation in the liver. Furthermore, it restored insulin production and action pathways. Based on these findings, citicoline can be considered as a modulating agent for arsenic-induced liver toxicity and hyperglycemia.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Marcelino Perez-Bermejo, Irene Mas-Perez, Maria Teresa Murillo-Llorente
Summary: Bisphenol A, a common endocrine disruptor found in daily products, is linked to obesity and diabetes due to its ability to mimic natural estrogen. This compound can stimulate adipocyte hypertrophy and alter the endocrine system. Despite some countries implementing policies, there is a lack of international agreement on the regulation of Bisphenol A exposure.
Review
Medicine, General & Internal
Milena Cioana, Jiawen Deng, Ajantha Nadarajah, Maggie Hou, Yuan Qiu, Sondra Song Jie Chen, Angelica Rivas, Laura Banfield, Haifa Alfaraidi, Ahlam Alotaibi, Lehana Thabane, M. Constantine Samaan
Summary: This systematic review and meta-analysis found that approximately 1 in 5 girls with T2D had PCOS. However, further evaluation is needed to assess the associations of obesity and race with PCOS prevalence among girls with T2D.
Article
Gastroenterology & Hepatology
Eduardo Vilar-Gomez, Luis Calzadilla-Bertot, Vincent Wai-Sun Wong, Marlen Castellanos, Rocio Aller-de la Fuente, Mohammed Eslam, Grace Lai-Hung Wong, Jacob George, Manuel Romero-Gomez, Leon A. Adams
Summary: Type 2 diabetes is associated with increased risk of death and liver-related outcomes in patients with NASH-related cirrhosis, while metformin use is significantly correlated with a reduction in these risks.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Dewei Ye, Jiating Huang, Jiaming Wu, Kang Xie, Xiang Gao, Kaixuan Yan, Pengfei Zhang, Ying Tao, Yun Li, Shufei Zang, Xianglu Rong, Jun Li, Jiao Guo
Summary: Gestational diabetes mellitus (GDM) is a condition characterized by high blood sugar and insulin resistance during the second or third trimester of pregnancy, which poses significant risks to both the mother and fetus. Through a study on a group of pregnant women with GDM and those with normal glucose tolerance (NGT), we discovered microbial and metabolic alterations associated with GDM. These findings provide insight into the mechanistic link between altered gut microbiota and GDM, and suggest that targeting the gut microbiota could be a promising intervention for GDM.
Article
Endocrinology & Metabolism
Caro Minschart, Nele Myngheer, Toon Maes, Christophe De Block, Inge Van Pottelbergh, Pascale Abrams, Wouter Vinck, Liesbeth Leuridan, Sabien Driessens, Chantal Mathieu, Jaak Billen, Christophe Matthys, Annouschka Laenen, Annick Bogaerts, Katrien Benhalima
Summary: This study aimed to identify risk factors for early postpartum weight retention (PPWR) and glucose intolerance (GI) in women with gestational diabetes (GDM). The results showed that excessive gestational weight gain, lack of breastfeeding, higher dietary fat intake, insulin use during pregnancy, multiparity, lower prepregnancy body mass index (BMI), and lower education degree were independent predictors for early PPWR. Women with high PPWR had a more impaired postpartum metabolic profile, breastfed less often, had higher rates of depression and anxiety, and lower quality of life. Additionally, 28% of participants had GI, with women with high PPWR being more likely to have GI. Only 12.9% of women with high PPWR perceived themselves at high risk for diabetes but were more willing to change their lifestyle.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Multidisciplinary Sciences
Fengming Tu, Aimei Fei
Summary: This study examines the impact of gestational diabetes mellitus (GDM) on maternal and neonatal outcomes in singleton and twin pregnancies. The results showed that singleton pregnancies with GDM had a lower risk of cesarean section, small-for-gestational age neonates, preterm delivery, respiratory morbidity, neonatal hyperbilirubinemia, and NICU admission compared to twin pregnancies with GDM. Therefore, interventions should be focused on twin pregnancies with GDM.
Article
Biochemistry & Molecular Biology
Maria Kaare, Kaie Mikheim, Kersti Lillevali, Kalle Kilk, Toomas Jagomae, Este Leidmaa, Maria Piirsalu, Rando Porosk, Katyayani Singh, Riin Reimets, Egon Taalberg, Michael K. E. Schaefer, Mario Plaas, Eero Vasar, Mari-Anne Philips
Summary: The NEGR1 gene plays a crucial role in maintaining systemic metabolism, particularly in glucose homeostasis, as revealed in studies with Negr1(-/-) mice under different diet conditions. The deficiency of Negr1 seems to affect energy storage efficiency and metabolism, leading to alterations in glucose tolerance and other metabolic pathways. Functional Negr1 appears to protect male mice from developing glucose intolerance, liver steatosis, and excessive weight gain in the presence of a high-fat diet.
Article
Endocrinology & Metabolism
Hanna Riekki, Linnea Aitokari, Laura Kivela, Siiri Lahti, Pauliina Hiltunen, Nina Vuorela, Heini Huhtala, Timo A. Lakka, Kalle Kurppa
Summary: This study investigated the prevalence, risk factors, and metabolic co-morbidities of metabolic-associated fatty liver disease (MAFLD) in overweight children. The prevalence of MAFLD was 15%, with higher rates in boys than girls, and was associated with gender, puberty stage, disturbances in glucose and lipid metabolism, age, and BMI.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Amir Moheet, Antoinette Moran
Summary: Cystic fibrosis-related diabetes (CFRD) is a common complication of cystic fibrosis (CF) and is associated with poor health outcomes. The pathophysiology of CFRD is complex and not fully understood, but factors such as inflammation, alterations in the hormone axis, insulin resistance, and genetic factors may contribute to its development. Further research is needed to better understand the mechanisms underlying CFRD and the impact of diabetes on clinical outcomes in CF.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)