Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Bai, Yu Shen, Rushi Chen, Xianchang Zhang, Mathias Nittka, Gregor Koerzdoerfer, Qiyong Gong, Meiyun Wang
Summary: Magnetic resonance fingerprinting (MRF) can effectively differentiate gonadotroph from non-gonadotroph pituitary macroadenomas, guiding treatment decisions.
EUROPEAN RADIOLOGY
(2021)
Review
Endocrinology & Metabolism
Stephanie Du Four, Jorn Van Der Veken, Johnny Duerinck, Elle Vermeulen, Corina E. E. Andreescu, Michael Bruneau, Bart Neyns, Van Velthoven, Brigitte Velkeniers
Summary: In this article, we report a case series of five patients with pituitary carcinoma (PC) and highlight the challenges in diagnosis and treatment. PCs are rare intracranial neoplasms that usually develop from aggressive pituitary adenomas. The mean time interval from initial diagnosis to PC diagnosis was 10.7 years. Various treatment approaches, including surgery, radiotherapy, temozolomide, and immunotherapy, were used, with some patients achieving stable disease. The lack of predictive factors for an aggressive clinical course makes management challenging for PCs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Georgia Ntali, Cristina Capatina
Summary: Functioning gonadotroph adenomas (FGAs) are rare tumors that can cause clinical syndromes due to over secretion of gonadotropins. Surgical removal of the tumor improves endocrine dysfunction and provides tissue for analysis. Medical therapies have limited effectiveness in treating these tumors.
MEDICINA-LITHUANIA
(2022)
Article
Clinical Neurology
Hirotaka Hasegawa, Cody L. Nesvick, Dana Erickson, Salomon Cohen Cohen, Yagiz U. Yolcu, Zaraq Khan, Aditya Raghunathan, Todd B. Nippoldt, John L. Atkinson, Jamie J. Van Gompel
Summary: Gonadotroph pituitary adenoma (Gn-PA) can rarely cause ovarian hyperstimulation syndrome, leading to infertility in women. Adenoma resection is the main treatment, which can reduce symptoms and increase the likelihood of successful pregnancy.
WORLD NEUROSURGERY
(2021)
Editorial Material
Medicine, General & Internal
Nanik Ram, Khan Sajjad Ali, Bhagwan Das, Najmul Islam
Summary: This study reports two cases of pituitary gonadotroph adenomas, both of which showed improvement in hormone levels, visual disturbances, and headaches after transsphenoidal resection.
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
(2022)
Article
Endocrinology & Metabolism
Keyi Zhang, Xuefei Shou, Hong Chen, Nidan Qiao, Wenqiang He, Zhengyuan Chen, Ming Shen, Shiqi Li, Yao Zhao, Zhaoyun Zhang, Yiming Li, Hongying Ye, Yongfei Wang
Summary: The study investigated the clinical characteristics of SCAs with positive and negative ACTH immunostaining, finding that ACTH-negative SCAs were more clinically silent and more likely to demonstrate multiple microcysts on MRI. The prevalence of SCAs, especially ACTH-negative SCAs, was substantially underestimated and should be given enough attention due to the high aggressiveness of this subtype of refractory pituitary adenoma.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Xiaohai Liu, Renzhi Wang, Mingchu Li, Ge Chen
Summary: Pituitary metastasis is a rare condition, but its incidence increases with age. Breast cancer in women and lung cancer in men are the most frequent primary origins. Misdiagnosing pituitary metastasis as primary pituitary adenoma can be challenging. This case report emphasizes the importance of differential diagnosis of invasive sellar region lesions, especially in individuals over 60 with diabetes insipidus.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cell Biology
Juan C. Hernandez-Prera, Alena Skalova, Alessandro Franchi, Alessandra Rinaldo, Vincent Vander Poorten, Peter Zbaren, Alfio Ferlito, Bruce M. Wenig
Summary: Pleomorphic adenoma, the most common salivary gland neoplasm, can present challenges in diagnosis due to its ability to mimic invasion, show atypical cytomorphology, and overlap morphological features with established salivary gland carcinomas. Recognizing early malignant transformation to carcinoma ex-pleomorphic adenoma remains a frequent challenge, and a systematic approach combining classic histopathology with novel immunohistochemical and molecular tests is recommended to avoid diagnostic pitfalls.
Article
Clinical Neurology
Mark T. Mills, Stephen B. Wharton, Daniel J. Connolly, Showkat Mirza, Saurabh Sinha
Summary: This is a rare case describing metastasis of breast cancer into a gonadotroph cell pituitary adenoma presenting as apoplexy.
BRITISH JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Robert C. Osorio, Matheus P. Pereira, Rushikesh S. Joshi, Kevin C. Donohue, Patricia Sneed, Steve Braunstein, Philip Theodosopoulos, Ivan H. El-Sayed, Jose Gurrola, Sandeep Kunwar, Lewis S. Blevins, Manish K. Aghi
Summary: This study examined the influence of socioeconomic status (SES) on the clinical presentations and outcomes of nonfunctional pituitary adenoma (NFPA) resections. The presence of a primary care provider (PCP) was found to be the most important factor, affecting hospital lengths of stay, readmission rates, follow-up adherence, and tumor recurrence.
JOURNAL OF NEUROSURGERY
(2022)
Review
Endocrinology & Metabolism
Antonio Bianchi, Sabrina Chiloiro, Antonella Giampietro, Simona Gaudino, Rosalinda Calandrelli, Ciro Mazzarella, Carmelo Caldarella, Mario Rigante, Marco Gessi, Liverana Lauretti, Laura De Marinis, Alessandro Olivi, Alfredo Pontecorvi, Francesco Doglietto
Summary: Growth hormone-secreting adenomas exhibit a wide range of behaviors and outcomes, from mild disease to aggressive neoplasms. Treatment for patients who do not respond to surgery or first-generation somatostatin receptor ligands may involve multiple surgical, medical, and radiation treatments. Currently, there are no markers that can predict the prognosis or aggressiveness of acromegaly. A multidisciplinary approach is necessary to tailor treatment for difficult/aggressive cases, including radiation therapy, chemotherapy, and emerging treatments.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Oncology
Xiaohai Liu, Renzhi Wang, Mingchu Li, Ge Chen
Summary: Pituitary adenomas are common intracranial neoplasms, most of which can be cured or controlled by conventional therapies, but some have invasive and malignant transformations. The International Pituitary Pathology Club proposed a new term "pituitary neuroendocrine tumor", which may cause patient confusion and anxiety according to some studies.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Endocrinology & Metabolism
Zhiyu Xi, Pamela S. Jones, Masaaki Mikamoto, Xiaobin Jiang, Alexander T. Faje, Chuansheng Nie, Kathryn E. Labelle, Yunli Zhou, Karen K. Miller, Roy J. Soberman, Xun Zhang
Summary: Aggressive pituitary adenomas have increased expression of PD-L2, CD80, and CD86 compared to normal pituitary glands, and significantly higher levels of CD80 and CD86 compared to non-aggressive tumors. These findings support further research on the potential role of immune checkpoint inhibition therapy in the treatment of pituitary adenomas.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Ben A. Strickland, Shane Shahrestani, Robert G. Briggs, Anna Jackanich, Sherwin Tavakol, Kyle Hurth, Mark S. Shiroishi, Chia-Shang J. Liu, John D. Carmichael, Martin Weiss, Gabriel Zada
Summary: SCAs are a subtype of NFAs that are more biologically aggressive, with patients presenting with more cranial neuropathy and headaches, and a shorter progression-free survival duration.
JOURNAL OF NEUROSURGERY
(2021)
Review
Oncology
Peng Du, Xuefan Wu, Kun Lv, Ji Xiong, Daoying Geng
Summary: Pituitary carcinoma is a rare and difficult-to-diagnose disease, with conventional treatments showing limited effectiveness. This article reports a case of sparsely granulated somatotroph carcinoma with a favorable treatment response to temozolomide combined with radiation therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Yana Stolyarov, James Mirocha, Adam N. Mamelak, Anat Ben-Shlomo
Article
Endocrinology & Metabolism
Vivien Bonert, John Carmichael, Zengru Wu, James Mirocha, Daniel A. Perez, Nigel J. Clarke, Richard E. Reitz, Michael J. McPhaul, Adam Mamelak
Article
Immunology
Svetlana Zonis, Joshua J. Breunig, Adam Mamelak, Kolja Wawrowsky, Catherine Bresee, Nadiya Ginzburg, Vera Chesnokova
JOURNAL OF NEUROINFLAMMATION
(2018)
Article
Clinical Neurology
Elliot Hogg, Emmanuel During, Echo E. Tan, Kishore Athreya, Jonathan Eskenazi, Jeffrey Wertheimer, Adam N. Mamelak, Ron L. Alterman, Michele Tagliati
MOVEMENT DISORDERS
(2018)
Article
Oncology
Tao Sun, Rameshwar Patil, Anna Galstyan, Dmytro Klymyshyn, Hui Ding, Alexandra Chesnokova, Webster K. Cavenee, Frank B. Furnari, Vladimir A. Ljubimov, Ekaterina S. Shatalova, Shawn Wagner, Debiao Li, Adam N. Mamelak, Serguei I. Bannykh, Chirag G. Patil, Jeremy D. Rudnick, Jethro Hu, Zachary B. Grodzinski, Arthur Rekechenetskiy, Vida Falahatian, Alexander V. Lyubimov, Yongmei L. Chen, Lai S. Leoh, Tracy R. Daniels-Wells, Manuel L. Penichet, Eggehard Holler, Alexander V. Ljubimov, Keith L. Black, Julia Y. Ljubimova
Article
Neurosciences
Zhongzheng Fu, Daw-An J. Wu, Ian Ross, Jeffrey M. Chung, Adam N. Mamelak, Ralph Adolphs, Ueli Rutishauser
Article
Engineering, Biomedical
Rameshwar Patil, Anna Galstyan, Tao Sun, Ekaterina S. Shatalova, Pramod Butte, Adam N. Mamelak, Christine Carico, David S. Kittle, Zachary B. Grodzinski, Antonella Chiechi, Hui Ding, Keith L. Black, Julia Y. Ljubimova, Eggehard Holler
Article
Neurosciences
Aneta Brzezicka, Jan Kaminski, Chrystal M. Reed, Jeffrey M. Chung, Adam N. Mamelak, Ueli Rutishauser
JOURNAL OF COGNITIVE NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Shuo Wang, Nand Chandravadia, Adam N. Mamelak, Ueli Rutishauser
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Neurosciences
Chrystal M. Reed, Clayton P. Mosher, Nand Chandravadia, Jeffrey M. Chung, Adam N. Mamelak, Ueli Rutishauser
JOURNAL OF NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Juri Minxha, Ralph Adolphs, Stefano Fusi, Adam N. Mamelak, Ueli Rutishauser
Article
Medicine, Research & Experimental
Anat Ben-Shlomo, Nan Deng, Evelyn Ding, Masaaki Yamamoto, Adam Mamelak, Vera Chesnokova, Artak Labadzhyan, Shlomo Melmed
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Endocrinology & Metabolism
Julie L. Chan, Kimberly D. Gregory, Sarah S. Smithson, Mariam Naqvi, Adam N. Mamelak
Article
Multidisciplinary Sciences
Zhongzheng Fu, Danielle Beam, Jeffrey M. Chung, Chrystal M. Reed, Adam N. Mamelak, Ralph Adolphs, Ueli Rutishauser
Summary: Monitoring one's own performance is crucial for flexibly achieving desired goals. In this study, single neurons in the human medial frontal cortex were recorded while subjects performed two tasks involving cognitive conflict. The findings suggest that neuronal representations of evaluative signals can be both abstract and task-specific, providing insights into the neuronal mechanism for estimating control demand.
Article
Multidisciplinary Sciences
Tobias Staudigl, Juri Minxha, Adam N. Mamelak, Katalin M. Gothard, Ueli Rutishauser
Summary: The coordination between neural communication in the human amygdala and hippocampus during the free viewing of images is found to be related to the execution of eye movements, especially when fixating on human faces. This suggests that the state of the human medial temporal lobe network is selectively coordinated with motor behavior, with interareal neural communication being facilitated for social stimuli.