期刊
PIGMENT CELL & MELANOMA RESEARCH
卷 24, 期 1, 页码 241-246出版社
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1755-148X.2010.00783.x
关键词
pink-eyed dilution; recessive yellow; agouti; melanocyte; eumelanin; pheomelanin
资金
- Japan Society for the Promotion of Science [14570829, 16591122, 18591262, 20591357]
- Grants-in-Aid for Scientific Research [20591357, 18591262, 14570829, 16591122] Funding Source: KAKEN
P>The mouse pink-eyed dilution (p) locus is known to control eumelanin synthesis, melanosome morphology, and tyrosinase activity in melanocytes. However, it has not been fully determined whether the mutant allele, p affects pheomelanin synthesis. Effects of the p allele on eumelanin and phemelanin synthesis were investigated by chemical analysis of dorsal hairs of 5-week-old mice obtained from the F(2) generations (black, pink-eyed black, recessive yellow, pink-eyed recessive yellow, agouti, and pink-eyed agouti) between C57BL/10JHir (B10)-congenic pink-eyed black mice (B10-p/p) and recessive yellow (B10-Mc1re/Mc1re) or agouti (B10-A/A) mice. The eumelanin content was dramatically (> 20-fold) decreased in pink-eyed black and pink-eyed agouti mice, whereas the pheomelanin content did not decrease in pink-eyed black, pink-eyed recessive yellow, or pink-eyed agouti mice compared to the corresponding P/- mice. These results suggest that the pink-eyed dilution allele greatly inhibits eumelanin synthesis, but not pheomelanin synthesis.
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