期刊
PIGMENT CELL & MELANOMA RESEARCH
卷 22, 期 6, 页码 724-739出版社
WILEY
DOI: 10.1111/j.1755-148X.2009.00627.x
关键词
Ror2; Wnt5A; melanoma; metastasis; endosome; clathrin
资金
- Intramural Research Program of the National Institute on Aging
P>The interplay between canonical and non-canonical Wnt pathways in development and tumorigenesis is tightly regulated. In this review we will describe the yin and the yang of canonical and non-canonical Wnt signaling pathways during melanocyte development, and melanoma genesis. Canonical Wnt signaling, represented by Wnts such as Wnt1 and Wnt3A, signals via beta-catenin to promote melanocyte differentiation and tumor development. Non-canonical Wnt signaling, specifically Wnt5A, regulates canonical pathways, and signals to induce melanoma metastasis. This review will focus on the role of Wnt5A during melanoma progression, and its relationship to canonical Wnt signaling.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据