Article
Oncology
Revati Darp, Craig Ceol
Summary: Melanoma, originating from the melanocyte lineage, is the most aggressive and lethal form of skin cancer. Genetic, genomic, and cellular changes are associated with melanoma initiation, affecting the melanoma cells of origin and promoting melanomagenesis.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Review
Dermatology
Megan H. Trager, Larisa J. Geskin, Faramarz H. Samie, Liang Liu
Summary: The rates of melanoma and non-melanoma skin cancer in the United States have been increasing due to increased ultraviolet radiation exposure. However, skin cancer prevention remains challenging due to the lack of reliable risk assessment methods. There has been significant interest in developing biomarkers for UV exposure in order to improve early detection of skin malignancies.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Cell Biology
Sara E. DiNapoli, Raul Martinez-McFaline, Hao Shen, Ashley S. Doane, Alexendar R. Perez, Akanksha Verma, Amanda Simon, Isabel Nelson, Courtney A. Balgobin, Caitlin T. Bourque, Jun Yao, Renuka Raman, Wendy Beguelin, Jonathan H. Zippin, Olivier Elemento, Ari M. Melnick, Yariv Houvras
Summary: Perturbations to the epigenome are known drivers of tumorigenesis. This study used a melanoma model to demonstrate the critical roles of histone methyltransferases in melanoma formation and innate immune response.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Dermatology
M. Lotz, T. Budden, S. J. Furney, A. Viros
Summary: This study establishes a mathematical approach using melanoma mutational data to analyze how sex and age shape the tumor genome. The results show that melanoma is primarily driven by cell-intrinsic age-related mutations and extrinsic ultraviolet radiation-induced mutations, with differences in magnitude and chronology by sex in distinct molecular subtypes. Sex and age play a role in determining the final mutational composition of melanoma.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Brandon M. Murphy, Elizabeth M. Terrell, Venkat R. Chirasani, Tirzah J. Weiss, Rachel E. Lew, Andrea M. Holderbaum, Aastha Dhakal, Valentina Posada, Marie Fort, Michael S. Bodnar, Leiah M. Carey, Min Chen, Craig J. Burd, Vincenzo Coppola, Deborah K. Morrison, Sharon L. Campbell, Christin E. Burd
Summary: In this study, the authors use conditional mouse models to investigate the molecular mechanisms underlying the enrichment of specific NRAS mutants in human melanoma. They find that different tumor types exhibit distinct profiles of NRAS mutants, suggesting mutagenic events or functional differences may contribute to the profiles. The study also identifies molecular interactions that enhance the binding affinity of melanomagenic NRAS mutants and their signaling pathways.
NATURE COMMUNICATIONS
(2022)
Article
Public, Environmental & Occupational Health
Reza Ghiasvand, Leon A. M. Berge, Bettina K. Andreassen, Jo S. Stenehjem, Trond Heir, Oystein Karlstad, Asta Juzeniene, Inger K. Larsen, Adele C. Green, Marit B. Veierod, Trude E. Robsahm
Summary: This nationwide study suggests a weak association between the use of antihypertensives and melanoma risk, with no dose-response relationship and no interaction with ambient ultraviolet radiation.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Bo Zhou, Jayati Basu, Hasan Raza Kazmi, Kumaraswamy Naidu Chitrala, Xuan Mo, Sarah Preston-Alp, Kathy Q. Q. Cai, Dietmar Kappes, M. Raza Zaidi
Summary: This study provides in vivo evidence that IFNG signaling may have tumor-promoting effects in melanoma by modulating the immune cell composition of the tumor microenvironment.
Article
Public, Environmental & Occupational Health
Flavie Perrier, Reza Ghiasvand, Simon Lergenmuller, Trude E. Robsahm, Adele C. Green, Kristin B. Borch, Torkjel M. Sandanger, Elisabete Weiderpass, Corina S. Rueegg, Marit B. Veierod
Summary: This study investigated the associations between physical activity (PA), UV radiation (UVR), and melanoma risk in Norwegian women, finding an inverse association between overall PA and sunburns, as well as a positive association with sunbathing vacations and indoor tanning. Overall PA was not associated with melanoma risk in all body sites combined, but reduced risk was found for upper limb melanomas.
PREVENTIVE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Mike Climstein, Brendan Doyle, Michael Stapelberg, Nedeljka Rosic, Isolde Hertess, James Furness, Vini Simas, Joe Walsh
Summary: The prevalence of pre-skin cancer, non-melanoma skin cancers, and melanoma skin cancers in Australian surfers and swimmers was found to be higher than the general population. These findings emphasize the importance of regular skin cancer screenings for individuals who engage in surfing or swimming activities, as well as the need for sun protection strategies to reduce the risk of skin cancer.
Review
Dermatology
Gennie L. Parkman, Mona Foth, David A. Kircher, Sheri L. Holmen, Martin McMahon
Summary: Phosphatidylinositol-3'-kinases (PI3Ks) are a family of lipid kinases that regulate various biological processes by phosphorylating inositol ring of phosphatidylinositides. Activation of PI3K leads to accumulation of PI3K-lipids, which play important roles in cell growth, death, and metabolism. In cancers, aberrant activation of PI3K pathway cooperates with other protein kinases to promote tumor progression and metastasis.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Genetics & Heredity
Yoon-Seob Kim, Minho Lee, Yeun-Jun Chung
Summary: Two mutational signatures were identified in cutaneous melanomas, dividing them into two clusters with distinct characteristics. The UV signature was found to be the most significant prognostic factor.
FRONTIERS IN GENETICS
(2022)
Article
Agronomy
Petronia Carillo, Christophe El-Nakhel, Veronica De Micco, Maria Giordano, Antonio Pannico, Stefania De Pascale, Giulia Graziani, Alberto Ritieni, Georgios A. Soteriou, Marios C. Kyriacou, Youssef Rouphael
Summary: This study investigates how different LED lighting systems can affect the phenotype and secondary metabolites of parsley microgreens. The results show that RGB light treatment alters the plant's morphology and increases secondary metabolite content. Red light leads to the highest yield, petiole length, and coumaric acid content. Plants under RGB light have the highest dry matter percentage and polyphenol content, while blue light results in the highest ascorbic acid and ABTS antioxidant activity. The specific spectral band not only modifies the metabolic profile but also impacts the differentiation of mesophyll cells. Light quality plays an essential role in shaping the final product of parsley microgreens in terms of yield, quality, and morpho-anatomical aspects.
Review
Oncology
Raj P. Fadadu, Maria L. Wei
Summary: The incidence of cutaneous melanoma is increasing worldwide, and it is a major contributor to skin cancer mortality. UVA radiation has negative effects on melanocytes and studies have shown a positive association between UVA exposure and melanoma.
Article
Materials Science, Multidisciplinary
Xiaoyi Huang, Huihui Cheng, Wei Luo, Weida Zhang, Min Jiang, Changsheng Yang, Tao Yu, Zhiping Cai, Zuowei Xu, Xuewen Shu, Zhongmin Yang, Jianrong Qiu, Shifeng Zhou
Summary: A compact all-fiber laser capable of lasing beyond 1630 nm is proposed and demonstrated using an Er-activated hybridized glass fiber. The hybridized fiber forms various distinct structure units, leading to notable inhomogeneous spectral broadening. A tunable fiber laser device is constructed with this fiber, allowing rational tuning of wavelength in the range from 1609 to 1631 nm, and a new fiber sensor system based on this rarely explored waveband is successfully demonstrated for efficient ethylene detection.
ADVANCED OPTICAL MATERIALS
(2021)
Article
Physics, Multidisciplinary
Hui Li, Haigang Liu, Yangfeifei Yang, Ruifeng Lu, Xianfeng Chen
Summary: In this study, perfect vector beams were generated in the ultraviolet region using nonlinear frequency conversion, and the radius of the generated beams remained invariant and independent of the topological charge. This provides a new method for generating ultraviolet beams and promotes their potential applications in optical trapping and optical communication.
CHINESE PHYSICS LETTERS
(2022)
Correction
Biochemistry & Molecular Biology
Ilaria Palmisano, Paola Bagnato, Angela Palmigiano, Giulio Innamorati, Giuseppe Rotondo, Domenico Altimare, Consuelo Venturi, Elena V. Sviderskaya, Rosanna Piccirillo, Massimiliano Coppola, Valeria Marigo, Barbara Incerti, Andrea Ballabio, Enrico M. Surace, Carlo Tacchetti, Dorothy C. Bennett, Maria Vittoria Schiaffino
HUMAN MOLECULAR GENETICS
(2017)
Letter
Dermatology
Jaskaren S. Kohli, Elena Tolomio, Simona Frigerio, Andrea Maurichi, Monica Rodolfo, Dorothy C. Bennett
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Himangi G. Marathe, Dawn E. Watkins-Chow, Matthias Weider, Alana Hoffmann, Gaurav Mehta, Archit Trivedi, Shweta Aras, Tupa Basuroy, Aanchal Mehrotra, Dorothy C. Bennett, Michael Wegner, William J. Pavan, Ivana L. de la Serna
NUCLEIC ACIDS RESEARCH
(2017)
Article
Oncology
Barbara Hernando, Viki B. Swope, Steven Guard, Renny J. Starner, Kevin Choi, Ayesha Anwar, Pamela Cassidy, Sancy Leachman, Ana Luisa Kadekaro, Dorothy C. Bennett, Zalfa A. Abdel-Malek
PIGMENT CELL & MELANOMA RESEARCH
(2019)
Article
Clinical Neurology
Emma J. Norton, Leslie R. Bridges, Lawrence C. Kenyon, Margaret M. Esiri, Dorothy C. Bennett, Atticus H. Hainsworth
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2019)
Review
Biochemistry & Molecular Biology
Vassilis Gorgoulis, Peter D. Adams, Andrea Alimonti, Dorothy C. Bennett, Oliver Bischof, Cleo Bishop, Judith Campisi, Manuel Collado, Konstantinos Evangelou, Gerardo Ferbeyre, Jesus Gil, Eiji Hara, Valery Krizhanovsky, Diana Jurk, Andrea B. Maier, Masashi Narita, Laura Niedernhofer, Joao F. Passos, Paul D. Robbins, Clemens A. Schmitt, John Sedivy, Konstantinos Vougas, Thomas von Zglinicki, Daohong Zhou, Manuel Serrano, Marco Demaria
Article
Oncology
Andrea Maurichi, Rosalba Miceli, Hanna Eriksson, Julia Newton-Bishop, Jeremie Nsengimana, May Chan, Andrew J. Hayes, Kara Heelan, David Adams, Roberto Patuzzo, Francesco Barretta, Gianfranco Gallino, Catherine Harwood, Daniele Bergamaschi, Dorothy Bennett, Konstantinos Lasithiotakis, Paola Ghiorzo, Bruna Dalmasso, Ausilia Manganoni, Francesca Consoli, Ilaria Mattavelli, Consuelo Barbieri, Andrea Leva, Umberto Cortinovis, Vittoria Espeli, Cristina Mangas, Pietro Quaglino, Simone Ribero, Paolo Broganelli, Giovanni Pellacani, Caterina Longo, Corrado Del Forno, Lorenzo Borgognoni, Serena Sestini, Nicola Pimpinelli, Sara Fortunato, Alessandra Chiarugi, Paolo Nardini, Elena Morittu, Antonio Florita, Mara Cossa, Barbara Valeri, Massimo Milione, Giancarlo Pruneri, Odysseas Zoras, Andrea Anichini, Roberta Mortarini, Mario Santinami
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Letter
Oncology
Andrea Maurichi, Rosalba Miceli, Hanna Eriksson, Julia Newton-Bishop, Jeremie Nsengimana, May Chan, Andrew J. Hayes, Kara Heelan, David Adams, Roberto Patuzzo, Francesco Barretta, Gianfranco Gallino, Catherine Harwood, Daniele Bergamaschi, Dorothy Bennett, Konstantinos Lasithiotakis, Paola Ghiorzo, Bruna Dalmasso, Ausilia Manganoni, Francesca Consoli, Ilaria Mattavelli, Consuelo Barbieri, Andrea Leva, Umberto Cortinovis, Vittoria Espeli, Cristina Mangas, Pietro Quaglino, Simone Ribero, Paolo Broganelli, Giovanni Pellacani, Caterina Longo, Corrado Del Forno, Lorenzo Borgognoni, Serena Sestini, Nicola Pimpinelli, Sara Fortunato, Alessandra Chiarugi, Paolo Nardini, Elena Morittu, Antonio Florita, Mara Cossa, Barbara Valeri, Massimo Milione, Giancarlo Pruneri, Odysseas Zoras, Andrea Anichini, Roberta Mortarini, Mario Santinami
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Oncology
Andrea Maurichi, Rosalba Miceli, Roberto Patuzzo, Francesco Barretta, Gianfranco Gallino, Ilaria Mattavelli, Consuelo Barbieri, Andrea Leva, Umberto Cortinovis, Elena Tolomio, Milena Sant, Gianpiero Castelli, Leonardo Zichichi, Giovanni Pellacani, Ignazio Stanganelli, Marco Simonacci, Ausilia Manganoni, Corrado Del Forno, Gioachino Caresana, Catherine Harwood, Daniele Bergamaschi, Konstantinos Lasithiotakis, Dorothy Bennett, Vittoria Espeli, Cristina Mangas, Sandra Leoni Parvex, Barbara Valeri, Mara Cossa, Marta Barisella, Alessandro Pellegrinelli, Claudia Miranda, Andrea Anichini, Roberta Mortarini, Odysseas Zoras, Mario Santinami
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2020)
Article
Cell Biology
Linh Le, Iliana E. Escobar, Tina Ho, Ariel J. Lefkovith, Emily Latteri, Kirk D. Haltaufderhyde, Megan K. Dennis, Lynn Plowright, Elena Sviderskaya, Dorothy C. Bennett, Elena Oancea, Michael S. Marks
MOLECULAR BIOLOGY OF THE CELL
(2020)
Article
Oncology
Idoya Martinez-Vicente, Marta Abrisqueta, Cecilia Herraiz, Julia Sires-Campos, Maria Castejon-Grinan, Dorothy C. Bennett, Conchi Olivares, Jose Carlos Garcia-Borron, Celia Jimenez-Cervantes
Article
Cell Biology
Shanna L. Bowman, Linh Le, Yueyao Zhu, Dawn C. Harper, Anand Sitaram, Alexander C. Theos, Elena Sviderskaya, Dorothy C. Bennett, Graca Raposo-Benedetti, David J. Owen, Megan K. Dennis, Michael S. Marks
Summary: The vSNARE VAMP7 is sorted into transport carriers in complex with the tSNARE STX13, with sorting requiring recognition by either AP-3 delta or pallidin subunit of BLOC-1, but not both. This mechanism allows for redundant recognition of sorting determinants on a SNARE complex by an AP-3-BLOC-1 super-complex.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Julia Sires-Campos, Ana Lambertos, Cedric Delevoye, Graca Raposo, Dorothy C. Bennett, Elena Sviderskaya, Celia Jimenez-Cervantes, Conchi Olivares, Jose Carlos Garcia-Borron
Summary: The absence of MGRN1 leads to cell-autonomous stimulation of pigment production in melanocytes by increasing tyrosinase activity through neutralizing melanosomal pH. Regulating melanosomal pH may involve several key genes such as subunits of V-ATPase and Mucolipin 3.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jiyoung Lee, Yeonjoo Kim, Paris Ataliotis, Hyung-Goo Kim, Dae-Won Kim, Dorothy C. Bennett, Nigel A. Brown, Lawrence C. Layman, Soo-Hyun Kim
Summary: WDR11 is an important gene associated with Kallmann syndrome and plays a role in reproductive system development. Its molecular mechanism is not fully understood. In this study, we found that WDR11 is required for the development of primordial germ cells (PGCs) by regulating both canonical and noncanonical Hedgehog signaling pathways. Loss of WDR11 affects PGC motility and proliferation through the noncanonical pathway, and also modulates the growth of somatic cells surrounding PGCs through the canonical pathway. We further discovered that WDR11 regulates ciliogenesis and interacts with IFT20 to regulate anterograde intraflagellar transport.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Julia K. Soo, Joanna T. Castle, Dorothy C. Bennett
Summary: This study reports the discovery of a synthetic peptide that can selectively kill human melanoma cells while being less toxic to normal cells. The peptide is derived from the target-binding site of the melanoma suppressor protein p16 and can induce apoptosis through a different pathway. The peptide also shows varying toxicity to other types of cancer cells.