Article
Endocrinology & Metabolism
Yunpeng Guan, Xiaoyu Hou, Peipei Tian, Luping Ren, Yong Tang, An Song, Jiajun Zhao, Ling Gao, Guangyao Song
Summary: The study investigated mechanisms of postprandial hypertriglyceridemia (PPT) through analyzing serum lipid and apolipoprotein levels before and after a high-fat meal. Results showed significantly higher levels of various parameters in the PPT group, indicating that elevated ApoCIII levels may be a risk factor for PPT.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kristen M. Gonzales, Leslie J. Donato, Pankaj Shah, Vinaya Simha
Summary: This study aimed to examine advanced lipoprotein profiles of hypertriglyceridemic patients with HTGP, in order to identify lipid and lipoprotein parameters that may help improve risk stratification. The results suggest that measuring serum apoB levels and calculating serum TG/apoB ratio could aid in identifying hypertriglyceridemic patients at risk for HTGP.
JOURNAL OF CLINICAL LIPIDOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Linda May-Zhang, Min Liu, Dennis Black, Patrick Tso
Summary: The discovery of APOA5 has raised questions about its role in lipid transport and TG homeostasis. APOA5 has been identified as a regulator of plasma TG levels and may also affect postprandial TG metabolism through influencing chylomicron formation and transport. Mysteries remain on how this liver-derived protein modulates TG homeostasis, especially via the gut.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Pharmacology & Pharmacy
Piao-Piao Huang, Wen-Qiang Zhu, Jing-Mei Xiao, Yi-Qi Zhang, Rong Li, Yang Yang, Li Shen, Fei Luo, Wen Dai, Ping-An Lian, Ya-Xin Tang, Juan-Li Ran, Xian-Sheng Huang
Summary: This study investigates the effects and mechanisms of short-term use of olanzapine on circulating triglyceride levels. The results show that short-term use of olanzapine induces hypertriglyceridemia and decreases plasma apoA5 levels. The study also demonstrates that this effect is associated with defects in sorting and secretion of hepatic apoA5 protein. Similar results are obtained in vitro experiments.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Health Care Sciences & Services
Zunaira Ali Baig, Amir Rashid, Asifa Majeed, Zahra Masood, Asma Faryal, Zahra Arshad Khan, Aden Razaq
Summary: This study assessed lipid abnormalities in newly diagnosed diabetics and non-diabetics and found that regardless of type 2 diabetes, lipid levels can independently cause derangement, which serves as an early onset indicator rather than a later-stage complication. These derangements of lipid levels are an independent risk factor for future cardiovascular pathology.
Article
Endocrinology & Metabolism
Maria Ramos-Caceres, Itziar Lamiquiz-Moneo, Ana Cenarro, Pilar Calmarza, Victoria Marco-Benedi, Ana M. Bea, Rocio Mateo-Gallego, Jose Puzo, Jose M. Ordovas, Fernando Civeira, Martin Laclaustra
Summary: This study analyzes the relationship between triglycerides (TGs) and lipoprotein(a) (Lp(a)) concentrations. It found an inverse relationship between TG and Lp(a). Larger VLDL size, VLDLs enriched in apoE, and the apoE2/E2 genotype were associated with lower levels of Lp(a).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medical Laboratory Technology
Junji Kobayashi, Takuya Minamizuka, Masaya Koshizaka, Yoshiro Maezawa, Hiraku Ono, Koutaro Yokote
Summary: The study found that serum HDL-C is an extremely useful marker for discriminating LPL deficiency from SHTG in the Japanese population, with high sensitivity and specificity, which can serve as an important indicator of the type of disease in patients.
CLINICA CHIMICA ACTA
(2021)
Review
Multidisciplinary Sciences
Manik Chhabra, Kota Vidyasagar, Sai Krishna Gudi, Jatin Sharma, Rishabh Sharma, Muhammed Rashid
Summary: This study evaluated the efficacy and safety of Saroglitazar in patients with dyslipidemia. The results showed that Saroglitazar effectively reduced low-density lipoprotein cholesterol and total cholesterol without causing adverse effects. This suggests that Saroglitazar is an effective and safe therapeutic option for improving dyslipidemia.
Review
Biochemistry & Molecular Biology
Chih-Kuo Lee, Che-Wei Liao, Shih-Wei Meng, Wei-Kai Wu, Jiun-Yang Chiang, Ming-Shiang Wu
Summary: Despite advancements in pharmacotherapy and intervention devices, residual cardiovascular risks remain a significant burden on public health. Molecular modifications of lipid and lipoprotein components play a critical role in atherogenicity, with levels of certain lipids and proteins closely associated with atherosclerotic cardiovascular disease. Therapies targeting these modifications are showing promising results in trials for reducing risks and enhancing cardiovascular health.
Article
Nutrition & Dietetics
Ewa Wieczorek, Agnieszka Cwiklinska, Agnieszka Kuchta, Barbara Kortas-Stempak, Anna Gliwinska, Maciej Jankowski
Summary: This study aimed to evaluate the impact of hypercholesterolemia and hypertriglyceridemia on the efficiency of lipoprotein lipase-mediated VLDL-triglyceride lipolysis, as well as the role of HDL in this process. The results showed that VLDL from patients with hypercholesterolemia and hypertriglyceridemia are more resistant to lipolysis, with HDL helping to enhance the efficiency of lipolysis in these groups.
Article
Medicine, General & Internal
Kajeen Hussein, Sherwan Salih, Dhia Al-Timimi
Summary: This study investigated the frequency of LPL -Hind lll and APO Cll-Ava ll gene polymorphism among Kurdish patients with severe hypertriglyceridemia.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Genovefa Kolovou, Vana Kolovou, Niki Katsiki
Summary: Familial chylomicronemia syndrome (FCS) is a rare inherited disease caused by lipoprotein lipase (LPL) gene mutations. Volanesorsen, a second-generation 2'-O-methoxyethyl (2'-MOE) chimeric antisense therapeutic oligonucleotide, has shown efficacy in reducing plasma apolipoprotein C3 and triglycerides (TG) levels in FCS patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Shuping Wang, Yiping Cheng, Yingzhou Shi, Wanyi Zhao, Ling Gao, Li Fang, Xiaolong Jin, Xiaoyan Han, Qiuying Sun, Guimei Li, Jiajun Zhao, Chao Xu
Summary: This study identified two novel compound heterozygous variants of LPL, which resulted in defects in the expression and function of LPL and caused type I hyperlipoproteinemia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Adrienn Tuennemann-Tarr, Hubert Scharnagl, Julius L. Katzmann, Paulina Stuerzebecher, Ulrich Laufs
Summary: Familial chylomicronemia syndrome is a genetic disorder associated with increased risk of acute pancreatitis due to severe hypertriglyceridemia. In this case report, treatment with the apoCIII inhibitor volanesorsen significantly reduced serum triglyceride levels in a patient with this syndrome, demonstrating good tolerability and potential efficacy for managing the condition.
Article
Cardiac & Cardiovascular Systems
Denis Sviridov, Amaury Dasseux, Mart Reimund, Milton Pryor, Steven K. Drake, Zack Jarin, Anna Wolska, Richard W. Pastor, Alan T. Remaley
Summary: A new generation of ApoC2 mimetic peptides based on hydrocarbon stapling and amino acid substitutions have been developed in this study. These peptides effectively lower plasma triglycerides and are shorter and more resistant to proteolysis compared to earlier peptides, which makes them a potential new therapy for hypertriglyceridemia.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Neurosciences
Stephanie S. Chassen, Veronique Ferchaud-Roucher, Claire Palmer, Cun Li, Thomas Jansson, Peter W. Nathanielsz, Theresa L. Powell
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Biochemistry & Molecular Biology
Theresa L. Powell, Kelsey Barner, Lana Madi, Michael Armstrong, Jonathan Manke, Charis Uhlson, Thomas Jansson, Veronique Ferchaud-Roucher
Summary: Maternal obesity affects placental metabolism and transport of fatty acids, leading to reduced DHA in male fetuses and altered esterification enzymes in female placentas. These differences may contribute to neurological consequences in male children and impaired lipid transfer in female placentas of obese mothers.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Kevin Chemello, Ali K. Jaafar, Gilles Lambert
EUROPEAN HEART JOURNAL
(2021)
Article
Nutrition & Dietetics
Fatima Kasbi-Chadli, Marine Coue, Audrey Aguesse, Isabelle Grit, Thomas Souque, Veronique Ferchaud-Roucher, Khadija Ouguerram
Summary: The study investigated the effects of Spirulysat(R), a Spirulina liquid extract enriched in phycocyanin, on metabolic abnormalities induced by high-fat diet. The findings showed that acute SLE supplementation reduced plasma cholesterol and non-esterified fatty acid concentrations without affecting triglyceridemia. Chronic SLE supplementation protected against hyperglycemia and lipid accumulation in the liver and aorta, indicating a potential protective effect against metabolic syndrome.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Letter
Clinical Neurology
Brice Nativel, Stephane Ramin-Mangata, David Couret, Cynthia Planesse, Mathias Roche, Antonio Gallo, Olivier Meilhac, Gilles Lambert, Steeve Bourane
Article
Biochemistry & Molecular Biology
Kepa B. Uribe, Kevin Chemello, Asier Larrea-Sebal, Asier Benito-Vicente, Unai Galicia-Garcia, Steeve Bourane, Ali K. Jaafar, Gilles Lambert, Cesar Martin
Summary: Research shows that GOF mutations of the PCS9 gene lead to familial hypercholesterolemia, while LOF mutations are associated with reduced cholesterol levels. By studying the effects of different PCS9 variants on LDLR expression and affinity through transient transfections of HEK293 and HepG2 cells, it is possible to reliably determine their GOF or LOF status.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Peripheral Vascular Disease
Kevin Chemello, Dirk J. Blom, A. David Marais, Gilles Lambert, Valentin Blanchard
Summary: Lp(a) is a highly atherogenic lipoprotein species with strong genetic determination of its concentration. The APOE gene, in addition to the LPA gene, plays an important role in modulating Lp(a) concentrations. Carriers of the APOE2 variant display lower Lp(a) levels, but this does not significantly affect circulating Lp(a). Mechanistically, apoE appears to affect the production, but not the catabolism, of Lp(a).
CURRENT ATHEROSCLEROSIS REPORTS
(2022)
Article
Neurosciences
Owen R. Vaughan, Fredrick J. Rosario, Jeannie Chan, Laura A. Cox, Veronique Ferchaud-Roucher, Karin A. Zemski-Berry, Jane E. B. Reusch, Amy C. Keller, Theresa L. Powell, Thomas Jansson
Summary: Obesity in pregnant women can lead to cardiac dysfunction in the fetus and increase the risk of cardiovascular disease for their offspring. This research shows that maternal obesity induces hypertrophy in the fetal heart of mice and alters the expression of genes related to nutrient metabolism. Maternal obesity also affects the metabolism of carbohydrates and lipids in adult offspring. The results suggest that excessive nutrition during pregnancy may contribute to increased cardiovascular disease risk in children of obese mothers.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Pediatrics
Alice Kuster, Mikael Croyal, Thomas Moyon, Dominique Darmaun, Khadija Ouguerram, Veronique Ferchaud-Roucher
Summary: This study found that very preterm infants born with low birth weight have altered lipidome and apolipoprotein profiles, which may contribute to impaired neurodevelopment and increased cardiovascular risk. The findings have important implications for nutritional strategies in premature infants.
PEDIATRIC RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Florian Kronenberg, Samia Mora, Erik S. G. Stroes, Brian A. Ference, Benoit J. Arsenault, Lars Berglund, Marc R. Dweck, Marlys Koschinsky, Gilles Lambert, Francois Mach, Catherine J. McNeal, Patrick M. Moriarty, Pradeep Natarajan, Borge G. Nordestgaard, Klaus G. Parhofer, Salim S. Virani, Arnold von Eckardstein, Gerald F. Watts, Jane K. Stock, Kausik K. Ray, Lale S. Tokgozoglu, Alberico L. Catapano
Summary: This consensus statement provides updated evidence on the role of Lp(a) in ASCVD and aortic valve stenosis, and offers clinical guidance on testing and treating elevated Lp(a) levels.
EUROPEAN HEART JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Alexandra K. Suchowerska, Geurt Stokman, James T. Palmer, Phillip A. Coghlan, Elsbet J. Pieterman, Nanda Keijzer, Gilles Lambert, Kevin Chemello, Ali K. Jaafar, Jasneet Parmar, Liping Yan, Yingtao Tong, Lin Mu, Hans M. G. Princen, James Bonnar, Benny J. Evison
Summary: This study reported the discovery of an orally bioavailable small-molecule inhibitor of PCSK9 called NYX-PCSK9i, which demonstrated significant cholesterol-lowering activity in hyperlipidemic APOE*3-Leiden.CETP mice. NYX-PCSK9i has the potential to be a new therapy for hypercholesterolemia and can enhance the lipid-lowering activities of statins.
JOURNAL OF LIPID RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Ali K. Jaafar, Romuald Techer, Kevin Chemello, Gilles Lambert, Steeve Bourane
Summary: This article comprehensively reviews the role of PCSK9 in lipid metabolism and cardiovascular health, as well as its potential roles in the central and peripheral nervous systems. It focuses particularly on its involvement in cerebrovascular and neurodegenerative diseases.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Endocrinology & Metabolism
Theresa L. Powell, Charis Uhlson, Lana Madi, Karin Zemski Berry, Stephanie S. Chassen, Thomas Jansson, Veronique Ferchaud-Roucher
Summary: Our study revealed that obesity affects the levels of DHA-containing plasmalogen and ether lipids differently in male and female fetuses. Female placentas demonstrate better adaptability to maintain optimal DHA transfer to fetuses in obesity, while male placentas show decreased levels of DHA-containing lipid species.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Biochemistry & Molecular Biology
Elena Silva, Veronique Ferchaud-Roucher, Anita Kramer, Lana Madi, Priyadarshini Pantham, Stephanie Chassen, Thomas Jansson, Theresa L. Powell
Summary: Normal fetal development depends on optimal nutrient supply by the placenta, and placental amino acid transport is positively associated with fetal growth. This study investigated the interaction between oleic acid (OA) and mechanistic target of rapamycin (mTOR) in primary human trophoblast (PHT) cells. The findings suggest that OA stimulates mTOR and amino acid transport in PHT cells through de novo synthesis of phosphatidic acid (PA). This lipid sensing mechanism is crucial for placental functions and nutrient transfer to the fetus.
Article
Cardiac & Cardiovascular Systems
Kevin Chemello, Sandra Beeske, Thi Thu Trang Tran, Valentin Blanchard, Elise F. Villard, Bruno Poirier, Jean-Christophe Le Bail, Gihad Dargazanli, Sophie Ho-Van-Guimbal, Denis Boulay, Olivier Bergis, Marie-Pierre Pruniaux, Mikael Croyal, Philip Janiak, Etienne Guillot, Gilles Lambert
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2020)