期刊
PHYTOTHERAPY RESEARCH
卷 28, 期 5, 页码 692-698出版社
WILEY
DOI: 10.1002/ptr.5044
关键词
American skullcap; Scutellaria lateriflora; phytotherapy; anxiety; mood states; clinical trial
资金
- University of Westminster's Institute of Health and Wellbeing
- Institute of Health and Wellbeing [HERT04004865K]
Scutellaria lateriflora, a traditional herbal remedy for stress and anxiety, was tested on human volunteers for its effects on mood. In a placebo-controlled, double-blind, crossover study, 43 healthy participants were randomised to a sequence of three times daily S. lateriflora (350 mg) or placebo, each over two weeks. In this relatively non-anxious population (81% were mildly anxious or less, i.e. Beck Anxiety Inventory (BAI) scores15), there was no significant difference between skullcap and placebo with BAI (p=0.191). However, there was a significant group effect (p=0.049), suggesting a carryover effect of skullcap. For Total Mood Disturbance measured by the Profile of Mood States, there was a highly significant (p=<0.001) decrease from pre-test scores with skullcap but not placebo (p=0.072). The limitations of carryover effect, generally low anxiety scores and differences in anxiety levels between groups at baseline (p=0.022), may have reduced the chances of statistical significance in this study. However, as S. lateriflora significantly enhanced global mood without a reduction in energy or cognition, further study assessing its putative anxiolytic effects in notably anxious subjects with co-morbid depression is warranted. Copyright (c) 2013 John Wiley & Sons, Ltd.
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