Article
Biochemistry & Molecular Biology
Kelly J. Peyton, Ghazaleh Behnammanesh, Giovanna L. Durante, William Durante
Summary: Research shows that canagliflozin can act as a novel inducer of HO-1 in human ECs. While HO-1 contributes to the anti-inflammatory action, it does not affect the anti-proliferative and antimigratory effects of the drug.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Seto
Summary: Ageing is a risk factor for degenerative diseases, including cardiovascular diseases. The tumor suppressor gene p53 may play a regulatory role in vascular remodeling, atherosclerosis, and pulmonary hypertension. Further studies are needed to fully understand the effects of p53 in cardiovascular function and its therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiulin Yang, An Chen, Qingchun Liang, Qianqian Dong, Mingwei Fu, Xiaoyu Liu, Siyi Wang, Yining Li, Yuanzhi Ye, Zirong Lan, Jing-Song Ou, Lihe Lu, Jianyun Yan
Summary: Celastrol effectively inhibits vascular calcification and osteogenic differentiation by suppressing oxidative stress and up-regulating the protein levels of HMOX-1. Modulation of HMOX-1 may provide a novel strategy for the treatment of vascular calcification in CKD.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Dan Shan, Ping Qu, Chao Zhong, Luling He, Qingshan Zhang, Guoyue Zhong, Wenhui Hu, Yulin Feng, Shilin Yang, Xiao-feng Yang, Jun Yu
Summary: This study identified Anemoside B4 as a potential therapeutic agent that regulates vascular smooth muscle cell plasticity and inhibits restenosis after vascular intervention.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Bing Zhou, Nan Wu, Yuan Yan, Lu-Lu Wu, Guo-Qing Zhu, Xiao-Qing Xiong
Summary: This study demonstrates that the upregulation of miR-31-5p and the downregulation of FNDC5 contribute to Ang II-induced VSMC proliferation and migration.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hui-Hsuan Lin, Ming-Chang Hsieh, Chi-Ping Wang, Pei-Rong Yu, Ming-Shih Lee, Jing-Hsien Chen
Summary: In this study, GTIN was found to inhibit VSMCs proliferation and migration, reduce ROS generation, and potentially play a role in controlling atherosclerosis and other cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Wangsheng Jiang, Wenfeng Ruan, Zhengqiang Wang
Summary: This study found that Dendrobium officinale polysaccharide (DOP) can alleviate vascular calcification in patients with chronic kidney disease (CKD) by suppressing inflammation and apoptosis through the activation of heme oxygenase-1 (HMOX-1). These results provide a promising treatment approach for vascular calcification in CKD.
Article
Cell Biology
Ying Tong, Jinyan Kai, Shuo Wang, Yiwen Yu, Suhong Xie, Hui Zheng, Yanchun Wang, Yixuan Liu, Keyu Zhu, Xiaolin Guan, Lin Guo, Renquan Lu
Summary: The expression of SIRT4 is reduced in ccRCC and is closely associated with malignancy stage, grade, and prognosis. SIRT4 promotes apoptosis by modulating ROS and HO-1 expression, indicating its potential role as a therapeutic target in VHL-deficient ccRCCs.
CELL DEATH & DISEASE
(2021)
Review
Chemistry, Medicinal
Diem Thi Ngoc Huynh, Kyung-Sun Heo
Summary: Mitochondrial dynamics and mitophagy play crucial roles in regulating VSMC proliferation and migration through different mechanisms, with dynamin-related protein-1 and mitofusion-2 being key molecules in this process.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Yishu Luo, Chen Huang
Summary: The study showed that circSFMBT2 is upregulated in neointimal tissue and PDGF-BB-treated VSMCs, and its knockdown inhibits VSMC proliferation and migration while enhancing the expression of contractile markers. CircSFMBT2 was found to regulate VSMC proliferation and migration through the miR-331/HDAC5/Aggf1 axis, suggesting a potential novel target for treating proliferative vascular diseases.
Article
Oncology
Jingying Liu, Xingbo Long, Hexin Li, Qiuxia Yan, Lu Wang, Ziyu Qin, Hong Zhang
Summary: This study reveals that C1QTNF4 is involved in the migration and proliferation of vascular smooth muscle cells. It inhibits abnormal neointimal formation by downregulating the FAK/PI3K/AKT pathway, thus protecting blood vessels. These findings provide new insights and potential treatments for vascular stenosis diseases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Fen Zheng, Chao Ye, Rui Ge, Yu Wang, Xiao-Lei Tian, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Bing Zhou
Summary: This study demonstrates the important roles of EVs-mediated miR21-3p transfer in promoting VSMC proliferation and migration in SHR and identifies SORBS2 as a target of miR-21-3p in this process.
Review
Biochemistry & Molecular Biology
Jia-Jing Lu, Ayitila Abudukeyoumu, Xing Zhang, Li-Bing Liu, Ming-Qing Li, Feng Xie
Summary: This review summarizes the different effects of HO-1 under normal and diseased conditions, with implications on the diagnosis and treatment of gynecological cancers, suggesting its potential role in cell proliferation, metastasis, immune regulation, and angiogenesis as an oncogene.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Nan Wu, Fen Zheng, Na Li, Ying Han, Xiao-Qing Xiong, Jue-Jin Wang, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Ye-Bo Zhou
Summary: The study revealed that RND3 plays critical roles in attenuating superoxide production, vascular smooth muscle cells migration and proliferation, and vascular remodeling in hypertension by inhibiting ROCK1-NOX1/2 and mitochondria superoxide signaling.
Article
Chemistry, Multidisciplinary
Chao Ye, Ying Tong, Nan Wu, Guo-wei Wan, Fen Zheng, Jing-yu Chen, Jian-zhen Lei, Hong Zhou, Ai-dong Chen, Jue-jin Wang, Qi Chen, Yue-hua Li, Yu-ming Kang, Guo-qing Zhu
Summary: The study demonstrated that miR-135a-5p promotes vascular smooth muscle cell (VSMC) proliferation in spontaneously hypertensive rats (SHRs), while FNDC5 inhibits it. Silencing miR-135a-5p or upregulating FNDC5 could attenuate VSMC proliferation and vascular remodeling in SHRs. These findings suggest that manipulating miR-135a-5p or FNDC5 levels may be a therapeutic strategy for reducing vascular remodeling and hypertension.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Chemistry, Multidisciplinary
Inhyeok Choi, Namho Kim, Yeonho Song, George C. Schatz, Hyonseok Hwang
Summary: An extended version of the kinetic lattice grand canonical Monte Carlo simulation method combined with mean field theory is presented in this article for the study of ion transport through a model nanopore. The extended method is able to handle ternary ion mixtures and incorporates a diffusion probability algorithm to describe the inhomogeneous diffusivity of ions. The performance of different types of polynomials for basis set expansion in the simulation is also compared. The presented method shows potential applications in nanopore systems involving ion correlations and anomalous effects.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Physical
Namho Kim, Ji Hye Lee, Yeonho Song, Jeong-Hyung Lee, George C. C. Schatz, Hyonseok Hwang
Summary: The effect of protonation state of glutamic acid on its translocation through cyclic peptide nanotubes (CPNs) was studied using molecular dynamics simulations. The study found that the protonation state of glutamic acid significantly influenced its transport through CPNs, as determined by the permeability coefficients. The potential of mean force calculations showed that the protonation state resulted in different free energy barriers, while the position-dependent diffusion coefficient profiles showed similar frictional behaviors.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)