Review
Biochemistry & Molecular Biology
Md Faruque Ahmad, Fakhruddin Ali Ahmad, Mohammed Idreesh Khan, Abdulrahman A. Alsayegh, Shadma Wahab, M. Intakhab Alam, Faiyaz Ahmed
Summary: Ganoderma lucidum polysaccharides and triterpenoids are the major bioactive compounds with immunomodulatory and antiviral properties, playing a potential role in preventing and treating various diseases by enhancing the immune system and producing immune responses.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pediatrics
Zuzana Rennerova, Leandro Pico Sirvent, Eva Carvajal Roca, Jaroslaw Pasnik, Mateja Logar, Katarina Milosevic, Juraj Majtan, Milos Jesenak
Summary: Preschool children are prone to recurrent respiratory tract infections (RRTIs) due to their immature immune system. This study assessed the incidence of respiratory tract infections in children with a history of RRTIs who were given pleuran supplementation. The results showed that pleuran supplementation significantly reduced the number and duration of infections compared to the previous year, and it was found to be safe for children.
FRONTIERS IN PEDIATRICS
(2022)
Article
Immunology
Juliana Ochoa-Grullon, Celina Benavente Cuesta, Ataulfo Gonzalez Fernandez, Gustavo Cordero Torres, Cristina Perez Lopez, Ascension Pena Cortijo, Laura Conejero Hall, Marta Mateo Morales, Antonia Rodriguez de la Pena, Carmen M. Diez-Rivero, Edgard Rodriguez de Frias, Kissy Guevara-Hoyer, Miguel Fernandez-Arquero, Silvia Sanchez-Ramon
Summary: The study demonstrates that MV130 can reduce infection rate and enhance humoral immune responses in vulnerable patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Jinghua Cui, Yuanyuan Zhang, Hanqing Zhao, Xuemei Sun, Zhen Chen, Qun Zhang, Chao Yan, Guanhua Xue, Shaoli Li, Yanling Feng, Han Liu, Xianghui Xie, Jing Yuan
Summary: The study found a correlation between the lower respiratory tract microbiome in children and allergic respiratory diseases, with significant differences in microbial composition and distribution, and some bacteria showing correlations with clinical indices.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Karen Leth Nielsen, Marc Stegger, Kristoffer Kiil, Berit Lilje, Karen Ejrnaes, Rikke Fleron Leihof, Line Skjot-Rasmussen, Paul Godfrey, Tor Monsen, Sven Ferry, Anette M. Hammerum, Niels Frimodt-Moller
Summary: This study used a genomic approach to investigate recurrent urinary tract infections, finding limited adaptation and polymorphisms in metabolism genes among recurrent isolates. Though some genes were more common in rUTI isolates, overall, recurrent isolates did not show distinct variation in the core genome compared to non-rUTI isolates.
Review
Biology
Amr S. Abu Lila, Azza A. H. Rajab, Marwa H. Abdallah, Syed Mohd Danish Rizvi, Afrasim Moin, El-Sayed Khafagy, Shams Tabrez, Wael A. H. Hegazy
Summary: Urinary tract infections are a common health care facility-associated infection, and bacteria can survive hostile environments by forming biofilms which provide protection and increase gene transfer. Understanding the role of biofilm formation in recurrent UTIs and finding strategies to eradicate biofilms are crucial for preventing this growing public health concern.
Article
Urology & Nephrology
Monique H. Vaughan, Jialiang Mao, Lisa A. Karstens, Li Ma, Cindy L. Amundsen, Kenneth E. Schmader, Nazema Y. Siddiqui
Summary: The study found associations between anaerobic bacteria in the urinary microbiome and postmenopausal recurrent UTI, suggesting a need for further investigation.
JOURNAL OF UROLOGY
(2021)
Article
Pediatrics
Wenhui Guo, Linghui Meng, Ling Cao
Summary: This study aimed to investigate the relationship between sleep-disordered breathing and malnutrition and the occurrence of recurrent respiratory tract infections (RRTIs) and acute respiratory failure (ARF) in children with spinal muscular atrophy (SMA). The research identified SMA type 1, apnea-hypopnea index (AHI), body mass index z score (BMIz), and mean pulse oxygen saturation (MSpO(2)) as risk factors or protective factors for RRTIs and ARF. Using MSpO(2) < 96% combined with AHI > 10 events/h or BMIz < -1 as an intervention standard, the occurrence of RRTIs and/or ARF in the following year can be predicted.
PEDIATRIC PULMONOLOGY
(2023)
Review
Urology & Nephrology
Mary Zare, Maria J. G. T. Vehreschild, Florian Wagenlehner
Summary: This review discusses the optimal management of recurrent urinary tract infections (UTIs) in women. Women are particularly susceptible to rUTI due to female anatomy, as well as behavioral, genetic, and urological factors. Various non-antibiotic strategies, prophylactic approaches, and emerging experimental treatments like faecal microbiota transfer (FMT) and bacteriophages show promising effects in interrupting the cycle of rUTI. Further clinical research is needed to explore the potential of these novel treatment options for bacterial infections, especially UTIs.
Article
Nutrition & Dietetics
Hongyan Guo, Xiaochen Xiang, Xuan Lin, Qiang Wang, Si Qin, Xinyan Lu, Jiawei Xu, Ying Fang, Yang Liu, Jing Cui, Zhi Li
Summary: The intake of oropharyngeal probiotic ENT-K12 as a dietary intervention can effectively reduce the episodes of respiratory tract infections in children with RRTi, as well as reduce the use of antibiotics and antiviral drugs, and decrease the absence days from school and work. Further studies are needed to confirm its clinical benefits.
FRONTIERS IN NUTRITION
(2022)
Review
Infectious Diseases
David Polo, Alberto Lema, Enia Gandara, Jesus L. Romalde
Summary: Through a systematic review and meta-analysis of 35 studies in Europe, it was found that HBoV has a moderate prevalence among European countries, with no significant differences in prevalence by country. The study also analyzed the prevalence of HBoV as a single infection or co-infection with other viruses.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Review
Immunology
Jonathan Josephs-Spaulding, Thoger Jensen Krogh, Hannah Clara Rettig, Mark Lyng, Mariam Chkonia, Silvio Waschina, Simon Graspeuntner, Jan Rupp, Jakob Moller-Jensen, Christoph Kaleta
Summary: This article discusses the ecological interactions of human urogenital microbial communities, the mechanism of imbalance between microbial ecology and host physiology. A greater understanding of environmental mechanisms and microbial ecology is needed for the treatment and management of UTIs. The use of next generation and systems level methods is recommended to elucidate the systemic consequences of rUTIs.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Infectious Diseases
Elin Dahlen, Julius Collin, Jenny Hellman, Christer Norman, Pontus Naucler, Anders Ternhag
Summary: This study aimed to compare the incidence rate for complications to upper respiratory tract infections (URTIs) and lower urinary tract infections (UTIs) between treated and untreated cases. The results showed that there was no increased risk of complications for untreated URTI cases compared to treated cases. However, for lower UTIs, patients who were not treated with antibiotics had an increased risk of severe infections within 30 days.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Fen Pan, Bingjie Wang, Hong Zhang, Yingying Shi, Qi Xu
Summary: This study enrolled 90 children, among whom 58 patients (64.4%) tested positive for 13 pathogens using FARP, with 18 patients showing multiple-virus infections. Human rhinovirus/enterovirus were most common in infants and toddlers, while adenovirus were common in the 3-5-year-old group. Only three pathogens were found in the 6-14-year-old group.
BMC INFECTIOUS DISEASES
(2021)
Article
Immunology
Ville Forsstroem, Laura Toivonen, Kiara Homil, Matti Waris, Casper-Emil T. Pedersen, Klaus Bonnelykke, Tuomas Jartti, Ville Peltola
Summary: This study found that genetic predisposition to childhood asthma is associated with early respiratory tract infections, particularly in the 17q21 and CDHR3 genes. Multiple asthma risk alleles are also associated with viral respiratory infections and asthma. Therefore, non-wheezing and wheezing respiratory infections and asthma may share common genetic risk factors.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Rheumatology
K. Granak, M. Jesenak, Matej Vnucak, P. Skalova, L. Laca, M. Mokan, I. Dedinska
Summary: Renal AA amyloidosis is the most serious complication of periodic fever syndrome, with most cases manifesting in early childhood. Occurrence in adults is rare and may have a poorer clinical course. Kidney transplantation is an effective treatment for end-stage chronic kidney disease based on AA amyloidosis, with early diagnosis and treatment crucial for protecting the graft from amyloid deposition.
CLINICAL RHEUMATOLOGY
(2021)
Review
Respiratory System
Khalid Abd-Elaziz, Milos Jesenak, Martina Vasakova, Zuzana Diamant
Summary: Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteases with various biological and pathological activities. Increased levels of MMP-12 have been associated with inflammation and structural changes in the lungs in conditions such as asthma, COPD, and pulmonary fibrosis. Targeting MMP-12 may provide further insights into disease mechanisms and potential therapeutic strategies, but further research is needed to fully understand its role in these pulmonary diseases.
CURRENT OPINION IN PULMONARY MEDICINE
(2021)
Letter
Allergy
Milan Terl, Milos Jesenak
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Multidisciplinary Sciences
Peter Liptak, Peter Banovcin, Robert Rosolanka, Michal Prokopic, Ivan Kocan, Ivana Ziacikova, Peter Uhrik, Marian Grendar, Rudolf Hyrdel
Summary: This study aimed to assess gastrointestinal and liver-related predictive factors for the risk of hospitalization associated with SARS-CoV-2. Through data collection and analysis using statistical methods and machine learning algorithms, the study identified factors such as AST as important predictors for COVID-19 hospitalizations.
Review
Biochemistry & Molecular Biology
Jacob A. Bauer, Monika Zamocka, Juraj Majtan, Vladena Bauerova-Hlinkova
Summary: Glucose oxidase (GOx) is a significant enzyme with important roles in biological processes. It is known for its fast mechanism of action, high stability, specificity, and antimicrobial effect. This review provides a summary of the structure, function, production strains, and biophysical and biochemical properties of GOx, as well as its applications in various industries and medical fields.
Article
Food Science & Technology
Eleni Tsavea, Fotini-Paraskevi Vardaka, Elisavet Savvidaki, Abdessamie Kellil, Dimitrios Kanelis, Marcela Bucekova, Spyros Grigorakis, Jana Godocikova, Panagiota Gotsiou, Maria Dimou, Sophia Loupassaki, Ilektra Remoundou, Christina Tsadila, Tilemachos G. Dimitriou, Juraj Majtan, Chrysoula Tananaki, Eleftherios Alissandrakis, Dimitris Mossialos
Summary: This study aims to investigate the physicochemical parameters, antioxidant, and antibacterial activity of pine honey samples produced in Greece. The study found that these pine honeys have good physicochemical characteristics and show comparable or even superior antibacterial activity.
Article
Food Science & Technology
Karolina Pelka, Marcela Bucekova, Jana Godocikova, Piotr Szweda, Juraj Majtan
Summary: Bee pollen and bee bread aqueous extracts have antibacterial activity, which is significantly enhanced in bee bread extracts in the presence of glucose. Immunoblot analysis revealed the presence of MRJP1 and glucose oxidase (GOX) in these extracts. Treatment of extracts with catalase restored bacterial growth, but only in samples where glucose supplementation caused an enhancement of antibacterial activity.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2022)
Review
Food Science & Technology
Juraj Deglovic, Nora Majtanova, Juraj Majtan
Summary: The successful application of honey in wound care management has led to its increasing usage in dental medicine for the prevention of dental caries. Laboratory studies have shown the antibacterial and antibiofilm effects of honey, particularly against Streptococcus mutans. Despite promising results, further clinical studies are needed to determine the effectiveness of honey in preventing dental caries.
Letter
Pediatrics
Juraj Deglovic, Nora Majtanova, Marcela Bucekova, Juraj Majtan
Article
Multidisciplinary Sciences
Marcela Bucekova, Jana Godocikova, Romain Gueyte, Celine Chambrey, Juraj Majtan
Summary: This study characterized the physicochemical and antibacterial properties of New Caledonian honey samples and found that they showed strong antibacterial activity primarily based on the action of hydrogen peroxide (H2O2). These honey samples could be a suitable source for medical-grade honey.
Article
Cardiac & Cardiovascular Systems
Milos Jesenak, Peter Durdik, Dasa Oppova, Sona Franova, Zuzana Diamant, Kornel Golebski, Peter Banovcin, Jarmila Vojtkova, Elena Novakova
Summary: Bronchial asthma is characterized by chronic airway inflammation, hyperresponsiveness, and structural changes. The impairment of airway remodeling and mucociliary clearance function are important factors contributing to the severity of asthma. Thus, new strategies targeting the restoration of remodeling changes and mucociliary clearance dysfunction could provide a new therapeutic approach for asthma and other chronic respiratory diseases.
RESPIRATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Jarmila Vojtkova, Peter Banovcin, Anna Durdikova, Elena Novakova, Milos Jesenak
Summary: The study aimed to investigate the association between moderate COVID-19 infection and hyperglycaemia. The results showed that COVID-19 patients had significantly higher average blood glucose levels compared to patients with other viral infections, especially those with gastrointestinal symptoms or fever. Therefore, COVID-19 infection is associated with an increased risk of hyperglycaemia.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Tomas Bolek, Matej Samos, Ingrid Skornova, Martin Schnierer, Jakub Jurica, Peter Banovcin, Jan Stasko, Peter Kubisz, Marian Mokan
Summary: This study compared the changes in hemostasis between diabetic and nondiabetic patients with mild COVID-19 pneumonia. The results showed hypercoagulation in patients with mild COVID-19 pneumonia, but diabetes did not affect ROTEM(R) parameters.
Article
Medicine, General & Internal
Martin Vorcak, Jan Sykora, Martin Duricek, Peter Banovcin, Marian Grendar, Kamil Zelenak
Summary: This study analyzed the technical and clinical effects of transcatheter arterial embolization in patients with severe non-variceal gastrointestinal bleeding. The results showed a high technical success rate and clinical success rate. The occurrence of complications and re-bleeding increased the mortality rate.
MEDICINA-LITHUANIA
(2022)
