Article
Biochemistry & Molecular Biology
Ann-Kathrin Schmidt, Karoline Pudelko, Jan-Eric Boekenkamp, Katharina Berger, Maik Kschischo, Holger Bastians
Summary: Whole chromosome instability is a hallmark of human cancer and can be induced by abnormal microtubule assembly rates during mitosis, triggering errors in chromosome segregation. Loss of tumor suppressor genes can lead to increased mitotic microtubule assembly rates and contribute to chromosome instability in cancer cells.
Article
Multidisciplinary Sciences
Francisco J. Sanchez-Rivera, Jeremy Ryan, Yadira M. Soto-Feliciano, Mary Clare Beytagh, Lucius Xuan, David M. Feldser, Michael T. Hemann, Jesse Zamudio, Nadya Dimitrova, Anthony Letai, Tyler Jacks
Summary: The level of mitochondrial apoptotic priming is a critical determinant of cell fate upon p53 reactivation, with cells having high initial priming tending to undergo apoptosis and cells with low priming tending to survive and arrest in the cell cycle. Manipulating the priming levels through BCL-2 or BCL-XL expression or inhibition can affect the outcome of p53 restoration, highlighting mitochondrial apoptotic priming as a key factor in determining cell fate. Moreover, less primed cells can be forced into apoptotic cell fate following p53 activation using p53-independent drugs that increase apoptotic priming.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Naga Padma Lakshmi Ch, Ananthi Sivagnanam, Sebastian Raja, Sundarasamy Mahalingam
Summary: RASSF10 inhibits Cdk1/cyclin-B complex formation to induce mitotic arrest and inhibit cell proliferation, while promoting nuclear accumulation of GADD45a. Nucleophosmin (NPM) is a novel functional target of RASSF10, critical for RASSF10-mediated G2/M phase arrest. Knockdown of NPM or GADD45a impairs RASSF10-mediated cell cycle regulation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Han Thi Ngoc To, Ji-Hong Park, Jeong Won Kim, Dongchul Kang
Summary: Upregulation of DNER expression is associated with advanced gastric cancer and poor prognosis. DNER regulates cell proliferation, survival, and invasive capacity through activation of Notch signaling, suggesting it could be a potential prognostic marker and therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yu Liu, Risheng Huang, Deyao Xie, Xiaoming Lin, Liangcheng Zheng
Summary: ZNF674-AS1 expression is decreased in NSCLC compared to normal tissues, and its downregulation is significantly correlated with advanced TNM stage and decreased overall survival of NSCLC patients. ZNF674-AS1 inhibits NSCLC cell proliferation, colony formation, and tumorigenesis, accompanied by G0/G1 cell cycle arrest, through upregulation of p21 and downregulation of miR-423-3p. This study suggests the therapeutic potential of ZNF674-AS1 in NSCLC treatment.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Environmental Sciences
Natsumi Fujiwara, Gary M. Whitford, John D. Bartlett, Maiko Suzuki
Summary: Curcumin can mitigate fluoride toxicity by modulating the p53-p21 pathway, inhibiting apoptosis induced by fluoride, and activating Akt to suppress fluoride-induced DNA damage.
ENVIRONMENTAL POLLUTION
(2021)
Article
Chemistry, Medicinal
Sameh M. Elsibaei, Asma Amleh, Mohamed A. Ismail, Wael M. El-Sayed
Summary: The current study tested the antiproliferative activity of three azafuramidines against different human cell lines and explored their molecular mechanisms. The azafuramidines demonstrated potent cytotoxicity, selectivity, and the ability to prevent metastasis. They also arrested cell cycles and increased apoptosis. The chlorophenyl derivatives could potentially act as anticancer agents.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Cell Biology
Dan Luo, Chune Yu, Jing Yu, Chao Su, Shun Li, Peng Liang
Summary: Killin has been found to play a role in p53-mediated G1 arrest by upregulating p21 protein expression independently of p53. Knockout of Killin significantly decreases p53-mediated G1 arrest, and double knockout of Killin and p21 completely abolishes this arrest. These findings suggest that Killin is involved in multiple cell cycle checkpoint controls, including p53-mediated G1 arrest.
Article
Oncology
Hardeep Singh Tuli, Sonam Mittal, Diwakar Aggarwal, Gaurav Parashar, Nidarshana Chaturvedi Parashar, Sushil Kumar Upadhyay, Tushar Singh Barwal, Aklank Jain, Ginpreet Kaur, Raj Savla, Katrin Sak, Manoj Kumar, Mehmet Varol, Ashif Iqubal, Anil Kumar Sharma
Summary: Silibinin, a naturally derived polyphenol with high antioxidant and anti-tumorigenic properties, exerts its anti-cancer effects through various cellular pathways including apoptosis induction, cell cycle arrest, inhibition of angiogenesis and metastasis. Despite its ability to modulate a wide array of cellular responses, the major obstacle in declaring Silibinin as a translational chemotherapeutic agent lies in its lower bioavailability.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jia Liu, Liangyan Deng, Lingyu Wang, Die Qian, Chengxun He, Qiang Ren, Qing Zhang, Yunhui Chen
Summary: The study suggests that Licochalcone A (LCA) has great therapeutic potential for esophageal cancer (EC) by regulating the p53 signaling pathway to induce cell cycle arrest and apoptosis. In vitro experiments showed that LCA inhibited EC cell proliferation, migration, and invasion, and promoted apoptosis. In vivo experiments demonstrated that LCA administration inhibited tumor growth without causing significant toxicities.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mir Mohd Faheem, Madhulika Bhagat, Pooja Sharma, Rythem Anand
Summary: The study describes the preparation, characterization, and anti-cancer evaluation of silver nanoparticles synthesized using an aqueous extract of Bergenia ligulata as a reducing agent. The silver nanoparticles showed strong cytotoxic effects on human breast cancer cells and induced apoptosis through mitochondrial damage and oxidative stress. Moreover, the nanoparticles had little or no cytotoxic effect on p53-deficient cancer cells. These findings suggest that Bergenia ligulata silver nanoparticles have promising anti-cancer potential and could be a cost-effective and environmentally friendly treatment strategy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Ying Zhou, Rishun Fu, Mei Yang, Weihuang Liu, Zan Tong
Summary: Lycopene, a natural carotenoid, inhibits the growth and induces apoptosis in gastric cancer cells. It decreases CCNE1 expression and increases the levels of TP53, making it a potential target therapy reagent for gastric cancer.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Yuan Wang, Huazhang Wu, Nannan Dong, Xu Su, Mingxiu Duan, Yaqin Wei, Jun Wei, Gaofeng Liu, Qingjie Peng, Yunli Zhao
Summary: The study demonstrated that SFN impairs colony-forming ability in GC cells, suppresses cell proliferation by arresting cell cycle at S phase, enhances cell apoptosis, and upregulates p53, p21 while downregulating CDK2 expression, suggesting a potential therapeutic application of SFN in GC treatment and prevention.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Haini Wang, Junli Zuo
Summary: Overexpressed survivin is associated with worse survival of several types of human tumors. In this study, the antitumor activity of shikonin in non-small-cell lung cancer (NSCLC) by regulating survivin pathway was investigated. Result showed that shikonin inhibited the NSCLC H1299 cell proliferation in a dose-dependent manner. Moreover, shikonin fits well with survivin by molecular docking. Shikonin also inhibited the mRNA expression and protein level of survivin in H1299 cells. Shikonin arrested H1299 cell cycle at the G0/G1 phase by regulating CDK/cyclin family members. In addition, shikonin regulated the expression of X-linked inhibitor of apoptosis- (XIAP-) mediated caspases 3 and 9, thus leading to the damage of mitochondrial membrane potential and induction of H1299 cell apoptosis. Overall, shikonin inhibited H1299 cell growth by inducing apoptosis and blocking the cell cycle. The underlying mechanism involves targeting survivin, which subsequently regulates the protein expression of XIAP/caspase 3/9, CDK2/4, and cyclin E/D1. Thus, shikonin, a survivin inhibitor, is a promising therapeutic strategy in NSCLC treatment.
ANALYTICAL CELLULAR PATHOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Tiangang Ma, Yanbing Hu, Yinxue Guo, Qinghua Zhang
Summary: The study demonstrates that miR-203 carried by extracellular vesicles from endothelial cells can inhibit the malignant phenotypes of NSCLC cells and delay tumor growth by targeting DTL and promoting p21 protein stability.
CANCER GENE THERAPY
(2022)
