期刊
PHYTOTHERAPY RESEARCH
卷 24, 期 -, 页码 S133-S138出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/ptr.3017
关键词
flavonoids; antihyperglycaemic effect; liver protection; kidney protection; Genista tenera
资金
- FCT - Fundacao para a Ciencia e Tecnologia [PTDC/QUI/67165/2006]
- Fundação para a Ciência e a Tecnologia [PTDC/QUI/67165/2006] Funding Source: FCT
The antihyperglycaemic effect of eight standard flavonoids, previously identified in the ethanol extract of the claimed antidiabetic plant Genista tenera, was evaluated on streptozotocin (STZ)-induced diabetic Wistar rats. The aglycones apigenin, chrysoeriol and genistein, the monoglucosides apigenin 7-O-glucoside, luteolin 7-O-glucoside and genistein 7-O-glucoside and the diglycosides rutin and luteolin 7,3'-di-O-glucoside were administered i.p. for 7 days (4 mg/kg b.w./day). The protective effect of these compounds over liver and kidneys of STZ-diabetic models was also evaluated by the determination of seric AST, ALT and urea levels. After 7 days of treatment, apigenin, chrysoeriol and genistein significantly lowered the blood glucose levels of diabetic animals; this effect was more pronounced (P < 0.01) in the oral glucose tolerance test. Glucose tolerance was also significantly improved in the rutin (P < 0.01) and in the genistein 7-O-glucoside (P < 0.05) treated groups. In addition, almost all the tested compounds effectively protected the liver and kidneys against STZ-induced damage in rats. Copyright (C) 2010 John Wiley & Sons, Ltd.
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