Article
Multidisciplinary Sciences
Qutaiba Ababneh, Sara Al Sbei, Ziad Jaradat, Sebawe Syaj, Neda'a Aldaken, Hamza Ababneh, Zeina Inaya
Summary: This study extensively sequenced five multi-drug resistant A. baumannii clinical isolates from three major Jordanian hospitals. Plasmids harboring resistance genes were detected, and experiments confirmed the transfer or loss of resistance phenotypes. The findings highlight the importance of plasmids in spreading resistance among A. baumannii clinical strains.
Article
Multidisciplinary Sciences
Thomas A. Russo, Timothy C. Umland, Xiaoyi Deng, Farah El Mazouni, Sreekanth Kokkonda, Ruth Olson, Ulrike Carlino-MacDonald, Janet Beanan, Cassandra L. Alvarado, Diana R. Tomchick, Alan Hutson, Hong Chen, Bruce Posner, Pradipsinh K. Rathod, Susan A. Charman, Margaret A. Phillips
Summary: New antimicrobials are necessary for treating extensively drug-resistant Acinetobacter baumannii. The results of genetic and chemical studies suggest that the de novo pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is essential for the survival of this bacterium. By repurposing a library of analogs developed for malaria DHODH program, researchers have identified 21 compounds with potent activity against Acinetobacter baumannii DHODH. One of these compounds, DSM186, has shown promise with minimal inhibitory concentrations against various strains of A. baumannii. These findings highlight the potential of DHODH as a target for the development of new antimicrobials for the treatment of high-risk bacterial infections.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Microbiology
Noor Zaidan, J. Patrik Hornak, David Reynoso
Summary: A successful case of treating XDR Acinetobacter baumannii pneumonia and septic shock with a novel antibiotic obtained via expanded access protocol was reported, suggesting that focused research and drug development efforts can mitigate the poor outcomes associated with these infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Manas S. Deolankar, Rachel A. Carr, Rebecca Fliorent, Sean Roh, Henry Fraimow, Valerie J. Carabetta
Summary: The spread of multidrug-resistant Acinetobacter baumannii in critically ill, hospitalized patients has been a serious concern for decades. Traditional antibiotic therapies have failed to effectively treat this pathogen, prompting the introduction of new antibiotics such as eravacycline and omadacycline. In this study, the effectiveness of various antibiotics, including eravacycline and omadacycline, against susceptible and extensively drug-resistant A. baumannii strains was examined. The results showed that while monotherapies with certain antibiotics were largely ineffective, eravacycline showed high efficacy against these strains. Combination therapy with eravacycline or omadacycline and the aminoglycoside amikacin yielded the most promising results. This comprehensive characterization provides valuable guidance for the treatment of this deadly infection in hospitalized patients.
Article
Chemistry, Medicinal
Jian Peng, Yue Wang, Zhaoyin Wu, Chengju Mao, Lu Li, Huijun Cao, Zhilang Qiu, Guo Guo, Guiyou Liang, Feng Shen
Summary: The antimicrobial peptide Cec4 effectively clears multidrug-resistant A. baumannii by altering bacterial cell membrane permeability, polarity, and increasing intracellular reactive oxygen species. Cec4 affects the expression of important genes related to the secretion system, outer membrane, and efflux pump in A. baumannii. It does not easily induce stable drug resistance in bacteria. In vivo experiments show that Cec4 has good therapeutic potential with low toxicity against cells and tissues, effectively improving survival rates and reducing bacterial load in infected mice.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Microbiology
Mohammad Al-Tamimi, Hadeel Albalawi, Mohamd Alkhawaldeh, Abdullah Alazzam, Hassan Ramadan, Majd Altalalwah, Ahmad Alma'aitah, Dua'a Al Balawi, Sharif Shalabi, Jumana Abu-Raideh, Ashraf Khasawneh, Farah Alhaj, Kamal Hijawi
Summary: This study is the first large-scale, multicenter, and prolonged research on Acinetobacter baumannii infections in Jordan, providing insights into the epidemiology and molecular characteristics of MDR-A. baumannii in the country. Attention to high-risk patients and early identification are crucial. Colistin and tigecycline are the most effective antimicrobials.
Article
Medicine, General & Internal
Yue Zheng, Nana Xu, Jiaojiao Pang, Hui Han, Hongna Yang, Weidong Qin, Hui Zhang, Wei Li, Hao Wang, Yuguo Chen
Summary: This study found that colonization with extensively drug-resistant A. baumannii (XDR-AB) was associated with lower long-term survival in critically ill patients, but not with short-term survival. Patients colonized with XDR-AB had significantly lower overall survival rates at 6 months.
FRONTIERS IN MEDICINE
(2021)
Article
Microbiology
Pooja Kumari, Grace Kaul, T. Anand Kumar, Abdul Akhir, Manjulika Shukla, Suraj Sharma, Siddhesh S. Kamat, Sidharth Chopra, Harinath Chakrapani
Summary: Discovery of novel antibiotics targeting multidrug-resistant (MDR) pathogens such as A. baumannii is an urgent, unmet medical need. Our work has highlighted the potential of this unique scaffold to annihilate MDR A. baumannii alone and in combination with amikacin both in vitro and in animals, that too without inducing resistance. Further in depth analysis identified central metabolism to be a putative target. Taken together, these experiments lay down the foundation for effective management of infections caused due to highly MDR pathogens.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biotechnology & Applied Microbiology
Elnaz Abbasi, Alex van Belkum, Ehsanollah Ghaznavi-Rad
Summary: The frequency of infections caused by wild-type A. baumannii, multidrug-resistant (MDR) or XDR A. baumannii, and CRAB were assessed in central Iran. Different antibiotic resistance genes were detected in the genomes of infectious A. baumannii strains.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Qutaiba Ababneh, Sally Abulaila, Ziad Jaradat
Summary: This study investigated the prevalence of Acinetobacter baumannii in the environment of intensive care and emergency units in Jordan. The results showed that high-touch surfaces in adult and pediatric ICUs were contaminated with extensively-resistant A. baumannii isolates, highlighting the need for optimized cleaning practices and personal hygiene habits of healthcare workers to control the spread of this pathogen.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Pharmacology & Pharmacy
Li Zeng, Fei Lin, Baodong Ling
Summary: This study explored the inhibitory effect of thirty-four traditional Chinese medicine monomers on drug-resistant Acinetobacter baumannii. It was found that nine traditional Chinese medicine monomers could inhibit the bacterial quorum sensing and downregulate the expression of virulence-associated genes. These results suggest that traditional Chinese medicine monomers could be developed as novel anti-virulence compounds to control extensively drug-resistant A. baumannii infections.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Infectious Diseases
Aamir Hussain, Shaheena Kousar, Ihsan Ullah, Aqsa Zulfiqar, Hafiz Arslan Ali, Amina Manzoor, Atif Aziz, Asghar Javaid, Mubashar Aziz, Binish Khaliq, Humera Nazir, Aleem Ahmed Khan, Ahmed Akrem, Muhammad Qamar Saeed
Summary: Enrichment of various phages against XDR clinical strains, including QAB 3.4 with broad lytic activity, shows promise for clinical applications and as environmentally friendly infection control agents.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Biochemistry & Molecular Biology
Manigandan Krishnan, Joonhyeok Choi, Ahjin Jang, Young Kyung Yoon, Yangmee Kim
Summary: Developed peptide R-Pro9-3D shows rapid and effective antibacterial activity against CRAB, damaging its outer membrane with lower cytotoxicity and better proteolytic stability. It can also reduce LPS-induced inflammation and lessen organ damage in a mouse model of CRAB-induced sepsis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Abolfazl Jahangiri, Alireza Neshani, Seyed Ali Mirhosseini, Kiarash Ghazvini, Hosna Zare, Hamid Sedighian
Summary: The study demonstrated the antimicrobial effects of Nisin and P10 peptides against drug-resistant bacterial strains, with the P10+Nisin combination showing synergistic effects against standard strains and additive effects against drug-resistant isolates. Additionally, synergistic combinations were found with P10+ceftazidim, P10+doripenem, and Nisin+colistin, highlighting potential therapeutic value against infections caused by colistin-resistant P. aeruginosa and XDR A. baumannii.
MICROBIAL PATHOGENESIS
(2021)
Review
Infectious Diseases
Stamatis Karakonstantis, Petros Ioannou, George Samonis, Diamantis P. Kofteridis
Summary: Combination antimicrobial therapy is currently the only potential treatment option for pandrug-resistant A. baumannii. Some combinations exhibit synergy at clinically relevant concentrations, with triple combinations showing greater activity than double combinations, but no combination consistently demonstrates synergy against all strains tested.
Review
Food Science & Technology
Lvting Fan, Qin Ye, Wenjing Lu, Di Chen, Cen Zhang, Lihan Xiao, Xianghe Meng, Yi-Chieh Lee, Hui-Min David Wang, Chaogeng Xiao
Summary: This article provides an overview of the structural characteristics, physiological functions, and applications of slow digestion starch (SDS) and resistant starch (RS) in the food industry. It also compares the preparation methods of functional starch from different plant sources. The lack of standardization in experimental methods has led to significant differences in research results, hindering the development of starch processing technology.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Biotechnology & Applied Microbiology
Wei-Chih Lien, Xin-Ran Zhou, Ya-Jyun Liang, Congo Tak-Shing Ching, Chia-Yih Wang, Fu- Lu, Huei-Cih Chang, Feng-Huei Lin, Hui-Min David Wang
Summary: Nanoceria (cerium oxide nanoparticles [CNPs]) may prevent the development of urological chronic pelvic pain syndrome (UCPPS) by scavenging reactive oxygen species (ROS) and downregulating SerpinB2, thus modulating the immune response in UCPPS.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Correction
Pharmacology & Pharmacy
Sichong Han, Zhe Wang, Jining Liu, Hui-Min David Wang, Qipeng Yuan
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ruei-Hong Lin, Hsu-Tung Lee, Chun-An Yeh, Yi-Chin Yang, Chiung-Chyi Shen, Kai-Bo Chang, Bai-Shuan Liu, Hsien-Hsu Hsieh, Hui-Min David Wang, Huey-Shan Hung
Summary: The research shows that using AuNPs at concentrations of 1.25 and 2.5 ppm can enhance cell proliferation, reduce reactive oxygen species generation, and attenuate platelet/monocyte activation. AuNPs can also promote cell adhesion, increase the expression of matrix metalloproteinase (MMP-2/9), decrease cell apoptosis and the release of inflammatory cytokines. Animal model experiments demonstrate that treating with 1.25 and 2.5 ppm AuNPs exhibits better biocompatibility and endothelialization. This suggests that AuNPs can be used as a biocompatible nanomedicine for regeneration research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
George R. Thompson III, Alex Soriano, Oliver A. Cornely, Bart Jan Kullberg, Marin Kollef, Jose Vazquez, Patrick M. Honore, Matteo Bassetti, John Pullman, Methee Chayakulkeeree, Ivan Poromanski, Cecilia Dignani, Anita F. Das, Taylor Sandison, Peter G. Pappas
Summary: This study compared the efficacy and safety of intravenous rezafungin with intravenous caspofungin in the treatment of candidaemia and invasive candidiasis. The results showed that rezafungin was non-inferior to caspofungin in terms of efficacy and safety.
Article
Environmental Sciences
Shin-Huei Kuo, Tzu-Yin Liu, Tun-Chieh Chen, Chih-Jen Yang, Yen-Hsu Chen
Summary: The study found that PVDC plastic wraps are the best choice for covering elevator buttons, with very low residual bacteria. Door-close and -open buttons were the most frequently touched sites, requiring more accurate and precise disinfection, therefore cleaning intervals of no longer than three hours may be warranted.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Immunology
Shu-Hsing Cheng, Chia En Lien, Szu-Min Hsieh, Chien-Yu Cheng, Wang-Da Liu, Ching-Lung Lo, Wen-Chien Ko, Yen-Hsu Chen, Ching-Tai Huang, Hsiao-Ting Chang, Shinn-Jang Hwang, Ning-Chi Wang, Ming-Che Liu, Yu-Lin Lee, I-Chen Tai, Josue Antonio Garcia Estrada, Tzou-Yien Lin, Wen-Sen Lee
Summary: This study assessed the safety and immunogenicity of the MVC-COV1901 vaccine in people living with HIV. The vaccine showed robust safety but weaker immune responses in this population, suggesting the need for further investigations to determine improved immunization strategies for HIV patients.
Article
Oncology
Wei-Ting Chen, Yuan-Hsin Tsai, Peggy Tan, Fei-Ting Hsu, Hui-Min David Wang, Wei-Chin Lin, Feng-Huei Lin, Ching-Te Wu
Summary: Osteosarcoma is a common bone malignancy with high metastatic characteristics and poor prognosis. Fluoxetine, an anti-depressant, has been shown to have antitumor potential. In this study, fluoxetine was found to induce cytotoxicity and apoptosis in osteosarcoma cells, while also suppressing metastasis and angiogenesis by targeting STAT3.
ANTICANCER RESEARCH
(2023)
Article
Food Science & Technology
Cam Thi Hong Tran, Parushi Nargotra, Hoa Thi Cam Pham, Dong My Lieu, Phung Kim Huynh, Hui-Min David Wang, Cheng-Di Dong, Chia-Hung Kuo
Summary: This study investigated the effect of carboxymethyl cellulose and beta-cyclodextrin on the bitterness and properties of bitter gourd extract (BGE). The results showed that 0.75% beta-cyclodextrin significantly reduced the bitterness of BGE, and the formation of a complex between beta-cyclodextrin and BGE components was confirmed. The debittering agents did not inhibit the bioactivities of BGE.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Oncology
I-Ching Kuo, Yi-Chi Chu, Yen-Hsu Chen, Ta-Chien Chan
Summary: This retrospective longitudinal cohort study aimed to explore the association between kidney function decline and cancer-related mortality in community-dwelling elderly individuals. The study found that rapid kidney function decline was significantly associated with increased risk of cancer mortality, particularly in gastrointestinal tract, hepatobiliary, lung, prostate, urinary tract, and hematological malignancies. Regular assessments of dynamic changes in estimated glomerular filtration rate (eGFR) might provide valuable information for cancer prognosis.
Article
Immunology
Hsin-Yun Sun, Bo-Huang Liou, Tun-Chieh Chen, Chia-Jui Yang, Sung-Hsi Huang, Po-Liang Lu, Chung-Hao Huang, Mao-Song Tsai, Shu-Hsing Cheng, Nan-Yao Lee, Wen-Chien Ko, Yen-Hsu Chen, Wang-Da Liu, Shang-Yi Lin, Shih-Ping Lin, Po-Lin Chen, Ling-Shan Syue, Yu-Shan Huang, Yu-Chung Chuang, Cheng-Bin Chen, Ya-Ting Chang, Yuan-Ti Lee, Szu-Min Hsieh, Li-Hsin Su, Chien-Yu Cheng, Chien-Ching Hung
Summary: Using 3-stage pooled-plasma hepatitis C virus (HCV) RNA testing performed quarterly among at-risk people with human immunodeficiency virus (PWH), we found that if testing had been performed every 6 or 12 months, 58.6%-91.7% of PWH who recently acquired HCV would be delayed for diagnosis and might contribute to onward HCV transmission with longer durations.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Immunology
Chien-Chih Chiu, Kai-Chun Cheng, Yi-Hsiung Lin, Chen-Xi He, Yung-Ding Bow, Chia-Yang Li, Chang-Yi Wu, Hui-Min David Wang, Shwu-Jiuan Sheu
Summary: Chronic hyperglycemia leads to retinal degeneration and disorders like diabetic retinopathy. In this study, a model of prolonged high-glucose exposure was established to investigate its effects on RPE cells. The results showed that prolonged high-glucose exposure caused oxidative stress, DNA damage, and premature senescence in RPE cells.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2023)
Review
Public, Environmental & Occupational Health
Muhammad Bilal Khan, Zih-Syuan Yang, Chih-Yen Lin, Ming-Cheng Hsu, Aspiro Nayim Urbina, Wanchai Assavalapsakul, Wen-Hung Wang, Yen-Hsu Chen, Sheng-Fan Wang
Summary: Dengue is a disease caused by dengue virus infection, and its clinical manifestations vary. Currently, there is a lack of effective antiviral drugs and vaccines, so it is necessary to study the virus characteristics, epidemiology, and develop treatment and control strategies.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Imaniar Noor Faridah, Haafizah Dania, Rita Maliza, Wan-Hsuan Chou, Wen-Hung Wang, Yen-Hsu Chen, Dyah Aryani Perwitasari, Wei-Chiao Chang
Summary: Dengue is a global arboviral disease that has become a major public health concern. This study investigated the associations of variations in the MICB and PLCE1 genes with dengue severity and thrombocytopenia in Indonesian and Taiwanese populations. The results showed associations between MICB rs3132468 and dengue shock syndrome (DSS), as well as between PLCE1 rs3740360 and secondary dengue hemorrhagic fever (DHF) in Indonesian patients.
Article
Chemistry, Applied
Cam Thi Hong Tran, Hui-Min David Wang, Le Thi Hong Anh, Chitsan Lin, Chun-Yung Huang, Chia-Hung Kuo
Summary: This study evaluates the impact of beta-cyclodextrin on the properties of bitter gourd extract under different heating conditions. It is found that beta-cyclodextrin mitigates the effect of heat treatment on the bitter gourd extract, improving its thermal stability and creating opportunities for its incorporation into heat-processed products.
