Article
Chemistry, Multidisciplinary
Saba Muzher Iqbal, Liaqat Hussain, Musaddique Hussain, Haseeb Akram, Muhammad Asif, Ayesha Jamshed, Ammara Saleem, Rida Siddique
Summary: Bambusa arundinacea is an important plant distributed in tropical regions, and it has been traditionally used as a folk remedy for various abdominal disorders. This study confirmed its folkloric uses and evaluated its nephroprotective potential. The results showed that the methanolic extract of Bambusa arundinacea exhibited significant antioxidant activity and improved renal function.
Article
Medicine, Research & Experimental
Abbas Rahdar, Parisa Hasanein, Muhammad Bilal, Hamid Beyzaei, George Z. Kyzas
Summary: Quercetin was formulated into microemulsions to improve bioavailability, with the nanoencapsulated form showing potential in protecting against gentamicin-induced renal oxidative stress and kidney damage in a rat model of nephrotoxicity. Further evaluations are warranted.
Article
Multidisciplinary Sciences
Esmaeel Babaeenezhad, Negar Nouryazdan, Maryam Nasri, Hassan Ahmadvand, Mostafa Moradi Sarabi
Summary: This study found that cinnamic acid has significant protective effects against Gentamicin-induced liver and kidney dysfunctions in rats, mainly by reducing relevant markers levels and alleviating pathological changes through antioxidant activities.
Article
Multidisciplinary Sciences
Muhammad Umar Ijaz, Shama Mustafa, Ali Hamza, Bader O. Almutairi, Mikhlid H. Almutairi, Mian Nadeem Riaz
Summary: Glabridin has shown protective effects against Gentamicin-induced nephrotoxicity through its antioxidant, anti-apoptotic, and anti-inflammatory properties.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Anatomy & Morphology
Morteza Saeedavi, Mehdi Goudarzi, Iman Fatemi, Zahra Basir, Seyyed Mohammad Ali Noori, Saeed Mehrzadi
Summary: This study evaluated the beneficial effects of gentisic acid (GA) on gentamicin (GEN)-induced nephrotoxicity in rat kidneys. GA treatment mitigated the deleterious effects of GEN on oxidative stress, inflammatory cytokines, and histopathological changes in the kidneys. GA improved biochemical, inflammatory, and oxidative stress indices against GEN-induced nephrotoxicity.
Article
Chemistry, Multidisciplinary
Noureddine Bencheikh, Sabir Ouahhoud, Mary Anne W. Cordero, Amal Alotaibi, Jamila Fakchich, Hayat Ouassou, Soufiane El Assri, Mohammed Choukri, Mostafa Elachouri
Summary: This study evaluated the nephroprotective effect of an aqueous extract from Thymelaea microphylla against gentamicin-induced nephrotoxicity. The findings showed that the extract is rich in antioxidant compounds and can improve the abnormal biochemical and histological parameters caused by gentamicin administration.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Itzel Pamela Zavala-Guevara, Manolo Sibael Ortega-Romero, Juana Narvaez-Morales, Tania Libertad Jacobo-Estrada, Wing-Kee Lee, Laura Arreola-Mendoza, Frank Thevenod, Olivier Christophe Barbier
Summary: The study evaluated the uptake of CdMT complex through 24p3R after proximal tubule injury. Findings showed increased uptake of CdMT complex and 24p3R expression in the distal tubules after proximal tubule injury, potentially compensating for protein losses associated with AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Adriana Elena Bulboaca, Alina Porfire, Sorana D. Bolboaca, Cristina Ariadna Nicula, Dana Gabriela Festila, Alexandra Roman, Ruxandra Mioara Rajnoveanu, Armand Rajnoveanu, Gabriela Dogaru, Paul-Mihai Boarescu, Vasile Rus, Corneliu Angelo Bulboaca, Alexandra Ina Bulboaca, Ioana Stanescu
Summary: This study demonstrated the protective effects of Curcumin nanoformulation on nephrotoxicity induced by Gentamicin in rats, showing improvements in oxidative stress, antioxidant capacity, and renal function. The nanoformulation was more effective than conventional Curcumin in improving kidney function and structure.
Article
Pharmacology & Pharmacy
Shubhangi Gumbar, Sudeep Bhardwaj, Sidharth Mehan, Zuber Khan, Acharan S. Narula, Reni Kalfin, Shams Tabrez, Torki A. Zughaibi, Samina Wasi
Summary: This study investigates the renoprotective effect of gymnemic acid (GA) on gentamicin-induced nephrotoxicity in rats. The results show that GA has antioxidant properties, restores renal oxidative stress markers, and reduces kidney inflammation and injury. GA demonstrates greater efficacy than Vitamin E in restoring antioxidant potential and mitochondrial enzymes.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Feng Zhou, Xu-Yang Liu, Lin -Lin Liu, Yan Hou, Zisheng Han, Liang Zhang
Summary: By conducting a metabolomics analysis, sensory evaluation, and transcriptomic analysis on tea leaves with and without mistletoe, it was found that mistletoe affects the secondary metabolites and gene expression in tea leaves, leading to a decrease in catechin content but an increase in free amino acid content.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Genetics & Heredity
Yuan Zhang, Chongli Deng, Junwen Yang, Dexin Wang, Guobin Deng
Summary: The complete chloroplast genome of Viscum articulatum was analyzed in this study, revealing a genome size of 131,825 base pairs, with 114 genes and 118 SSRs identified. Phylogenetic analysis showed that V. articulatum forms a distinct lineage independent of other species in the genus Viscum within Loranthaceae.
MITOCHONDRIAL DNA PART B-RESOURCES
(2021)
Article
Pharmacology & Pharmacy
Osama Y. Althunibat, Mohammad H. Abukhalil, Saleem H. Aladaileh, Haitham Qaralleh, Wesam Al-Amarat, Manal A. Alfwuaires, Abdulmohsen I. Algefare, Nader Ibrahim Namazi, Sahar J. Melebary, Ahmad O. Babalghith, Carlos Adam Conte-Junior
Summary: Formononetin protects against gentamicin-induced renal damage in rats by exhibiting antioxidant, anti-inflammatory, and antiapoptotic activities and augmenting Nrf2 signaling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Fisheries
Guihong Fu, Jian Wang, Minglang Cai, Junzhi Zhang, Haibo Hu, Chaozhou Dai, Xin Zheng, Yi Hu, Kaijian Chen
Summary: This study investigated the effects of dietary oleanolic acid (OA) on the growth performance, antioxidant activity, innate immunity, and intestinal microbiota structure of red swamp crayfish. The results showed that OA supplementation improved growth performance, enhanced antioxidant capacity, and did not significantly alter the structure of the intestinal microbiota.
AQUACULTURE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Hsuan Fu, Feng-Lin Yen, Pao-Hsien Huang, Chun-Yin Yang, Chia-Hung Yen
Summary: The study found that oleanolic acid nanofibers significantly improved water solubility and skin penetration compared to oleanolic acid, leading to enhanced antioxidant, anti-inflammatory, and anti-skin aging effects in keratinocytes exposed to airborne particulate matter (PM).
Article
Environmental Sciences
Manal M. Hussein, Hussam A. Althagafi, Fahad Alharthi, Ashraf Albrakati, Khalaf F. Alsharif, Abdulrahman Theyab, Rami B. Kassab, Ahmad H. Mufti, Mohammad Algahtani, Atif Abdulwahab A. Oyouni, Roua S. Baty, Ahmed E. Abdel Moneim, Maha S. Lokman
Summary: This study aimed to investigate the therapeutic effects of apigenin on gentamicin-induced nephrotoxicity. The results showed that apigenin administration could alleviate kidney impairments, enhance antioxidant capacity, and suppress renal inflammation and apoptosis. The findings suggest that apigenin treatment may be beneficial in alleviating gentamicin-induced renal impairments.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Shvetank Bhatt, Lakshman Puli, Chandragauda R. Patil
Summary: The pathogenesis of Alzheimer's disease involves neurodegeneration, with oxidative stress being a key detrimental factor. Antioxidants have therapeutic effects in preventing and delaying the progression of AD pathology.
DRUG DISCOVERY TODAY
(2021)
Article
Biochemistry & Molecular Biology
Yogeeta O. Agrawal, Umesh B. Mahajan, Vinit V. Agnihotri, Mayur S. Nilange, Hitendra S. Mahajan, Charu Sharma, Shreesh Ojha, Chandragouda R. Patil, Sameer N. Goyal
Summary: Ezetimibe was successfully encapsulated into nanostructured lipid carriers using high pressure homogenization technique, showing promising pharmaceutical properties and significant therapeutic effects on hyperlipidemia in rats. The Ezetimibe nanostructured lipid carriers demonstrated superiority in terms of bioavailability enhancement and reduced side effects.
Article
Pharmacology & Pharmacy
Niraj Kumar Jha, Charu Sharma, Hebaallah Mamdouh Hashiesh, Seenipandi Arunachalam, M. F. Nagoor Meeran, Hayate Javed, Chandragouda R. Patil, Sameer N. Goyal, Shreesh Ojha
Summary: Beta-caryophyllene (BCP) as a selective functional agonist on CB2 receptors, exhibits anti-inflammatory, antiviral, and immunomodulatory properties. It is considered a promising therapeutic candidate for COVID-19 due to its tissue protective properties, modulation of signaling pathways, and inhibitory effects on inflammatory mediators. Further preclinical and clinical studies are warranted to explore its potential as an immunomodulator, anti-inflammatory agent, and antiviral compound.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Pharmacology & Pharmacy
Charu Sharma, Niraj Kumar Jha, M. F. Nagoor Meeran, Chandragouda R. Patil, Sameer N. Goyal, Shreesh Ojha
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Santoshi Sahu, C. R. Patil, Sachin Kumar, Subbu Apparsundaram, Ramesh K. Goyal
Summary: COVID-19 virus uses ACE2 to enter human body, reducing ACE2 expression restricts viral entry into cells and decreases viral load, leading to post-COVID-19 complications. Some food components may modulate the ACE2-Ang (1-7)-Mas (AAM) axis, influencing susceptibility and complications of COVID-19 infection.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Neurosciences
Shvetank Bhatt, Jovita Kanoujia, S. Mohana Lakshmi, CR. Patil, Gaurav Gupta, Dinesh Kumar Chellappan, Kamal Dua
Summary: The human gut microbiota has a significant impact on central nervous system-related diseases, including major depressive disorder (MDD). The imbalance of the brain-gut-microbiota axis plays a crucial role in the pathogenesis of depression. The regulation of gut microbiota is emerging as a new treatment modality for MDD.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Plant Sciences
Dhanraj R. Mahajan, Anilkumar U. Tatiya, Manoj Girase, Chandragauda R. Patil, Prasad G. Jamkhande, Sanjay J. Surana, Mohan G. Kalaskar
Summary: This study aimed to investigate and validate the ethnobotanical knowledge on anti-inflammatory medicinal plants in the South-western Satpuda ranges. The results identified 32 plants with anti-inflammatory properties, including Grewia flavescens and Eulophia herbacea. These plants exhibited significant antiarthritic and anti-inflammatory activities, potentially attributed to the presence of gallic acid, quercetin, beta-sitosterol, and lupeol. Further research is needed to elucidate the exact mechanism of action of these plants.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Physical
Rahul Pawara, Iqrar Ahmad, Deepika Nayak, Sateesh Belamkar, Sanjay Surana, Chanakya Nath Kundu, Chandragauda Patil, Harun Patel
Summary: A series of novel double mutant EGFR-L858R/T790M TK inhibitors were discovered using structure-based drug design and traditional optimization strategies. These inhibitors showed improved selectivity and lower toxicity, making them promising candidates for targeting the double mutant EGFR-L858R/T790M TK.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biology
Harshal D. Pawar, Umesh B. Mahajan, Kartik T. Nakhate, Yogeeta O. Agrawal, Chandragouda R. Patil, M. F. Nagoor Meeran, Charu Sharma, Shreesh Ojha, Sameer N. Goyal
Summary: The study demonstrates that curcumin can protect the heart from diabetic-induced myocardial damage by activating the CB2 cannabinoid receptor, improving inflammatory markers in the blood, maintaining antioxidant capacity, and restoring cardiac function.
Article
Biochemistry & Molecular Biology
Chaitali Prajapati, Yogeeta O. Agrawal, Vinit V. Agnihotri, Umesh B. Mahajan, Kalpesh R. Patil, Dipak D. Patil, Chandragouda R. Patil
Summary: This study compared the protective effects of thymoquinone (TQ) and thymoquinone nanoparticles (TQ-NP) against cyclophosphamide-induced haemorrhagic cystitis. The results showed that TQ-NP had better anti-inflammatory and DNA protective effects, as well as improved kidney targeted delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Nutrition & Dietetics
Sumit Rathod, Yogeeta Agrawal, Abdulla Sherikar, Kartik T. Nakhate, Chandragouda R. Patil, M. F. Nagoor Meeran, Shreesh Ojha, Sameer N. Goyal
Summary: The study suggests that thymoquinone (TQ) can have cardioprotective effects at lower doses, even in short-term regimens. TQ was found to improve heart health indicators, regulate inflammatory cytokines, and enhance the antioxidant defense system.
Review
Environmental Sciences
Ruchika Sharma, Chandragouda Patil, Jaseela Majeed, Subodh Kumar, Geeta Aggarwal
Summary: Medicinal plants have been widely used as traditional herbal medicines for various diseases. The increased demand for these plants emphasizes the need for conservation, especially for endangered species. Next-generation sequencing (NGS) technologies have made significant advancements in medicinal plant research, making it more cost-effective and time-efficient. NGS systems allow for high-throughput whole genome sequencing, RNA sequencing, and transcriptome analysis, providing valuable data for various areas of study.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Oncology
Ganesh R. Pawar, Yogeeta O. Agrawal, Kartik T. Nakhate, Chandragouda R. Patil, Charu Sharma, Shreesh Ojha, Umesh B. Mahajan, Sameer N. Goyal
Summary: This study confirmed the ameliorative effect of ghrelin on depression-like behavior induced by a high-fat diet and disturbed diurnal rhythm. The study also found that ghrelin has antioxidant and anti-inflammatory effects.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Tropical Medicine
Shivani S. Wagh, Kalpesh R. Patil, Umesh B. Mahajan, Pradnya D. Bagal, Avinash R. Wadkar, Basavraj Bommanhalli, Prabhakar R. Patil, Sameer N. Goyal, Shreesh Ojha, Chandragouda R. Patil
Summary: The study showed that phloretin can inhibit doxorubicin-induced oxidative stress and reduce nitric oxide levels in cardiac tissues. Phloretin can attenuate changes in hemodynamic parameters induced by doxorubicin, suppress the expression of pro-inflammatory cytokines, and reduce cardiac injury markers.
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
(2022)
Article
Tropical Medicine
Aarti S. Kale, Avinash R. Wadkar, Umesh B. Mahajan, Lalit A. Birari, Sateesh Belemkar, Sameer N. Goyal, Shreesh Ojha, Sanjay J. Surana, Chandragouda R. Patil, Kalpesh R. Patil
Summary: Aloin effectively alleviates chronic constriction injury (CCI)-induced neuropathic pain in rats by reducing mechanical and thermal allodynia, improving motor nerve conduction velocity, decreasing oxidative stress, lowering pro-inflammatory cytokine levels, and restoring the histoarchitecture of compressed sciatic nerve.
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
(2021)
