Article
Pediatrics
Anna Gora, Maciej Przybyl, Elzbieta Swietochowska, Edyta Machura
Summary: This study aimed to evaluate the levels of various cytokines and chemokines in the serum of children with acute and chronic urticaria and compare them with healthy volunteers. The results showed significant differences in the concentrations of certain cytokines and chemokines between patients with urticaria and the control group. IL-6 and IP-10 may be useful in distinguishing children with acute urticaria from healthy ones.
ITALIAN JOURNAL OF PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
Xiaoli Ren, Yuying Fan, Dongmei Shi, Yun Liu
Summary: Mammary gland tumors are a common malignant disease that poses a serious threat to women and female dogs. The lack of an effective tumor marker hinders the early diagnosis and prognosis of these tumors in veterinary clinical medicine. This study investigated the expression of IL-6, IL-8, and IL-10 in canine mammary gland tumors to determine their association with tumor progression. The results suggest that IL-6 and IL-8 could potentially serve as diagnostic or biomarkers for canine mammary gland tumors.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Jurgen Scheller, Julia Ettich, Christoph Wittich, Silke Pudewell, Doreen M. M. Floss, Puyan Rafii
Summary: IL-6-type cytokines play important roles in immunomodulation and homeostasis. Synthetic biology approaches including mutations, fusion proteins, and inter-cytokine swapping have resulted in IL-6-type cytokines with altered properties. These synthetic cytokines show potential for clinical applications such as aiding type 2 diabetes and brain injuries.
Article
Biochemistry & Molecular Biology
Birte Weber, Ramona Sturm, Dirk Henrich, Ludmila Lupu, Katrin Rottluff, Ingo Marzi, Liudmila Leppik
Summary: Trauma is a major cause of death and disability, and accurate diagnosis is crucial for polytraumatized patients to prevent complications. This study suggests that cytokines in exosomes have a longer half-life and can be used as diagnostic and prognostic markers in these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Leile Camila Jacob-Nascimento, Caroline Xavier Carvalho, Monaise Madalena Oliveira Silva, Mariana Kikuti, Rosangela Oliveira Anjos, Jordana Rodrigues Barbosa Fradico, Ana Carolina Campi-Azevedo, Laura Beatriz Tauro, Gubio Soares Campos, Patricia Sousa dos Santos Moreira, Moyra Machado Portilho, Olindo Assis Martins-Filho, Guilherme Sousa Ribeiro, Mitermayer Galvao Reis
Summary: The study found that CHIKV-infected patients had significantly higher levels of chemokines compared to HC, and CCL2, CCL5, and CXCL10 levels were also significantly higher compared to patients with OAFD. Among patients with arthralgia lasting more than 3 months, CXCL8 levels were significantly increased. Multivariable analyses further indicated that high levels of CXCL8 and female sex were associated with arthralgia lasting more than 3 months.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Riddhi Thaker, Hina Oza, Vinita Verma, Mansi Gor, Sunil Kumar
Summary: This study explored the role of cytokines IL-6 and IL-10 in cases of spontaneous abortion, finding a positive correlation between IL-6 and the number of SAb cases, and a negative correlation with IL-10. The results suggest a beneficial role for IL-10 and detrimental role for IL-6 on pregnancy outcomes. Additional data is needed to confirm these findings.
REPRODUCTIVE SCIENCES
(2021)
Article
Oncology
Gang Liu, Xiang-Ting Chen, Hao Zhang, Xin Chen
Summary: This study investigated the relationship between changes in peripheral blood VEGF, IL-5, IL-6, IL-8, and IL-17 concentrations in breast cancer patients and their significance in breast cancer staging and invasive metastasis. The results showed that IL-6, IL-17, and VEGF were strongly associated with breast cancer development and could be used as reference indicators for diagnosis and postoperative follow-up.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Paula Roberta Aguiar Pastrez, Ana Margarida Barbosa, Vania Sammartino Mariano, Rhafaela Lima Causin, Antonio Gil Castro, Egidio Torrado, Adhemar Longatto-Filho
Summary: Esophageal squamous cell carcinoma (ESCC) is a rapidly progressing cancer with high mortality rates. In this study, we investigated the levels of inflammatory cytokines in ESCC patients and healthy individuals. We found increased levels of IL-1 beta, IL-6, IL-8, and IL-10 in ESCC patients. Among these cytokines, IL-8 was identified as an independent prognostic factor for ESCC. Additionally, patients with low IL-6, IL-8, TNM I/II, or those who underwent surgery had a higher overall survival rate. Our findings suggest IL-8 as a potential biomarker for ESCC.
Article
Cell Biology
Ayako Nishimoto-Kakiuchi, Izumi Sato, Kiyotaka Nakano, Hiroshi Ohmori, Yoko Kayukawa, Hiromi Tanimura, Sachiya Yamamoto, Yuichiro Sakamoto, Genki Nakamura, Atsuhiko Maeda, Kentaro Asanuma, Atsuhiko Kato, Tadashi Sankai, Ryo Konno, Hisafumi Yamada-Okabe
Summary: Current pharmacological treatments for endometriosis are limited and cannot cure the disease. However, a long-acting recycling antibody against IL-8 (AMY109) has shown potential as a disease-modifying therapy for endometriosis. Studies in monkeys with surgically induced endometriosis demonstrated that AMY109 reduced lesion volume, improved reproductive scores, and alleviated fibrosis and adhesions.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Silvia Selene Moreno-Guerrero, Arturo Ramirez-Pacheco, Luz Maria Rocha-Ramirez, Gabriela Hernandez-Pliego, Pilar Eguia-Aguilar, Maria Argelia Escobar-Sanchez, Alfonso Reyes-Lopez, Luis Enrique Juarez-Villegas, Juan Jose Luis Sienra-Monge
Summary: Neuroblastoma (NB) is a heterogeneous disease with varying characteristics, and genetic variants of cytokines such as IL-6 and IL-8 may influence tumor progression and metastasis. Elevated levels of IL-6 and IL-8 could potentially serve as biomarkers for predicting poor outcomes in NB patients. The study suggests that genetic polymorphisms and serum levels of IL-6 and IL-8 play a significant role in the prognosis of NB patients, particularly in Mexican children.
Review
Immunology
Elnaz Roohi, Nematollah Jaafari, Farshad Hashemian
Summary: Alterations in IL-6 levels may contribute to depression symptomatology in various ways, both in the periphery and the brain. IL-6 acts on multiple target tissues throughout the body, and dysregulation of this cytokine can lead to events relevant to depression. Blocking the effects of IL-6 may prevent further escalation of inflammatory responses and open new avenues in diagnosis, treatment, and prevention of this debilitating disorder.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Medicine, General & Internal
Nimish Godbole, Iiris Nyholm, Maria Hukkinen, Joseph R. Davidson, Athanasios Tyraskis, Katja Eloranta, Noora Andersson, Jouko Lohi, Paivi Heikkila, Antti Kyronlahti, Marjut Pihlajoki, Mark Davenport, Markku Heikinheimo, Mikko P. Pakarinen
Summary: This study revealed that IL-8 is overexpressed in the liver and serum of biliary atresia patients, especially during the postoperative period. IL-8 expression is positively correlated with ductular reaction, liver fibrogenesis, and related cellular markers.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Elettra Capogna, Leiv Otto Watne, Oystein Sorensen, Carlijn Jamila Guichelaar, Ane Victoria Idland, Nathalie Bodd Halaas, Kaj Blennow, Henrik Zetterberg, Kristine Beate Walhovd, Anders Martin Fjell, Didac Vidal-Pineiro
Summary: Concentrations of pro-inflammatory cytokines IL-6 and IL-8 increase with age and in Alzheimer's disease (AD). It is unclear whether these cytokine concentrations in the central nervous system can predict brain and cognitive changes over time, and whether this relationship is influenced by core AD biomarkers. This study followed 219 cognitively healthy older adults with baseline CSF measures of IL-6 and IL-8 for up to 9 years, and found that higher CSF IL-8 levels were associated with better memory performance over time, particularly when CSF p-tau and p-tau/Aβ-42 levels were lower. Higher CSF IL-6 levels were also related to less CSF p-tau changes over time. These findings support the hypothesis that upregulation of IL-6 and IL-8 in the brain may have a neuroprotective role in cognitively healthy older adults with lower AD pathology burden.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Editorial Material
Immunology
Travis E. Faust, Dorothy P. Schafer
Summary: The study reveals that the pro-inflammatory cytokine IL-6 specifically increases synaptogenesis in immature excitatory neurons through downstream neuronal STAT3-dependent transcriptional regulation of Rgs4.