期刊
PHYTOTHERAPY RESEARCH
卷 22, 期 12, 页码 1677-1681出版社
WILEY
DOI: 10.1002/ptr.2562
关键词
radioprotection; fucoidan; irradiation
资金
- Basic Atomic Energy Research Institute (BAERI)
- Ministry of Science and Technology (MOST) of Korea
The effects of fucoidan on the survival rate of mice treated with total body irradiation were examined. BALB/c mice were pretreated with various doses of fucoidan prior to total-body irradiation and were monitored for 30 days. A significant improvement of survival was observed by pretreatment with fucoidan at 100 mg/kg body weight. Using this optimal dosage, survival was examined by radiation dose reduction analysis and a dose reduction factor (DRF) of 1.20 was determined at 30 days post-irradiation. Mice pretreated with fucoidan also exhibited dose-dependent increases in the number of bone marrow cells and endogenous spleen cell colonies at day 9 post-irradiation. It is concluded that the increased survival of whole-body irradiated mice pretreated with fucoidan may be attributable to the radioprotective effects of fucoidan on hematopoietic cell viability, proliferation and/or mobility, possibly through antioxidation or antiinflammatory mechanisms. Copyright (C) 2008 John Wiley & Sons, Ltd.
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