Review
Biochemistry & Molecular Biology
Nuri Gueven, Pranathi Ravishankar, Rajaraman Eri, Emma Rybalka
Summary: Idebenone is widely described as an antioxidant drug, but there is a significant discrepancy between its pharmacokinetics and achievable tissue levels in target tissues, casting doubt on our current understanding. A new framework has been proposed based on recent discoveries to explain its mode of action, providing a rational approach for testing its effects in novel indications.
Review
Pharmacology & Pharmacy
Yang Jiang, Qi Zhao, Lin Li, Shumin Huang, Shuai Yi, Zhixi Hu
Summary: Traditional Chinese medicine (TCM) is a healthcare system based on clinical trials that relies on specific theories and practical experiences to treat diseases and improve public health.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Cedric Barthel, Georges Massiot, Catherine Lavaud
Summary: This article studies the interactions between saponins and active principles in traditional Chinese medicine formulations. The partition coefficient (logP) between water and octanol was used to indicate these interactions. Four distinct patterns of interactions were identified, which were linked to the ability of saponins to form micelles in water. These findings provide insights into the detoxification and synergistic effects of herbal preparations.
PHYTOCHEMICAL ANALYSIS
(2023)
Article
Medicine, Research & Experimental
Shan Dongjie, R. Samuel Rajendran, Qing Xia, Gaimei She, Pengfei Tu, Yun Zhang, Kechun Liu
Summary: The neuroprotective effects of Tongtian Oral Liquid (TTKFY) were evaluated in an animal model of Parkinson's disease. The results showed that TTKFY protected dopaminergic neurons, improved behavioral function, increased antioxidant activities, and regulated gene expression. This suggests that TTKFY has potential in preventing and treating Parkinson's disease.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Clinical Neurology
Song Li, Zhengzhi Wu, Weidong Le
Summary: In Western medicine, dementia affects cognition, mental health, and physical abilities, while Traditional Chinese Medicine explains it from the perspectives of brain dystrophy, Spleen-Kidney weakness, Blood stasis, and Phlegm stagnation. Ancient Chinese physicians believed that dementia manifests not only as cognitive symptoms but also as psychiatric disorders and sleep disturbance, offering various treatment methods.
ALZHEIMERS & DEMENTIA
(2021)
Review
Pharmacology & Pharmacy
Mingtao Zhu, Yanping Sun, Haodong Bai, Yimeng Wang, Bingyou Yang, Qiuhong Wang, Haixue Kuang
Summary: Cancer is a serious health threat, and the search for safe and effective drugs for its treatment has become a long-term goal. Traditional Chinese herbal medicine (TCM) has shown outstanding results in the treatment of cancer, particularly with the use of saponins. However, there is still limited research on the effect of saponins on signal transduction pathways involved in cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Veterinary Sciences
Xiaoyu Wang, Yun Wang, Yaqin Mao, Aiming Hu, Tianfang Xu, Yan Yang, Feibing Wang, Guangbin Zhou, Xiaowang Guo, Huabin Cao, Fan Yang
Summary: This study identified the effects of Xiao-Jian-Zhong-Tang (XJZT) and Jingsananli-sepsis (JJS) on oxidative stress and inflammation in the liver of piglets. The results showed that these traditional Chinese medicine prescriptions enhanced the antioxidant and anti-inflammatory capabilities of the liver through the Nrf2/NF-κB pathway, indicating their potential as functional treatments.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Ruiying Wang, Min Wang, Jiahui Zhou, Daoshun Wu, Jingxue Ye, Guibo Sun, Xiaobo Sun
Summary: Myocardial ischemia-reperfusion injury is a high-risk disease without effective treatment methods. Saponins in traditional Chinese medicine show significant cardioprotective effects and provide a broad application prospect for the development of highly effective and low-toxicity anti-MIRI drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Siyuan Rao, Yongpeng Lin, Rui Lin, Jinggong Liu, Hongshen Wang, Weixiong Hu, Bolai Chen, Tianfeng Chen
Summary: In this study, TSIIA@SeNPs-APS, a nanotechnology-based combination of TCM active ingredients, showed promise in the antioxidant therapy of spinal cord injuries. It improved the bioavailability of Huangqi and Danshen and had therapeutic effects by promoting cell survival and alleviating oxidative stress-induced cell damage.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Lei Li, Man Wang, Jikuai Chen, Juelin Chen, Yawei Wang, Minghao Zhao, Qing Song, Shuogui Xu
Summary: As global warming continues, heat waves are becoming more frequent and intense, leading to an increase in the incidence of heat stroke. Heat stroke is associated with significant morbidity and mortality, and further research is urgently needed to address this issue. Traditional Chinese medicine offers potential treatment methods, including herbal therapies and external treatments, which may provide clinical benefits and research directions for heat stroke.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Clare L. Higgins, Sorin V. Filip, Ashfaq Afsar, Howard M. Colquhoun, Wayne Hayes
Summary: Taking inspiration from the food industry, an assay was developed to test the efficiency of new phenolic antioxidants by spectrophotometric measurement of the stable free radical DPPH. The kinetics of the reaction were categorized as fast, medium, or slow based on the disappearance of the absorbance band. The study also analyzed the stoichiometry of the radical scavenging reaction and its relationship with the structure-activity of phenolic antioxidants.
Article
Plant Sciences
Wei Zhuang, Shao-Li Liu, Sheng-Yan Xi, Ying-Nan Feng, Ke Wang, Teliebald Abduwali, Ping Liu, Xiao-Jiang Zhou, Lan Zhang, Xian-Zhe Dong
Summary: This article summarizes the frequently used traditional Chinese medicine decoctions and Chinese patent medicines for treating depression, reviews their clinical therapeutic effects and possible mechanisms, and highlights the importance of traditional Chinese medicine in the management of depression.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xue Bai, Meng Zhang
Summary: Research has shown that traditional Chinese medicine has a clinical impact on vascular dementia, improving patients' cognitive function and quality of life. The pharmacological mechanisms of TCM for VD treatment include targeting the kidneys, eliminating turbidity, and promoting blood circulation, indicating promising prospects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Chao Mo, Jie Zhao, Jingyan Liang, Huiling Wang, Yu Chen, Guodong Huang
Summary: Exosomes play a crucial role in intercellular communication, and the interaction between exosomes and traditional Chinese medicine (TCM) has beneficial effects on various diseases. TCM formulas and compounds can modulate exosomes to inhibit cell proliferation, reduce inflammation, and attenuate fibrosis. Additionally, exosomes serve as a natural delivery system for TCM compounds, and they may also be potential biomarkers for TCM syndromes.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Qi Wang, Wenjun Li, Haibo Hu, Xuechao Lu, Song Qin
Summary: Pulmonary fibrosis (PF) is a chronic and irreversible pulmonary disease that can result in decreased lung function, respiratory failure, and even death. Traditional Chinese medicine monomeric compounds have various biological activities and high safety, making them potential candidate drugs for preventing and treating PF. This review explores the mechanism of action and potential value of these compounds in attenuating lung inflammation, oxidative stress, and fibroblast activation and differentiation, providing new ideas for the development of effective and low-toxicity anti-PF drugs.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
