Article
Plant Sciences
Huan He, Jianling Deng, Maochun Yang, Linjing An, Xiaoli Ye, Xuegang Li
Summary: JAT from RC has an effect on treating obesity, and its anti-obesity effect may be exerted via the IRS1/PI3K/AKT signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Luying He, Man Chen, Qilian Liang, Yitao Wang, Wen Tan
Summary: Coptidis Rhizoma (C. Rhizoma), a classical Chinese medicinal plant, has been shown to have anticancer effects on gastrointestinal cancer. This review summarizes the chemical components, anticancer mechanisms, and clinical applications of C. Rhizoma, and highlights its potential as an adjuvant candidate against cancers.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Wei Zheng, Guixia Sun, Jianhua Chen, Zhihui Li, Ting Zhang, Guijie Wei, Hongya Wang, Xiurui Sun, Zhe Zhang, Wenwen Zhao, Pengkai Ma, Yujie Zhang, Chunyue Zhang
Summary: The study found that Coptidis Rhizoma (CR) decreased the metabolism and absorption of flavonoids in Scutellariae Radix (SR), especially exerting different effects on aglycones and glycosides. This may be one of the potential mechanisms underlying the therapeutic effects of the combination of SR and CR on diabetes mellitus.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Oh-Jun Kwon, Ji-Won Noh, Byung-Cheol Lee
Summary: The study demonstrates that Coptidis Rhizoma has therapeutic effects on obesity-induced inflammation by inhibiting macrophage-mediated inflammation in adipose tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Tianwei Meng, Jiawen Liu, Hong Chang, Rui Qie
Summary: Bioinformatics and network analysis were used to reveal the mechanism of Rhizoma Pinelliae-Rhizoma Coptidis herb pair in the treatment of lung adenocarcinoma. The target and pathway of the herb pair were explored, and potential biomarkers were predicted. A total of 294 therapeutic targets and 47 core targets were obtained.
Article
Biochemistry & Molecular Biology
Lan Xie, Shanshan Feng, Xiaoling Zhang, Wenlong Zhao, Juan Feng, Chengmei Ma, Ruijun Wang, Weifang Song, Jing Cheng
Summary: This study analyzed the differences in typical alkaloids of Rhizoma Coptidis at a systematic level, providing comprehensive information on their pharmaceutical mechanisms. Berberine and coptisine showed stronger inhibitory effects on cell proliferation than palmatine, with some similarities in cellular pathways. Additionally, these alkaloids had different regulatory effects on genes involved in lipid metabolism.
Article
Nanoscience & Nanotechnology
Jing Zhao, Qing Zhao, Jing-Ze Lu, Dan Ye, Sheng Mu, Xiao-Di Yang, Wei-Dong Zhang, Bing-Liang Ma
Summary: Proteinaceous nanoparticles isolated from Coptidis Rhizoma extract can form a natural nano-drug delivery system with BBR, thus significantly improving the pharmacokinetics of oral BBR.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Yuanming Yang, Yiwei Hua, Weihuan Chen, Huan Zheng, Haomeng Wu, Shumin Qin, Shaogang Huang
Summary: This study utilizes bioinformatics analysis to reveal the molecular mechanisms of key phytochemicals in Coptidis Rhizoma against ulcerative colitis. The findings suggest that these phytochemicals have ideal physicochemical properties and bioactivity, and their potential pharmacological mechanisms involve various signaling pathways. This research provides valuable directions for future investigations.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Aeyung Kim, Su-Jin Baek, Sarah Shin, Seo-Young Lee, Sun-Ku Chung
Summary: In cell-based regenerative medicine, induced pluripotent stem cells (iPSCs) generated from adult somatic cells have shown promise as a cell source due to the lack of ethical concerns and immune rejection risk. However, the risk of teratoma formation remains a safety concern. In this study, an ethanol extract of coptidis rhizoma (ECR) is explored for its ability to eliminate undifferentiated iPSCs and prevent teratoma formation. The results demonstrate that ECR induces apoptotic cell death and DNA damage in iPSCs, while leaving differentiated cells unharmed. The active components of ECR, berberine and coptisine, show selective cytotoxicity to iPSCs. This research highlights the potential of ECR in producing safe and effective iPSC-based therapies.
Article
Biochemistry & Molecular Biology
So Young Kim, Cheol Park, Min Yeong Kim, Seon Yeong Ji, Hyun Hwangbo, Hyesook Lee, Su Hyun Hong, Min Ho Han, Jin-Woo Jeong, Gi-Young Kim, Chang-Gue Son, JaeHun Cheong, Yung Hyun Choi
Summary: Coptidis Rhizoma has anti-tumor effects on hepatocellular carcinoma by inducing cell apoptosis and autophagy, reducing cell invasion and migration, and suppressing tumor growth. These effects are mediated by the generation of reactive oxygen species (ROS) and suggest a potential pharmacological intervention for HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Jinming Liu, Haiman Xu, Li Zhang, Shuai Wang, Danyi Lu, Min Chen, Baojian Wu
Summary: Identifying drugs with dosing time-dependent effects and understanding the role of REV-ERB alpha as a drug target can improve drug treatment outcomes. The herbal medicines Puerariae radix and Coptidis rhizoma have demonstrated chronoeffects in mice, with PR alleviating hyperhomocysteinemia and CR attenuating chronic colitis in a dosing time-dependent manner, possibly attributed to diurnal expression of REV-ERB alpha.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Ning Zhou, Yongxiang Wang, Zhenkai Zhang, Tong Liu, Jinying Zhang, Yumin Cao, Bingxian Zhang, Weisheng Feng, Xiaoke Zheng, Kai Li
Summary: Metabolomics was used to compare the chemical composition and efficacy differences between the processed products of Coptidis Rhizoma. Different processing methods had different effects on the chemical composition and efficacy mechanism, providing guidance for the rational use of Coptidis Rhizoma.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Pharmacology & Pharmacy
Yong-Hwi Kang, Jing-Hua Wang, Jin-Seok Lee, Nam-Hun Lee, Chang-Gue Son
Summary: Colorectal cancer is the second most lethal malignancy worldwide, and its high mortality rate is largely due to cancer metastasis. Suppression of epithelial-to-mesenchymal transition (EMT) has emerged as a promising strategy for treating metastatic cancer. This study evaluated the antimetastatic effect of Coptidis Rhizoma, a traditional Chinese medicine, on drug-resistant colon cancer cells and found that it inhibits EMT through the TGF-beta signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Ziwei Huang, Minhua Li, Zehui Qin, Xingdong Ma, Ronglei Huang, Yuhong Liu, Jianhui Xie, Huifang Zeng, Ruoting Zhan, Ziren Su
Summary: This study reveals the hypolipidemic mechanism of Berberine (BBR) from Rhizoma Coptidis (RC) through its unique intestines-erythrocytes-mediated biotransformation and disposition pathways. BBR undergoes biotransformation in both intestines and erythrocytes to the major metabolite oxyberberine (OBB). BBR and OBB are mainly presented and transported in the protein-bound form within circulating erythrocytes, potentially resulting in hepatocyte targeting accompanied by enterohepatic circulation. The unique extrahepatic metabolism and disposition of BBR via intestines and erythrocytes contribute significantly to its hypolipidemic effect. OBB is the important material basis for the hypolipidemic effect of BBR and RC.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pediatrics
Xue Fan, Xin Guo, Ying Li, Mingguo Xu
Summary: This study aimed to identify the main active ingredients in Coptidis Rhizoma for treating Kawasaki disease and explore the molecular mechanisms involved. The network pharmacology approach revealed potential therapeutic targets of Berberine on Kawasaki disease, with significant effects on biological processes and signaling pathways. Protein expression analysis confirmed the modulation of key targets in the treatment of the disease.
FRONTIERS IN PEDIATRICS
(2021)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.