Article
Plant Sciences
Elnaz Bafandeh, Farnaz Kheirandish, Zeinab Hosseini, Saeed Veiskarami, Marzieh Rashidipour, Bahram Kazemi, Atiyeh Darbandi, Shirzad Fallahi, Arian Karimi Rouzbahani
Summary: Olive leaf extract (OLE) can significantly reduce the expression of DHFR gene and have a slight effect on the expression of PTR1 gene in Leishmania major parasite.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Nutrition & Dietetics
Doretta Cuffaro, Simone Bertini, Marco Macchia, Maria Digiacomo
Summary: This study examines the combination of olive leaf extract and extra virgin olive oil extract, which shows improved antioxidant and anti-inflammatory properties compared to the singular olive oil extract. This extract may have potential in the field of nutraceuticals.
Article
Plant Sciences
Nawraj Rummun, Elisabete Pires, James McCullagh, Timothy W. D. Claridge, Theeshan Bahorun, Wen-Wu Li, Vidushi S. Neergheen
Summary: The study investigated the antioxidant and anti-proliferative properties of three endangered Syzygium species endemic to Mauritius. Results showed that S. coriaceum exhibited the most potent antioxidant activities and induced dose-dependent decrease in cell viability. The study identified gallic acid and methyl gallate as major bioactive components in S. coriaceum leaf extract, which effectively induced cell death in HepG2 cells by upregulating ROS levels.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Mechanics
Demet Sonmezler, Gulum Sumnu, Serpil Sahin
Summary: The effects of different concentrations of pea flour and homogenization methods on the properties of emulsions were investigated. It was found that pea flour acted as an emulsifier to enhance the stability of the emulsions, and the stability was correlated with viscosity and particle size. Emulsions stored at 20 degrees C degraded faster than those stored at 4 degrees C.
Article
Food Science & Technology
Dalel Mechi, Antonio Fernandez, Bechir Baccouri, Leila Abaza, Daniel Martin-Vertedor
Summary: This research focuses on improving food quality by using olive leaf extracts, particularly studying a Tunisian variety named 'Chetoui'. The study found that adult 'Chetoui' olive leaf extract had higher phenolic content and methanol was the most effective solvent. Sensory analysis showed that adding OLE (1:100) to table olives was most appealing for consumers.
Article
Microbiology
Yanhong Liu, Ting Fang, Yujuan Suo, Shigang Gao, Gian Marco Baranzoni, Cheryl M. Armstrong
Summary: Listeria monocytogenes, a regulated foodborne pathogen, is inhibited by olive leaf extract which decreases its virulence potential. RNA-Seq analysis revealed differential expression of genes upon OLE treatment, with several virulence-related genes being downregulated. Validation using quantitative reverse-transcription PCR confirmed the gene expression changes observed in the study.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jose Gustavo De la Ossa, Alessandra Fusco, Bahareh Azimi, Jasmine Esposito Salsano, Maria Digiacomo, Maria-Beatrice Coltelli, Karen De Clerck, Ipsita Roy, Marco Macchia, Andrea Lazzeri, Giovanna Donnarumma, Serena Danti, Rossella Di Stefano
Summary: The research demonstrates that PHA fiber meshes containing olive leaf extract can reduce the expression of pro-inflammatory cytokines, showing potential anti-inflammatory and antibacterial properties, which are crucial for wound healing and tissue regeneration.
APPLIED SCIENCES-BASEL
(2021)
Article
Food Science & Technology
Michela Famiglietti, Alessandro Savastano, Rosa Gaglione, Angela Arciello, Daniele Naviglio, Loredana Mariniello
Summary: Nowadays, active and functional packaging is used to improve food product safety and shelf life. Chitosan-based films are studied due to their antibacterial and antifungal activity. This study developed CH-based films containing Dried Olive Leaf Extract (DOLE) and investigated their polyphenols yield and antioxidant activity. The results showed that DOLE-containing films exhibited antimicrobial effects against different bacterial strains in a dose-dependent manner.
Article
Biochemistry & Molecular Biology
Elda M. Melchor-Martinez, Juan F. Tamez-Fernandez, Gloria Maria Gonzalez-Gonzalez, David A. Silva-Mares, Noemi Waksman-Minsky, Luis Alejandro Perez-Lopez, Veronica M. Rivas-Galindo
Summary: Candida albicans is the most common pathogen in invasive human fungal infections, with candidemia having high mortality rates. Studies have shown that C. glabrata is often resistant to fluconazole. Mexican plant extracts, particularly from Colubrina greggii, have shown activity against various Candida species. Isolated compounds from the plant exhibited antifungal activity only against fluconazole-resistant C. glabrata, with no toxicity in bioassays. Ethyl acetate and butanol extracts, along with flavonoid mixtures, were particularly effective against Candida spp.
Article
Food Science & Technology
Oguz Bayraktar, Charis M. Galanakis, Turki M. S. Aldawoud, Salam A. Ibrahim, Merve Deniz Kose, Mehmet Emin Uslu
Summary: The study demonstrates the potential use of waste eggshell membrane to adsorb bioactive compounds from olive leaf extract, designing functional biomaterials with bioactive properties, showing promising market prospects.
Article
Chemistry, Physical
Sylwia Grabska-Zielinska, Magdalena Gierszewska, Ewa Olewnik-Kruszkowska, Mohamed Bouaziz
Summary: This study aimed to obtain PLA films with improved antioxidant properties by adding PEG and OLE. Characterization of OLE was conducted using LC-MS/MS techniques. The results showed that the addition of OLE increased material crystallinity and enhanced antioxidant properties in PLA/PEG films.
Article
Chemistry, Medicinal
Paola De Cicco, Giuseppe Ercolano, Gian Carlo Tenore, Angela Ianaro
Summary: This study investigated the effects of an extract from olive tree leaves (OLE) on metastatic melanoma, a highly aggressive and deadly form of skin cancer. The results showed that OLE inhibited melanoma cell proliferation, migration, invasion, and colonies formation both in vitro and in vivo. These effects were attributed to the targeting of mitogen-activated protein kinase and PI3K pathways. The findings suggest that OLE has the potential to be a new add-on therapy for the management of metastatic melanoma.
PHYTOTHERAPY RESEARCH
(2022)
Article
Engineering, Environmental
Ana L. S. Oliveira, Sheila Gondim, Ricardo Gomez-Garcia, Tania Ribeiro, Manuela Pintado
Summary: Olea europaea L. is historically significant in Mediterranean countries. Polyphenols extracted from olive leaves have antioxidant properties and can be used as antiaging ingredients and cosmetic/food preservatives. Additionally, they exhibit antimicrobial activity.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Environmental Sciences
Harith Abdulrhman Ahmed, Huda Abdullah Ali, Thulfiqar Fawwaz Mutar
Summary: In conclusion, the study found that olive leaf extract has protective and ameliorative effects against lead acetate-induced oxidative stress, apoptosis, alterations in testicular tissue, and sperm quality in rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Food Science & Technology
Graziana Difonzo, Michela Pia Totaro, Francesco Caponio, Antonella Pasqualone, Carmine Summo
Summary: This study investigated the effects of olive leaf extract (OLE) on ripened pork sausages and found that OLE can reduce the residual content of nitrate/nitrite (NO) without significant changes in moisture, pH, and hardness of the sausages.
Article
Environmental Sciences
Olfa Bachrouch, Houwaida Nefzi, Souhir Belloumi, Karima Horchani-Naifer, Jazia Sriti Eljazi, Soumaya Haoual Hamdi, Kamel Msaada, Jalel Labidi, Manef Abderrabba, Jouda Mediouni Ben Jemaa
Summary: This study investigated the composition and toxicity of Thyme essential oils (EOs) against two main stored grain insect pests. The results showed that the EOs had higher toxicity to the L. serricorne than the T. castaneum. The study also tested the combination of EOs with Tunisian Diatomaceous earths (DEs), which showed promising results in protecting stored grains.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Medicine, Research & Experimental
Ruben L. Rodriguez-Exposito, Desiree San Nicolas-Hernandez, Ines Sifaoui, Cristina Cuadrado, Lizbeth Salazar-Villatoro, Maria Reyes-Batlle, Antonio Hernandez-Daranas, Maritza Omana-Molina, Jose J. Fernandez, Ana R. Diaz-Marrero, Jose E. Pinero, Jacob Lorenzo-Morales
Summary: Six meroterpenoids were isolated from Gongolaria abies-marina, with Gongolarones A and C showing the lowest IC50 values against different stages of Acanthamoeba. These compounds were found to induce programmed cell death (PCD) in Acanthamoeba.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Desiree San Nicolas-Hernandez, Carlos J. Bethencourt-Estrella, Atteneri Lopez-Arencibia, Eduardo Hernandez-Alvarez, Ines Sifaoui, Isabel L. Bazzocchi, Jacob Lorenzo-Morales, Ignacio A. Jimenez, Jose E. Pinero
Summary: This study reports the leishmanicidal and trypanocidal activities of twenty-four known silyl-ether derivatives of withaferin A. Among them, derivative 10 exhibited higher activity against Leishmania and Trypanosoma parasites with lower cytotoxicity. These derivatives appear to induce apoptosis-like and autophagy events leading to programmed cell death.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Environmental
Youssef Snoussi, Ines Sifaoui, Mohamed El Garah, Ahmed M. Khalil, Mohamed Jouini, Souad Ammar, Jacob Lorenzo -Morales, Mohamed M. Chehimi
Summary: The conversion processes of sugarcane generate a large amount of waste called sugarcane bagasse. This study proposes a zero-waste pathway to turn sugarcane bagasse into high added-value functional materials. By macerating and ultrasonication, a natural extract was obtained and used as a bio-reducing medium. Then, the sugarcane bagasse was impregnated with a bimetallic solution to produce a composite and carbonized to fabricate biochar, while residual liquid waste was used to obtain free nanoparticles. The biochar showed high catalytic activity and the nanoparticles exhibited exceptional effects against certain protozoans.
Article
Environmental Sciences
Djeniffer Sousa-Ramos, Maria Reyes-Batlle, Natalia Karla Bellini, Ruben Leocadio Rodriguez-Exposito, Jose Enrique Pinero, Jacob Lorenzo-Morales
Summary: Despite being found in various natural environments, not all Naegleria species can infect humans and they can complete their life cycle in the environment. The presence of this genus suggests the presence of the highly pathogenic Naegleria fowleri, which poses a risk to public health. This study confirmed the presence of potentially pathogenic Naegleria australiensis in the wastewater treatment plant in Santiago Island, Cape Verde, highlighting the low efficiency of wastewater treatment and the potential threat to public health. Further studies are needed to prevent and control possible infections in the country.
JOURNAL OF WATER AND HEALTH
(2023)
Article
Chemistry, Medicinal
Inigo Arberas-Jimenez, Nathalia Nocchi, Javier Chao-Pellicer, Ines Sifaoui, Angelica Ribeiro Soares, Ana R. R. Diaz-Marrero, Jose J. Fernandez, Jose E. Pinero, Jacob Lorenzo-Morales
Summary: This study aimed to identify new anti-Naegleria marine natural products from a collection of chamigrane-type sesquiterpenes with structural variety, and (+)-Elatol was found to be the most effective compound against Naegleria fowleri.
Article
Chemistry, Medicinal
Sara Garcia-Davis, Atteneri Lopez-Arencibia, Carlos J. Bethencourt-Estrella, Desiree San Nicolas-Hernandez, Ezequiel Viveros-Valdez, Ana R. Diaz-Marrero, Jose J. Fernandez, Jacob Lorenzo-Morales, Jose E. Pinero
Summary: In this study, it was found that five compounds isolated from the red alga Laurencia johnstonii exhibited leishmanicidal activity. Among them, laurequinone showed the strongest activity and was capable of inducing programmed cell death or apoptosis in the parasite. These findings highlight the potential of laurequinone as a novel therapeutic agent against kinetoplastid parasites.
Article
Genetics & Heredity
Angelica Dominguez-de-Barros, Ines Sifaoui, Zuzanna Borecka, Roberto Dorta-Guerra, Jacob Lorenzo-Morales, Rafael Castro-Fuentes, Elizabeth Cordoba-Lanus
Summary: This study found that telomeres shorten with age in Psittacidae species and that short-lived birds accumulate more oxidative stress products but have lower antioxidant capacity compared to long-lived birds. Breeding is also related to telomere shortening, with short-lived birds experiencing increased oxidative damage during breeding while long-lived birds are able to counteract this damage with increased antioxidant capacity.
FRONTIERS IN GENETICS
(2023)
Article
Chemistry, Medicinal
Desiree San Nicolas-Hernandez, Ruben L. Rodriguez-Exposito, Atteneri Lopez-Arencibia, Carlos J. Bethencourt-Estrella, Ines Sifaoui, Lizbeth Salazar-Villatoro, Maritza Omana-Molina, Jose J. Fernandez, Ana R. Diaz-Marrero, Jose E. Pinero, Jacob Lorenzo-Morales
Summary: In this study, four meroterpenoids were isolated and purified from a brown alga, and their activity and toxicity were evaluated. The results showed that these meroterpenoids could induce apoptosis and autophagy, indicating their potential value in the treatment of parasitic infections.
Article
Chemistry, Multidisciplinary
Ali Saad, Khouloud Jlassi, Manef Abderrabba, Mohamed M. Chehimi
Summary: A novel sorbent based on clickable mesoporous silica was successfully prepared, which exhibited high adsorption efficiency and fast removal rate for organic dyes, indicating significant potential for environmental applications.
CHEMISTRY AFRICA-A JOURNAL OF THE TUNISIAN CHEMICAL SOCIETY
(2023)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.
