Article
Multidisciplinary Sciences
Carrie Cuttler, Emily M. LaFrance, Amanda Stueber
Summary: Statewide legislation has increased access to high-potency cannabis, but federal restrictions limit access to research on low-potency whole-plant cannabis. This study examined the acute cognitive effects of high-potency cannabis, finding that high-potency flower with CBD impaired free recall, flower without CBD and concentrates affected source memory, and all three products increased susceptibility to false memories.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Veronica Arreaza-Gil, Ivan Escobar-Martinez, Manuel Suarez, Francisca Isabel Bravo, Begona Muguerza, Anna Arola-Arnal, Cristina Torres-Fuentes
Summary: Gut microbiota and biological rhythms are key factors that affect physiological and metabolic processes. This study found that seasonal changes in photoperiod significantly altered gut microbiota composition and influenced diet-induced obesity development.
Article
Food Science & Technology
Hatice Ozcaliskan Ilkay, Derya Karabulut, Gonca Kamaci Ozocak, Ecmel Mehmetbeyoglu, Emin Kaymak, Betul Kisioglu, Betul Cicek, Asli Akyol
Summary: The study aimed to investigate the protective effects of quinoa in glucose homeostasis in a model of cafeteria diet-induced obesity. Results showed that quinoa lowered body weight, blood glucose, and insulin levels, increased liver IRS-1 and AMPK gene expressions, and enhanced pancreatic beta-cell insulin immunoreactivity. Quinoa may be useful in preventing obesity and associated metabolic disorders.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Andreu Gual-Grau, Maria Guirro, Noemi Boque, Lluis Arola
Summary: Genetic factors and sex can influence the gut microbiota composition and obesity status of rats fed a CAF diet.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Agricultural Engineering
Avia Saloner, Nirit Bernstein
Summary: Nitrogen supply affects cannabinoid and terpenoid metabolism, with the optimal N level for both yield quantity and relatively high secondary metabolites content being 160 mg L-1. High N supply has adverse effects on the production of secondary compounds in cannabis, while promoting plant growth and biomass production.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Biology
Syed Mohammed Basheeruddin Asdaq, Shrey Tambe, Yahya Mohzari, Ahmed Alrashed, Hamdan Najib Alajami, Awad Othman Aljohani, Abdullah Ali Al Mushtawi, Majed Sultan Alenazy, Rakan Fahad Alamer, Abdulmajead Khalid Alanazi, Syed Imam Rabbani
Summary: This study evaluated the anti-obesity potential of almonds under different dietary conditions. Results showed that almond can prevent weight gain, improve lipid parameters, and stabilize CNS parameters. The high dose almond preparation was most effective in reducing body weight.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Jakub Poloczek, Wojciech Kazura, Elzbieta Chelmecka, Katarzyna Michalczyk, Jerzy Jochem, Janusz Gumprecht, Dominika Stygar
Summary: Over-nutrition leads to glycemic control failure and obesity, which can be mitigated by bariatric surgery and specific dietary protocol. The study measured the levels of antioxidant markers and lipid peroxidation markers in rats fed with different diets and subjected to surgery. The results showed that the diet change strongly influenced antioxidant marker activity, while bariatric surgery had a greater effect on superoxidase dismutase activity. All dietary protocols increased ceruloplasmin activity, and cafeteria diet decreased total antioxidant capacity levels. Bariatric surgery and no change in diet reduced lipid peroxidation and lipofuscin levels, respectively.
Review
Pharmacology & Pharmacy
Arash Salehi, Keely Puchalski, Yalda Shokoohinia, Behzad Zolfaghari, Sedigheh Asgary
Summary: Hemp and marijuana differ in terms of chemical and genetic composition, production practices, product uses, and regulatory status. Hemp seed and hemp seed oil have nutritional value, and the non-intoxicating phytocannabinoid CBD has high medicinal potential. It is now easier to differentiate between hemp and marijuana in the laboratory, and regulations and testing guidelines for cannabis are still evolving.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Brianna F. Moore, Katherine A. Sauder, Allison L. B. Shapiro, Tessa Crume, Gregory L. Kinney, Dana Dabelea
Summary: The study assessed the impact of fetal exposure to cannabis on adiposity and glucose-insulin traits in early life. The results suggest that fetal exposure to cannabis may be associated with increased adiposity and fasting glucose in childhood.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Arzu Kabasakal Cetin, Tugba Alkan Tug, Atila Gulec, Asli Akyol
Summary: The study showed that maternal taurine supplementation has modest protective effects against cafeteria diet-induced maternal obesity. However, in the setting of normal pregnancy, taurine supplementation may lead to increased neonatal mortality. Further research is needed to explore the optimal dosage of taurine supplementation and its long-term effects on offspring.
Article
Biochemistry & Molecular Biology
Aynaz Tajaddini, Michael D. Kendig, Kelly V. Prates, R. Frederick Westbrook, Margaret J. Morris
Summary: Maternal obesity increases the risk of health complications in offspring, and the effects can be exacerbated by offspring exposure to unhealthy diets. This study found that offspring from obese mothers who were fed an unhealthy "cafeteria" diet had smaller size, more abdominal fat, and altered gene expression in the liver. Additionally, maternal obesity enhanced the negative effects of postweaning unhealthy diet on male offspring, while having minimal impact on female offspring. These findings highlight the importance of understanding the sex-specific detrimental effects of maternal obesity on offspring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Psychiatry
Janni Leung, Daniel Stjepanovic, Danielle Dawson, Wayne D. Hall
Summary: Research shows that some experimental studies suggest individuals can titrate their THC doses when using higher potency cannabis for recreational purposes, but there is limited evidence on whether regular cannabis users actually do so. Further experimental and epidemiological research is needed to inform regulatory policies aiming to reduce harms from the use of high THC cannabis products.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Amir Englund, Dominic Oliver, Edward Chesney, Lucy Chester, Jack Wilson, Simina Sovi, Andrea De Micheli, John Hodsoll, Paolo Fusar-Poli, John Strang, Robin M. Murray, Tom P. Freeman, Philip McGuire
Summary: As countries adopt more permissive cannabis policies, it is increasingly important to identify strategies that can reduce the harmful effects of cannabis use. This study aimed to determine if increasing the CBD content of cannabis can reduce its harmful effects. The results showed that increasing the CBD content did not reduce the harmful effects of cannabis on memory and psychotic symptoms. Therefore, CBD may not protect against the acute adverse effects of cannabis.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Agricultural Engineering
Nadav Danziger, Nirit Bernstein
Summary: Plant architecture modulation can increase standardization of the cannabinoid profile in cannabis by increasing concentrations at the lower parts of the plant. Genotype and architectural modulation have specific effects on cannabinoid standardization.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Nutrition & Dietetics
Arzu Kabasakal Cetin, Yucel Buyukdere, Atila Gulec, Asli Akyol
Summary: Maternal taurine supplementation can reduce adiposity and alter hepatic gene expression patterns, mitigating the detrimental effects of maternal obesogenic diet on offspring. The offspring supplemented with taurine showed lower fat deposition and body fat compared to those without supplementation. Genes related to steroid hormone biosynthesis, cholesterol metabolism, and fatty acid degradation were down-regulated in the taurine-supplemented offspring.
NUTRITION RESEARCH
(2023)
Article
Cell Biology
Bruno R. Salu, Silvana Cristina Pando, Marlon De Brito, Andre Fernando Medina, Frank Odei-Addo, Carminita Frost, Ryno Naude, Misako U. Sampaio, Jonas Emsley, Francisco Humberto A. Maffei, Maria Luiza Oliva
Article
Biochemistry & Molecular Biology
Jason Krause, Carminita L. Frost
Article
Chemistry, Multidisciplinary
Felix Odame, Jason Krause, Eric C. Hosten, Richard Betz, Kevin Lobb, Zenixole R. Tshentu, Carminita L. Frost
BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA
(2018)
Article
Biochemistry & Molecular Biology
Natasha Beukes, Ruby-Ann Levendal, Earl Prinsloo, Carminita Frost
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2019)
Article
Biotechnology & Applied Microbiology
L. K. S. De Almeida, B. Pletschke, C. L. Frost
Article
Chemistry, Multidisciplinary
Felix Odame, Richard Betz, Eric C. Hosten, Jason Krause, Michelle Isaacs, Heinrich C. Hoppe, Setshaba D. Khanye, Yasien Sayed, Carminita Frost, Kevin A. Lobb, Zenixole R. Tshentu
Article
Pharmacology & Pharmacy
Wynand van Losenoord, Jason Krause, Shirley Parker-Nance, Rui Krause, Stoyan Stoychev, Carminita Lara Frost
Article
Biochemistry & Molecular Biology
Recardia Schoeman, Natasha Beukes, Carminita Frost
Article
Biochemistry & Molecular Biology
Amy de la Harpe, Natasha Beukes, Carminita L. Frost
Summary: ER stress is an imbalance between protein-folding load and ER capacity, which can be re-established through UPR. Studies suggest that CBD may induce ER stress via Ca2+ influx through the TRPV1 receptor, increasing ROS levels and disrupting protein folding.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2022)
Article
Plant Sciences
F. Odei-Addo, S. Ramlugon, R. -A. Levendal, C. L. Frost
Summary: This study investigated the anti-diabetic properties of L. Leonurus extract and marrubiin, revealing a mechanism of action primarily at the adipose tissue level. The increase in expression of certain genes may play a protective role towards liver and muscle tissues.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
F. Odame, Eric C. Hosten, R. Betz, J. Krause, Carminita L. Frost, K. Lobb, Zenixole R. Tshentu
Summary: A new method for synthesizing novel triazatetracyclic compounds has been reported, with their structures characterized using spectroscopy. The antioxidant activity of the compounds was evaluated, showing that certain functional groups within the compounds may play a key role in their activity, according to experimental and computational results.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Medicinal
Felix Odame, Recardia Schoeman, Jason Krause, Eric C. Hosten, Zenixole R. Tshentu, Carminita Frost
Summary: Various benzoxazepine derivatives were synthesized and characterized, with RS03 and RS12 showing potent cytotoxicity against breast cancer cells while displaying limited toxicity against noncancerous breast cells. These compounds induced cell cycle arrest in the G2/M phase and were more selective towards cancer cells, especially RS03 with the most potent activity.
MEDICINAL CHEMISTRY RESEARCH
(2021)
Article
Microbiology
Benesh M. Somai, Vuyokazi Belewa, Carminita Frost
Summary: The study confirmed that T. violacea extract affects ergosterol synthesis by inhibiting oxidosqualene cyclase, preventing the formation of downstream intermediates in the ergosterol pathway and ultimately resulting in inhibition of ergosterol production.
CURRENT MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Recardia Schoeman, Amy de la Harpe, Natasha Beukes, Carminita L. Frost
Summary: This study investigated the anti-proliferative effects of different ratios of THC and CBD in cannabis and their interactions with phytochemicals found in Cannabis sativa extract. The results showed that recreational cannabis formulations had anti-proliferative effects, while medicinal cannabis formulations did not. Additionally, the study found that the simultaneous treatment of cannabinoids and tamoxifen resulted in a diminished anti-proliferative activity of tamoxifen, particularly when combined with recreational cannabis formulations.
Article
Chemistry, Multidisciplinary
Felix Odame, Eric Hosten, Jason Krause, Michelle Isaacs, Heinrich Hoppe, Setshaba D. Khanye, Yasien Sayed, Carminita Frost, Kevin Lobb, Zenixole Tshentu
ACTA CHIMICA SLOVENICA
(2020)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.