Article
Multidisciplinary Sciences
Ma. Florencia Peralta, Ma. Laura Guzman, Ma. Estefania Bracamonte, J. Diego Marco, Ma. Eugenia Olivera, Dolores C. Carrer, Paola A. Barroso
Summary: Topical application of risedronate and EuE-Ris complexes demonstrates promising efficacy in treating cutaneous leishmaniasis, showing reduction in ulcer size, promotion of healing, and significant parasitic inhibition of 69.5% to 73.7%, with a potential trend towards cure. Further enhancements of the system are needed for complete parasite elimination.
Article
Pharmacology & Pharmacy
Juliana Figueiredo Peixoto, Luiz Filipe Goncalves-Oliveira, Franklin Souza-Silva, Luzia Monteiro de Castro Cortes, Geovane Dias-Lopes, Flavia de Oliveira Cardoso, Rafael de Oliveira Santos, Beatriz Ferreira de Carvalho Patricio, Caroline Deckmann Nicoletti, Carolina Guimaraes de Souza Lima, Katia da Silva Calabrese, Davyson de Lima Moreira, Helvecio Vinicius Antunes Rocha, Fernando de Carvalho da Silva, Vitor Francisco Ferreira, Carlos Roberto Alves
Summary: Oil-in-water microemulsions loaded with epoxy-alpha-lapachone (ELAP-ME) were successfully developed and showed good stability. ELAP-ME demonstrated promising activity against murine infection with Leishmania (Leishmania) amazonensis.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biophysics
Daniela Coelho, Beatriz Veleirinho, Leticia Mazzarino, Thais Alberti, Elizandra Buzanello, Regina Eva Oliveira, Rosendo Augusto Yunes, Milene Moraes, Mario Steindel, Marcelo Maraschin
Summary: Cutaneous leishmaniasis is a global public health issue, and the use of synthetic chalcones shows promise in developing molecules with anti-leishmaniasis activity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Rafael M. Oliveira, Thaise L. Teixeira, Cassiano C. Rodrigues, Aline A. da Silva, Bruna C. Borges, Rebecca T. S. Brigido, Samuel C. Teixeira, Marlus A. Dos Santos, Joao Paulo S. Servato, Debora de O. Santos, Marcelo J. B. Silva, Luiz R. Goulart, Claudio da Silva
Summary: The study revealed the critical role of gal-3 in the host response to infection by L. (L.) amazonensis, controlling parasite invasion, replication, and formation of endocytic vesicles. Mice with gal-3 deficiency showed an exacerbated inflammatory response.
Review
Parasitology
Taylon Felipe Silva, Fernanda Tomiotto-Pellissier, Aline Kuhn Sbruzzi Pasquali, Fernanda Pinto-Ferreira, Wander Rogerio Pavanelli, Ivete Conchon-Costa, Italmar Teodorico Navarro, Eloiza Teles Caldart
Summary: The study revealed that the exact mechanism leading to different clinical manifestations among strains of the same species is still uncertain, and future studies are needed to better elucidate this phenomenon.
Article
Pharmacology & Pharmacy
Patricia de A. Machado, Pollyanna S. Gomes, Monique P. D. Carneiro, Victor Midlej, Elaine S. Coimbra, Herbert L. de Matos Guedes
Summary: This study demonstrates the importance of serine proteases in Leishmania and evaluates the antileishmanial effects of a serine protease inhibitor, TPCK. TPCK shows selectivity for the parasite and has significant activity against both promastigote and intracellular amastigote forms. The treated parasites exhibit various alterations, suggesting potential mechanisms contributing to their death. In vivo studies show that TPCK reduces lesion size and parasite loads, highlighting its potential as a therapeutic target for leishmaniasis.
Article
Chemistry, Applied
Luciana Grus Silva, Kaio S. Gomes, Thais A. Costa-Silva, Maiara M. Romanelli, Andre G. Tempone, Patricia Sartorelli, Joao Henrique G. Lago
Summary: The MeOH extract from Calophyllum brasiliense stems exhibited activity against Trypanosoma cruzi and Leishmania infantum, leading to the isolation of two coumarins calanolides E1 and E2. Compound E2 demonstrated the best selectivity index among the two compounds, suggesting their potential as scaffolds for novel drug candidates for leishmaniasis and Chagas disease.
NATURAL PRODUCT RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Sarah Kymberly Santos de Lima, italo Novaes Cavallone, Dolores Remedios Serrano, Brayan J. Anaya, Aikaterini Lalatsa, Marcia Dalastra Laurenti, Joao Henrique Ghilardi Lago, Dalete Christine da Silva Souza, Gabriela Pustiglione Marinsek, Beatriz Soares Lopes, Renata de Britto Mari, Luiz Felipe Domingues Passero, Bozena B. Michniak-Kohn
Summary: This study developed a topical formulation containing 8-HQ and demonstrated its efficacy in experimental cutaneous leishmaniasis. The formulation was able to reduce parasite burden and lesion size without causing significant side effects.
Article
Multidisciplinary Sciences
Fernanda V. Cabral, Michela Cerone, Saydulla Persheyev, Cheng Lian, Ifor D. W. Samuel, Martha S. Ribeiro, Terry K. Smith
Summary: The emergence of drug resistance in cutaneous leishmaniasis has become a major problem. Photodynamic therapy has shown effectiveness against drug-resistant strains and may be an attractive strategy for treatment.
Article
Chemistry, Multidisciplinary
Ravinder Kumar, Rahul Singh, Ayla das Chagas Almeida, Juliana da Trindade Granato, Ari Sergio de Oliveira Lemos, Kushvinder Kumar, Madhuri T. Patil, Adilson D. da Silva, Ambadas B. Rode, Elaine S. Coimbra, Deepak B. Salunke
Summary: Leishmania poses a substantial threat to the human population and the current drugs against it have limitations. Developing new drugs is crucial, and a library of imidazo-fused heterocycles was synthesized and screened. Compound 24 showed the strongest antileishmanial activity, with selectivity for a stage related to human disease. It was also more destructive to the parasites than host cells. These findings support the potential of imidazo-pyrimidine as a new antileishmanial pharmacophore and encourage further animal studies.
Review
Immunology
Matheus B. Carneiro, Nathan C. Peters
Summary: This review focuses on the interaction between Leishmania amazonensis infection and host innate immune response, particularly addressing the impact of adaptive immunity on phagocytic host cell recruitment and activation. Experimental observations indicate that most mouse strains are susceptible to L. amazonensis infection, unlike other Leishmania species. The CD4(+) T helper (Th)1/Th2 paradigm does not fully explain the chronic disease established by L. amazonensis, with recent findings complicating the understanding of the Th1/Th2 paradigm.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Parasitology
Andreza Geisiane Maia Souza, Ivana Helena Rocha Oliveira, Aliani Moura Fonseca, Thamires Queiroz-Oliveira, Erica S. Martins-Duarte, Dawidson Gomes, Thiago de Castro-Gomes, Helida Monteiro de Andrade
Summary: Leishmaniasis is a disease caused by protozoa of the genus Leishmania, with each genome containing about 8000 genes encoding proteins. The protein LinJ.30.3360 is conserved in various Leishmania species and may constitute a potential drug target and/or vaccine for leishmaniasis, as it is specific to trypanosomatids and displays antigenicity.
EXPERIMENTAL PARASITOLOGY
(2021)
Article
Multidisciplinary Sciences
Anna Carolina Silva de Jesus Passaes, Juliana Arantes Dantas, Fernanda Landim Lopes, Diego Pereira Sangi, Magaly Girao Albuquerque, Celso Vataru Nakamura, Julliane Yoneda
Summary: Neglected tropical diseases, such as leishmaniasis, have significant impacts on affected societies. This study focused on the relationship between quinoxaline derivatives and the activity against Leishmania amazonensis. A new derivative was designed and synthesized, and a quantitative structure-activity relationship model was established, showing good predictive capacity.
SCIENTIFIC REPORTS
(2023)
Article
Nanoscience & Nanotechnology
Brunno R. F. Vercoza, Robson R. Bernardo, Luiz Augusto S. de Oliveira, Juliany C. F. Rodrigues
Summary: The therapeutic potential of green superparamagnetic iron oxide nanoparticles (SPIONs) produced with coconut water for treating cutaneous leishmaniasis caused by Leishmania amazonensis was evaluated. Optical and electron microscopy techniques were used to assess the effects on cell proliferation, infectivity percentage, and ultrastructure. The synthesized SPIONs exhibited promising activity against Leishmania and could be considered as a strong candidate for a new therapeutic approach for treating leishmaniases.
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2023)
Article
Ecology
Elena Prieto-Rodao, Martin Ricker, Miguel Martinez-Ramos
Summary: Plant species produce more seedlings than those who survive to adulthood. Relocating seedlings to desired restoration sites could be a reasonable approach to utilize their excess production. However, there is limited information available on this issue. This study transplanted naturally regenerated seedlings of two native species, Calophyllum brasiliense and Vochysia guatemalensis, to enrich a secondary tropical forest in Veracruz, Mexico. Survival rates and growth trajectories of the transplanted seedlings were compared with direct seeding methods used in previous studies. The results showed that the success of transplanting naturally regenerated seedlings depended on the species and the monetary value of the treelets after 2 years.
RESTORATION ECOLOGY
(2023)
Article
Polymer Science
Giovanna Amaral Filipe, Victoria Akemi Itakura Silveira, Marcelly Chue Goncalves, Rayanne R. Beltrame Machado, Celso Vataro Nakamura, Cristiani Baldo, Suzana Mali, Renata Katsuko Takayama Kobayashi, Maria Antonia P. Colabone Celligoi
Summary: This study aims to develop biodegradable films based on cassava starch, pullulan, and sophorolipids for the treatment of skin infections. By adding sophorolipids and citric acid, the properties of the films were modified, resulting in antimicrobial effects. The results of the study show that these films can inhibit the growth of common skin pathogens.
Article
Polymer Science
Flavia Amanda Pedroso de Morais, Ana Carolina Vieira De Oliveira, Rodolfo Bento Balbinot, Danielle Lazarin-Bidoia, Tania Ueda-Nakamura, Sueli de Oliveira Silva, Katieli da Silva Souza Campanholi, Ranulfo Combuca da Silva Junior, Renato Sonchini Goncalves, Wilker Caetano, Celso Vataru Nakamura
Summary: Biotin, spermine, and folic acid were covalently linked to the F127 copolymer to form a drug delivery system for treating B16F10 cells with HY-loaded PDT. Spectroscopy and spectrophotometric techniques were used to analyze the chemical structures and binders quantification. The hydrophobicity of the binders was found to affect the physicochemical parameters such as critical micelle concentration, critical micelle temperature, size, polydispersity, and zeta potential. The modification with spermine resulted in less changes in the physical and chemical parameters of the micelles.
Article
Biochemistry & Molecular Biology
Aline Pinto Zani, Caroline Pinto Zani, Zia Ud Din, Edson Rodrigues-Filho, Tania Ueda-Nakamura, Francielle Pelegrin Garcia, Sueli de Oliveira Silva, Celso Vataru Nakamura
Summary: In this study, a new synthetic compound A3K2A3 was found to have anti-tumor activity against cervical cancer cells. The potential mechanism of action includes regulation of redox balance, damage to cell membrane and DNA, and inhibition of cell division leading to apoptosis. These findings suggest that A3K2A3 could be a promising alternative for the treatment of cervical cancer.
Article
Biochemistry & Molecular Biology
Alex Graca Contato, Vanessa Kaplum, Debora Botura Scariot, Francielle Pelegrin Garcia, Hugo Falzirolli, Fabio Vandresen, Tania Ueda-Nakamura, Sueli de Oliveira Silva, Cleuza Conceicao da Silva, Celso Vataru Nakamura
Summary: Leishmaniasis is a tropical disease that affects approximately 1.3 million people annually. Current treatments for this disease have dangerous side effects. This study discovered that a limonene-acylthiosemicarbazide compound (ATZ-S-04) shows promising antiproliferative activity against Leishmania parasites and affects their morphology.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Caroline Pinto Zani, Aline Pinto Zani, Cristiane Melissa Thomazini, Karina Miyuki Retamiro, Aline Rufino de Oliveira, Debora Lais Goncalves, Maria Helena Sarragiotto, Francielle Pelegrin Garcia, Sueli de Oliveira Silva, Celso Vataru Nakamura, Tania Ueda-Nakamura
Summary: In this study, the cytotoxic potential and mechanism of action of a compound called BCP-1 were analyzed in breast cancer cells and non-tumor breast cells. The results showed that BCP-1 inhibited cancer cell proliferation, induced cell cycle arrest and oxidative stress, and activated apoptosis and autophagy pathways. BCP-1 also demonstrated antimetastatic potential.
Article
Pharmacology & Pharmacy
Rafaela Said dos Santos, Jessica Bassi da Silva, Camila Felix Vecchi, Katieli da Silva Souza Campanholi, Helen Cassia Rosseto, Mariana Carla de Oliveira, Francielle Pelegrin Garcia, Rodolfo Bento Balbinot, Lidiane Vizioli de Castro Hoshino, Tania Ueda Nakamura, Celso Vataru Nakamura, Mauro Luciano Baesso, Wilker Caetano, Marcos Luciano Bruschi
Summary: The environment has the ability to modify the physiology and protective function of the skin. Combining propolis and curcumin with photodynamic therapy can provide important antioxidant and antimicrobial properties. Emulgels, which control drug release, can serve as an effective platform for delivering propolis and curcumin together. This study investigated the effects of different emulgels on stability, antioxidant activity, drug release, antimicrobial activity, and skin permeation and retention of propolis and curcumin. The formulations containing C974P or PC exhibited improved stability, antioxidant activity, antimicrobial activity, and modified drug release, making them good candidates for further research on their benefits to skin health.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2023)
Article
Oncology
Ranulfo Combuca da Silva Junior, Katieli da Silva Souza Campanholi, Bianca Cristina Maciel, Laura Adriane de Morais Pinto, Flavia Amanda Pedroso de Morais, Fabiana dos Santos Rando, Paulo Cesar de Souza Pereira, Magali Soares dos Santos Pozza, Celso Vataru Nakamura, Wilker Caetano
Summary: Good management practices, such as post-dipping applications, can improve the health of dairy cattle during lactation and reduce the occurrence of mastitis. Antimicrobial Photodynamic Therapy (aPDT) is a potential alternative to conventional post-dipping procedures using iodine-based solutions. The study explored the photodynamic efficiency of two natural photosensitizers, Chlorophyll-rich spinach extract (CHL) and Curcumin (CUR), incorporated into a Pluronic (R) F127 micellar copolymer.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Microbiology
Gabriella Maria Andriani, Lais Fernanda de Almeida Spoladori, Marcieli Fabris, Priscila Goes Camargo, Patricia Morais Lopes Pereira, Jussevania Pereira Santos, Guilherme Bartolomeu-Goncalves, Lais Alonso, Cesar Armando Contreras Lancheros, Antonio Alonso, Celso Vataru Nakamura, Fernando Macedo Jr, Phileno Pinge-Filho, Lucy Megumi Yamauchi, Marcelle de Lima Ferreira Bispo, Eliandro Reis Tavares, Sueli Fumie Yamada-Ogatta
Summary: This study evaluated the effects of the synthetic thiourea derivative BTU-01 on planktonic and sessile cells of Cryptococcus neoformans, and its combination with amphotericin B (AmB). The results showed that BTU-01 exhibited inhibitory activity against C. neoformans cells and had relevant interactions with cryptococcal urease. The combination of BTU-01 and AmB demonstrated synergistic fungicidal activity, without hemolytic activity or cytotoxicity to mammalian cells.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Chemistry, Medicinal
Naiara Cassia Gancedo, Raquel Isolani, Natalia Castelhano de Oliveira, Celso Vataru Nakamura, Daniela Cristina de Medeiros Araujo, Andreia Cristina Conegero Sanches, Fernanda Stumpf Tonin, Fernando Fernandez-Llimos, Danielly Chierrito, Joao Carlos Palazzo de Mello
Summary: This study aimed to synthesize the anticancer and anti-proliferative potential of Limonium species through a systematic review. The results indicate that Limonium species have the potential to be a source of new potential cytotoxic and anticancer agents. However, further research and improved experimental designs are needed to better understand the mechanism of action of these compounds.
Article
Chemistry, Physical
Ellyessa Nascimento Borges, Lais Alonso, Murilo Barros Silveira, Rodolfo Bento Balbinot, Celso V. Nakamura, Andre Luis Batista da Rocha, Evilanna Lima Arruda, Gabriel Franco dos Santos, Boniek G. Vaz, Christian Dias Gomides, Luciano Morais Liao, Ricardo Menegatti, Antonio Alonso
Summary: In this study, novel chalcone-like compounds were synthesized and evaluated for their activity against Leishmania (L.) amazonensis. The compounds showed varying potency against the parasite, with compound 4 being the most effective. Electron paramagnetic resonance spectroscopy revealed that the compounds induced membrane rigidity in a concentration-dependent manner. The compounds also exhibited high affinity for the parasite membrane, similar to the antileishmanial drug miltefosine.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Flavia Amanda Pedroso de Morais, Rodolfo Bento Balbinot, Amanda Beatriz Kawano Bakoshi, Danielle Lazarin-Bidoia, Katieli da Silva Souza Campanholi, Ranulfo Combuca da Silva Junior, Renato Sonchini Goncalves, Tania Ueda-Nakamura, Sueli de Oliveira Silva, Wilker Caetano, Celso Vataru Nakamura
Summary: The study developed biomodified coated-lipid vesicles with the photosensitizer hypericin (HY) incorporated. The results demonstrated good stability, low tendency to form complexes with proteins, and promising photodynamic potential. These nanosystems hold potential for future therapeutic and diagnostic applications.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Karina Miyuki Retamiro, Karine Campos Nunes, Aline Pinto Zani, Caroline Pinto Zani, Laiza Bergamasco Beltran, Sueli de Oliveira Silva, Francielle Pelegrin Garcia, Tania Ueda-Nakamura, Rosangela Bergamasco, Celso Vataru Nakamura
Summary: Ionized water has been found to aid in tissue repair and wound healing. Water purifiers can produce ionized water by using activated charcoal with silver and minerals to reduce contaminants. Additionally, subjecting water to a magnetic field causes a reorganization of water molecules, resulting in alkaline water that has been shown to be non-toxic to mice and can extend survival.
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.
