Article
Agriculture, Multidisciplinary
Takashi Akazawa, Hikaru Itami, Toshio Furumoto, Chie Nozaki, Hiroyuki Koike, Saika Iritani, Naoyuki Amimoto, Masahiro Ogawa
Summary: The cold-water extract from olive leaves improves the texture of food protein gels by enhancing protein cross-linking activity, with 3,4-DHPEA-EDA identified as a major contributor to this enhancement.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ali Akbar Asghari, Maryam Mahmoudabady, Zahra Mousavi Emadi, Seyed Javad Hosseini, Hossein Salmani
Summary: This study demonstrates that olive leaf extract can attenuate fibrosis and reduce myocardial hypertrophy markers, thus improving cardiac function and structure in diabetic rats.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Costas S. Papageorgiou, Paraskevi Lyri, Ioanna Xintaropoulou, Ioannis Diamantopoulos, Dimitris P. Zagklis, Christakis A. Paraskeva
Summary: The aim of this study was to explore high-yield production of hydroxytyrosol, a phenolic compound with high antioxidant capacity. Olive leaves were chosen as the feedstock due to their significant oleuropein content. Various techniques were used, including drying, mechanical pretreatment, solid-liquid extraction, hydrolysis, and extraction with ethyl acetate. The hydroxytyrosol content was significantly increased through these steps.
Article
Horticulture
Marija Polic Paskovic, Nikolina Vidovic, Igor Lukic, Paula Zurga, Valerija Majetic Germek, Smiljana Goreta Ban, Tomislav Kos, Lepomir Coga, Tea Tomljanovic, Suncana Simonic-Kocijan, Dean Ban, Sara Godena, Igor Paskovic
Summary: This study investigated the effects of different sampling periods and olive cultivars on the quantity and composition of olive leaf phenolic compounds and mineral nutrients. The results showed that the pruning collecting period had higher oleuropein leaf content, with 'Leccino' and 'Buza' having the highest levels. Cultivar significantly influenced the phenolic compounds, with higher concentrations in the pruning period. Differences in mineral composition were related to phenolic profiles and significantly affected by genotype. Some mineral nutrients were found to be correlated with the most abundant phenolic compounds, oleuropein and verbascoside.
Article
Food Science & Technology
Maria del Pilar Fernandez-Poyatos, Eulogio J. Llorent-Martinez, Antonio Ruiz-Medina
Summary: The phenolic composition and mineral content of three olive fruit varieties were investigated during two harvesting seasons, revealing that total phenolic contents reached the highest values between December and January, while no clear tendency was observed between mineral content and harvest time.
Article
Horticulture
Chenhe Wang, Li Xue, Qizhen Cui, Qingqing Liu, Jianguo Zhang, Guodong Rao
Summary: This study analyzed the cytochrome P450 superfamily in olive at the whole-genome level and identified certain genes that regulate the synthesis of oleuropein. The findings provide a foundation for further verification of the functions of these genes and can inform the cultivation of new varieties of Olea europaea.
SCIENTIA HORTICULTURAE
(2022)
Article
Pharmacology & Pharmacy
Ali Akbar Asghari, Maryam Mahmoudabady, Sadegh Shabab, Saeed Niazmand
Summary: In this study, it was found that standardized aqueous ethanolic olive leaf extract can improve cardiac damage caused by diabetes through attenuating inflammation, oxidative stress and apoptosis.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Food Science & Technology
Mariem Zakraoui, Hedia Hannachi, Igor Paskovic, Nikolina Vidovic, Marija Polic Paskovic, Igor Palcic, Nikola Major, Smiljana Goreta Ban, Lamia Hamrouni
Summary: This study investigated the impact of pedological parameters and altitude variation on the mineral nutrients, phenolic compounds, and antioxidant activities of olive leaves. Samples from the Chetoui cultivar were collected from eight locations with varying altitudes. Levels of phenolic compounds showed variation based on altitude, with high levels of secoiridoids and simple phenols at altitude 1 (>500m), and higher flavonoid levels at altitude 2 (500-300m) and altitude 3 (<300m). The abundance of oleuropein and luteolin-7-O glucoside, the most important phenols in Chetoui olive leaves, were significantly correlated with levels of Mn, Ca, and B in the leaves, as well as Zn in the soil. These findings suggest that environmental conditions, in addition to pedological criteria, influence the formation of phenolic compounds.
Article
Environmental Sciences
Debabrata Majumder, Rahul Debnath, Priyatosh Nath, K. V. Libin Kumar, Mousumi Debnath, Prosun Tribedi, Debasish Maiti
Summary: Lung cancer, the most aggressive and deadly form of cancer, is directly linked to smoking. The combination treatment of ethanolic olive leaf extract and bromelain can synergistically reduce lung cancer incidence by reducing inflammation and oxidative stress, regulating the expression of inflammatory markers, and modulating pulmonary antioxidant activity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Rosamaria Pennisi, Ichrak Ben Amor, Bochra Gargouri, Hamadi Attia, Rihab Zaabi, Ahlem Ben Chira, Mongi Saoudi, Anna Piperno, Paola Trischitta, Maria Pia Tamburello, Maria Teresa Sciortino
Summary: The study aimed to evaluate the antioxidant and antiviral efficacy of leaf extracts from Olea europaea L. var. sativa and Olea europaea L. var. sylvestris. Both extracts exhibited reducing abilities and protected human HeLa cells from lipid peroxidation. Oleuropein-rich extract showed a stronger effect on inhibiting viral DNA accumulation and stimulating the phosphorylation of PKR, c-FOS, and c-JUN proteins. These findings enhance our understanding of the potential health benefits and mechanisms of action of oleuropein and oleuropein-rich extracts.
Review
Plant Sciences
Roberto Buonaurio, Leen Almadi, Franco Famiani, Chiaraluce Moretti, Giovanni Enrico Agosteo, Leonardo Schena
Summary: Olive leaf spot (OLS) caused by Venturia oleaginea is a prevalent disease in olive-growing areas worldwide, leading to significant yield losses. Early detection of leaf symptoms is difficult, and the pathogen-induced leaf drop creates the illusion of healthy and restored plants. This review provides updated information on taxonomy, pathogen life cycle, epidemiology, diagnosis, and control strategies for OLS. Copper-based fungicides, the main method of control, are facing potential substitution due to regulations, making it urgent to find alternative strategies, especially for organic agriculture.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Barbara Torrecillas-Baena, Marta Camacho-Cardenosa, Maria Dolores Carmona-Luque, Gabriel Dorado, Miriam Berenguer-Perez, Jose Manuel Quesada-Gomez, Maria Angeles Galvez-Moreno, Antonio Casado-Diaz
Summary: Olive tree leaf extract (OELE) has antioxidant and anti-inflammatory properties, and a hydrogel containing OELE called EHO-85 has been developed for skin ulcer treatments. In this study, the effectiveness of EHO-85 was compared with treatments containing other ingredients in a rat model. Results showed that EHO-85 had equal or superior healing effects compared to other treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agronomy
Julieta Ines Monteleone, Elisa Sperlinga, Laura Siracusa, Giovanni Spagna, Lucia Parafati, Aldo Todaro, Rosa Palmeri
Summary: Olive leaves are a main by-product of the olive oil industry, containing a plethora of bioactive compounds, with oleuropein being a main component. The extraction solvent and temperature significantly influence the phenolic content and antioxidant activity of the extracts, with hot water being the preferred solvent for bioactive compound extraction. Water extracts show ideal characteristics and can be used for various industrial applications and human consumption.
Article
Plant Sciences
Chaim Engelen, Tahel Wechsler, Ortal Bakhshian, Ilan Smoly, Idan Flaks, Tamar Friedlander, Giora Ben-Ari, Alon Samach
Summary: With global warming, it is crucial to understand how warmer winters will affect olive flower induction for predicting future olive oil production sustainability. This study investigated the impact of fruit load, winter drought, and different temperature regimes on olive flower induction. The findings highlighted the importance of studying trees without previous fruit load and showed that soil water content during winter does not significantly affect flower induction. Additionally, the study proposed an efficient method to calculate accumulated chill units correlated with flower induction.
Article
Horticulture
Jinhua Li, Xinyue Ji, Zhaoshan Wang, Yanfei Zeng, Jianguo Zhang
Summary: This study aimed to investigate the morphological and molecular characteristics of two inter-subspecific F-1 hybrids obtained by crossing olive cultivars with pollen donors from olive subspecies. The study identified significant differences in morphological traits between genotypes and confirmed the inter-specific hybrid nature of the two hybrids through molecular analysis.
Article
Chemistry, Medicinal
Annisa Rahma, Melissa Adriani, Puji Rahayu, Raymond R. Tjandrawinata, Heni Rachmawati
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2019)
Article
Biochemistry & Molecular Biology
Wangsa T. Ismaya, Raymond R. Tjandrawinata, Bauke W. Dijkstra, Jaap J. Beintema, Najwa Nabila, Heni Rachmawati
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Food Science & Technology
Fathma Syahbanua, Elisabeth Kezia, Narwastu Puera, Puspo Edi Giriwono, Raymond Ruby Tjandrawinata, Maggy Thenawidjaja Suhartono
FOOD SCIENCE AND TECHNOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Wangsa Tirta Ismaya, Raymond Rubianto Tjandrawinata, Heni Rachmawati
Article
Food Science & Technology
Fathma Syahbanu, Puspo Edi Giriwono, Raymond R. Tjandrawinata, Maggy T. Suhartono
Summary: This study used bioinformatic analysis and molecular docking methods to predict the mechanism of action for the fibrinolytic enzyme Subtilisin K2. The analysis revealed a hydrolysis reaction between Subtilisin K2 and the fibrin substrate, suggesting that Subtilisin K2 acts more as a fibrin-degrading enzyme than as a fibrinogen-degrading enzyme.
FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wangsa Tirta Ismaya, Raymond Rubianto Tjandrawinata, Heni Rachmawati
Summary: Agaricus bisporus mannose-binding protein (Abmb) was discovered as part of the mushroom tyrosinase (PPO3) complex, but its function and activity in mushrooms remain largely unknown. Molecular docking was used to predict the mannose-binding site of Abmb, showing similarity to its structural homologs. This suggests potential interactions with specific residues such as Arg15, Thr45, Gln48, Asp49, Asp51, and Arg51, despite variations in amino acid sequence among Abmb homologs.
Article
Medicine, Research & Experimental
Olivia M. Tandrasasmita, Guntur Berlian, Raymond R. Tjandrawinata
Summary: The study showed that DLBS3733 can significantly reduce lipid accumulation and TG synthesis in HepG2 cells by increasing adiponectin expression, regulating PPAR alpha and AMPK signaling pathways, and inhibiting the expression of HMGCR, ACC, SREBP. Additionally, DLBS3733 exhibits high antioxidant activity, suggesting its potential as a treatment for hepatic steatosis-related diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Microbiology
Raymond Rubianto Tjandrawinata, Medicia Kartawijaya, Apriliana Wahyu Hartanti
Summary: The anti-hypercholesterolemic effect of 11 Lactobacillus isolates, particularly DLBSH104 and DLBSK207, have been confirmed in this study. These isolates showed outstanding potential in lowering cholesterol levels, with DLBSH104 attaching cholesterol to its cell surface for removal.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Frans Kurnia, Gestria Novirani, Fatiha Khairunnisa, Vincencius F. Meidianto, Wangsa T. Ismaya, Raymond R. Tjandrawinata
Summary: Escherichia coli cells rapidly respond to environmental changes, including an elevation in membrane protein expression. However, high expression of membrane proteins during fermentation can reduce the expression of target proteins and decrease process efficiency. Despite this drawback, the expression of outer membrane protein A (OmpA) can be used as an indicator for E. coli's response to fermentation conditions.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2023)
Article
Nutrition & Dietetics
Happy Kurnia Permatasari, Queen Intan Permatasari, Nurpudji Astuti Taslim, Dionysius Subali, Rudy Kurniawan, Reggie Surya, Faqrizal Ria Qhabibi, Melvin Junior Tanner, Siti Chairiyah Batubara, Nelly Mayulu, William Ben Gunawan, Andi Yasmin Syauki, Netty Salindeho, Moon Nyeo Park, Juan Alessandro Jeremis Maruli Nura Lele, Raymond R. Tjandrawinata, Bonglee Kim, Fahrul Nurkolis
Summary: This study aimed to reveal the potential of edible bird nest (EBN) as a functional food candidate in fighting metabolic syndrome. The study found that EBN contains terpenoids that have strong inhibitory effects on key receptors involved in metabolic dysfunction. In vitro and in vivo tests showed that EBN has antioxidant, antidiabetic, and anti-obesity activities, and high-dose dietary supplementation of EBN led to significant improvements in lipid profile, blood glucose, and inflammatory biomarkers.
Article
Obstetrics & Gynecology
Syarief Thaufik Hidayat, Inu Mulyantoro, Suhartono Damas, Raymond R. Tjandrawinata
Summary: In this study, DLBS3233 and Metformin were evaluated for their efficacy and safety in insulin-resistant women with polycystic ovary syndrome (PCOS). The results showed that DLBS3233 alone and the DLBS3233/Metformin combination did not exhibit significant efficacy in PCOS subjects and did not negatively affect cardiovascular function, liver and kidney function.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2023)
Article
Pharmacology & Pharmacy
Yurike Yuliana, Olivia M. Tandrasasmita, Raymond R. Tjandrawinata
Summary: The study demonstrates that Predimenol exhibits anti-inflammatory activities through NF-kB inactivation-mediated COX-2 suppression, leading to reduced expression of inflammatory markers. This suggests that Predimenol may serve as a potential analgesic and anti-inflammatory agent.
RECENT ADVANCES IN INFLAMMATION & ALLERGY DRUG DISCOVERY
(2021)
Article
Peripheral Vascular Disease
Rizaldy Taslim Pinzon, Raymond R. Tjandrawinata, Vincent Ongko Wijaya, Vanessa Veronica
Summary: DLBS1033, as an add-on therapy, showed significant improvements in functional outcomes in acute ischemic stroke patients when compared to standard care alone, with a similar safety profile.
STROKE RESEARCH AND TREATMENT
(2021)
Article
Engineering, Multidisciplinary
Jennifer Lheman, Anthony Sutiono, Yanti Yanti, Raymond Rubianto Tjandrawinata, Bibiana Widiyati Lay
Summary: Metabolic syndrome is a major global health issue, and cider beverages made from bignay fruits have potential as functional beverages with antioxidant and antidiabetic effects for managing metabolic syndrome.
JURNAL TEKNOLOGI-SCIENCES & ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Fathma Syahbanu, Puspo Edi Giriwono, Raymond R. Tjandrawinata, Maggy T. Suhartono
MOLECULAR BIOLOGY REPORTS
(2020)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.