Article
Cell Biology
Wenxia Gong, Kexin Wang, Xueyuan Wang, Yupeng Chen, Xuemei Qin, Aiping Lu, Daogang Guan
Summary: Depression, a complex and prevalent mental disorder worldwide, is difficult to treat. Traditional Chinese medicine (TCM) has shown promising efficacy and minimal side effects in depression treatment. This study introduces a novel mathematical algorithm to identify the functional components and molecular mechanisms of TCM in depression treatment. Using a specific TCM formula Danggui-Shaoyao-San (DSS) as an example, the algorithm successfully captured the key core function motifs and functional components which contribute to the antidepressant effect. The results provide a methodological reference for understanding the TCM formula and discovering functional components for complex diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jing Yin, Jiaxi Lu, Peng Lei, Mingshuai He, Shengjie Huang, Jialin Lv, Yan Zhu, Zhidong Liu, Miaomiao Jiang
Summary: DSS has been shown to improve pathological symptoms of MetS by better regulating intestinal floras and improving hepatic gene expressions and metabolites.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yunxia Luo, Hansen Chen, Bun Tsoi, Qi Wang, Jiangang Shen
Summary: Ethanol extract of DSS is effective in reducing infarct sizes and improving neurological deficit scores in post-ischemic stroke rats; it attenuates apoptotic cell death by down-regulating cleaved-caspase 3 and Bax expression, up-regulating bcl-2, and decreasing oxidative/nitrosative stress. Additionally, DSS increases the expression of SIRT1 in the brain, leading to neuroprotective effects against cerebral ischemic-reperfusion injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Neurosciences
Xin Fu, Qiantong Liu, Xiaowei Sun, Hui Chang, Ying Liu, Jiatong Han
Summary: Alzheimer's disease is a common neurodegenerative disease, and recent research has shown that Chinese medicine, specifically Danggui Shaoyao San, may provide new options for its treatment. Polysaccharides extracted from Danggui Shaoyao San have been found to play a crucial role in the treatment of Alzheimer's disease, in addition to their anti-inflammatory and immune regulatory properties.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Chemistry, Medicinal
Mengdi Xia, Na Ai, Junjie Pang
Summary: The study demonstrates the effectiveness of MDSS in improving depressive symptoms in CKD patients, with network pharmacology analysis identifying multiple compounds and targets, and molecular docking confirming the relationship between active compounds and proteins.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Plant Sciences
Mo Yang, Lianghou Ni, Yunlai Wang, Zihua Xuan, Huan Wu, Wenjing Zhan, Xinyu Wan, Jinghui Wang, Fan Xu
Summary: This study examined the effects and mechanisms of Danggui-shaoyao-san (DSS) in improving sodium retention and identified potential bioactive compounds. The results showed that DSS can intervene in sodium retention by inhibiting the generation and activity of plasmin in the urine, suggesting that it may be a potential treatment for nephrotic syndrome.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jinfei Yang, Chenrui Li, Yan Liu, Yachun Han, Hao Zhao, Shilu Luo, Chanyue Zhao, Na Jiang, Ming Yang, Lin Sun
Summary: This study investigated the molecular mechanisms and bioactive ingredients of Danggui-Shaoyao-San (DSS) in the treatment of diabetic kidney disease (DKD) using network pharmacology. The results suggest that DSS may treat DKD by targeting multiple pathways such as inflammation, oxidative stress, autophagy, and fibrosis. TNF and PPARG were identified as hub genes, and poricoic acid C and stigmasterol were identified as main active components in the network.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Yuke Wang, Ying Pan, Mirong Hou, Rongsiqing Luo, Jiawei He, Fan Lin, Xiaofang Xia, Ping Li, Chunxiang He, Pan He, Shaowu Cheng, Zhenyan Song
Summary: This study investigated the effects of Danggui Shaoyao San (DSS) on lipid metabolism in hyperlipidemia using a zebrafish model. The results showed that DSS can ameliorate lipid metabolic disorders in hyperlipidemia by modulating the PPAR signaling pathway, leading to a reduction in lipid accumulation within the body.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Integrative & Complementary Medicine
Yuemeng Sun, Yushan Gao, Lu Zhou, Yixing Lu, Yulin Zong, Haoyu Zhu, Yang Tang, Fengjie Zheng, Yan Sun, Yuhang Li
Summary: Danggui-Shaoyao-San (DGSY), a traditional Chinese medicine prescription, has anti-atherosclerosis effects. It reduces blood lipid levels, inhibits plaque formation, suppresses inflammation, and regulates the expression of genes related to vascular endothelial cells. DGSY alleviates endothelial damage and delays the occurrence of atherosclerosis.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Plant Sciences
Jing-Jing Shi, Hao-Fei Liu, Tian Hu, Xin Gao, Yong-Bin Zhang, Wei-Rong Li, Qi Wang, Shi-Jie Zhang, Dan Tang, Yun-Bo Chen
Summary: The study aimed to investigate the neuroprotective effects of Danggui-Shaoyao-San (DSS) on db/db mice with diabetes-induced cognitive dysfunction. Results showed that DSS treatment improved learning and memory abilities, relieved hippocampal neuronal damage, enhanced glucose tolerance and insulin resistance, reduced hyperlipemia, and increased antioxidant enzyme activities while decreasing inflammatory mediator levels. Additionally, DSS upregulated neurotrophic factors and decreased apoptosis in db/db mice.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Immunology
Piaoxue Liu, Xun Zhou, Haoran Zhang, Rui Wang, Xiaolang Wu, Wenxuan Jian, Weirong Li, Dongsheng Yuan, Qi Wang, Wei Zhao
Summary: This study investigates the effects of Danggui-Shaoyao-San (DSS) on cognitive impairment induced by scopolamine, focusing on the microbiota-gut-brain axis. The results show that DSS treatment improves memory function in mice and affects brain function through bidirectional regulation with the gut-brain axis. Furthermore, fecal microbial transplantation also improves cognitive function, supporting the role of the gut microbiota-brain axis in mediating cognition.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Na Li, Xiaoyan Cui, Chunyan Ma, Yongzhou Yu, Zhe Li, Lanqingqing Zhao, Hui Xiong
Summary: This study investigated the effects and mechanism of DSS on PD rats using an integrative UPLC-Q-TOF-MS-based serum metabolomics approach. The results identified potential biomarkers related to PD and suggested that DSS exhibited a therapeutic effect on PD rats by regulating multiple abnormal pathways.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2022)
Article
Integrative & Complementary Medicine
Lian Fan, Hui-hua Chen, Hua-jun Liu, Hui-juan Chen, Ling-ling Zhu, Ting Zhang
Summary: Danggui Shaoyao San (DSS) has been proven to have anti-fibrotic and anti-apoptotic effects on renal fibrosis, possibly achieved through promoting autophagy.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Integrative & Complementary Medicine
Sijie Li, Yong Yang, Wei Zhang, Haiyan Li, Wantong Yu, Chen Gao, Jiali Xu, Wenbo Zhao, Changhong Ren
Summary: The study investigates the active compounds and mechanisms of Danggui Shaoyao San (DSS) for treating ischemic stroke (IS) through network pharmacology, molecular docking, and animal experiments. The results demonstrate that DSS acts on multiple targets and pathways to treat IS, providing new insights into the mechanisms of DSS against IS.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Hui Xiong, Na Li, Lanqingqing Zhao, Zhe Li, Yongzhou Yu, Xiaoyan Cui, Qi Liu, Chunying Zhao
Summary: This study aimed to reveal the material basis and mechanism of Danggui Shaoyao San (DSS) in treating primary dysmenorrhea (PD) through an integrative approach of serum pharmacochemistry, metabolomics, and network pharmacology. The results showed that DSS significantly improved the symptoms of PD by modulating arachidonic acid metabolism, pentose and glucuronate interconversions, and phenylalanine metabolism. Network pharmacology analysis revealed that active components of DSS were closely related to steroid hormone biosynthesis, arachidonic acid metabolism, and sphingolipid signaling pathway. This study provides a solid basis for the application of DSS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Environmental
Guijiao Zhang, Tianfeng Gu, Yongchao Zhou, David Z. Zhu, Yiping Zhang
Summary: The study shows that intermittent addition of ferric iron or hydrogen peroxide has limited inhibitory effects on VSCs, while intermittent addition of nitrate has a relatively stable control effect on H2S and VOSCs. Methyl mercaptan is the most abundant compound of released VOSCs, indicating the need for more attention on VOSCs.
ENVIRONMENTAL ENGINEERING RESEARCH
(2022)
Article
Computer Science, Information Systems
Kun Zhu, Shi Ying, Weiping Ding, Nana Zhang, Dandan Zhu
Summary: The study proposes a robust data-driven HDP model called IVKMP, which utilizes advanced techniques such as deep generation networks, multi-objective optimization, and deep networks to improve the accuracy and performance of software defect prediction.
INFORMATION SCIENCES
(2022)
Article
Food Science & Technology
Yuanqiang Hao, Yintang Zhang, Lijie Luo, Dandan Zhu, Maotian Xu, Rongjin Zeng, Shu Chen
Summary: Cysteine is a critical biologically active sulfhydryl molecule that plays essential roles in anti-oxidation and maintains protein structure and function. An effective fluorescent probe (DDP-C) for sensing Cysteine has been presented, which shows high selectivity and sensitivity.
FOOD ANALYTICAL METHODS
(2022)
Article
Biology
Yalei Zhao, Lingjian Zhang, Qingqing Hu, Danhua Zhu, Zhongyang Xie
Summary: In this study, the role of C17orf53 in hepatocellular carcinoma (HCC) was analyzed using public datasets. The findings suggest that C17orf53 is highly expressed and predicts poor survival in HCC patients. It also correlates positively with the abundance of B cells, macrophages, and dendritic cells. Functional analysis revealed that C17orf53 is involved in cell cycle, DNA replication, and Fanconi anemia pathways. Knockdown of C17orf53 inhibited cell proliferation and decreased the expression of MCM8, cyclin D1, and PCNA. Overall, C17orf53 is a novel prognostic signature for HCC.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Plant Sciences
Junqing Wu, Wenru Sun, Chao Sun, Chunmiao Xu, Shuang Li, Pengxue Li, Huimin Xu, Danyang Zhu, Meng Li, Liling Yang, Jinbo Wei, Aya Hanzawa, Sumaiya Jannat Tapati, Reiko Uenoyama, Masao Miyazaki, Abidur Rahman, Shuang Wu
Summary: Fruit malformation is a widespread issue in fruit production, causing significant economic losses. Although farmers have long observed the association between chilling temperature before blooming and malformed fruits, the molecular mechanism behind this phenomenon remains unclear. In this study, we investigated how tomato fruit development responded to cold stress and found that short-term cold stress led to increased callose accumulation in both shoot apical and floral meristems. This caused symplastic isolation and altered intercellular movement of WUS, resulting in expanded stem cell population and malformed fruits. Our findings suggest that the callose dynamics during short-term cold stress involve the interplay of abscisic acid and gibberellin, similar to bud dormancy mechanisms. This study provides new insights into the regulation of fruit malformation under cold stress.
Article
Materials Science, Multidisciplinary
Junlin Wu, Jiyang Ding, Xinyou Huang, Zhengfa Dai, Xiaoying Li, Danyang Zhu, Dong Huang, TengFei Xie, Jianrong Zhou, Xingfen Jiang, Zhijia Sun, Dariusz Hreniak, Jiang Li
Summary: Gd2O2S:Tb nanopowders were synthesized by hot water-bath method using Gd2O3 and H2SO4 as raw materials. The properties of precursors and powders were influenced by the initial bathing temperature. The size and thickness of flakes in the precursors and powders increased with the increase of initial temperature. Gd2O2S:Tb scintillation ceramics were fabricated using the obtained powders and showed different properties based on the initial temperature of synthesis.
Article
Physics, Multidisciplinary
Danni Zhu, Yancheng Cui, Jin Meng, Yuzhang Yuan, Haitao Wang, Jiangfeng Han
Summary: Magnetically insulated coaxial diodes are commonly used in high power microwave devices for generating intense annular electron beams. This study conducted electrical and optical measurements on a long-pulse magnetically insulated coaxial diode to observe the emission characteristics and plasma properties. The impact of cathode material, blade angle, diode voltage, and guiding magnetic field on the emission characteristics and plasma properties of six types of annular cathodes was investigated. The metal-dielectric cathode showed excellent emission characteristics and plasma properties, achieving impressive diode performance. Additionally, high voltage and small blade angle were found to enhance the emission capability and uniformity, while a strong magnetic field or large diode voltage reduced the axial and radial expansion velocities.
Article
Toxicology
Zhanxun Wu, Wenping Yan, Ke Wang, Genghua Xu, Danyan Zhu, Xuyun Li, Huafeng Wang, Min Yang, Xiangnan Zhang, Jiaying Wu
Summary: Bortezomib (BTZ) is an effective drug for multiple myeloma treatment, but it often leads to BTZ-induced peripheral neuropathy (BIPN). In this study, it was found that BTZ caused demyelination in sciatic nerves, leading to mechanical hyperalgesia and impaired nerve conduction. The mechanism was identified as the dysfunction of lysosomes and autophagy blockage in Schwann cells. However, the use of the lysosomal activator Torin1 reversed the autophagy blockage and improved the BIPN pathology.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Plant Sciences
Xingnan Ouyang, Danyang Zhu, Yujie Huang, Xuejian Zhao, Rui Xu, Jiaying Wang, Wenjun Li, Xu Shen
Summary: This study found that MAOB was highly overexpressed in the spinal cord and DRG tissues of PIPN mice, rather than MAOA, and Khellin as a selective MAOB inhibitor could improve PIPN-like pathology. Moreover, Khellin promoted neurite outgrowth, alleviated apoptosis, and improved mitochondrial dysfunction of DRG neurons by targeting MAOB, while inhibiting spinal astrocytes activation and suppressing neuroinflammation through the MAOB/NF-kappa B/NLRP3/ASC/Caspase1/IL-1 beta pathway. These findings provide potential therapeutic approaches for treating the side effects of PTX-induced neuropathy using selective MAOB inhibitors.
Article
Engineering, Environmental
Rui Liu, Ying Xu, Liang Song, Shiyu Liu, Zixuan Liang, Danyang Zhu, Xiaohu Dai
Summary: This study investigated the influence of binding strength (BS) of extracellular organic substances (EOS) on organic matter (OM) recovery from sewage sludge. The results revealed the effects of multivalent metals, floc structures, and rheological properties on the release of EOS. The power-law distribution of BS was found to determine the state of organic molecules, stability of floc structures, and rheological properties. Hierarchical cluster analysis identified three levels of BS in EOS, indicating three stages of OM release or recovery from sludge. This study provides a theoretical basis for developing methods for OM release and recovery from sludge.
Article
Physics, Multidisciplinary
Dan Zhu, Khai-Ming Wong, Guo-Quan Wong
Summary: We further investigate the properties of axially symmetric monopole-antimonopole pair in the standard Weinberg-Salam model. Using a novel data sampling approach, we obtained and analyzed 300 numerical solutions corresponding to specific values of Higgs self-coupling and Weinberg angle. The calculated energy of these solutions falls within the range of 13.1690-21.0221 TeV, and a unique oscillation pattern is observed when the data is arranged based on the system's symmetry.
EUROPEAN PHYSICAL JOURNAL PLUS
(2023)
Article
Microbiology
Zhenghao Zhao, Busen Wang, Shipo Wu, Zhe Zhang, Yi Chen, Jinlong Zhang, Yudong Wang, Danni Zhu, Yao Li, Jinghan Xu, Lihua Hou, Wei Chen
Summary: Designing a modified virus that can be controlled to replicate facilitates the study of viral pathogenic mechanisms and virus-host interactions. A universal switch element has been developed to precisely control virus replication using a small molecule. The insertion of inteins into the vesicular stomatitis virus (VSV) allows for regulated replication of the virus, which can be restored by intein splicing induced by 4-hydroxytamoxifen. This tool provides a simple and highly adaptable method for regulating virus replication.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Oncology
Danhua Zhu, Xiaoxi Ouyang, Yanhong Zhang, Xiaopeng Yu, Kunkai Su, Lanjuan Li
Summary: Long noncoding RNAs (lncRNAs) are noncoding RNAs with a length of more than 200 nucleotides. Dysregulation of lncRNAs is involved in various diseases, and is closely associated with patient clinical features. EGFR-AS1, a lncRNA, is aberrantly expressed in many types of cancers and is associated with multiple clinical characteristics. It regulates various cellular activities, making it a promising marker for cancer management.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biology
Ian Cooney, Deirdre C. Mack, Aaron J. Ferrell, Michael G. Stewart, Shuxin Wang, Helen M. Donelick, Daniela Tamayo-Jaramillo, Dakota L. Greer, Danyang Zhu, Wenyan Li, Peter S. Shen
Summary: Single-particle electron cryo-microscopy (cryo-EM) is an effective method for determining high-resolution structures of macromolecular complexes. This study presents a protocol using budding yeast to isolate tagged proteins and their associated complexes within three hours, prioritizing speed to recover intact, low-abundant complexes for cryo-EM specimen preparation. The protocol is applicable to soluble yeast proteins that tolerate C-terminal epitope tags.
Article
Physics, Nuclear
Zhizhou Ren, Yiwei Yang, Rong Liu, Bangjiao Ye, Zhongwei Wen, Jie Wen, Hairui Guo, Yonghao Chen, Han Yi, Weili Sun, Jie Yan, Zijie Han, Xingyan Liu, Qiping Chen, Tao Ye, Jiangbo Bai, Qi An, Huaiyong Bai, Jie Bao, Ping Cao, Pinjing Cheng, Zengqi Cui, Ruirui Fan, Changqing Feng, Minhao Gu, Fengqin Guo, Changcai Han, Guozhu He, Yongcheng He, Yuefeng He, Hanxiong Huang, Weiling Huang, Xiru Huang, Xiaolu Ji, Xuyang Ji, Haoyu Jiang, Wei Jiang, Hantao Jing, Ling Kang, Mingtao Kang, Bo Li, Lun Li, Qiang Li, Xiao Li, Yang Li, Shubin Liu, Guangyuan Luan, Yinglin Ma, Changjun Ning, Binbin Qi, Jie Ren, Xichao Ruan, Zhaohui Song, Hong Sun, Xiaoyang Sun, Zhijia Sun, Zhixin Tan, Hongqing Tang, Jingyu Tang, Pengcheng Wang, Qi Wang, Taofeng Wang, Yanfeng Wang, Zhaohui Wang, Zheng Wang, Qingbiao Wu, Xiaoguang Wu, Xuan Wu, Likun Xie, Li Yu, Tao Yu, Yongji Yu, Guohui Zhang, Jing Zhang, Linhao Zhang, Liying Zhang, Qingmin Zhang, Qiwei Zhang, Xianpeng Zhang, Yuliang Zhang, Zhiyong Zhang, Yingtan Zhao, Liang Zhou, Zuying Zhou, Danyang Zhu, Kejun Zhu, Peng Zhu
Summary: The neutron-induced uranium fission reactions have significant implications in advanced nuclear energy research and nuclear science. Using the time-of-flight method, the fission cross sections of U-236 and U-238 relative to U-235 were measured, providing valuable experimental data for further research and nuclear data evaluations.
EUROPEAN PHYSICAL JOURNAL A
(2023)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.
