期刊
PHYTOMEDICINE
卷 16, 期 10, 页码 935-941出版社
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2009.02.020
关键词
Rosa damascena; alpha-glycosidase inhibitor; Postprandial; Diabetic rats
资金
- Kerman Physiology Research Center
- Kerman University of Medical Sciences
The effect of a methanol extract of Rosa damascena Mill. flowers was studied, in comparison to the alpha-glucosidase inhibitor acarbose, in normal and diabetic rats. The inhibition mode of this extract was examined by measuring enzyme activity in different concentrations of substrate for Lineweaver-Burk plot analysis. The results show that Rosa damascena extract has an intensive inhibitory effect on alpha-glucosidase. Its inhibition was found to be noncompetitive. Oral administration of this plant extract (100 to 1000mg/kg body wt.) significantly decreased blood glucose after maltose loading in normal and diabetic rats in a dose-dependent manner. These results suggest that Rosa damascena might exert an anti-diabetic effect by suppressing carbohydrate absorption from the intestine and can reduce the postprandial glucose level. (C) 2009 Elsevier GrnbH. All rights reserved.
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