Article
Urology & Nephrology
Zhiheng Liu, Yunjing Liu, Lin Dang, Meijuan Geng, Yongzhan Sun, Yi Lu, Zhongze Fang, Hui Xiong, Yupeng Chen
Summary: Genome-wide mapping and transcriptomic analysis revealed the mechanism of CREB in ADPKD, showing its activation of ribosome biogenesis genes promoting cystogenesis. The integrated analysis concluded that CREB is closely associated with cyst growth.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dana R. Chambers, Agnieszka Sulima, Dan Luo, Thomas E. Prisinzano, Arthur E. Jacobson, Kenner C. Rice
Summary: The 5-(3-hydroxy)phenylmorphan structural class of compounds have an equatorially oriented aromatic ring and retain antinociceptive activity. The synthesized C9-alkyl diastereomers have been found to interact with opioid receptors and exhibit varying efficacy, including potent MOR agonists and a selective MOR antagonist that is more potent than naltrexone and antagonizes the EC90 of fentanyl to a greater extent.
Article
Environmental Sciences
Patrice Rat, Pascale Leproux, Sophie Fouyet, Elodie Olivier
Summary: This study evaluated the placental toxicity of Forskolin in pregnant women. The results showed that Forskolin activated P2X7 receptors and disrupted the secretion of estradiol, progesterone, hPL, and hyperglycosylated hCG in placental cells. This suggests that Forskolin may pose risks to pregnant women and should be restricted.
Article
Biochemistry & Molecular Biology
Zisheng Huang, Han Nie, Geng Liu, Peilin Li, Yong-Hua Peng, Jie Xiao, Weili Gu, Tao-Sheng Li
Summary: This study investigated the effectiveness and mechanism of angiotensin receptor blockers (ARBs) in alleviating renal fibrosis. It found that losartan, even at a low dose, can attenuate renal fibrosis by inhibiting the epithelial to mesenchymal transition (EMT) of renal epithelial cells induced by biomechanical stress.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Yuzuru Kubohara, Yuko Fukunaga, Haruhisa Kikuchi, Hidekazu Kuwayama, Wei-dong Xie
Summary: DIF-1 promotes glucose uptake in mouse 3T3-L1 fibroblast cells at least partly by increasing intracellular cAMP level.
Review
Pharmacology & Pharmacy
Rashid Giniatullin
Summary: 5-hydroxytryptamine (5-HT) is considered a key mediator in migraine, but the role of 5-HT3 receptors in pain transmission remains controversial. The applicability of currently available 5-HT3 antagonists in migraine treatment is not clearly supported by clinical data.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yue Chen, Xiabing Gu, Yikai Zhang, Xianrui Zhang, Ce Zhang, Meng Liu, Shijin Sun, Ningzheng Dong, Qingyu Wu
Summary: Vitamin B12 is absorbed and reabsorbed through receptor-mediated endocytosis, with CD320 playing a key role in cellular uptake. This study explores the distribution and cellular expression of CD320 in mouse kidneys and intestines, revealing its involvement in vitamin B12 absorption in the small intestine and reabsorption in the kidney. Furthermore, a specific amino acid motif in CD320 is identified as crucial for its apical membrane targeting in both renal and intestinal epithelial cells, and this targeting is mediated by a Rab11a-dependent mechanism.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Organic
Nikhil R. Tasker, Peter Wipf
Summary: This study describes the total synthesis of ergot alkaloids, including the previously unknown stereoisomers, using key transformations and streamlined experimental procedures. The synthesized compounds can be used for pharmacological evaluation.
Article
Chemistry, Applied
Gamze Toydemir, Linda M. P. Loonen, Prashanna Balaji Venkatasubramanian, Jurriaan J. Mes, Jerry M. Wells, Nicole De Wit
Summary: Research shows that coffee induces beneficial adaptive responses in cells, with AHR-activating potencies being rapidly absorbed and metabolized in intestinal epithelial cells. Coffee can increase the expression of genes like CYP1A1, contributing to antioxidant defense and detoxification processes in vivo.
Article
Physiology
Yushi Uchida, Kumiko Torisu, Kenji Ueki, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono
Summary: The study showed that autophagy regulates albumin transcytosis in proximal tubule epithelial cells by modulating FcRn transport, and inhibition of autophagy leads to albumin accumulation and cytotoxicity.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
Jun-Qing Zhang, Ying-Ying Li, Xue-Yan Zhang, Zeng-Hui Tian, Cheng Liu, Shi-Tao Wang, Fa-Rong Zhang
Summary: Renal fibrosis is a common pathological manifestation of chronic kidney diseases and a major cause of end-stage renal disease, but its pathogenesis remains unclear. Renal tubular epithelial cell senescence has been found to accelerate the progression of renal fibrosis. Oxidative stress, telomere attrition, and DNA damage are the major causes of renal tubular epithelial cell senescence. Interventions and therapeutic strategies targeting cellular senescence, such as calorie restriction, exercise, Klotho, senolytics, and senostatics, show potential for the treatment of renal fibrosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Neurosciences
Jingsheng Gu, Zhijie Hou, Xiaotao Zhou, Qinglei Wang, Yanmei Chen, Jichuan Zhang
Summary: This study found that activation of 5-HT1 receptor in the lateral habenula (LHb) impairs the acquisition of fear memory and increases anxiety-like behavior in rats.
NEUROSCIENCE LETTERS
(2022)
Article
Immunology
Sean E. DeWolf, Sashi G. Kasimsetty, Alana A. Hawkes, Lisa M. Stocks, Sunil M. Kurian, Dianne B. McKay
Summary: This study demonstrates for the first time that endogenous DAMPs released from injured RTECs directly activate PRR signaling in healthy RTECs. These findings provide new insights for the treatment of renal IRI.
Article
Environmental Sciences
Jing Chen, Yawen Song, Yining Liu, Wenyan Chen, Yanli Cen, Mingdan You, Guanghong Yang
Summary: A study found that the combined exposure to dibutyl phthalate (DBP) and benzo(a)pyrene (BaP) has more severe effects on kidney health than individual exposure to either DBP or BaP. The combined exposure increased histopathological abnormalities, renal function impairment, IL-1 beta and IL-18 excretion, and LDH release in rat renal tubular epithelial cells. Moreover, it upregulated marker molecules of pyroptosis and activated TLR4/NF-Kappa B signaling in the kidney. These findings highlight the importance of studying the combined effects of DBP and BaP on kidney injury.
Article
Cell Biology
Rafiquel Sarker, Ruxian Lin, Varsha Singh, Mark Donowitz, Chung -Ming Tse
Summary: In polarized intestinal epithelial cells, the downregulated in adenoma (DRA) is involved in both NaCl absorption and anion secretion. Forskolin (FSK) and adenosine 50-triphosphate (ATP) can stimulate the activity of DRA in a concentration-dependent manner. The synergistic increase of intracellular Ca2+ is essential for the stimulation of DRA by FSK and ATP.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.