Bioavailability of silymarin flavonolignans: drug formulations and biotransformation

Enzymatic preparation of silybin phase II metabolites: sulfation using aryl sulfotransferase from rat liver

(2013) Kateřina Purchartová et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Bioconversion of silybin to phase I and II microbial metabolites with retained antioxidant activity

(2012) Ehab A. Abourashed et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Preparation of silybin and isosilybin sulfates by sulfotransferase from Desulfitobacterium hafniense

(2012) Petr Marhol et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Preparative method for isosilybin isolation based on enzymatic kinetic resolution of silymarin mixture

(2012) Radek Gažák et al.   PROCESS BIOCHEMISTRY

Base-catalyzed oxidation of silybin and isosilybin into 2,3-dehydro derivatives

(2012) Radek Gažák et al.   TETRAHEDRON LETTERS

Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II)

(2011) Martina Zatloukalová et al.   BIOELECTROCHEMISTRY

Regioselective alcoholysis of silybin A and B acetates with lipases

(2011) Kateřina Purchartová et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Biocatalytic synthesis and antitumor activities of novel silybin acylated derivatives with dicarboxylic acids

(2011) Eleni Theodosiou et al.   New Biotechnology

Silybin and the liver: From basic research to clinical practice

(2011) Carmela Loguercio   WORLD JOURNAL OF GASTROENTEROLOGY

Development of Silymarin Self-Microemulsifying Drug Delivery System with Enhanced Oral Bioavailability

(2010) Xinru Li et al.   AAPS PHARMSCITECH

Dehydrosilybin attenuates the production of ROS in rat cardiomyocyte mitochondria with an uncoupler-like mechanism

(2010) Eva Gabrielová et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins

(2010) Tianzuo Zhan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Enzymatic Kinetic Resolution of Silybin Diastereoisomers⊥

(2010) Daniela Monti et al.   JOURNAL OF NATURAL PRODUCTS

In vitroandin vivoevaluation of silybin nanosuspensions for oral and intravenous delivery

(2010) Yancai Wang et al.   NANOTECHNOLOGY

Large-scale separation of silybin diastereoisomers using lipases

(2010) Radek Gažák et al.   PROCESS BIOCHEMISTRY

Enzymatic transformation of flavonoids and terpenoids: Structural and functional diversity of the novel derivatives

(2010) Epameinondas Xanthakis et al.   PURE AND APPLIED CHEMISTRY

Formulation and Evaluation of Swellable and Floating Gastroretentive Ciprofloxacin Hydrochloride Tablets

(2009) Ramji Anil Kumar Arza et al.   AAPS PHARMSCITECH

Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquid media and evaluation of their antitumor proliferative activity

(2009) Eleni Theodosiou et al.   BIOCATALYSIS AND BIOTRANSFORMATION

Preparation and Evaluation of Gastroretentive Floating Tablets of Silymarin

(2009) Rajeev Garg et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Preparation of silybin 23-esters and evaluation of their inhibitory ability against LPO and DNA protective properties

(2009) Ke Xin Huang et al.   CHINESE CHEMICAL LETTERS

Antioxidant and antiviral activities of silybin fatty acid conjugates

(2009) Radek Gažák et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Micronization of silybin by the emulsion solvent diffusion method

(2009) Zhi-Bing Zhang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Chemoenzymatic preparative separation of silybins A and B

(2009) Vladimír Křen et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Two Flavonolignans from Milk Thistle (Silybum marianum) Inhibit CYP2C9-Mediated Warfarin Metabolism at Clinically Achievable Concentrations

(2009) S. J. Brantley et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Significantly greater antioxidant anticancer activities of 2,3-dehydrosilybin than silybin

(2008) Axel Huber et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Multitargeted therapy of cancer by silymarin

(2008) Kumaraguruparan Ramasamy et al.   CANCER LETTERS

2,3-Dehydrosilybin Is a Better DNA Topoisomerase I Inhibitor than Its Parental Silybin

(2008) Piyanut Thongphasuk et al.   CHEMOTHERAPY

Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms

(2008) Bo Tang et al.   DRUG DISCOVERY TODAY

Hepatic Metabolism and Biliary Excretion of Silymarin Flavonolignans in Isolated Perfused Rat Livers: Role of Multidrug Resistance-Associated Protein 2 (Abcc2)

(2008) S. R. Miranda et al.   DRUG METABOLISM AND DISPOSITION

Molecular mechanisms of silybin and 2,3-dehydrosilybin antiradical activity—role of individual hydroxyl groups

(2008) Radek Gažák et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanism of the Antioxidant Action of Silybin and 2,3-Dehydrosilybin Flavonolignans: A Joint Experimental and Theoretical Study

(2008) Patrick Trouillas et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Enhanced dissolution of silymarin/polyvinylpyrrolidone solid dispersion pellets prepared by a one-step fluid-bed coating technique

(2007) Ningyun Sun et al.   POWDER TECHNOLOGY