Review
Chemistry, Medicinal
Roberta Esposito, Serena Federico, Marco Bertolino, Valerio Zupo, Maria Costantini
Summary: Marine organisms, especially marine sponges belonging to the class of Demospongiae, have shown great potential as a source of bioactive compounds with various pharmacological activities, such as antiviral, anticancer, antifouling, antimicrobial, antiplasmodial, antifungal, and antioxidant properties. Compounds isolated from these sponges, like avarol from the marine sponge Disidea avara, have the potential to be developed into new drugs.
Review
Biochemistry & Molecular Biology
Lixiang Sun, Huannan Wang, Maocai Yan, Chunmei Sai, Zhen Zhang
Summary: Marine fungi Aspergillus sp. is an important source of natural active lead compounds with biological and chemical diversity, and sesquiterpenoids are an extremely important class of bioactive secondary metabolites. This paper reviews the sources, chemical structures, bioactivity, biosynthesis, and druggability evaluation of sesquiterpenoids discovered from marine fungi Aspergillus sp. since 2008.
Review
Biochemistry & Molecular Biology
Rodion Khotimchenko, Igor Bryukhovetskiy, Maksim Khotimchenko, Yuri Khotimchenko
Summary: The study reviews the outcomes of screening studies of natural compounds with high anti-glioma activity, emphasizing the potential for greater diversity of marine compounds and likelihood of finding effective molecules. It covers the main problems of glioma chemotherapy and provides information on at least 15 classes of organic compounds with their chemical formulas and pharmacokinetic profiles. The taxonomic diversity of marine species containing bioactives with antiglioma activity is analyzed, noting cytotoxicity indicators and comparing them to similar indicators of antitumor agents for clinical use.
Review
Engineering, Marine
Zhen Qiao, Jialin Li, Song Qin
Summary: Quorum sensing is a bacterial sensor system in which bacteria secrete bioactive compounds to coordinate group behavior in response to cell density. This review focuses on the compounds involved in quorum sensing in the marine phycosphere and summarizes their types, structures, detection methods, and ecological functions. The potential applications of these compounds, such as controlling harmful algal blooms and producing biofuel, are also discussed.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Article
Chemistry, Medicinal
Muhammad R. Faisal, Matthias Y. Kellermann, Sven Rohde, Masteria Y. Putra, Tutik Murniasih, Chandra Risdian, Kathrin I. Mohr, Joachim Wink, Dimas F. Praditya, Eike Steinmann, Matthias Koeck, Peter J. Schupp
Summary: Two PBDEs, 3,4,5-tribromo-2-(2',4'-dibromophenoxy)phenol (1d) and 3,4,5,6-tetrabromo-2-(2',4'-dibromophenoxy)phenol (2b), isolated from the Indonesian marine sponge Lamellodysidea herbacea, showed a wide range of bioactivities, including strong deterrence against pufferfish, potent inhibition against bacterial and fungal strains, and inhibition of Hepatitis C Virus. The addition of a bromine atom into compound 2b resulted in higher fish feeding deterrence, while compound 1d showed more powerful inhibition against other human pathogenic bacteria and fungi. The compounds' chemical defense against fish feeding and pathogenic bacteria might explain the widespread occurrence of Lamellodysidea herbacea in Indonesia and the Indo-Pacific.
Review
Environmental Sciences
Pengfei Cheng, Yantao Li, Chun Wang, Jiameng Guo, Chengxu Zhou, Renchuan Zhang, Yiwei Ma, Xiaochen Ma, Lu Wang, Yanling Cheng, Xiaojun Yan, Roger Ruan
Summary: Marine microalgae have the potential to be used as feedstock for biofuels and other valuable compounds, but currently it is not economically viable. Developing efficient cultivation systems and production modes, as well as screening dominant algal strains, are necessary for utilizing algal biomass for biorefinery applications.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Chemistry, Medicinal
Disha Varijakzhan, Jiun-Yan Loh, Wai-Sum Yap, Khatijah Yusoff, Rabiha Seboussi, Swee-Hua Erin Lim, Kok-Song Lai, Chou-Min Chong
Summary: Marine sponges are valuable sources of bioactive compounds with antimicrobial and antiviral properties. These compounds can be used as antibacterial, antiviral, anti-malarial, and antifungal agents against human pathogens and fish pathogens. Their application as antimicrobial agents in veterinary commodities is also discussed.
Article
Environmental Sciences
Thamires Martins, Claudia Schinke, Sonia C. N. Queiroz, Patricia A. de C. Braga, Fabio S. P. Silva, Itamar S. Melo, Felix G. R. Reyes
Summary: The fungus Acremonium camptosporum associated with the marine sponge Aplysina fulva was found to produce antibacterial secondary metabolites. Analysis of mass spectra data revealed the presence of cytotoxic compounds, indicating a close association between the sponge and the fungus with its compounds.
Article
Microbiology
Qiao Wen, Ruizhe Liu, Zhenxiao Ouyang, Tianliang He, Weini Zhang, Xinhua Chen
Summary: A new antifungal peptide W1 was purified from Bacillus amyloliquefaciens W0101, isolated from the Arctic Ocean, and showed potential antifungal activity against several plant pathogenic fungi. The peptide W1 demonstrated stability and resistance to various environmental conditions, indicating its potential application in the biocontrol of plant diseases.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Food Science & Technology
Francisco Illueca, Ana Moreno, Jorge Calpe, Tiago de Melo Nazareth, Victor Dopazo, Giuseppe Meca, Juan Manuel Quiles, Carlos Luz
Summary: Nowadays, consumers are opting for biopreservation methods, like using sourdough instead of synthetic preservatives in bread. This study investigated the impact of L. plantarum 5L1 on the properties of bread, as well as its antifungal and biopreservation capacity. The results showed significant differences in the bread's properties, with higher levels of L. plantarum 5L1 leading to increased phenolic and lactic acid content, as well as higher alcohol and ester levels. Furthermore, the higher concentration of L. plantarum 5L1 delayed fungal growth and reduced the content of AFB1 and AFB2 compared to the control.
Review
Microbiology
Martin Muthee Gakuubi, Madhaiyan Munusamy, Zhao-Xun Liang, Siew Bee Ng
Summary: Fungi have long served as repositories of bioactive secondary metabolites and the demand for new drugs is increasing. Exploring understudied and specialized microbes is a promising way to discover potential new drug lead compounds. Plant-associated fungi known as endophytes, with unique bioactive compounds, have emerged as an important source for drug discovery.
Review
Biochemistry & Molecular Biology
Cong Wang, Huanyun Lu, Jianzhou Lan, K. H. Ahammad Zaman, Shugeng Cao
Summary: Marine fungi produce a variety of halogenated compounds with diverse structures and biological activities, mainly derived from Penicillium and Aspergillus strains. These compounds have been investigated for their potential pharmaceutical applications, including anticancer, antiviral, antibacterial, anti-inflammatory, antifungal, antifouling, and insecticidal properties.
Review
Biology
Fuad Ameen, Saleh AlNadhari, Ali A. Al-Homaidan
Summary: Marine microorganisms, with high biodiversity, are promising sources of new bioactive compounds with unique properties for a wide variety of industrial and biotechnological applications. These microorganisms, able to survive in extreme marine environments, produce complex molecules that have potential value to humans.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Suryaa Manoharan, Ekambaram Perumal
Summary: Cancer is characterized by alterations that cause cell over-proliferation and hyperactivation of signaling pathways. Bioactive compounds derived from marine sources, known as Marine Bioactive Compounds (MBCs), have been a focus in cancer therapy due to their diverse nature. This review summarizes the pathways predominantly targeted by different classes of MBCs and concludes that PI3K/AKT, ROS, and p53 are the key signaling pathways for induction of apoptosis in cancer cells. Carbohydrates, peptides, and terpenes are the major classes of MBCs regulating cancer signaling pathways. Future anticancer research could focus on MBCs from these classes that adhere to the PI3K/AKT, ROS, and p53 pathways to achieve excellent results.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Food Science & Technology
Raffaele Romano, Alessandra Aiello, Giuseppe Meca, Lucia De Luca, Fabiana Pizzolongo, Paolo Masi
Summary: This study investigated the extraction of bioactive compounds from Juglans regia L. green husk using supercritical carbon dioxide and compared it to traditional extraction techniques. The results showed that the extracts obtained with supercritical CO2 had high levels of polyphenols and juglone, as well as strong antioxidant and antifungal activity.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Applied
Manzura A. Agzamova, Nilufar Z. Mamadalieva, Andrea Porzel, Hidayat Hussain, Mthandazo Dube, Katrin Franke, Abdulaziz Janibekov, Ludger A. Wessjohann
Summary: In this study, a new cycloartane triterpene glycoside, named lehmanniaside, was isolated and identified from the aerial parts of Astragalus lehmannianus Bunge. Its structure was determined through spectroscopic analysis, and it exhibited weak anthelmintic, antifungal, and cytotoxic activities.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Susann Herrmann, Martin Dippe, Pascal Pecher, Evelyn Funke, Markus Pietzsch, Ludger A. Wessjohann
Summary: 4-Hydroxyphenylacetate 3-hydroxylase (4HPA3H), a flavin-dependent monooxygenase, was modified to convert larger substrates, especially phenolic natural products. The modified enzyme showed improved conversion of spacious substrates and demonstrated selective transformation of specific compounds without generating byproducts.
Article
Cell Biology
Ibrahim Morgan, Ludger A. Wessjohann, Goran N. Kaluderovic
Summary: Anthraquinone derivatives are a class of compounds that exhibit various biological activities, including antifungal, antibacterial, antiviral, and anticancer activities. This study tested various synthetic anthraquinone derivatives against different cancer cell lines and found that most of them exhibit anticancer effects. One specific compound, 1,4-bis(benzyloxy)-2,3-bis(hydroxymethyl)anthracene-9,10-dione, exhibited the highest cytotoxicity against PC3 cells and was further investigated for its mechanism of action. The compound was found to induce apoptosis, disrupt cellular equilibrium, and cause cell cycle arrest.
Article
Food Science & Technology
Asmaa M. Otify, Ahmed Serag, Andrea Porzel, Ludger A. Wessjohann, Mohamed A. Farag
Summary: This study characterized the metabolite profiles of five Cymbopogon species using NMR-based metabolomics. The results showed that Cymbopogon citratus has high essential oil and phenolic content, indicating strong antioxidant activity. Additionally, compounds with antimicrobial, insecticidal, antidiabetic, and antioxidant properties were identified and can serve as biomarkers for species authentication.
FOOD ANALYTICAL METHODS
(2022)
Article
Food Science & Technology
Mohamed A. Farag, Ahmed Zayed, Ibrahim E. Sallam, Amr Abdelwareth, Ludger A. Wessjohann
Summary: Coffee is a popular global beverage with unique flavor and multiple health benefits. Its chemical composition is complex, with metabolites that are endogenous to coffee seeds and generated during processing. Metabolomics technologies can help analyze and understand the chemical composition of coffee, and they have important implications for quality control and research on coffee's effects.
Article
Chemistry, Organic
Aldrin V. Vasco, Leonardo G. Ceballos, Ludger A. Wessjohann, Daniel G. Rivera
Summary: The replacement of the disulfide bridge by other side chain linkages is a method for developing cyclic peptide drugs. This study describes a method on resin that enables the substitution of the disulfide bond with a tertiary lactam bridge and allows the addition of various exocyclic moieties. Conformational analysis in comparison with octreotide provides important information on the functionalization type for mimicking the bioactive peptide.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ismail Ware, Katrin Franke, Hidayat Hussain, Ibrahim Morgan, Robert Rennert, Ludger A. Wessjohann
Summary: Peperomia obtusifolia is an ornamental plant native to Middle America, known for its mild antimicrobial properties. Chemical investigation of its leaves led to the discovery of two new compounds and five known compounds. Peperoside showed promising activity against cancer cells and bacteria, but no anthelmintic activity.
Article
Chemistry, Physical
Tamara Krajnovic, Nebojsa D. Pantelic, Katharina Wolf, Thomas Eichhorn, Danijela Maksimovic-Ivanic, Sanja Mijatovic, Ludger A. Wessjohann, Goran N. Kaluderovic
Summary: Xanthohumol and isoxanthohumol, compounds derived from hops, have been shown to possess a range of anti-tumor and protective properties. This study demonstrates that loading these compounds into mesoporous silica enhances their anti-cancer potential.
Article
Biochemistry & Molecular Biology
Ismail Ware, Katrin Franke, Mthandazo Dube, Hesham Ali El Enshasy, Ludger A. Wessjohann
Summary: In this study, three new compounds and 31 known compounds were isolated from Piper sarmentosum leaves, including 21 compounds that were isolated for the first time from this plant. The compounds were evaluated for their anthelmintic, antifungal, antibacterial, and cytotoxic activities. Several compounds showed significant activities against various pathogens, while exhibiting only mild cytotoxic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Yen T. H. Lam, Jana Hoppe, Quang N. Dang, Andrea Porzel, Alena Soboleva, Wolfgang Brandt, Robert Rennert, Hidayat Hussain, Mehdi D. Davari, Ludger Wessjohann, Norbert Arnold
Summary: Three new azepino-indole alkaloids, named purpurascenines A-C (1-3), along with a new-to-nature 7-hydroxytryptophan (4) and two known compounds, adenosine (5) and riboflavin (6), were isolated from the fruiting bodies of Cortinarius purpurascens. The structures of 1-3 were determined using spectroscopic analysis and ECD calculations. The biosynthesis of purpurascenine A (1) was investigated, and a biosynthetic route involving a direct Pictet-Spengler reaction between alpha-keto acids and 7-hydroxytryptophan (4) was proposed. Compound 1 showed no antiproliferative or cytotoxic effects against human cancer cells and exhibited some antagonistic effects on the 5-HT-dependent 5-HT2A activation and putative constitutive activity of the 5-HT2A receptor.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Luay. J. J. Rashan, Nadire Oezenver, Joelle. C. C. Boulos, Mona Dawood, Wynand. P. P. Roos, Katrin Franke, Ioannis Papasotiriou, Ludger. A. A. Wessjohann, Heinz-Herbert Fiebig, Thomas Efferth
Summary: A study found that a cold-water leaf extract called Breastin from Nerium oleander L. has potential as an anticancer agent, inhibiting the growth of multiple cancer cell lines and bypassing some traditional drug resistance mechanisms. The study also showed that protein expression profiles can be used to predict the sensitivity of tumor cells to Breastin constituents.
Article
Biochemistry & Molecular Biology
Duncan Mutiso Chalo, Katrin Franke, Vaderament-A. Nchiozem-Ngnitedem, Esezah Kakudidi, Hannington Origa-Oryem, Jane Namukobe, Florian Kloss, Abiy Yenesew, Ludger A. Wessjohann
Summary: The study found that Dalbergia melanoxylon is effective against microbial infections and contains several new prenylated isoflavanones. Two of these compounds showed promising antibacterial activity, including against methicillin-resistant Staphylococcus aureus (MRSA) and Mycobacterium. These findings support the traditional use of Dalbergia melanoxylon and suggest further research into its potential as an antibacterial lead compound.
Article
Food Science & Technology
Nehal S. Ramadan, Nesrin M. Fayek, Magdy M. El-Sayed, Rasha S. Mohamed, Ludger A. Wessjohann, Mohamed A. Farag
Summary: This study investigated the metabolite profile of Averrhoa carambola L. grown in tropical and temperate regions, using UPLC/MS-based molecular networking and chemometrics. The study also compared the immunostimulatory effect of ripe fruit and stem, and identified differences in secondary metabolite profiles between different origins and organ types. The study revealed the potential immune enhancing effect of A. carambola L. and its mechanisms of action.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Plant Sciences
Carlos Henrique Correa dos Santos, Pauline Stark, Paride Rizzo, Katrin Franke, Ludger Wessjohann
Summary: Two previously unknown prenylated acylphloroglucinol derivatives (hypercorisins A-B) and their two peroxide derivatives (hypercorisins C-D), along with seven known compounds, were isolated from Hypericum coris. The structures were determined using NMR experiments and mass spectrometry. Hypercorisins A, B, and D showed complete inhibition against the gram-positive bacterium Bacillus subtilis at the highest concentration tested, but had no significant antibacterial effect on the gram-negative Aliivibrio fischeri or cytotoxic activity on PC-3 or HCT-116 cancer cell lines.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Mohamed A. A. Farag, Mostafa H. H. Baky, Ibrahim Morgan, Mohamed R. R. Khalifa, Robert Rennert, Osama G. G. Mohamed, Magdy M. M. El-Sayed, Andrea Porzel, Ludger A. A. Wessjohann, Nehal S. S. Ramadan
Summary: This study conducted a comprehensive metabolic profiling and fingerprinting analyses of different parts of Balanites aegyptiaca, and evaluated its nutritional and cytotoxic activities. The results revealed a wide range of primary and secondary metabolites, including alkaloids, saponins, flavonoids, sugars, and amino and fatty acids. Additionally, the study identified specific markers for different parts of the plant, such as α-glucose, sucrose, and isorhamnetin for fruits and stems, and unsaturated fatty acids for seeds. Furthermore, potential antidiabetic compounds were discovered, such as nicotinic acid, trigonelline, and d-pinitol. In vitro cytotoxicity assays demonstrated the efficacy of immature fruits and seeds against prostate and colorectal cancer cell lines.
Article
Plant Sciences
Yi Zhu, Junlin Wang, Lu Tang, Yuxin Shang, Weiyi Zhao, Wei Zhang, Ping Hai, Yongbiao Zheng, Wenbo Li, Yanfang Su
Summary: One new iridoid glucoside and two new lignan glycosides, along with three known compounds, were isolated from the whole plants of Lancea tibetica. The structures were determined by spectroscopic methods and X-ray crystallographic analysis. One of the new iridoid glucosides and the known compounds exhibited moderate antioxidant activity.
PHYTOCHEMISTRY LETTERS
(2024)
Article
Plant Sciences
Yi Deng, Minghua Chen, Junming Yi, Yuguo Zheng
Summary: This study successfully designed and synthesized a series of quinazolinone derivatives containing purine molecules, and found that some compounds exhibited strong antiviral activity against tobacco mosaic virus. The findings have important implications for further development of antiviral drugs.
PHYTOCHEMISTRY LETTERS
(2024)
