期刊
PHYTOCHEMISTRY
卷 145, 期 -, 页码 85-92出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2017.10.013
关键词
Cyclocarya paliurus; Juglandaceae; Seco-dammarane triterpenoids; Cytotoxicity
资金
- National Natural Science Foundation of People's Republic of China [81374062, 85673179]
- National Ministry of Education Overseas Returnees Star-up Fund [2013-693]
- United States Department of Agriculture, Discovery & Development of Natural Products for Pharmaceutical & Agricultural Applications [58-6060-6-015]
The leaves of Cyclocarya paliurus with sweet taste are often used as herbal tea in People's Republic of China. In this study eight previously undescribed seco-dammarane type triterpenoids, cyclocariols A-H along with seven known compounds were isolated and characterized from its leaves. A possible biogenetic pathway for seco-dammarane type triterpenoids formation has been discussed. Cyclocariols A-H were evaluated for their cytotoxicities against human liver (SMMC-7721) and breast cancer (BT-549) cell lines. Cyclocariols A, B, E, and H were also tested against human colon tumor (HCT-116) cell lines, where all four exhibited good activities with IC50 values of 6.53, 4.94, 8.24, and 6.48 mu M, respectively. (C) 2017 Elsevier Ltd. All rights reserved.
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