期刊
PHYTOCHEMISTRY
卷 73, 期 -, 页码 57-64出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2011.10.002
关键词
Nemalion helminthoides; Nemaliales; Sulfated mannans; Sulfated xylomannans; Oversulfation of mannans; Smith degradation of sulfated xylomannans; Antiherpetic activity; Anticoagulant activity
资金
- National Research Council of Argentina (CONICET)
- Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT)
- University of Buenos Aires
- PRONEX-Carboidratos (Araucaria/CNPq-Brazil)
The structures of two sulfated xylomannans extracted from the red alga Nemalion helminthoides were determined. These two fractions plus a sulfated mannan, isolated from the same alga and whose structure was previously reported, were subjected to chemical modification. The mannan was oversulfated with SO3-pyridine in dimethyl sulfoxide at 60 degrees C during two and three hours and the xylomannans were subjected to Smith degradation in order to eliminate xylose side-chains. Structural analysis of all derivatives was carried out by methylation analysis and C-13 NMR spectroscopy. Antiviral activity against herpes simplex virus type 1 and 2, and dengue virus type 2 of native and modified mannans and xylomannans was estimated. Anticoagulant effect of the active fractions was also determined. (C) 2011 Elsevier Ltd. All rights reserved.
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