Article
Chemistry, Applied
G. N. Veremeichik, V. P. Grigorchuk, E. S. Butovets, L. M. Lukyanchuk, E. Brodovskaya, D. Bulgakov, V. P. Bulgakov
Summary: The study analyzed the biosynthesis of isoflavones in wild and cultivated soybeans grown in adverse climate conditions, finding that the Hefeng25 and Sfera varieties have the highest isoflavone content and fungal tolerance.
Article
Biochemistry & Molecular Biology
Ana Paula Magrini Iacopucci, Pamela da Silva Pereira, Dalila Andrade Pereira, Fabiano Beraldi Calmasini, Valeria Pittala, Leonardo Oliveira Reis, Arthur L. Burnett, Fernando Ferreira Costa, Fabio Henrique Silva
Summary: In this study, a mouse model was used to investigate the effect of intravascular hemolysis on corpus cavernosum smooth muscle relaxation and oxidative stress in the penis. The results showed that intravascular hemolysis promotes increased corpus cavernosum smooth muscle relaxation, accompanied by upregulation of HO-1 expression and oxidative stress. This study provides support for clinical studies that have shown a strong positive correlation between priapism and high levels of intravascular hemolysis in men with SCD.
Article
Biochemistry & Molecular Biology
Valeria Sorrenti, Agata Grazia D'Amico, Ignazio Barbagallo, Valeria Consoli, Salvo Grosso, Luca Vanella
Summary: The overexpression of HO-1 in NSCLC cells and the inhibitory effect of SnMP on cell proliferation and migration, as well as the increase in oxidative stress, suggest that HO activity inhibition may be a potential target for selective chemotherapy in lung cancer subtypes.
Article
Plant Sciences
Yanyan Wang, Jianyu Li, Yuhu Pan, Jingye Chen, Ying Liu
Summary: The toxicity of excess manganese (Mn) on soybean plants inhibits their growth and development, affecting enzyme activity and metabolic pathways. Different reactions are observed in soybean roots and leaves in response to Mn toxicity.
Article
Plant Sciences
Nusrat Jahan Methela, Anjali Pande, Mohammad Shafiqul Islam, Waqas Rahim, Adil Hussain, Da-Sol Lee, Bong-Gyu Mun, Nirmal Prashanth Maria Joseph Raj, Sang-Jae Kim, Yoonha Kim, Byung-Wook Yun
Summary: This study highlights the potential of nano-technology-based delivery systems for nitric oxide donors to improve plant growth and development and protect against stresses. The chitosan-GSNO nanoparticles showed promising results in enhancing drought tolerance in soybean plants by regulating gene expression and physiological responses.
Article
Immunology
Philippa Seika, Monika Janikova, Sahana Asokan, Lubica Janovicova, Eva Csizmadia, Mckenzie O'Connell, Simon C. Robson, Jonathan Glickman, Barbara Wegiel
Summary: Gastrointestinal inflammation and bleeding are commonly induced by cancer radiotherapy and chemotherapy, and our study suggests that the accumulation of heme in the colon following hemolysis and exposure to genotoxic stress plays a role in these conditions. We found an increased number of HO-1+ macrophages and levels of hemopexin in human colonic biopsies from patients treated with radiation or chemoradiation, and rectal bleeding was correlated with higher HO-1+ cell infiltration. Using knockout mouse models, we demonstrated that deficiency of HO-1 or hemopexin led to higher levels of DNA damage and inflammation in the colon.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jose Angel Alonso-Pineiro, Almudena Gonzalez-Rovira, Ismael Sanchez-Gomar, Juan Antonio Moreno, Ma Carmen Duran-Ruiz
Summary: Atherosclerosis, the underlying cause of cardiovascular diseases and high mortality rates, progresses with the formation of atherosclerotic plaques due to oxidative stress. Strategies aimed at reducing oxidative damage, including the use of antioxidant molecules such as Nrf2 and HO-1, have been studied to inhibit the progression of atherosclerosis.
Article
Biochemistry & Molecular Biology
Fernanda Tomiotto-Pellissier, Daniela Ribeiro Alves, Selene Maia de Morais, Bruna Taciane da Silva Bortoleti, Manoela Daiele Goncalves, Taylon Felipe Silva, Eliandro Reis Tavares, Lucy Megumi Yamauchi, Idessania Nazareth Costa, Emmanuel Silva Marinho, Marcia Machado Marinho, Ivete Conchon-Costa, Milena Menegazzo Miranda-Sapla, Wander Rogerio Pavanelli
Summary: The study showed that extracts from Caryocar coriaceum fruit had antileishmanial effects by inducing apoptosis-like processes, causing damage to the mitochondria and plasma membrane of the parasite, and reducing infection rates in infected cells. Additionally, the extracts exhibited antioxidant properties and up-regulated Nrf2/HO-1/Ferritin expression, leading to a depletion of available iron for Leishmania replication. Molecular modeling experiments suggested that flavonoids in the extracts can act as synergistic inhibitors of Leishmania proteins, with rutin showing a preference for the active site.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Review
Chemistry, Inorganic & Nuclear
Ana C. Pena, Ana Pamplona
Summary: Transition metals, especially iron, play important roles in the chemistry of life. Hemoproteins, including hemoglobin, are common targets for binding with biologically active gases such as NO and CO. Heme oxygenases, particularly HO-1, are crucial enzymes involved in heme metabolism and have documented antioxidant and anti-inflammatory properties. However, their role in infection, such as malaria, can be dual, either limiting pathogen burden or promoting pathogen growth. CO-releasing molecules have been considered as a potential alternative to CO gas inhalation for therapeutic purposes.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Psychiatry
Thomas Bertrand, Ayda Tavitian, Julia M. Galindez, Vimal Kothari, Shrisha Mohit, Carmela Galindez, Adrienne Liberman, Judy Glass, Ana M. Velly, Mervyn Gornitsky, Karl Looper, Soham Rej, Hyman M. Schipper
Summary: This study found that higher levels of salivary HO-1 expression were detected in patients experiencing an acute psychotic episode compared to control participants, and this overexpression was positively associated with psychiatric symptom severity and disability. The results suggest that overexpression of HO-1 in saliva may serve as a potential biomarker for psychosis and should be explored further in larger clinical trials.
PSYCHIATRY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Jia-Jing Lu, Ayitila Abudukeyoumu, Xing Zhang, Li-Bing Liu, Ming-Qing Li, Feng Xie
Summary: This review summarizes the different effects of HO-1 under normal and diseased conditions, with implications on the diagnosis and treatment of gynecological cancers, suggesting its potential role in cell proliferation, metastasis, immune regulation, and angiogenesis as an oncogene.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ilaria Buro, Valeria Consoli, Angela Castellano, Luca Vanella, Valeria Sorrenti
Summary: The aim of this research is to recover valuable substances from waste and by-products in the Mediterranean area, and extract natural extracts that can potentially prevent the complications of fatty liver disease.
Article
Nanoscience & Nanotechnology
Liping Zou, Guiping Cheng, Chengcheng Xu, Heyu Liu, Yingying Wang, Nianyu Li, Xiaorong Fan, Changhong Zhu, Wei Xia
Summary: CuNPs induce oxidative stress in human ovarian granulosa cells, possibly through the MAPK14-Nrf2 signaling pathway to induce HO-1 expression, but HO-1 can protect cells from oxidative stress induced by CuNPs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Akihiro Yachie
Summary: HO-1 is crucial in protecting tissues and organs from oxidative stress and excessive inflammatory reactions. Deficiency in HO-1 leads to dysfunction in monocytes, macrophages, and endothelial cells, resulting in systemic inflammatory response syndrome. Therapeutic induction of HO-1 production through pharmacological intervention shows promise in controlling inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Nana Su, Ze Liu, Lu Wang, Yuanyuan Liu, Mengyang Niu, Xin Chen, Jin Cui
Summary: This study reveals that hemin treatment increases anthocyanin accumulation in radish sprouts through HO-1 and NO signaling network.
Article
Peripheral Vascular Disease
Julieta S. Del Mauro, Paula D. Prince, Miguel A. Allo, Yanina Santander Plantamura, Marcela A. Moretton, German E. Gonzalez, Facundo M. Bertera, Andrea Carranza, Susana B. Gorzalczany, Diego A. Chiappetta, Celina Morales, Ricardo J. Gelpi, Carlos A. Taira, Ariel H. Polizio, Martin Donato, Christian Hocht
JOURNAL OF HYPERTENSION
(2020)
Article
Agronomy
Maria C. Perez-Piza, Pablo E. Grijalba, Ezequiel Cejas, Juan C. Chamorro Garces, Matias Ferreyra, Carla Zilli, Pablo Vallecorsa, Diego Santa-Cruz, Gustavo Yannarelli, Leandro Prevosto, Karina Balestrasse
Summary: Exposure of D. longicolla colonies to NTP severely compromised fungal biology, with negative effects on fungal growth, biomass, and colony appearance. Ozone production during treatment and lipid peroxidation of fungal cell membranes appeared to be involved in the observed effects. Asexual spores (conidia) of the fungi were also highly susceptible to NTP exposure.
PEST MANAGEMENT SCIENCE
(2021)
Article
Peripheral Vascular Disease
Julieta S. Del Mauro, Paula D. Prince, Yanina Santander Plantamura, Miguel A. Allo, Luciano Parola, Nahuel Fernandez Machulsky, Marcela A. Moretton, Eliana P. Bin, German E. Gonzalez, Facundo M. Bertera, Andrea Carranza, Gabriela Berg, Carlos A. Taira, Martin Donato, Diego A. Chiappetta, Ariel H. Polizio, Christian Hocht
Summary: By comparing the effects of nebivolol and atenolol on hypertensive rats, it was found that nebivolol was more effective in reducing central systolic blood pressure and blood pressure variability, as well as providing greater protection against target organ damage.
HYPERTENSION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Yoshimitsu Yura, Emiri Miura-Yura, Yasufumi Katanasaka, Kyung-Duk Min, Nicholas Chavkin, Ariel H. Polizio, Hayato Ogawa, Keita Horitani, Heather Doviak, Megan A. Evans, Miho Sano, Ying Wang, Katharina Boroviak, George Philippos, Ana Filipa Domingues, George Vassiliou, Soichi Sano, Kenneth Walsh
Summary: The study showed that a mouse model of Ppm1d-mediated t-CH was more susceptible to cardiac stress, leading to cardiac dysfunction through disruption of the DDR pathway and inflammatory response. Inhibiting the NLRP3 inflammasome could reverse the cardiac phenotype induced by Ppm1d mutations under Ang II-induced stress.
CIRCULATION RESEARCH
(2021)
Review
Oncology
M. C. Sanmartin, F. R. Borzone, M. B. Giorello, N. Pacienza, G. Yannarelli, N. A. Chasseing
Summary: Breast cancer, a common pathology in women, often leads to bone metastases with high mortality. Research shows that breast cancer cells prepare a pre-metastatic niche for colonization in the future. While the role of different cellular components in bone metastasis is well described, studying the changes in the microenvironment before tumor cells arrive is a novel field of research.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Claudia Martini, Fernando Nicolas Sosa, Ricardo Malvicini, Natalia Pacienza, Gustavo Yannarelli, Maria del C. Vila
Summary: Alendronate inhibits adipocyte differentiation, decreases triglyceride content, prevents oxidative stress, and inhibits macrophage inflammatory response. These effects may contribute to preventing adipocyte enlargement, oxidative stress in adipocytes, and activation of macrophages to a pro-inflammatory state, events associated with adipose tissue dysfunction and insulin resistance.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Cell & Tissue Engineering
Mujib Ullah, Nicole Pek Min Qian, Gustavo Yannarelli, Asma Akbar
Summary: Overexpression of HSP20 enhances the pluripotency and proliferation of iPSCs in a SIRT1-dependent manner, providing insights into the mechanisms controlling cell proliferation and potential improvements for stem cell-based therapies.
WORLD JOURNAL OF STEM CELLS
(2021)
Article
Medicine, Research & Experimental
Soichi Sano, Ying Wang, Hayato Ogawa, Keita Horitani, Miho Sano, Ariel H. Polizio, Anupreet Kour, Yoshimitsu Yura, Heather Doviak, Kenneth Walsh
Summary: The study established a model of TP53-mediated therapy-related clonal hematopoiesis, revealing that neutrophil infiltration in the heart significantly contributes to doxorubicin-induced cardiac toxicity, particularly amplified in the TP53-mediated clonal hematopoiesis model. This data suggests that therapy-related clonal hematopoiesis could increase the risk of heart failure in cancer survivors treated with genotoxic agents.
Article
Cell & Tissue Engineering
Ricardo Malvicini, Diego Santa-Cruz, Giada De Lazzari, Anna Maria Tolomeo, Cecilia Sanmartin, Maurizio Muraca, Gustavo Yannarelli, Natalia Pacienza
Summary: This study standardized a quick, cheap, and reproducible in vitro macrophage assay to evaluate and estimate the anti-inflammatory activity of MSC-sEVs.
Review
Cardiac & Cardiovascular Systems
Christian Hocht, Miguel A. Allo, Ariel Hector Polizio, Marcela A. Moretton, Andrea Carranza, Diego A. Chiappetta, Marcelo Roberto Choi
Summary: This article summarizes recent advances in the development of antihypertensive drugs and other emerging treatments for hypertension, including optimized formulation design and the potential role of intestinal microbiota modification.
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2022)
Letter
Cardiac & Cardiovascular Systems
Kyung-Duk Min, Ariel H. Polizio, Anupreet Kour, Mark C. Thel, Kenneth Walsh
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Peripheral Vascular Disease
Ariel H. Polizio, Eunbee Park, Kenneth Walsh
Summary: This review summarizes the relationship between clonal hematopoiesis (CH) and aging, atherosclerotic cardiovascular disease (CVD), and inflammation. It highlights the importance of epidemiological and mechanistic studies and potential therapeutic options for treating CVDs associated with CH.
CURRENT ATHEROSCLEROSIS REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Jesse D. Cochran, Yoshimitsu Yura, Mark C. Thel, Heather Doviak, Ariel H. Polizio, Yuka Arai, Yohei Arai, Keita Horitani, Eunbee Park, Nicholas W. Chavkin, Anupreet Kour, Soichi Sano, Nitin Mahajan, Megan Evans, Mahalia Huba, Nadia Martinez Naya, Hanna Sun, Young Ho Ban, Karen K. Hirschi, Stefano Toldo, Antonio Abbate, Todd E. Druley, Frederick L. Ruberg, Mathew S. Maurer, Justin A. Ezekowitz, Jason R. B. Dyck, Kenneth Walsh
Summary: The study identified an enrichment of TET2-mediated CH in patients with HFpEF, which was associated with exacerbated diastolic dysfunction. Patients with HFpEF, aged >= 70 years and CH, exhibited a worse prognosis in terms of 5-year cardiovascular-related hospitalization rate compared with those without CH.
Article
Biochemistry & Molecular Biology
Armando Moreno-Velasco, Mabel Fragoso-Serrano, Pedro de Jesus Flores-Tafoya, Sebastian Carrillo-Rojas, Elihu Bautista, Suzana Guimara Leitao, Jhon F. Castaneda-Gomez, Rogelio Pereda-Miranda
Summary: This study investigated the roots of Operculina hamiltonii, a traditional medicinal plant in Brazil. Three new acyl sugars or resin glycosides were identified and their structures elucidated. The combination of these compounds with other drugs showed enhanced cytotoxic effects on breast cancer cells.
Article
Biochemistry & Molecular Biology
Qian-Qing Liu, Lin-An Xiong, Jia-Yu Qian, Ting-Ting Gong, Lie-Feng Ma, Luo Fang, Zha-Jun Zhan
Summary: A new naturally occurring compound, Linderagatins C-F (1-4), with the structures of diaryltetrahydrofuran-type 7,9'-dinorlignans, was discovered in the roots of Lindera aggregata. The neuroprotective effects of compounds 2 and 3 on erastin-induced ferroptosis in HT-22 cells were found to be significant.