Article
Chemistry, Organic
Panpan Zhang, Shang Xue, Wansha Huang, Chengcheng Wang, Zhirong Cui, Jun Luo, Lingyi Kong
Summary: The study identified new limonoid compounds, confirmed their structures through methods like X-ray crystallographic diffraction, and established a method to solve difficulties in structural determination. Chemical conversions verified that specific reactions are key steps in forming specific bonds, providing new insights for the study of limonoid compounds.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Plant Sciences
Shi-Li Wu, Qiu-Ping Zou, Xiao-Yan Xie, Jia-Jia Ren, Zhang Fan, Jing-Rong OuYang, Peng-Cheng Yin, Fa-Wu Dong, Hong-Ping He
Summary: Two new triucallane triterpenoids, polystanin F (1) and polystanin G (2), were isolated from the fruits of Aphanamixis polystachya, along with eight known compounds (3-10). The structures of these compounds were determined through extensive spectroscopic analysis. Furthermore, compound 7 exhibited significant cytotoxic activity against colon cancer HCT-116 cells with an IC50 of 1.27 μM after evaluation for their cytotoxicity against three cancer cell lines using the MTT method.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2022)
Article
Chemistry, Medicinal
Xing Yang, Shi-Li Wu, Bao-Jing Li, Yan-Ping Li, Hong-Ping He, Fa-Wu Dong
Summary: Nineteen triterpenoids, including five new compounds, were isolated from the fruits of Aphanamixis polystachya. These compounds exhibited anti-inflammatory activity by inhibiting nitric oxide production in macrophages.
Article
Biochemistry & Molecular Biology
Min Song, Ging Chan, Li-Gen Lin, Derong Li, Kehan Zhang, Xiao-Qi Zhang, Wen-Cai Ye, Na Li, Qing-Wen Zhang
Summary: Eleven undescribed tetracyclic triterpenoids, along with twenty-six known compounds, were isolated from the fruits of Melia azedarach L.. Some of these compounds showed significant cytotoxicity against human cancer cells.
Article
Chemistry, Applied
Binh T. D. Trinh, Dzung N. Bui, Ly T. T. Nguyen, Hieu T. Nguyen, Chi N. Nguyen, Lien-Hoa D. Nguyen, Tuyen N. M. Huynh, Tien T. C. Cao, Le-Thu T. Nguyen
Summary: Two new triterpenoids, entanolide (1) and methyl 3,4-secotirucalla-23-oxo-4(28),7,24-trien-21-al-3-oate (2), were isolated from the bark of Entandrophragma angolense. Compound 2-5 exhibited weak activities in cytotoxicity evaluation against HepG2 cells.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Raduis Melong, Pierre Carolle Tamokoue Kengne, Jean Paul Dzoyem, Angelbert Awantu Fusi, Eric Allemann, Florence Delie, Christian G. Bochet, Uwe Beifuss, Gilbert Deccaux Wabo Fotso Kapche
Summary: The phytochemical study of Carapa procera DC's stem bark extract led to the isolation of a new natural limonoid, along with seven known compounds. The cytotoxicity of these compounds was evaluated on human lung adenocarcinoma A549 and Raw 264.7 mouse macrophage cell lines, with obacunone showing the most potent effect against both cell lines. These results suggest that limonoid derivatives could be promising sources of natural bioactive metabolites against cancer.
NATURAL PRODUCT RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Meihong Lin, Sifan Yang, Jiguang Huang, Lijuan Zhou
Summary: Plant-originated triterpenes are important insecticidal molecules, with molecules from Meliaceae plants showing a variety of insecticidal activities. Among the 102 triterpenoid molecules discussed in the paper, azadirachtin from Azadirachta indica A. Juss is the most well-known and highly effective botanical insecticide. However, it is notable that species from Cedrela also showed insecticidal activity and warrant further study.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Nattawut Suchaichit, Kwanjai Kanokmedhakul, Trinop Promgool, Panawan Moosophon, Apiwat Chompoosor, Natcha P. Suchaichit, Somdej Kanokmedhakul
Summary: Phytochemical investigation of the roots of Walsura trichostemon, a Thai medicinal plant, led to the discovery of a new tirucallane and four known compounds. These compounds showed antibacterial and acetylcholinesterase inhibitory activities, with the new compound exhibiting promising results against certain bacteria.
NATURAL PRODUCT RESEARCH
(2021)
Article
Integrative & Complementary Medicine
Liu Fang-Shen, Zhang Ting-Ting, Xu Jun, Jing Qin-Xue, Gong Chi, Dong Bang-Jian, Li Da-Hong, Liu Xiao-Qiu, Li Zhan-Lin, Yuan Zhong, Hua Hui-Ming
Summary: Six new tirucallane-type triterpenoids were isolated from the resin of Boswellia carterii Birdw, along with ten known triterpenoids. The structures were determined using spectroscopic data and the absolute configurations were assigned by comparing experimental and calculated electronic circular dichroism spectra. Compounds 5 and 6, possessing a unique skeleton, showed inhibitory activity against NO formation in cells, with compound 9 exhibiting significant inhibitory effect.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Biochemistry & Molecular Biology
Bingyang Zhang, Di Liu, Shijie Cao, Tie Yao, Guanke Liu, Liyi Chen, Feng Qiu
Summary: Eight new tirucallane triterpenoids and two known compounds were isolated from the gum resin of Boswellia sacra. Compound 10 exhibited remarkable inhibitory activity against HepG2 cells, inducing apoptosis and inhibiting EGFR.
BIOORGANIC CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Al Arofatus Naini, Tri Mayanti, Unang Supratman
Summary: This study analyzes the ethnobotanical, chemical, and biological activities of triterpenoid compounds from the Dysoxylum genus. These compounds have diverse structures, potential biosynthetic pathways, and therapeutic applications. They exhibit various activities, including anti-malarial, anti-inflammatory, and antioxidant properties. The research on these compounds is of great significance for the development of traditional medicine and the discovery of new drugs.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Wei Liu, Jie Gao, Miaomiao Li, Haji Akber Aisa, Tao Yuan
Summary: Phytochemical investigation of mastic isolated and identified 16 tirucallane triterpenoids from resin produced by Pistacia lentiscus, including 13 undescribed compounds. Compounds 7, 8, 14, and 16 showed stronger anti-inflammatory activity, while compound 1 exhibited comparable cytotoxic activity against HepG2 cells to doxorubicin.
Article
Chemistry, Medicinal
Li-Kang Zhao, Bin-Liang Tong, Jian Su, Yan Fu, Zhen Pei, Ying-Ying Gao, Zhi-Yu Ni, Yi-Bing Wu
Summary: A new geranyl phenylacetate glycoside, 14,15-dehydroxy-16-hydroxy-& UDelta;(14)-cinnacasside E (1), was isolated from the twigs of Aphanamixis polystachya. The structure of the compound was determined through various spectroscopic techniques, including 1D and 2D NMR experiments.
CHEMISTRY OF NATURAL COMPOUNDS
(2023)
Article
Plant Sciences
Alphonce Ignace Marealle, Ester Innocent, Kerstin Andrae-Marobela, Michael Qwarse, Francis Machumi, Ramadhani S. O. Nondo, Matthias Heydenreich, Mainen Julius Moshi
Summary: The extract of Morella salicifolia exhibited antimycobacterial activity against different mycobacteria species, and the isolated compounds showed potential for drug development targeting M. tuberculosis. The most active compound, maslinic acid, displayed activity against rifampicin-resistant clinical isolates. Additionally, the crude extract showed good safety profile in vitro and in vivo.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Applied
Saheb Ali, Kattakgoundar Govindaraj Sudha, Gopalu Karunakaran, Mariyappan Kowsalya, Evgeny Kolesnikov, Mikhail V. Gorshenkov, Mohan Prasanna Rajeshkumar
Summary: The study utilized Leea grandifolia leaf extract to obtain ZnO nanorods, which exhibited excellent antioxidant, photocatalytic, and antibacterial properties. In vitro toxicological studies showed the nanorods to be non-toxic to organisms and exhibited cytotoxic effects on tumor cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Shang Li, Lailiang Qu, Xiaobing Wang, Lingyi Kong
Summary: This review provides a comprehensive overview of the potential role of RIPK1 in the progression of Alzheimer's disease (AD). It explores the underlying linkages between RIPK1 and AD, including neuronal death, Aβ and Tau, inflammasome activation, BBB rupture, AMPK/mTOR, mitochondrial dysfunction, and O-glcNAcylation. The review also covers the discovery of RIPK1 inhibitors, ongoing clinical trials, and future RIPK1-targeted therapeutics.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Plant Sciences
Lingyu Ruan, Wenli Zhao, Buzha-xi Luo, Qi Zheng, Zhichao Liu, Wenya Liu, Daji-deng Ba, Jiage Zhong, Hui Luo, Junsong Wang, Xin Feng
Summary: High-dose HR caused hepatotoxicity and nephrotoxicity in rats, while low-dose ESP showed advantages in reducing toxicity. ESP may induce hepatotoxicity and nephrotoxicity, with HR being the main potential source of nephrotoxicity in ESP.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Organic
Fucheng Yin, Wan Peng, Cheng Wang, Lailiang Qu, Xinye Chen, Lingyi Kong, Xiaobing Wang
Summary: A protocol for Rh(III)-catalyzed cascade reaction was established, which allows the efficient construction of phthalides and isocoumarins skeleton with broad applicability. The method can potentially be applied to the total synthesis of natural products.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Dehua Lu, Lailiang Qu, Cheng Wang, Heng Luo, Shang Li, Fucheng Yin, Xingchen Liu, Xinye Chen, Zhongwen Luo, Ningjie Cui, Wan Peng, Limei Ji, Lingyi Kong, Xiaobing Wang
Summary: Combining HDAC inhibitors with DNA damage agents has shown promise in treating solid tumors. We designed a series of harmine-based inhibitors, with compound 27 showing potential in binding to DNA and causing DNA damage. Compound 27 induced cell apoptosis through the p53 signaling pathway and exhibited significant anti-proliferation effects against HCT-116 cells.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Fucheng Yin, Yifan Chen, Zhongwen Luo, Shang Li, Lingyi Kong, Xiaobing Wang
Summary: This study demonstrates the application of aryl halides in organic synthesis, specifically focusing on the usage of methyl 2-bromobenzoate and 2-nitrophenyl iodides as mild and effective bromination and iodination reagents. This efficient cascade catalysis method can be applied to the total synthesis of natural products Mafaicheenamine A and Claulamine A.
Article
Chemistry, Medicinal
Jiafu Leng, Yongjun Zhao, Ping Sheng, Yuanzheng Xia, Tingting Chen, Shifang Zhao, Shanshan Xie, Xiangyu Yan, Xiaobing Wang, Yong Yin, Lingyi Kong
Summary: The newly synthesized compound C3 exhibits potential anticancer activity by targeting tubulin to inhibit cancer cell proliferation and angiogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Yunlin Li, Fengye Wu, Qinyan Wu, Wenya Liu, Guanghui Li, Benxing Yao, Ran Xiao, Yudie Hu, Junsong Wang
Summary: This study presents a low-cost and automatic zebrafish behavior assay apparatus for evaluating the neurobehavioral performance of zebrafish. It utilizes a custom-written behavior analysis algorithm, data processing on a Raspberry Pi, and implements Kalman filter algorithm and ROI region to increase accuracy. The setup was also used to analyze zebrafish behavioral changes under different alcohol concentrations, demonstrating its reliability and accuracy.
Article
Chemistry, Physical
Dong Cui, Xiaohan Shi, Wenya Liu, Keren Zheng, Guangji Yin, Jing Wang, Guantong Han, Yi Wan, Junsong Wang, Wenting Li
Summary: Investigation of the neutralizing behavior of concrete is important for understanding its durability. This study used anthocyanin extracted from February orchid petals to characterize the neutralized regions of cement-based materials. The durability of the indicator was evaluated through comparison and verification using different detection methods. The results showed that the F. orchid indicator was effective in characterizing leaching and sulfate attack.
Article
Biochemistry & Molecular Biology
Xinye Chen, Cheng Wang, Dehua Lu, Heng Luo, Shang Li, Fucheng Yin, Zhongwen Luo, Ningjie Cui, Lingyi Kong, Xiaobing Wang
Summary: Aberrant expression of EZH2 is frequently observed in cancers, but EZH2 inhibitors are not effective in treating solid tumors. Combination of EZH2 and BRD4 inhibitors may be a promising strategy. Therefore, a series of EZH2/BRD4 dual inhibitors were designed and synthesized. Compound 28 (KWCX-28) showed the most potential and inhibited cell proliferation, induced apoptosis, arrested cell cycle, and resisted H3K27ac upregulation. KWCX-28 is a potential dual EZH2/BRD4 inhibitor for treating solid tumors.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Ningjie Cui, Shang Li, Yonglei Zhang, Fucheng Yin, Xinye Chen, Zhongwen Luo, Siyuan Wan, Xinxin Li, Lingyi Kong, Xiaobing Wang
Summary: This study synthesized and evaluated a series of structural analogues of Sibiriline and found that the optimal compound KWCN-41 can inhibit cell death, protect cell survival, and reduce inflammation levels. It is expected to be a potential drug for treating inflammatory diseases.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Panhu Zhu, Tao Zhou, Hong Chen, Xingru Chen, Xiaobing Wang, Lingyi Kong, Minghua Yang
Summary: Triazoles have shown significant efficacy in treating fungal infections, but the increasing drug resistance limits their effectiveness. By designing well-crafted side chains, triazoles can have advantages such as higher potency and overcoming drug resistance. In this study, we synthesized fluconazole-core compounds and optimized their side chains to develop a potent antifungal agent, S-F24, which exhibited excellent broad-spectrum activity and maintained its effectiveness against multi-resistant Candida albicans.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Huihui Meng, Di Xu, Qing Wang, Lin Liu, Wenya Liu, Junsong Wang
Summary: This study suggests that Coptis chinensis water extract (CCWE) has the potential to alleviate the severity and progression of sepsis by modulating the gut microbiome and immune response. CCWE treatment reversed the loss of beneficial bacteria and restored gut microbial balance in sepsis. By increasing energy supply, curbing inflammation, and modulating immune function, CCWE shows promise for sepsis treatment.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Review
Integrative & Complementary Medicine
Liu Xingchen, Wang Xiaobing
Summary: Parthenolide (PTL), derived from feverfew, has shown significant anticancer activity and has the potential to be a first-line drug. Structural modification strategies are recommended to enhance its anticancer activity. This review focuses on representative PTL derivatives and their mechanisms in cancer therapy.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Chemistry, Multidisciplinary
Dong Cui, Wenya Liu, Jing Wang, Chunping Gu, Yi Wan, Junsong Wang
Summary: This study investigates the potential of anthocyanins extracted from fresh or stale Orychophragmus violaceus flowers as a substitute for phenolphthalein in tracing carbonation in cementitious materials. The reliability of the anthocyanin indicator in tracing carbonation is verified, and factors affecting the width of the partially carbonated zone in cementitious slurries are studied.
Article
Chemistry, Medicinal
Dehua Lu, Cheng Wang, Lailiang Qu, Fucheng Yin, Shang Li, Heng Luo, Yonglei Zhang, Xingchen Liu, Xinye Chen, Zhongwen Luo, Ningjie Cui, Lingyi Kong, Xiaobing Wang
Summary: Aberrance of epigenetic modification is an important factor in hematological malignancies. There is promising potential in using HDAC and EZH2 dual inhibitors as a therapeutic strategy. Compound 20 exhibited excellent inhibitory activity against HDAC1 and EZH2, and also showed good antiproliferation activity against tumor cells, indicating its potential in treating hematological malignancies.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Armando Moreno-Velasco, Mabel Fragoso-Serrano, Pedro de Jesus Flores-Tafoya, Sebastian Carrillo-Rojas, Elihu Bautista, Suzana Guimara Leitao, Jhon F. Castaneda-Gomez, Rogelio Pereda-Miranda
Summary: This study investigated the roots of Operculina hamiltonii, a traditional medicinal plant in Brazil. Three new acyl sugars or resin glycosides were identified and their structures elucidated. The combination of these compounds with other drugs showed enhanced cytotoxic effects on breast cancer cells.
Article
Biochemistry & Molecular Biology
Qian-Qing Liu, Lin-An Xiong, Jia-Yu Qian, Ting-Ting Gong, Lie-Feng Ma, Luo Fang, Zha-Jun Zhan
Summary: A new naturally occurring compound, Linderagatins C-F (1-4), with the structures of diaryltetrahydrofuran-type 7,9'-dinorlignans, was discovered in the roots of Lindera aggregata. The neuroprotective effects of compounds 2 and 3 on erastin-induced ferroptosis in HT-22 cells were found to be significant.
