期刊
PHYTOCHEMISTRY
卷 71, 期 14-15, 页码 1729-1735出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2010.07.001
关键词
Lyngbya majuscula; Malyngamide; Variable temperature Mosher ester method
资金
- NIH/NIEHS [00210]
- NIH [CA CA100851, NS053398]
Two epimers of malyngamide C, 8-O-acetyl-8-epi-malyngamide C (1) and 8-epi-malyngamide C (3) have been isolated along with known compounds 6-O-acetylmalyngamide F (5), H (6), J (7) K (8), and characterized from a Grenada field collection of the marine cyanobacterium Lyngbya majuscula. The structures of these compounds were deduced by 10 and 20 NMR spectroscopic and mass spectral data interpretation. Absolute configurations were determined by a combination of CD-spectroscopy, chemical degradation and the variable temperature Mosher's method. Compounds 1-5, 7 and 8 displayed moderate cytotoxicity to NCI-H460 human lung tumor and neuro-2a cancer cell lines, with IC(50) values ranging between 0.5 and 20 mu g/mL. (C) 2010 Elsevier Ltd. All rights reserved.
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