期刊
PHYTOCHEMISTRY
卷 70, 期 7, 页码 913-919出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2009.04.012
关键词
Narcissus bujei; Amaryllidaceae; Lycorine; Apoptosis-induction; Anticancer agent; Alkaloid
资金
- NSERC
- Lotte & John Hecht Memorial Foundation, Vancouver, B.C.
The direct chemoselective differential functionalization of the ring-C hydroxyl groups present in the Amaryllidaceae alkaloid lycorine is described allowing for selective manipulation of the 1,2-hydroxyl groups. A mini-library comprised of synthetic and natural lycorane alkaloids was prepared and their apoptosis-inducing activity investigated in human leukemia (Jurkat) cells. Further insights into the nature of this interesting apoptosis-inducing pharmacophore are described, including the requirement of both free hydroxyl groups in ring-C. (C) 2009 Elsevier Ltd. All rights reserved.
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