期刊
PHYTOCHEMISTRY
卷 70, 期 8, 页码 1062-1068出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2009.05.001
关键词
Nemalion helminthoides; Red seaweed; Nemaliales; Sulfated (1 -> 3)-linked alpha-D-mannans; Sulfated mannans; Antiherpetic activity
资金
- National Research Council of Argentina (CONICET) [PIP 5699]
- Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT) [PICT 06-14237]
- University of Buenos Aires (UBACYT) [X325, X137]
- PRO-NEX-Carboidratos (Fund. Araucaria/CNPq-Brazil)
- National Research Council of Brazil (CNPq)
- Doctoral Fellowship from ANPCyT
Nemalion helminthoides, collected in the Argentine South Atlantic coast, was extracted with hot water and the crude product fractionated using cetrimide. The complexed material was subjected to fractional solubilization in solutions of increasing sodium chloride concentration and seven fractions were separated and analyzed. Structural analysis of the main fractions, those soluble in 3.0 and 4.0 M NaCl (yields 21.0% and 13.8%, respectively) and those insoluble in 4.0 M NaCl (yield 20.0%), indicated that this seaweed bio-synthesizes (1 -> 3)-linked alpha-D-mannans that are sulfated at positions 4 and 6. Three mannan fractions comprising considerable amounts of xylose were also isolated in very low total yield (2.0%). The fractions that were soluble in 3.0 and 4.0 M NaCl showed low antiherpetic activity whereas this activity was considerable for the fraction solubilized in 2.0 M NaCl (yield 0.5%) which contained single stubs Of P-D-xylose. A xylan, soluble in cetrimide solution, containing (1 -> 3, 1 -> 4)-linked beta-D-xylose residues, was also isolated in minor amount. (C) 2009 Elsevier Ltd. All rights reserved
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