期刊
PHYTOCHEMISTRY
卷 69, 期 9, 页码 1886-1889出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2008.04.011
关键词
Hovea parvicalyx; Fabaceae; beta-hydroxychalcone; isoprenylcysteine carboxyl methyltransferase (Icmt); 2 '-methoxy-3 '-prenyl-licodione; 2 '-methoxy-3 ' 3 ''-diprenyl-licodione; structure elucidation
Isoprenylcysteine carboxyl methyltransferase (Icmt) is enzyme target in anticancer drug discovery. An Icmt natural product high-throughput screening campaign was conducted and a hit extract from the roots of Hovea parvicalyx was identified. 2'-Methoxy-3'-prenyl-licodione and 2'-methoxy-3',3 ''-diprenyl-licodione, two prenylated beta-hydroxychalcone compounds, together with the known flavanone (S)-glabrol, were isolated and identified as bioactive constituents. Their structures were determined largely by 1D and 2D NMR spectroscopy. (C) 2008 Elsevier Ltd. All rights reserved.
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