期刊
PHYTOCHEMISTRY
卷 69, 期 10, 页码 2061-2066出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2008.04.009
关键词
Nymphaea caerulea; Nymphaeaceae; antioxidant activity; 2S 3S,4S-trihydroxypentanoic acid; myricetin 3-O-(3 ''-O-acetyl)-alpha-L-rhamnoside
资金
- NCRR NIH HHS [P20 RR 021929] Funding Source: Medline
As part of an ongoing search for antioxidants from medicinal plants, 20 constituents were isolated from the Nymphaea caerulea flowers, including two 2S,3S,4S-trihydroxypentanoic acid (1), and myricetin 3-O(3 ''-Oacetyl)-alpha-L-rhamnoside (2), along with the known myricetin 3-O-alpha-L-rhamnoside (3), myricetin 3-O-beta-D-glucoside (4), quercetin 3-O-(3 ''-O-acetyl)-alpha-L-rhamnoside (5), quercetin 3-O-alpha(-L-rhamnoside (6), quercetin 3-O-beta-D-glucoside (7), kaempferol 3-O-(3 ''-O-acetyl)-alpha-L-rhamnoside (8), kaempferol 3-O-beta-D-glucoside (9), naringenin (10), (S)-naringenin 5-O-beta-D-glucoside (11), isosalipurposide (12), P-sitosterol (13), beta-sitosterol palmitate (14), 24-methylenecholesterol palmitate (15), 4 alpha-methyl-5 alpha-ergosta-7,24(28)-diene-3 beta,4 beta-diol (16), ethyl gallate (17), gallic acid (18), p-coumaric acid (19), and 4-methoxybenzoic acid (20). The structures were determined by spectroscopic means. Compounds were tested for antioxidant activity and nine compounds 2-7,11,12 and 18 were considered active with IC(50) of 1.16,4.1, 0.75, 1.7, 1.0, 0.34, 11.0, 1.7 and 0.95 mu g/ml, respectively, while 1 was marginally active (IC(50) > 31.25 mu g/ml). The most promising activity was found in the EtOAc fraction (IC(50) 0.2 mu g/ml). This can be attributed to the synergistic effect of the compounds present in it. (C) 2008 Elsevier Ltd. All rights reserved.
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