Article
Plant Sciences
Hong Wang, Ruofang Gao, Jing Liu, Shuang Zhang, Yunli Zhao, Zhiguo Yu
Summary: This study aims to objectively understand the scientific connotations of the properties (Flavors and Natures) of traditional Chinese medicine from the perspective of metabolomics and characterize them by metabolites. The results show that the characterized metabolites of Natures are closely related to lipid and energy metabolism. Warm stimulates lipid metabolism to produce energy, while Cold inhibits lipid metabolism to decrease energy. The characterized metabolites of Flavors can provide a theoretical basis for the rules of Flavors and can be used in the development and quality control of traditional Chinese medicine resources.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Jillian L. Capodice, Barbara M. Chubak
Summary: Traditional Chinese Medicine (TCM) is a comprehensive medical system that has been developed over thousands of years and is utilized in the treatment of COVID-19. This paper highlights the use of TCM in treating COVID-19, discussing concepts and challenges of integrating TCM into medical settings.
Article
Plant Sciences
Yun Zhang, Qing Xia, Jiabo Wang, Kaiyan Zhuang, Hongtao Jin, Kechun Liu
Summary: Traditional Chinese medicine (TCM) has been used for over 2000 years, but modern research on its safety is limited. Zebrafish has been increasingly used as a model for toxicity research, offering low cost, high-throughput screening, and exemption from ethical legislation up to 5 dpf. Although zebrafish shows promise in evaluating TCM toxicity, further development of toxicity testing criteria and high throughput assays are needed.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Wei Jiang, Mingze Tang, Limin Yang, Xu Zhao, Jun Gao, Yue Jiao, Tao Li, Cai Tie, Tianle Gao, Yanxing Han, Jian-Dong Jiang
Summary: Chronic pain is a common health problem, and the current medication options have limited effectiveness and side effects. Alkaloids from traditional Chinese medicine (TCM) have been studied for their potential multi-target effects. This article introduces several well-studied analgesic alkaloids derived from TCM and their mechanisms and clinical applications, using the concept of drug-cloud (dCloud) theory. Drug combinations and the combination of herbal drugs with specific properties in TCM are explored for better therapeutic effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Fengyan Zhao, Caiwang Peng, Yang Sun, Hengli Li, Ke Du, Fang Liu
Summary: This article reviews the latest research findings on the treatment of cerebral ischemia with traditional Chinese medicine focused on ferroptosis as a target, and discusses the correlation with other cell death pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Letter
Pharmacology & Pharmacy
Lisha You, Kun Liang, Rui An, Xinhong Wang
Summary: This review provides a brief overview of the global contribution of traditional Chinese medicine (TCM), as well as the underlying obstacles and limitations for its development and modernization. The laborious progression of TCM globalization is illustrated through statistics and corresponding reasons. Innovative strategies and advanced technologies are advised to facilitate and accelerate TCM's expansion into the global markets.
PHARMACOLOGICAL RESEARCH
(2022)
Letter
Pharmacology & Pharmacy
Lisha You, Kun Liang, Rui An, Xinhong Wang
Summary: This review focuses on the global contribution of traditional Chinese medicine and the obstacles faced in its development and modernization. It also presents statistics and reasons to illustrate the challenges of TCM globalization, while offering innovative strategies and advanced technologies to facilitate its expansion into global markets.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Medicine, Research & Experimental
Min-Rui Ding, Yan-Jie Qu, Bing Hu, Hong-Mei An
Summary: Traditional Chinese medicine can modulate multiple signal pathways related to the pathological progression of Alzheimer's disease, thereby improving cognitive impairment. In-depth research on the prevention and treatment of Alzheimer's disease with traditional Chinese medicine can provide new ideas for exploring the pathogenesis of Alzheimer's disease and developing new anti-AD drugs.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Dongyang Qian, Hui Zhou, Pan Fan, Tao Yu, Anish Patel, Morgan O'Brien, Zhe Wang, Shiguang Lu, Guoqiang Tong, Yimin Shan, Lei Wang, Yuan Gao, Yuan Xiong, Lily Zhang, Xin Wang, Yuancai Liu, Shuanhu Zhou
Summary: The study found that traditional Chinese medicine herbal extracts can prevent alcohol-induced osteopenia in male mice, effectively regulate abnormal bone metabolism, improve bone density, and have the potential therapeutic effect.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Huimin Jiang, Cheng Hu, Meijuan Chen
Summary: With the establishment and optimization of CMAP, the functional relationships among drugs, genes, and diseases are further explored, providing new opportunities for research on traditional Chinese medicine.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biodiversity Conservation
Tom P. Moorhouse, Zhao-min Zhou, Yun-chun Ye, Youbing Zhou, Neil C. D'Cruze, David W. Macdonald
Summary: Global wildlife trade impacts around 24% of terrestrial vertebrates, with demand for traditional medicinal materials, especially traditional Chinese medicine, being a major driver. The classification of TCM into three components - zhongyi, TCM, and CMP - reveals distinct markets and communities within the industry, which could aid in developing strategies for reducing demand and redirecting towards more sustainable practices. This approach highlights the need to engage with official TCM authorities, professional bodies, academics, and practitioners to address concerns related to species conservation and animal welfare.
GLOBAL ECOLOGY AND CONSERVATION
(2021)
Review
Medicine, Research & Experimental
Jie Gao, Tianshu Hou
Summary: Cardiovascular disease is a leading cause of disability and death worldwide, and traditional Chinese medicine has been proven to be efficient in treating it by manipulating the quality and function of mitochondria.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Health Care Sciences & Services
Zhengfei Wang, Lai Wang, Fu'an Xiao, Qingsong Chen, Liming Lu, Jiaming Hong
Summary: A lightweight blockchain framework is proposed to address issues with traditional drug traceability systems. This framework greatly reduces the size of the blockchain and improves verification efficiency.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Biochemical Research Methods
Yinyin Wang, Hongbin Yang, Linxiao Chen, Mohieddin Jafari, Jing Tang
Summary: Traditional Chinese medicine has been practiced for treating human diseases for thousands of years, where one of its advantages is the principle of herb compatibility in TCM formulae, consisting of multiple herbs to achieve maximum treatment effects. A network-based method was proposed to quantify interactions in herb pairs, revealing that frequently used herb pairs tend to affect neighboring proteins in the human interactome. The study provides a network pharmacology framework to explore herb combinations more effectively based on network topology.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Neurosciences
Wei Shen, Ning Jiang, Wenxia Zhou
Summary: Adult neurogenesis is important for cognitive function and mood regulation, but abnormal adult neurogenesis is linked to neurological and psychiatric diseases. Traditional Chinese medicine (TCM) has been shown to have unique advantages in improving adult neurogenesis and treating these diseases through regulating various stages of adult neurogenesis. This review summarizes the progress and key mechanisms through which TCM improves adult neurogenesis, and suggests possible strategies of TCM in the treatment of neuropsychiatric disorders.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Chemistry, Analytical
Taiping Li, Mengli Zhang, Zhien Tan, Jianhua Miao, Yanmei He, Aihua Zhang, Min Ou, Danna Huang, Fangfang Wu, Xijun Wang
Summary: A rapid and robust method was established for the comprehensive analysis of the chemical composition of Jigucao capsule for the first time in this study, providing important reference for the quality control and pharmacodynamic material basis research of Jigucao capsule.
JOURNAL OF SEPARATION SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Hui-Yu Li, Hui Sun, Ai-Hua Zhang, Lu-Wen He, Shi Qiu, Jun-Ru Xue, Fangfang Wu, Xi-Jun Wang
Summary: Through urine metabolomics analysis, SMYAT was found to have significant antithrombotic and anti-inflammatory effects on thromboangiitis obliterans. It can regulate the metabolic profile of TAO rats, and the therapeutic effect is closely related to tyrosine metabolism, vitamin B6 metabolism, and cysteine and methionine metabolism.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yanmei He, Mengli Zhang, Taiping Li, Zhien Tan, Aihua Zhang, Min Ou, Danna Huang, Fangfang Wu, Xijun Wang
Summary: This study investigated the mechanism of Jigucao capsule (JGCC) in the treatment of Dampness-heat Jaundice Syndrome (DHJS) using urine metabolomics. The results showed that JGCC significantly improved clinical biochemical indexes and histopathological changes, and adjusted disturbed biomarkers, indicating its remarkable effect on the treatment of DHJS.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Jing Li, Ai-hua Zhang, Fang-fang Wu, Xi-jun Wang
Summary: Dysbiosis of gut bacteria is associated with colorectal cancer (CRC), and the association analysis of metabolomics and gut microbiome will provide novel strategies for the prevention, diagnosis, and therapy of CRC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Microbiology
Changhong Ding, Dan Yu, Yiyang Chen, Junyi Zhu, Junkai Wu, Xiaowei Du, Xijun Wang
Summary: This study sequenced and analyzed the genome of endophytic fungus Fusarium sp. C39 and found key enzyme genes involved in saponin synthesis. The proposed mechanism of saponin production in Fusarium sp. C39 provides a theoretical basis for efficient and low-cost production of saponins.
JOURNAL OF BASIC MICROBIOLOGY
(2022)
Article
Biochemical Research Methods
Taiping Li, Yanmei He, Mengli Zhang, Zhien Tan, Aihua Zhang, Min Ou, Danna Huang, Fangfang Wu, Xijun Wang
Summary: This study explored the potential mechanism of the Chinese patent medicine Jigucao capsule in treating the serum metabolic profile of rats with Yanghuang syndrome. The results showed that Jigucao capsule reduced inflammatory cells, inhibited the proliferation of bile duct epithelial cells and hepatocyte necrosis. It also significantly reversed abnormal levels of certain metabolites related to lipid and carbohydrate metabolism. In conclusion, Jigucao capsule has a therapeutic effect on rats with Yanghuang syndrome, and this study provides basic data for further pharmacodynamic studies.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Xing-Hua Li, Feng-Ting Yin, Xiao-Hang Zhou, Ai-Hua Zhang, Hui Sun, Guang-Li Yan, Xi-Jun Wang
Summary: This study summarizes the key pathways and targets of natural compounds from traditional Chinese medicine in the treatment of ischemic stroke by reviewing relevant literature over the past five years. This provides a valuable information base for the future development of effective treatments for ischemic stroke.
Article
Biochemistry & Molecular Biology
Qingyu Zhang, Aihua Zhang, Fangfang Wu, Xijun Wang
Summary: This study used metabonomics technology to reveal the regulatory effect of Yunnan Baiyao on small molecular metabolites in promoting blood circulation and removing blood stasis, and identified 28 urine biomarkers. The results demonstrated that Yunnan Baiyao improved the pathological indexes in rats with blood stasis syndrome and clarified the relevant metabolic pathways involved in its treatment.
Article
Chemistry, Analytical
Nannan Huang, Dan Yu, Jinhai Huo, Junkai Wu, Yiyang Chen, Xiaowei Du, Xijun Wang
Summary: This study conducted solid fermentation of Dioscorea nipponica using endophytic fungi C39 and found that it could effectively transform the saponin components, leading to a significant increase in diosgenin concentration. Furthermore, 11 new metabolites were identified during the biotransformation process of D. nipponica, and the transformation pathways were inferred based on the variation trend of saponins.
JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Wen-feng Wei, Hui Sun, Shao-bo Liu, Sheng-wen Lu, Ai-hua Zhang, Wan-ying Wang, Wen-jun Chai, Fang-fang Wu, Guang-li Yan, Yu Guan, Xi-jun Wang
Summary: By studying animal models and utilizing metabonomics tools, the effective components of ZhiziBaipi Decoction in treating Damp-heat jaundice syndrome and their correlation with biomarkers were identified, providing new insights into its therapeutic mechanism.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Taiping Li, Fangfang Wu, Aihua Zhang, Hui Dong, Ihsan Ullah, Hao Lin, Jianhua Miao, Hui Sun, Ying Han, Yanmei He, Xijun Wang
Summary: By combining untargeted metabolomics and serum pharmacochemistry of traditional Chinese medicine, this study revealed the metabolic mechanisms and key pharmacodynamic components of Wutou decoction in rheumatoid arthritis rats, providing a theoretical basis for quality control investigation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ling Kong, Ye Sun, Hui Sun, Ai-hua Zhang, Bo Zhang, Nan Ge, Xi-jun Wang
Summary: This study applied the chinmedomics strategy to discover the effective constituents of KLX in the treatment of diabetic retinopathy (DR), and revealed some of the mechanisms involved.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Ye Sun, Ling Kong, Ai-Hua Zhang, Ying Han, Hui Sun, Guang-Li Yan, Xi-Jun Wang
Summary: Diabetic retinopathy, a serious complication of diabetes, is a leading cause of blindness worldwide. The irreversibility of the condition makes current treatment methods unsatisfactory. Early detection and intervention are important in reducing the damage caused by diabetic retinopathy. Metabolomics, a branch of systems biology, can identify characteristic metabolic changes associated with the progression of diabetic retinopathy and discover potential biomarkers for clinical diagnosis and treatment. This review summarizes the known metabolomics biomarkers of diabetic retinopathy and discusses the possibility of the arginine-creatine metabolic pathway as a therapeutic strategy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Plant Sciences
Feng-ting Yin, Xiao-hang Zhou, Shu-yu Kang, Xing-hua Li, Jing Li, Ihsan Ullah, Ai-hua Zhang, Hui Sun, Xi-jun Wang
Summary: This study explored the main constituents and potential targets of Dachengqi Decoction (DCQ) in the treatment of colorectal cancer (CRC) using serum pharmacochemistry and network pharmacology. The results showed that flavonoids and anthraquinones were the main active substances of DCQ, which may exert anti-tumor effects by regulating targets such as MAPK, IL-6, and VEGF, as well as pathways including PI3K-AKT signaling pathway, AGE-RAGE signaling pathway, and IL-17 signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Nan Ge, Ling Kong, Ai-hua Zhang, Ye Sun, Man-qian Zhao, Bo Zhang, Lei Xu, Xiao Ke, Hui Sun, Xi-jun Wang
Summary: This study utilized high-throughput lipidomics combined with multivariate statistical analysis to identify 30 lipid biomarkers and 7 metabolic pathways associated with DR. The findings suggest that KLX intervention can regulate 22 biomarkers and the PI3K/MAPK pathway may be closely related to DR development. High-throughput lipidomics combined with multivariate statistical analysis can provide valuable insights into the molecular mechanisms and potential treatment targets for DR.