Article
Agriculture, Dairy & Animal Science
Michail Kakanis, Katerina Marinou, Evangelia N. Sossidou
Summary: This study examines the attitudes of Greek pig farmers towards tail biting and tail docking through a structured questionnaire. The study found that in case of an outbreak, Greek farmers mainly choose to remove the victim, while 64.4% have tried raising pigs with intact tails. Chains are still the most commonly used enrichment material. Feed quality, environmental factors, and health problems are considered the most important risk factors. The study suggests that solutions for reducing tail docking should consider farmers' perceptions and practices.
Article
Veterinary Sciences
Christina Veit, Andrew M. Janczak, Birgit Ranheim, Judit Vas, Anna Valros, Dale A. Sandercock, Petteri Piepponen, Daniela Dulgheriu, Janicke Nordgreen
Summary: Research has shown that injection of pigs with lipopolysaccharide (LPS) affects pig behavior and neurotransmitters in the brain, with nonsteroidal anti-inflammatory drugs mitigating these effects.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Agriculture, Multidisciplinary
T. Wilder, J. Krieter, N. Kemper, K. Buttner
Summary: This study investigated the robustness of node-level network parameters based on tail-biting observations in pigs. The results showed that there were substantial deviations between observers, and outgoing network parameters provided better accuracy scores than ingoing network parameters. Increasing error rates led to decreasing accuracy scores. Longer observation periods yielded better accuracy scores.
JOURNAL OF AGRICULTURAL SCIENCE
(2022)
Article
Veterinary Sciences
Marc Bagaria, Laura Kuiper, Ellen Meijer, Elisabeth H. M. Sterck
Summary: This study examines the relationship between tail biting and general behaviors at the individual level in piglets. The results suggest that explorative behaviors are related to the type of tail biting, and provide directions for farmers to prevent tail biting behavior in piglets.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Behavioral Sciences
Danielle Santana-Coelho, Samantha L. Hodges, Saul I. Quintero, Paige D. Womble, D. Greg Sullens, David A. Narvaiz, Rebecca Herrera, Melanie J. Sekeres, Joaquin N. Lugo
Summary: This study investigated whether Fmr1 mutant mice have altered sickness behavior in response to inflammation by stimulating wildtype and knockout mice with LPS. The ELISA confirmed an increase in IL-6 levels in the blood serum of mice treated with LPS. Treated Fmr1 mutants exhibited decreased distance traveled in the wheel running test, similar to treated controls.
BRAIN AND BEHAVIOR
(2023)
Review
Agriculture, Dairy & Animal Science
Maggie Henry, Hannah Jansen, Maria del Rocio Amezcua, Terri L. O'Sullivan, Lee Niel, Anna Kate Shoveller, Robert M. Friendship
Summary: Tail-biting in commercial pig-rearing facilities is a welfare concern with varying viewpoints on common risk factors and intervention strategies. Providing rooting material as a prevention strategy for alleviating pigs' innate exploratory behavior is commonly suggested.
Article
Plant Sciences
Meenakshi Bhardwaj, Sugumar Mani, R. Malarvizhi, Veeresh Kumar Sali, Hannah R. Vasanthi
Summary: The study showed that a sulfated polysaccharide extracted from marine algae has significant immunomodulatory effects in experimental rats, reducing systemic inflammation and possessing antioxidant and anti-inflammatory potential.
Article
Immunology
Eoin O'Neill, Eadaoin W. Griffin, Ruairi O'Sullivan, Carol Murray, Lucy Ryan, Justin Yssel, Andrew Harkin, Colm Cunningham
Summary: Experimental evidence demonstrates that significant depletion of noradrenaline in the hippocampus and frontal cortex does not lead to acutely exaggerated neuroinflammation, nor does it leave the brain susceptible to acute, transient working memory deficits upon low dose LPS challenge.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Veterinary Sciences
Anna Valros, Maria Jose Lopez-Martinez, Camilla Munsterhjelm, Marina Lopez-Arjona, Jose Joaquin Ceron
Summary: Feasible and reliable measures are needed to improve and evaluate production animal health and welfare. Oxytocin and procalcitonin show promise as stress-related and sepsis biomarkers in pigs, respectively. The study validated these measures in a tail-biting outbreak situation, providing further evidence for the link between stress and tail biting in pigs.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Immunology
Mingzhu Pan, Jiahuan Liu, Dong Huang, Yanlin Guo, Kai Luo, Mengxi Yang, Weihua Gao, Qiaoqing Xu, Wenbing Zhang, Kangsen Mai
Summary: This study characterized the foxo3 in turbot and investigated its functions in liver inflammation through both in vitro and in vivo experiments. The results suggest that FoxO3 may modulate LPS-activated hepatic inflammation in turbot by decreasing proinflammatory cytokines, levels of liver enzymes, and activating specific pathways, providing valuable insights for immune regulation and potential therapies for liver inflammation in fish.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Bora Tastan, Burak I. Arioz, Kemal Ugur Tufekci, Emre Tarakcioglu, Ceren Perihan Gonul, Kursad Genc, Sermin Genc
Summary: In this study, DMF was shown to alleviate NLRP3 inflammasome activation by reducing levels of IL-1 beta, IL-18, caspase-1, and NLRP3, oxidative stress, and pyroptotic cell death via the Nrf2/NF-kappa B pathways. Additionally, DMF improved LPS-induced sickness behavior in male mice and decreased caspase-1/NLRP3 levels through Nrf2 activation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Renato D. R. Cardoso, Sandmary D. Chambo, Tiago H. Zaninelli, Beatriz H. S. Bianchini, Matheus Deroco Veloso da Silva, Mariana M. Bertozzi, Telma Saraiva-Santos, Anelise Franciosi, Geovana Martelossi-Cebinelli, Pamela E. Garcia-Miguel, Sergio M. Borghi, Rubia Casagrande, Waldiceu A. Verri
Summary: In the study, it was found that RvD5 enhances bacteria phagocytosis, reduces inflammatory mediators, and protects kidneys from tissue injury in gram-negative Escherichia coli infection and LPS endotoxemia. This effect is associated with improved histopathological parameters, reduced leukocyte infiltration, decreased pro-inflammatory cytokine production, and increased antioxidant markers. RvD5 also reduces the activation of NF kappa B and promotes the Nrf2 pathway.
Article
Multidisciplinary Sciences
Jian-Quan Luo, Huan Ren, Man-Yun Chen, Qing Zhao, Nian Yang, Qian Liu, Yong-Chao Gao, Hong-Hao Zhou, Wei-Hua Huang, Wei Zhang
Summary: Hydrochlorothiazide (HCTZ) impairs glucose tolerance and may induce new onset of diabetes through its interaction with the gut microbiome. HCTZ consumption disrupts the intestinal microbiota, leading to elevated levels of Gram-negative bacteria and lipopolysaccharide (LPS), which results in intestinal barrier dysfunction. Activation of TLR4 signaling by HCTZ further induces macrophage polarization, inflammation, and metabolic disorders in the liver. Blocking TLR4 signaling can alleviate HCTZ-induced macrophage polarization and metabolic disorders.
Article
Agriculture, Dairy & Animal Science
Katherine R. VanValin, Remy N. Carmichael-Wyatt, Erin L. Deters, Elizabeth M. Messersmith, Katie J. Heiderscheit, Katherine G. Hochmuth, Trey D. Jackson, Joshua M. Peschel, Anna K. Johnson, Stephanie L. Hansen
Summary: Increased supplemental Zn may alter the rate of recovery of Zn status from an acute inflammatory event. Ear-tag-based accelerometers are effective at detecting sickness behavior in feedlot steers, with rumination being potentially more sensitive than other variables.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Immunology
Rishabh Sharma, Akram Zamani, Larissa K. Dill, Mujun Sun, Erskine Chu, Marcus J. Robinson, Terence J. O'Brien, Sandy R. Shultz, Bridgette D. Semple
Summary: The study revealed that TBI patients exhibit widespread physiological symptoms after infection, but these symptoms do not synergize with prior TBI. This finding provides new insights into the potential impact of this "two-hit insult" to the injured pediatric brain.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Substance Abuse
Maryna Koskela, T. Petteri Piepponen, Jaan-Olle Andressoo, Vootele Voikar, Mikko Airavaara
Summary: This study developed a model to investigate alcohol-seeking behavior in group-housed female mice after withdrawal. The results suggest that long-term conditioning with alcohol reward can lead to cue-induced alcohol-seeking behavior. The number of nosepokes in the conditioned corner may be a determining factor for alcohol-seeking after withdrawal.
ALCOHOL AND ALCOHOLISM
(2022)
Article
Agriculture, Dairy & Animal Science
A. Valros
Summary: Tail biting is a serious problem in pig production, but Finland has successfully managed to rear non-docked pigs. The success in Finland may be attributed to improved farming conditions, government support, and industry recommendations. The experiences from Finland demonstrate that it is possible to rear non-docked pigs in intensive production, with potential positive effects including good growth rate, reduced use of antimicrobials, and improved animal welfare levels.
Article
Fisheries
Baojian Sun, Dino van Dissel, Ingrid Mo, Preben Boysen, Hanne Haslene-Hox, Hege Lund
Summary: This study used a proteomic approach to identify biomarkers of acute response in Atlantic salmon blood plasma. Infected fish showed increased expression of certain antimicrobial and immune-related proteins, as well as a decrease in some components. Selected biomarkers were further validated by Western blot analysis and real time PCR, revealing changes in expression levels post-infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Review
Veterinary Sciences
Laura A. Boyle, Sandra A. Edwards, J. Elizabeth Bolhuis, Francoise Pol, Manja Zupan Semrov, Sabine Schuetze, Janicke Nordgreen, Nadya Bozakova, Evangelia N. Sossidou, Anna Valros
Summary: Damaging behaviors, such as tail and ear biting, are common in pig production and negatively impact welfare and performance. Poor health and tail damage show high correlations within and between pig farms. There are common risk factors for both tail-biting and health problems, including respiratory, enteric, and locomotory diseases. Limited evidence supports two potential causal mechanisms linking damaging behaviors and health problems, either poor health increasing the risk of tail-biting or tail-biting causing poor health.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Kart Matlik, Daniel R. Garton, Ana R. Montano-Rodriguez, Soophie Olfat, Feride Eren, Laoise Casserly, Anastasios Damdimopoulos, Anne Panhelainen, L. Lauriina Porokuokka, Jaakko J. Kopra, Giorgio Turconi, Nadine Schweizer, Erika Bereczki, Fredrik Piehl, Goran Engberg, Simon Cervenka, T. Petteri Piepponen, Fu-Ping Zhang, Petra Sipila, Johan Jakobsson, Carl M. Sellgren, Sophie Erhardt, Jaan-Olle Andressoo
Summary: This study found that increased striatal dopamine signaling in a subgroup of schizophrenia patients may be related to the increase of GDNF. A possible mediator of GDNF-driven dopaminergic abnormalities is A(2A)R. By inhibiting A(2A)R with a drug, striatal and cortical dopamine levels can be partially normalized. These results provide potential therapeutic targets for the treatment of schizophrenia.
MOLECULAR PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Elodie F. Briefer, Ciara C. -R. Sypherd, Pavel Linhart, Lisette M. C. Leliveld, Monica Padilla de la Torre, Eva R. Read, Carole Guerin, Veronique Deiss, Chloe Monestier, Jeppe H. Rasmussen, Marek Spinka, Sandra Dupjan, Alain Boissy, Andrew M. Janczak, Edna Hillmann, Celine Tallet
Summary: The vocal indicators of emotions in pigs are valid across call types and contexts, and an automated recognition system can be developed to monitor pig welfare on-farm.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Kamilla Wiull, Preben Boysen, Katarzyna Kuczkowska, Lars Fredrik Moen, Harald Carlsen, Vincent G. H. Eijsink, Geir Mathiesen
Summary: Despite the long history of BCG vaccine, tuberculosis remains a deadly disease. This study explored new approaches to develop a more efficient vaccine, focusing on mucosal vaccines. The findings showed that surface-displaying vaccine candidates with tuberculosis antigen anchored to the cell membrane were more effective in stimulating immune response compared to candidates with intracellular antigen. This highlights the importance of antigen exposure and supports the potential of L. plantarum as a mucosal vaccine delivery vehicle against tuberculosis.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Hege Lund, Anne Bakke, Preben Boysen, Sergey Afanasyev, Alexander Rebl, Farah Manji, Gordon Ritchie, Aleksei Krasnov
Summary: The assessment of immune competence in farmed Atlantic salmon during smoltification and early sea life is crucial. Recent tools were used to analyze gene expression, antibody levels, and IgM transcripts in salmon from different farming systems. The study found differences in immune gene expression and antibody levels between the two cohorts, suggesting a more agitated immune system in RAS-raised salmon initially, but leveling off over time.
Article
Veterinary Sciences
Tuva Onarheim, Andrew M. Janczak, Janicke Nordgreen
Summary: This study investigated the impact of social isolation on whole-body cortisol levels and behavioral responses in zebrafish. The results showed that zebrafish housed in groups had higher cortisol levels and exhibited different behavioral responses in the novel tank-diving test (NTDT) and the black-white preference test (BWPT) compared to individually housed zebrafish. Additionally, certain behavioral responses in the BWPT were correlated with behavioral responses in the NTDT.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Mirjami Anttila, Marja Raekallio, Anna Valros
Summary: This study investigated the variation in oral dimensions related to bit fit in adult horses and ponies. It found that the majority of horse owners use a bit that does not fit the horse correctly, potentially causing discomfort. The study provides valuable information for choosing the correct bit size and recommends regular evaluation of bit fit as the horse ages.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Hanna Nurmi, Sauli Laaksonen, Taija Haatyla, Anna Valros, Mikaela Sauvala, Laura Hanninen
Summary: This study aimed to investigate the effects of castration on reindeer behavior and rectal temperature, and the impact of handling, lidocaine anesthesia, and meloxicam on these factors. The results showed that reindeer displayed pain-related behaviors during castration, and local lidocaine anesthesia did not significantly reduce the pain. In addition, prolonged handling time increased the rectal temperature of reindeer.
APPLIED ANIMAL BEHAVIOUR SCIENCE
(2022)
Article
Neurosciences
Soophie Olfat, Kart Matlik, Jaakko J. Kopra, Daniel R. Garton, Vilma H. Iivanainen, Dipabarna Bhattacharya, Johan Jakobsson, T. Petteri Piepponen, Jaan-Olle Andressoo
Summary: Parkinson's disease is a progressive neurodegenerative disease with a wide range of motor and nonmotor symptoms. Glial cell line-derived neurotrophic factor (GDNF) has been tested in clinical trials for PD treatment, but the results have been variable. This study aimed to investigate the therapeutic potential of endogenous GDNF in a mouse model of PD.
Article
Agriculture, Dairy & Animal Science
Manon Fetiveau, Davi Savietto, Andrew M. Janczak, Carole Bannelier, Anne-Sophie Plagnet, Mathilde Tauveron, Laurence Fortun-Lamothe
Summary: Providing rabbits with outdoor access allows them to express a variety of species-specific behaviors. This study investigated the behaviors of rabbits living outdoors and the effects of genotype and pasture size. The results showed that rabbits spent more time on the pastures than inside the building, with grazing being the predominant behavior on the pastures and resting being predominant in the pens. A larger pasture size promoted the expression of specific behaviors, and certain behaviors varied according to genotype.
APPLIED ANIMAL BEHAVIOUR SCIENCE
(2023)
Article
Multidisciplinary Sciences
Henriette Arnesen, Turhan Markussen, George Birchenough, Signe Birkeland, Elisabeth E. L. Nystroem, Gunnar C. Hansson, Harald Carlsen, Preben Boysen
Summary: By raising laboratory mice in a farmyard-type environment, the intestinal barrier properties can be altered, leading to a stronger protection against disease.
SCIENTIFIC REPORTS
(2023)
Meeting Abstract
Immunology
Mikael Kerboeuf, Anita Haug Haaland, Lars Moe, David Argyle, Preben Boysen
JOURNAL OF IMMUNOLOGY
(2022)
Article
Psychology, Biological
Umit Yilmaz, Kevser Tanbek
Summary: This study investigated the effects of intracerebroventricular administration of Spexin on the hypothalamus-pituitary-thyroid axis and energy expenditure in rats. The results showed that Spexin reduced food consumption and body weight, increased thyroid hormones, and enhanced energy metabolism.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Kuei-Yu Chien, Yun-Ju Chen, Kuo-Jen Hsu, Chiao-Nan Chen
Summary: This study investigated the effects of a high-protein diet and high-intensity interval training on appetite and weight loss in obese middle-aged individuals. The results showed that consuming a high-protein drink and following a high-protein diet after exercise can reduce post-exercise appetite and the frequency of late-night snacking.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Melissa Alves Braga Oliveira, Ana Carolina Odebrecht Vergne de Abreu, Debora Barroggi Constantino, Andre C. Tonon, Antoni Diez-Noguera, Fernanda Gaspar Amaral, Maria Paz Hidalgo
Summary: Biological processes in living organisms exhibit strong rhythmicity and are regulated by internal timing systems. Understanding the influence of biological rhythms is crucial for experimental design and reporting.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Yanqun Cao, Hao Chen, Yinna Tan, Xu-Dong Yu, Chuli Xiao, Yin Li, James Reilly, Zhiming He, Xinhua Shu
Summary: There is evidence to suggest that chronic stress impacts neurochemical homeostasis and contributes to mental disorders. This study investigates the therapeutic potential of p-coumaric acid (p-CA), a natural compound found in vegetables and fruits, against stress-associated mental disorders. The findings suggest that p-CA could alleviate cognitive deficits and depression-like behavior in mice exposed to chronic restraint stress (CRS) by regulating the PKA-CREB-BDNF signaling pathway.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Mai O. Spaulding, Jessica R. Hoffman, Grace C. Madu, Magen N. Lord, Caroline Soares Iizuka, Kevin P. Myers, Emily E. Noble
Summary: Food insecurity is associated with obesity and disordered eating behaviors. Studying a rodent model, researchers found that adolescent food insecurity may increase susceptibility to obesity and altered eating behaviors during adulthood.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
K. Oberman, B. L. van Leeuwen, M. Nabben, J. E. Villafranca, R. G. Schoemaker
Summary: The present study investigated the post-operative complications and therapeutic potential of J147 in male Zucker rats, and found that J147 treatment had positive effects on behavioral and metabolic parameters, but did not affect neuroinflammation. The results suggest that a combination of acute and chronic J147 treatment may be optimal for treatment.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Mathieu Cournoyer, Alice Maldera, Alexandre-Charles Gauthier, Fabien Dal Maso, Marie-Eve Mathieu
Summary: This article provides a comprehensive view of the literature on the effect of different odors on physical activity through a systematic review. It was found that pleasant odors have a positive impact on participants' physical activity. However, better methodological consistency is needed in studies to produce more meaningful results.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Gabriel R. Gilmore, Jeff Dyche
Summary: This study examined sleep, sleep/wake regularity, and cognition in college students diagnosed with depression and using serotonergic antidepressants, comparing them to those without a depression diagnosis. The results showed that students using antidepressants had slightly longer wake after sleep onset and lower sleep efficiency, but these differences were likely not noticed by the participants. There were no differences in sleep regularity or cognition between the two groups.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Erica A. Cross, Kim L. Huhman, H. Elliott Albers
Summary: Social stress plays a significant role in the development of neuropsychiatric disorders and can lead to behavioral deficits such as social withdrawal. This study investigates the impact of social stress on social reward in Syrian hamsters. The results show that subordinate and socially defeated males have reduced motivation for social interactions compared to dominant males. Additionally, winning males exhibit greater activation in the mesolimbic dopamine system compared to losers. In females, there were no differences in social entries between winners and losers, but winning females display more activation in the NAc shell.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Daniel A. R. Cabral, Maria L. M. Rego, Eduardo B. Fontes, Vagner D. O. Tavares
Summary: This study examined the association between body mass index (BMI) and negative emotional states (NES) in men with substance use disorders (SUD) undergoing treatment. The findings showed a positive correlation between BMI and stress, anxiety, and depression. These results suggest that reducing body fat accumulation may contribute to improving mental health in individuals with SUD during recovery.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Elizabeth Agbor Epse Muluh, Jessica C. McCormack, Yunfan Mo, Michael Garratt, Mei Peng
Summary: This PROSPERO pre-registered systematic review and meta-analysis evaluated the olfactory and gustatory changes in pregnant individuals. The meta-analysis revealed that pregnant individuals performed poorer in odour identification, rated olfactory stimuli to be more intense during the second and third trimester, and had increased pleasantness for sweet taste in the first trimester. No major difference was observed in terms of gustatory functions between pregnant and non-pregnant subjects.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Renee Spiteri Douglas, Mackenzie R. Hartley, J. Renee Yang, Tamara B. Franklin
Summary: The expression of Hdac2 in the hippocampus is associated with social status, while the expression of closely related genes Hdac1 and HDAC2 protein is not associated with social rank in the hippocampus.
PHYSIOLOGY & BEHAVIOR
(2024)