Article
Chemistry, Medicinal
Hany H. Arab, Ali Khames, Shuruq E. Alsufyani, Azza A. K. El-Sheikh, Amany M. Gad
Summary: The study investigated the neuroprotective potential of magnesium sulfate in a rat model of chronic-restraint stress (CRS)-induced depression-like behavioral disturbance and the underlying molecular mechanisms. The results demonstrated that magnesium sulfate attenuated the depression-like behavioral outcomes and histopathological changes in the brain by dampening inflammation, ER stress, and the associated PERK/GRP78/CHOP pathway. These findings suggest the promising neuroprotective/antidepressant actions of magnesium sulfate in CRS.
Article
Chemistry, Medicinal
Natalia Gorska, Wieslaw Jerzy Cubala, Jakub Slupski, Mariusz Stanislaw Wiglusz, Maria Galuszko-Wegielnik, Mateusz Kawka, Agata Grzegorzewska
Summary: This observational study examined the relationship between depression and magnesium levels, particularly changes during ketamine treatment, as well as the association between magnesium concentrations and treatment response or comorbidity. Results showed no significant correlation between changes in magnesium serum levels and treatment response or comorbidity, supporting the role of magnesium in treatment-resistant depression but lacking clear evidence of direct association.
Article
Clinical Neurology
Lal Chandra Vishwakarma, Binney Sharma, Vishwajeet Singh, Ashok Kumar Jaryal, Hruda Nanda Mallick
Summary: The study using rats found that sleep deprivation led to significant increases in body, hypothalamic, and cortical temperatures, with body and cortical temperatures recovering faster during the recovery sleep period, while hypothalamic temperature remained higher. Notably, cortical temperature decreased immediately during recovery sleep and returned to near baseline levels within 4 hours, indicating a quicker recovery compared to hypothalamic and body temperature.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Multidisciplinary Sciences
Alexandra Blaney, Katechan Jampachaisri, Monika K. Huss, Cholawat Pacharinsak
Summary: This study demonstrates that a single dose of low or high sustained release buprenorphine effectively reduces thermal hypersensitivity in neonatal rat pups for at least 8 hours.
Article
Emergency Medicine
Amy M. DeLaroche, Fabrice I. Mowbray, Maryam Bohsaghcheghazel, Kristina Zalewski, Katherine Obudzinski
Summary: Early administration of IV Mg was associated with more timely delivery of first-line asthma therapies, such as bronchodilators and systemic corticosteroids. Factors associated with early administration of IV Mg included hypoxia, respiratory rate, retractions, and prior hospital use for asthma-related complaints.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Chemistry, Physical
Xinkuang Ning, Chengyou Wu, Hongdu Chen
Summary: In this study, novel high-purity basic magnesium sulfate whiskers were successfully prepared under low-temperature and atmospheric-pressure conditions using a sodium citrate admixture. The whisker products were characterized in terms of their structure and morphology, and it was found that they could be further converted into high-purity MgO whiskers with smooth surfaces. These findings provide technical support for the cost-effective industrial-scale preparation of basic magnesium sulfate whiskers and related whisker products.
Article
Obstetrics & Gynecology
Moeun Son, Archana Roy, William A. Grobman, Emily S. Miller, Annie Dude, Alan M. Peaceman, Bethany Stetson
Summary: Despite lack of evidence, many hospitals set a maximum oxytocin dose rate. This study found no significant associations between exceeding 20 milliunits/min of oxytocin and adverse outcomes such as cesarean delivery or peripartum infection.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jiacui Zheng, Meirong Tian, Lanlan Liu, Xueqin Jia, Meiling Sun, Yongjing Lai
Summary: This study found that magnesium sulfate can reduce the apoptosis of vascular endothelial cells (VECs) in rats with preeclampsia (PE) through the miR-218-5p/HMGB1 pathway, providing a new strategy for the treatment of preeclampsia.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Environmental Sciences
Shirin Bahrami, Ramin Sarikhani, Amin Jamshidi, Artimes Ghassemi Dehnavi, Mohammad Reza Emami Mybodi
Summary: This paper compares the effects of sodium and magnesium sulfates on the physico-mechanical characteristics of travertine. The results show that the impact of sodium sulfate is more severe than that of magnesium sulfate.
ENVIRONMENTAL EARTH SCIENCES
(2023)
Article
Anesthesiology
Erhan Ozyurt, Zekiye Bigat, Bilge Karsli, Arda Tasatargil, Inanc Elif Gurer, Nurten Kayacan
Summary: Dexmedetomidine, preservative-free racemic ketamine, and magnesium sulfate have analgesic effects when administered intrathecally in rats. Among these drugs, preservative-free racemic ketamine appears to be the safest in terms of histopathological evaluation.
AIN SHAMS JOURNAL OF ANESTHESIOLOGY
(2021)
Article
Construction & Building Technology
Xiaoyuan Zhang, Huifang Zhang, Chengyou Wu
Summary: This study investigated the effect of coexisting boron impurities from a salt lake on the performance of basic magnesium sulfate cement (BMSC). The results showed that the addition of boron significantly affected the hydration rate, setting and hardening times, and compressive strength of BMSC. The specific surface area, crystal grain size, and degree of crystallinity of the magnesium oxide precursor were found to be influenced by the calcination temperature and the presence of boron impurities.
CONSTRUCTION AND BUILDING MATERIALS
(2022)
Article
Construction & Building Technology
Yifei Wang, Caijun Shi, Lei Lei, Yihan Ma, Jianhui Liu, Xiang Hu
Summary: This study investigates the effects of an alkali-free accelerator (AMD) on the hydration and mechanical properties of Portland cement. It is found that AMD accelerator can effectively shorten the setting time and enhance the early strength of Portland cement. Though it may retard the early hydration of alite and lead to higher porosity, it has no negative impact on the long-term strength development and may even slightly increase it.
CEMENT & CONCRETE COMPOSITES
(2022)
Article
Neurosciences
Hamed Shafiee, Farahnaz Riahipour, Ahmad Hormati, Sajjad Ahmadpour, Mohammad Amin Habibi, Mostafa Vahedian, Reza Aminnejad, Mohammad Saeidi
Summary: This study investigates the sedative effect of ketamine, magnesium sulfate, and propofol in endoscopy, and finds that the combination of midazolam and propofol, as well as the combination of midazolam and ketamine, produce satisfactory results for endoscopists.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Behavioral Sciences
Merve Akan, Ivan Skorodumov, Marcus W. Meinhardt, Resit Canbeyli, Gunes Unal
Summary: Due to the delayed onset of traditional antidepressants and disadvantages of their administration routes, alternative non-invasive delivery methods with rapid therapeutic effects are needed. Ketamine has attracted attention as a fast-acting glutamatergic antidepressant with ideal physiochemical properties for alternative routes of administration. However, there is currently insufficient data on its transdermal use in depression.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biology
Hye Sun Kim, YoungIm Kim, Sang Bong Jeon, Hyung Do Choi, Ae-Kyoung Lee, Hae-June Lee, Jeong-Ki Pack, Nam Kim, Young Hwan Ahn
Summary: This study found that RF exposure at a whole-body average specific absorption rate of 4 W/kg does not cause significant changes in body temperature in healthy rats over a 6-hour exposure period.
JOURNAL OF THERMAL BIOLOGY
(2022)
Article
Environmental Sciences
Sarah Kittel-Schneider, Ethel Felice, Rachel Buhagiar, Mijke Lambregtse-van den Berg, Claire A. Wilson, Visnja Banjac Baljak, Katarina Savic Vujovic, Branislava Medic, Ana Opankovic, Ana Fonseca, Angela Lupattelli
Summary: This study examined the availability and content of national clinical practice guidelines (CPGs) for the treatment of peripartum depression, including comorbid anxiety, with antidepressants and other psychotropics across Europe, as well as the compliance of prescribers to these guidelines based on utilization data. The study found a need for harmonized and up-to-date CPGs to guide the pharmacological management of peripartum depression and comorbid anxiety in Europe, based on the latest available evidence.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Pharmacology & Pharmacy
Vera Jokic, Katarina Savic-Vujovic, Jelena Spasic, Zoran Bukumiric, Mladen Marinkovic, Davorin Radosavljevic, Milena Cavic
Summary: This study evaluated the clinical and low-cost genetic determinants of treatment outcomes in EGFR mutation positive advanced lung adenocarcinoma patients. The findings showed that genetic factors had a significant impact on the response to TKI therapy, leading to pain alleviation.
Article
Pharmacology & Pharmacy
Ana Opankovic, Srdan Milovanovic, Branimir Radosavljevic, Milena Cavic, Irina Besu Zizak, Zoran Bukumiric, Milan Latas, Branislava Medic, Sonja Vuckovic, Dragana Srebro, Katarina Savic Vujovic
Summary: The study aimed to evaluate the serum concentration of ionized Mg and its correlation with biomarkers of oxidative stress and inflammation in patients with anxiety and depression. The results showed that ionized Mg could be a potential biomarker for anxiety and depression, and its correlation with oxidative stress parameters differed between anxious and depressive patients.
Article
Pharmacology & Pharmacy
Dragana Srebro, Branko Dozic, Katarina Savic Vujovic, Branislava Medic Brkic, Sonja Vuckovic
Summary: This study aimed to investigate the anti-edematous effect of magnesium sulfate (MS) in different protocols of use and the possible mechanism of its action. The results showed that systemic administration of MS reduced edema, but it was more effective in preventing inflammatory edema. Additionally, the effect of MS may be mediated through the production of nitric oxide.
Article
Biochemistry & Molecular Biology
Dragana Srebro, Branko Dozic, Sonja Vuckovic, Katarina Savic Vujovic, Branislava Medic Brkic, Ivan Dozic, Milorad Srebro
Summary: The study investigated the antinociceptive effect of cromoglycate and magnesium in orofacial pain. It was found that magnesium significantly reduced mast cell degranulation but antagonized the antinociceptive effect of cromoglycate in the formalin test.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Dolika D. Vasovic, Miodrag Karamarkovic, Milan Stojicic, Milan Jovanovic, Katarina Savic Vujovic, Dejan Rasic, Milan Colic, Nikola Music
Summary: This split-face study suggests that buffered lidocaine with sodium bicarbonate produces significantly lower pain scores compared to other non-buffered anesthetic solutions, which could help surgeons choose the appropriate combination of local anesthetics for patients with lower pain threshold and tolerance.
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Cell Biology
Katarina Savic Vujovic, Andjela Zivkovic, Ivan Dozic, Andja Cirkovic, Branislava Medic, Dragana Srebro, Sonja Vuckovic, Jovica Milovanovic, Ana Jotic
Summary: This study aimed to assess the correlation between oxidative stress and inflammation parameters and postoperative pain management in patients surgically treated with laryngeal cancer. The results showed a correlation between oxidative stress and inflammation biomarkers and postoperative pain modulation. Age, more extensive surgery, CRP values, and use of tramadol were predictors for oxidative stress parameters.
Article
Chemistry, Medicinal
Dragana D. Bozic, Ivana Cirkovic, Jovica Milovanovic, Biljana Bufan, Miljan Folic, Katarina Savic Vujovic, Bojan Pavlovic, Ana Jotic
Summary: The fixed combination of N-acetyl-L-cysteine (NAC) and dry propolis extract has a synergistic effect on biofilm formation and eradication in bacteria isolated from chronic upper respiratory tract infections.
Article
Pharmacology & Pharmacy
Bojan Stopic, Branislava Medic-Brkic, Katarina Savic-Vujovic, Zeljko Davidovic, Jovana Todorovic, Nada Dimkovic
Summary: Chronic kidney disease is an important contributor to increased mortality and morbidity in non-communicable diseases, particularly cardiovascular disease. Various risk factors, including inflammation, oxidative stress, acute kidney injury, and microRNA, have been studied to understand the unfavorable cardiovascular outcomes in CKD patients. Valid studies on clinical and biohumoral predictors are crucial, especially in the early stages of renal disease, to implement effective preventive measures.
Article
Pharmacology & Pharmacy
Branislava Medic Brkic, Branislav Rovcanin, Marko Stojanovic, Dragana Srebro, Sonja Vuckovic, Katarina Savic Vujovic
Summary: The study investigates the effects of chloroquine on gentamicin-induced nephrotoxicity in rats. The results suggest that chloroquine attenuates the renal damage caused by gentamicin.
Article
Pharmacology & Pharmacy
Dragana Srebro, Katarina Rajkovic, Branko Dozic, Katarina Savic Vujovic, Branislava Medic Brkic, Petar Milic, Sonja Vuckovic
Summary: The study found that Juglans nigra extract had different effects on acute nociceptive and inflammatory pain. In rats, the extract reduced chemically induced pain but had no effect on heat-induced pain. Additionally, the antinociceptive effect was dose-dependent and could impair motor function.
Article
Pharmacology & Pharmacy
M. Roksandic Milenkovic, A. Klisic, V Ceriman, J. Kotur Stevuljevic, K. Savic Vujovic, D. Mirkov, M. Gajic, B. Ilic, N. Dimic, N. Samardzic, D. Jovanovic
Summary: This study analyzed oxidative stress parameters, inflammation markers, and vitamin D levels in patients with idiopathic pulmonary fibrosis (IPF). The results showed that IPF patients have severe oxidative stress and inflammation. Additionally, sPD-L1 may play a significant role in the immune response in IPF.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Psychology, Biological
Umit Yilmaz, Kevser Tanbek
Summary: This study investigated the effects of intracerebroventricular administration of Spexin on the hypothalamus-pituitary-thyroid axis and energy expenditure in rats. The results showed that Spexin reduced food consumption and body weight, increased thyroid hormones, and enhanced energy metabolism.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Kuei-Yu Chien, Yun-Ju Chen, Kuo-Jen Hsu, Chiao-Nan Chen
Summary: This study investigated the effects of a high-protein diet and high-intensity interval training on appetite and weight loss in obese middle-aged individuals. The results showed that consuming a high-protein drink and following a high-protein diet after exercise can reduce post-exercise appetite and the frequency of late-night snacking.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Melissa Alves Braga Oliveira, Ana Carolina Odebrecht Vergne de Abreu, Debora Barroggi Constantino, Andre C. Tonon, Antoni Diez-Noguera, Fernanda Gaspar Amaral, Maria Paz Hidalgo
Summary: Biological processes in living organisms exhibit strong rhythmicity and are regulated by internal timing systems. Understanding the influence of biological rhythms is crucial for experimental design and reporting.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Yanqun Cao, Hao Chen, Yinna Tan, Xu-Dong Yu, Chuli Xiao, Yin Li, James Reilly, Zhiming He, Xinhua Shu
Summary: There is evidence to suggest that chronic stress impacts neurochemical homeostasis and contributes to mental disorders. This study investigates the therapeutic potential of p-coumaric acid (p-CA), a natural compound found in vegetables and fruits, against stress-associated mental disorders. The findings suggest that p-CA could alleviate cognitive deficits and depression-like behavior in mice exposed to chronic restraint stress (CRS) by regulating the PKA-CREB-BDNF signaling pathway.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Mai O. Spaulding, Jessica R. Hoffman, Grace C. Madu, Magen N. Lord, Caroline Soares Iizuka, Kevin P. Myers, Emily E. Noble
Summary: Food insecurity is associated with obesity and disordered eating behaviors. Studying a rodent model, researchers found that adolescent food insecurity may increase susceptibility to obesity and altered eating behaviors during adulthood.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
K. Oberman, B. L. van Leeuwen, M. Nabben, J. E. Villafranca, R. G. Schoemaker
Summary: The present study investigated the post-operative complications and therapeutic potential of J147 in male Zucker rats, and found that J147 treatment had positive effects on behavioral and metabolic parameters, but did not affect neuroinflammation. The results suggest that a combination of acute and chronic J147 treatment may be optimal for treatment.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Mathieu Cournoyer, Alice Maldera, Alexandre-Charles Gauthier, Fabien Dal Maso, Marie-Eve Mathieu
Summary: This article provides a comprehensive view of the literature on the effect of different odors on physical activity through a systematic review. It was found that pleasant odors have a positive impact on participants' physical activity. However, better methodological consistency is needed in studies to produce more meaningful results.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Gabriel R. Gilmore, Jeff Dyche
Summary: This study examined sleep, sleep/wake regularity, and cognition in college students diagnosed with depression and using serotonergic antidepressants, comparing them to those without a depression diagnosis. The results showed that students using antidepressants had slightly longer wake after sleep onset and lower sleep efficiency, but these differences were likely not noticed by the participants. There were no differences in sleep regularity or cognition between the two groups.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Erica A. Cross, Kim L. Huhman, H. Elliott Albers
Summary: Social stress plays a significant role in the development of neuropsychiatric disorders and can lead to behavioral deficits such as social withdrawal. This study investigates the impact of social stress on social reward in Syrian hamsters. The results show that subordinate and socially defeated males have reduced motivation for social interactions compared to dominant males. Additionally, winning males exhibit greater activation in the mesolimbic dopamine system compared to losers. In females, there were no differences in social entries between winners and losers, but winning females display more activation in the NAc shell.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Daniel A. R. Cabral, Maria L. M. Rego, Eduardo B. Fontes, Vagner D. O. Tavares
Summary: This study examined the association between body mass index (BMI) and negative emotional states (NES) in men with substance use disorders (SUD) undergoing treatment. The findings showed a positive correlation between BMI and stress, anxiety, and depression. These results suggest that reducing body fat accumulation may contribute to improving mental health in individuals with SUD during recovery.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Elizabeth Agbor Epse Muluh, Jessica C. McCormack, Yunfan Mo, Michael Garratt, Mei Peng
Summary: This PROSPERO pre-registered systematic review and meta-analysis evaluated the olfactory and gustatory changes in pregnant individuals. The meta-analysis revealed that pregnant individuals performed poorer in odour identification, rated olfactory stimuli to be more intense during the second and third trimester, and had increased pleasantness for sweet taste in the first trimester. No major difference was observed in terms of gustatory functions between pregnant and non-pregnant subjects.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Renee Spiteri Douglas, Mackenzie R. Hartley, J. Renee Yang, Tamara B. Franklin
Summary: The expression of Hdac2 in the hippocampus is associated with social status, while the expression of closely related genes Hdac1 and HDAC2 protein is not associated with social rank in the hippocampus.
PHYSIOLOGY & BEHAVIOR
(2024)
