期刊
PHYSIOLOGY & BEHAVIOR
卷 119, 期 -, 页码 86-91出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2013.06.006
关键词
Cellular prion protein; PrP; PrP-KO; Behavior; Transgenic mice
资金
- Italian Ministry of University and Research
- University of Padova [CPDA089551708]
- EC [285203]
The biological function of the prion protein, which is intimately involved in the onset of prion diseases, remains unclear. To understand whether the prion protein could play a role in animal behavior, a battery of tests was applied to young and aged mice that express, or not, the prion protein. In contrast to the similar results obtained in all young animals, we found that aged mice lacking the prion protein reacted to new and stressful environments differently than their wild-type counterparts. This may suggest that, upon aging, the absence of the prion protein results in altered neural processing at the basis of adaptation to new situations. (C) 2013 Elsevier Inc. All rights reserved.
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