Article
Clinical Neurology
Sara C. Staubo, Ole Martin Fuskevag, Mathias Toft, Ingeborg H. Lie, Kirsti M. J. Alvik, Pal Jostad, Stein H. Tingvoll, Hallvard Lilleng, Kristina Rosqvist, Elisabet Storset, Per Odin, Espen Dietrichs, Erik Sveberg Dietrichs
Summary: The study suggests that the occurrence of impulse control disorders (ICDs) among patients using ropinirole is dependent on serum concentration and drug exposure, while the use of pramipexole may inherently increase ICD risk.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Manuela Contin, Giovanna Lopane, Luca Marini, Susan Mohamed, Luisa Sambati, Patrizia De Massis, Maria Guarino, Simonetta Sermi, Chiara Persichella, Pietro Cortelli, Giovanna Calandra-Buonaura
Summary: This study investigated the relationship between dopamine agonist (DA) plasma concentrations and impulse control disorders (ICDs) in Parkinson's disease (PD) patients. The results showed that there were no significant differences in DA plasma levels between PD patients with positive and negative screening for ICDs. However, patients with positive screening showed higher levels of motor impulsiveness. The Barratt Impulsiveness Scale (BIS-11) may be a useful tool for screening PD patients eligible for DA therapy.
NEUROLOGICAL SCIENCES
(2023)
Letter
Clinical Neurology
Pedro Barbosa, Bimali Hapuarachchi, Atbin Djamshidian, Kate Strand, Andrew J. Lees, Rohan de Silva, Janice L. Holton, Thomas T. Warner
Summary: Pagano and collaborators found lower D3 receptor availability in the ventral striatum of Parkinson's disease patients, while our study reported lower alpha-synuclein pathology and D3R levels in the nucleus accumbens of PD patients with ICD. These findings together support the hypothesis that D3R levels are downregulated due to excessive synaptic dopamine.
PARKINSONISM & RELATED DISORDERS
(2021)
Review
Neurosciences
Andrea Augustine, Catharine A. Winstanley, Vaishnav Krishnan
Summary: Parkinson's disease patients are not only affected by motor impairments, but also at risk for impulse control disorders. There is currently a lack of consensus on the best approach to addressing these symptoms.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Clinical Neurology
Johann Faouzi, Jean-Christophe Corvol, Louise-Laure Mariani
Summary: Recent studies have found that prevalence of impulse control disorders and related behaviors increases during Parkinson's disease progression, with around 10% annual incidence in patients receiving dopaminergic therapy. Management is focused on reducing dopamine agonist use, while cognitive behavioral therapy and deep brain stimulation have also shown improvement. Research into individual prediction models and the use of machine learning in precision medicine is ongoing.
CURRENT OPINION IN NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
Anahid Hamidianjahromi, Nicholas A. Tritos
Summary: Dopamine agonists (DAs), commonly used for hyperprolactinemia and prolactinomas, may lead to impulse control disorders (ICDs) such as gambling addiction, compulsive shopping, and hypersexuality. Diagnosing ICDs in patients receiving DAs requires suspicion and screening questionnaires. Patients with ICDs should discontinue or reduce DA therapy and receive psychiatric consultation and cognitive behavioral therapy.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Clinical Neurology
Jorryt G. Tichelaar, Ceyda Sayali, Rick C. Helmich, Roshan Cools
Summary: Tichelaar et al. investigated the impact of dopaminergic medication on reward learning in Parkinson's disease, specifically focusing on patients with impulse control disorders. They found that these patients were more sensitive to rewards when taking medication, and this sensitivity was associated with increased value signalling in the medial prefrontal cortex. The study also revealed individual differences in medication effects, suggesting that dopamine's effects on reinforcement learning vary depending on comorbid impulse control disorder and that they reflect deficits in value computation in the medial frontal cortex rather than in reward prediction error signalling in the striatum.
Article
Clinical Neurology
Alexander K. Song, Kaitlyn R. Hay, Paula Trujillo, Megan Aumann, Adam J. Stark, Yan Yan, Hakmook Kang, Manus J. Donahue, David H. Zald, Daniel O. Claassen
Summary: This study demonstrates that reward-based behaviors in Parkinson's disease are regulated by ventral striatal dopamine release, and suggests that loss of inhibitory feedback from midbrain autoreceptors may underlie the manifestation of impulsive-compulsive behaviors.
Article
Clinical Neurology
David Mata-Marin, Jose angel Pineda-Pardo, Mario Michiels, Cristina Pagge, Claudia Ammann, Raul Martinez-Fernandez, Jose Antonio Molina, Lydia Vela-Desojo, Fernando Alonso-Frech, Ignacio Obeso
Summary: This study provides evidence for the balance between enhanced desire towards reward and cognitive control deficits in patients with impulse-control disorder, specifically hypersexuality, in Parkinson's disease under dopamine replacement therapy. The study also identifies the underlying fronto-striatal and mesolimbic circuitry involved in uncontrollable sexual responses and demonstrates that cortical neuromodulation can alleviate this symptom.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Endocrinology & Metabolism
Serdar Sahin, Tugce Sudutan, Yasin Kavla, Emre Durcan, Yeliz Yagiz Ozogul, Burc Cagri Poyraz, Muge Sayitoglu, Hande Mefkure Ozkaya, Pinar Kadioglu
Summary: This study aims to investigate the genetic component of dopamine agonist-induced impulse control disorder (ICD) in patients with prolactinoma. By evaluating polymorphisms of dopamine receptors and other genes, it is found that there is a significant increase in genetic diversity associated with DA-induced ICD in patients receiving dopamine agonist treatment for prolactinoma.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Clinical Neurology
G. Pagano, S. Molloy, P. G. Bain, E. A. Rabiner, K. Ray Chaudhuri, D. J. Brooks, N. Pavese
Summary: The study found that lower ventral striatum D3 receptor availability is associated with greater severity of ICD in PD patients. The results suggest that the occurrence and severity of ICD in Parkinson's disease may be linked to reductions in ventral striatum dopamine D3 receptor availability. Further studies in larger cohort of patients are needed to confirm these findings and clarify the underlying mechanisms.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Xiaobo Zhu, Jing Gan, Na Wu, Ying Wan, Lu Song, Zhenguo Liu, Yu Zhang
Summary: This study explored the predictors of impulse control behaviors (ICBs) in Parkinson's disease (PD) and the biological correlates of ICBs. Over a period of 5 years, the prevalence of ICBs increased in PD while it decreased in healthy controls. The presence of ICBs in PD was associated with depression, anxiety, autonomic dysfunction, and excessive daytime sleepiness, but not with cognitive dysfunction or motor severity. Treatment with dopamine agonists and certain baseline characteristics were identified as predictors for the development of ICBs in early PD.
FRONTIERS IN NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kathryn Lanza, Christopher Bishop
Summary: Parkinson's Disease (PD) and long-term L-DOPA treatment induce plasticity that contributes to L-DOPA-induced dyskinesia (LID), with the dopamine D3 receptor (D3R) emerging as a promising target in LID management due to its upregulation in LID. D3R undergoes dynamic changes in both PD and LID, and recent genetic and pharmacologic tools have helped clarify its role in LID.
Article
Health Care Sciences & Services
Mauricio Ivan Garcia-Rubio, Maria Elisa Otero-Cerdeira, Christian Gabriel Toledo-Lozano, Sofia Lizeth Alcaraz-Estrada, Juan Antonio Suarez-Cuenca, Ramon Mauricio Coral-Vazquez, Paul Mondragon-Teran, Juan Antonio Pineda-Juarez, Luis Fernando Diaz-Lopez, Silvia Garcia
Summary: This study identified dopamine agonists as being associated with the development of ICDs in PD patients, while the tremorgenic form may have a protective effect. Positive associations were found between the rigid-akinetic form and compulsive shopping, and between males and hypersexuality. Binge eating, compulsive shopping, and hypersexuality were the most common ICDs observed.
Article
Neuroimaging
Teresa Esteban-Penalba, Pedro M. Paz-Alonso, Irene Navalpotro-Gomez, Maria C. Rodriguez-Oroz
Summary: Our findings indicate that PD patients with ICD completed the inhibition task correctly, showing altered engagement of inhibitory and attentional areas. During proactive inhibition they showed bilateral hyperactivation of two inhibitory regions, while during restrained inhibition they showed additional involvement of attentional areas responsible for alerting and orienting.
NEUROIMAGE-CLINICAL
(2021)
Article
Psychology, Biological
Umit Yilmaz, Kevser Tanbek
Summary: This study investigated the effects of intracerebroventricular administration of Spexin on the hypothalamus-pituitary-thyroid axis and energy expenditure in rats. The results showed that Spexin reduced food consumption and body weight, increased thyroid hormones, and enhanced energy metabolism.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Kuei-Yu Chien, Yun-Ju Chen, Kuo-Jen Hsu, Chiao-Nan Chen
Summary: This study investigated the effects of a high-protein diet and high-intensity interval training on appetite and weight loss in obese middle-aged individuals. The results showed that consuming a high-protein drink and following a high-protein diet after exercise can reduce post-exercise appetite and the frequency of late-night snacking.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Melissa Alves Braga Oliveira, Ana Carolina Odebrecht Vergne de Abreu, Debora Barroggi Constantino, Andre C. Tonon, Antoni Diez-Noguera, Fernanda Gaspar Amaral, Maria Paz Hidalgo
Summary: Biological processes in living organisms exhibit strong rhythmicity and are regulated by internal timing systems. Understanding the influence of biological rhythms is crucial for experimental design and reporting.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Yanqun Cao, Hao Chen, Yinna Tan, Xu-Dong Yu, Chuli Xiao, Yin Li, James Reilly, Zhiming He, Xinhua Shu
Summary: There is evidence to suggest that chronic stress impacts neurochemical homeostasis and contributes to mental disorders. This study investigates the therapeutic potential of p-coumaric acid (p-CA), a natural compound found in vegetables and fruits, against stress-associated mental disorders. The findings suggest that p-CA could alleviate cognitive deficits and depression-like behavior in mice exposed to chronic restraint stress (CRS) by regulating the PKA-CREB-BDNF signaling pathway.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Mai O. Spaulding, Jessica R. Hoffman, Grace C. Madu, Magen N. Lord, Caroline Soares Iizuka, Kevin P. Myers, Emily E. Noble
Summary: Food insecurity is associated with obesity and disordered eating behaviors. Studying a rodent model, researchers found that adolescent food insecurity may increase susceptibility to obesity and altered eating behaviors during adulthood.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
K. Oberman, B. L. van Leeuwen, M. Nabben, J. E. Villafranca, R. G. Schoemaker
Summary: The present study investigated the post-operative complications and therapeutic potential of J147 in male Zucker rats, and found that J147 treatment had positive effects on behavioral and metabolic parameters, but did not affect neuroinflammation. The results suggest that a combination of acute and chronic J147 treatment may be optimal for treatment.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Mathieu Cournoyer, Alice Maldera, Alexandre-Charles Gauthier, Fabien Dal Maso, Marie-Eve Mathieu
Summary: This article provides a comprehensive view of the literature on the effect of different odors on physical activity through a systematic review. It was found that pleasant odors have a positive impact on participants' physical activity. However, better methodological consistency is needed in studies to produce more meaningful results.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Gabriel R. Gilmore, Jeff Dyche
Summary: This study examined sleep, sleep/wake regularity, and cognition in college students diagnosed with depression and using serotonergic antidepressants, comparing them to those without a depression diagnosis. The results showed that students using antidepressants had slightly longer wake after sleep onset and lower sleep efficiency, but these differences were likely not noticed by the participants. There were no differences in sleep regularity or cognition between the two groups.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Erica A. Cross, Kim L. Huhman, H. Elliott Albers
Summary: Social stress plays a significant role in the development of neuropsychiatric disorders and can lead to behavioral deficits such as social withdrawal. This study investigates the impact of social stress on social reward in Syrian hamsters. The results show that subordinate and socially defeated males have reduced motivation for social interactions compared to dominant males. Additionally, winning males exhibit greater activation in the mesolimbic dopamine system compared to losers. In females, there were no differences in social entries between winners and losers, but winning females display more activation in the NAc shell.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Daniel A. R. Cabral, Maria L. M. Rego, Eduardo B. Fontes, Vagner D. O. Tavares
Summary: This study examined the association between body mass index (BMI) and negative emotional states (NES) in men with substance use disorders (SUD) undergoing treatment. The findings showed a positive correlation between BMI and stress, anxiety, and depression. These results suggest that reducing body fat accumulation may contribute to improving mental health in individuals with SUD during recovery.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Elizabeth Agbor Epse Muluh, Jessica C. McCormack, Yunfan Mo, Michael Garratt, Mei Peng
Summary: This PROSPERO pre-registered systematic review and meta-analysis evaluated the olfactory and gustatory changes in pregnant individuals. The meta-analysis revealed that pregnant individuals performed poorer in odour identification, rated olfactory stimuli to be more intense during the second and third trimester, and had increased pleasantness for sweet taste in the first trimester. No major difference was observed in terms of gustatory functions between pregnant and non-pregnant subjects.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Renee Spiteri Douglas, Mackenzie R. Hartley, J. Renee Yang, Tamara B. Franklin
Summary: The expression of Hdac2 in the hippocampus is associated with social status, while the expression of closely related genes Hdac1 and HDAC2 protein is not associated with social rank in the hippocampus.
PHYSIOLOGY & BEHAVIOR
(2024)