Article
Biochemistry & Molecular Biology
Mariangela Pucci, Claudio D'Addario, Emanuela Micioni Di Bonaventura, Francesca Mercante, Eugenia Annunzi, Federico Fanti, Manuel Sergi, Luca Botticelli, Giacomo Einaudi, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura
Summary: This study investigated the molecular alterations in the hypothalamus of rats experiencing recurrent binge eating episodes. The findings suggest that the endocannabinoid system plays a significant role in regulating food intake, particularly through CB1 and FAAH modulation of AEA signaling. The epigenetic regulation of the Faah gene may hold potential for developing new therapeutical approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Carlos Eduardo Ferreira de Moraes, Marina Maria Leite Antunes, Carla Mourilhe, Rosely Sichieri, Phillipa Hay, Jose Carlos Appolinario
Summary: A study in a metropolitan city in Brazil found that individuals with BESC exhibited different eating patterns. BED and RBE participants consumed staple foods more frequently, while those with BN preferred high calorie foods.
Article
Nutrition & Dietetics
Ramona De Amicis, Letizia Galasso, Riccardo Cavallaro, Sara Paola Mambrini, Lucia Castelli, Angela Montaruli, Eliana Roveda, Fabio Esposito, Alessandro Leone, Andrea Foppiani, Alberto Battezzati, Simona Bertoli
Summary: Men are more likely to have subthreshold overeating disorders, and lifestyle and chronotype are determinants. Evening chronotypes are more likely to have unhealthy dietary patterns and a higher propensity to substance addiction than morning types.
Article
Psychiatry
Brenna Bray, Adam Sadowski, Chris Bray, Ryan Bradley, Heather Zwickey
Summary: This study collected data from experts in the field of binge eating disorder to gain insight into the clinical aspects of this disorder. The findings reveal the importance of understanding the relationship between binge eating disorder and obesity, as well as the role of food/eating restriction and emotion dysregulation in the pathology of this disorder. The study also highlights paradigm shifts in the understanding of eating disorders and the need for further research in classification issues.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Nutrition & Dietetics
Alessandro Alberto Rossi, Stefania Mannarini, Gianluca Castelnuovo, Giada Pietrabissa
Summary: The purpose of this study was to examine the psychometric properties and factorial structure of the Addiction-like Eating Behaviors Scale (AEBS) in an Italian sample, and to assess its measurement invariance across clinical and nonclinical populations. The results indicated that the AEBS-IT is a valid and reliable measure of addictive-like eating behaviors.
Article
Food Science & Technology
Camilla Cattaneo, Sara Paola Mambrini, Luisa Gilardini, Massimo Scacchi, Gianluca Castelnuovo, Ella Pagliarini, Simona Bertoli
Summary: Eating disorders, such as food addiction and binge eating, are significant causes of morbidity and mortality and are common underlying causes of weight loss failure. The mechanisms underlying the perception of food properties and possible sensory deficits in eating disorders have been scarcely investigated, despite their central role in food choice and potential relevance in maintaining disordered eating behaviors in obese patients.
FOOD QUALITY AND PREFERENCE
(2023)
Article
Nutrition & Dietetics
Alessandro Alberto Rossi, Giada Pietrabissa, Ashley N. Gearhardt, Alessandro Musetti, Gianluca Castelnuovo, Stefania Mannarini
Summary: This study aimed to validate and investigate the psychometric properties of the Italian version of the Measure of Eating Compulsivity-10 (MEC10-IT) in a sample of inpatients with severe obesity (Study 1), and to test the measurement invariance of the measure across non-clinical and clinical samples (Study 2). The MEC10-IT was found to have a confirmed factorial structure among Italian adult inpatients with severe obesity and demonstrated to be invariant between clinical and community samples, showing good psychometric properties and screening abilities for classifying individuals with problematic eating behaviors.
Article
Nutrition & Dietetics
Matteo Martini, Paola Longo, Tiziano Tamarin, Federica Toppino, Annalisa Brustolin, Giovanni Abbate-Daga, Matteo Panero
Summary: Reduction in food intake is an important feature of eating disorders (EDs), and this study aimed to evaluate the actual reduction in caloric intake and its relationships with various factors in individuals with EDs. The study found that caloric restriction was significantly related to eating symptomatology, state anxiety, and body image. The best predictors of caloric intake and restriction at discharge for underweight inpatients were perfectionistic concern over mistakes and state anxiety. These findings highlight the importance of a multidimensional assessment of ED psychopathology.
Review
Nutrition & Dietetics
Anoop Sankaranarayanan, Karthika Johnson, Sanop J. Mammen, Helen E. Wilding, Deepali Vasani, Vijaya Murali, Deborah Mitchison, David J. Castle, Phillipa Hay
Summary: Studies have found that individuals with schizophrenia spectrum disorder exhibit disordered eating behaviors such as binge eating, food craving, food addiction, and night eating, with higher prevalence rates compared to the general population. Positive associations were reported between certain disordered eating behaviors and factors such as antipsychotic use, female gender, weight gain, and increased dietary intake.
Article
Clinical Neurology
Namiko Kawamura, Ela Novianti, Nobuko Yamada-Goto, Riho Nakama, Akihiro Asakawa, Goro Katsuura, Akio Inui
Summary: The mesolimbic dopamine system plays a critical role in the rewarding and motivational aspects of consuming palatable food. Nicotinic receptors, particularly the alpha 7 subtype, have been found to suppress sucrose addiction in mice. Increasing sucrose concentrations lead to higher sucrose preference and intake in mice, with levels rising even after sucrose withdrawal.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Endocrinology & Metabolism
Franziska Plessow, Francesca Galbiati, Kamryn T. Eddy, Madhusmita Misra, Karen K. Miller, Anne Klibanski, Anna Aulinas, Elizabeth A. Lawson
Summary: Anorexia nervosa (AN) is commonly accompanied by depression, anxiety, and socioemotional dysfunction. However, the relationship between oxytocin and psychopathology in individuals with primarily food restriction (AN/AtypAN-R) or restriction plus binge/purge behaviors (AN/AtypAN-BP) has not been explored, which is crucial for understanding the neurobiology of different AN presentations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Anja Hilbert, Christian Staerk, Annika Stromer, Thomas Mansfeld, Johannes Sander, Florian Seyfried, Stefan Kaiser, Arne Dietrich, Andreas Mayr
Summary: This study found that nonnormative eating behaviors and eating disorders were common among patients undergoing obesity surgery, and postoperative improvements were observed. Loss-of-control eating and binge-eating disorder of low frequency and/or limited duration were prospectively associated with reduced long-term health-related quality of life following surgery.
Article
Psychology, Clinical
Jason M. Nagata, Jonathan Chu, Levi Cervantez, Kyle T. Ganson, Alexander Testa, Dylan B. Jackson, Stuart B. Murray, Sheri D. Weiser
Summary: The objective of this study was to determine the associations between food insecurity and binge-eating disorder in early adolescence. The research found that food insecurity in early adolescence is associated with higher odds of developing future binge-eating and binge-eating disorder (BED). Clinicians should consider assessing for binge eating in adolescents with food insecurity and provide support in accessing appropriate food resources.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2023)
Article
Nutrition & Dietetics
Olga Dmitrichenko, Yuchan Mou, Trudy Voortman, Tonya White, Pauline W. Jansen
Summary: Food-approach eating behaviors, especially enjoyment of food and food responsiveness, are positively associated with brain morphology in adolescence.
FRONTIERS IN NUTRITION
(2022)
Article
Psychology, Biological
Richard Quansah Amissah, Diellor Basha, Olga Bukhtiyarova, Elena Timofeeva, Igor Timofeev
Summary: Binge eating disorder (BED) is the most prevalent eating disorder, with little known about its neurobiological underpinnings. Rats with binge-like eating behavior showed lower neuronal firing rates in the mPFC and VTA before and during sucrose consumption compared to non-bingeing rats. Consuming palatable food increased neuronal firing rates during and between active bingeing episodes in bingeing rats, potentially contributing to the sense of relief experienced by BED patients.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Neurosciences
X. -X. Peng, A. Lister, A. Rabinowitsch, R. Kolaric, S. Cabeza De Vaca, E. B. Ziff, K. D. Carr
Article
Neurosciences
Danielle Zheng, Soledad Cabeza de Vaca, Zachary Jurkowski, Kenneth D. Carr
PSYCHOPHARMACOLOGY
(2015)
Article
Multidisciplinary Sciences
Melissa A. Stouffer, Catherine A. Woods, Jyoti C. Patel, Christian R. Lee, Paul Witkovsky, Li Bao, Robert P. Machold, Kymry T. Jones, Soledad Cabeza de Vaca, Maarten E. A. Reith, Kenneth D. Carr, Margaret E. Rice
NATURE COMMUNICATIONS
(2015)
Article
Psychology, Biological
C. A. Woods, Z. R. Guttman, D. Huang, R. A. Kolaric, A. I. Rabinowitsch, K. T. Jones, S. Cabeza de Vaca, A. Sclafani, K. D. Carr
PHYSIOLOGY & BEHAVIOR
(2016)
Article
Neurosciences
Caroline Jung, Ariana Rabinowitsch, Wei Ting Lee, Danielle Zheng, Soledad Cabeza de Vaca, Kenneth D. Carr
PSYCHOPHARMACOLOGY
(2016)
Article
Neurosciences
Jiangyong Ouyang, Ioana Carcea, Jennifer K. Schiavo, Kymry T. Jones, Ariana Rabinowitsch, Rhonda Kolaric, Soledad Cabeza de Vaca, Robert C. Froemke, Kenneth D. Carr
EUROPEAN JOURNAL OF NEUROSCIENCE
(2017)
Article
Biochemistry & Molecular Biology
Kymry T. Jones, Catherine Woods, Juan Zhen, Tamara Antonio, Kenneth D. Carr, Maarten E. A. Reith
JOURNAL OF NEUROCHEMISTRY
(2017)
Article
Neurosciences
Jyoti C. Patel, Melissa A. Stouffer, Maria Mancini, Charles Nicholson, Kenneth D. Carr, Margaret E. Rice
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
David S. Tukey, Jainne M. Ferreira, Shannon O. Antoine, James A. D'amour, Ipe Ninan, Soledad Cabeza de Vaca, Salvatore Incontro, Charlotte Wincott, Julian K. Horwitz, Diana T. Hartner, Carlo B. Guarini, Latika Khatri, Yossef Goffer, Duo Xu, Roseann F. Titcombe, Megna Khatri, Dave S. Marzan, Shahana S. Mahajan, Jing Wang, Robert C. Froemke, Kenneth D. Carr, Chiye Aoki, Edward B. Ziff
JOURNAL OF NEUROSCIENCE
(2013)
Article
Neurosciences
Danielle Zheng, Shan Liu, Soledad Cabeza de Vaca, Kenneth D. Carr
PSYCHOPHARMACOLOGY
(2013)
Article
Neurosciences
Xing-Xiang Peng, Soledad Cabeza de Vaca, Edward B. Ziff, Kenneth D. Carr
PSYCHOPHARMACOLOGY
(2014)
Review
Pharmacology & Pharmacy
Kenneth D. Carr
CURRENT PHARMACEUTICAL DESIGN
(2020)
Review
Psychology, Biological
Kenneth D. Carr
PHYSIOLOGY & BEHAVIOR
(2020)
Review
Biochemistry & Molecular Biology
Jyoti C. Patel, Kenneth D. Carr, Margaret E. Rice
Summary: Insulin can enter the brain from the periphery by crossing the blood-brain barrier, and it has established actions in the hypothalamus and the midbrain's mesolimbic dopamine neurons. Insulin receptors (InsRs) are abundantly expressed in the striatum, found on interneurons, striatal projection neurons, glial cells, and dopamine axons. Insulin elevation in the striatum promotes an increase in stimulated dopamine release through InsRs on cholinergic interneurons, but it also increases dopamine uptake through InsRs on dopamine axons. This striatal insulin signaling is crucial for flavor-nutrient learning and can influence dopaminergic transmission and striatal function.
Review
Behavioral Sciences
Kenneth D. Carr
CURRENT OPINION IN BEHAVIORAL SCIENCES
(2016)
Article
Psychology, Biological
Umit Yilmaz, Kevser Tanbek
Summary: This study investigated the effects of intracerebroventricular administration of Spexin on the hypothalamus-pituitary-thyroid axis and energy expenditure in rats. The results showed that Spexin reduced food consumption and body weight, increased thyroid hormones, and enhanced energy metabolism.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Kuei-Yu Chien, Yun-Ju Chen, Kuo-Jen Hsu, Chiao-Nan Chen
Summary: This study investigated the effects of a high-protein diet and high-intensity interval training on appetite and weight loss in obese middle-aged individuals. The results showed that consuming a high-protein drink and following a high-protein diet after exercise can reduce post-exercise appetite and the frequency of late-night snacking.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Melissa Alves Braga Oliveira, Ana Carolina Odebrecht Vergne de Abreu, Debora Barroggi Constantino, Andre C. Tonon, Antoni Diez-Noguera, Fernanda Gaspar Amaral, Maria Paz Hidalgo
Summary: Biological processes in living organisms exhibit strong rhythmicity and are regulated by internal timing systems. Understanding the influence of biological rhythms is crucial for experimental design and reporting.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Yanqun Cao, Hao Chen, Yinna Tan, Xu-Dong Yu, Chuli Xiao, Yin Li, James Reilly, Zhiming He, Xinhua Shu
Summary: There is evidence to suggest that chronic stress impacts neurochemical homeostasis and contributes to mental disorders. This study investigates the therapeutic potential of p-coumaric acid (p-CA), a natural compound found in vegetables and fruits, against stress-associated mental disorders. The findings suggest that p-CA could alleviate cognitive deficits and depression-like behavior in mice exposed to chronic restraint stress (CRS) by regulating the PKA-CREB-BDNF signaling pathway.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Mai O. Spaulding, Jessica R. Hoffman, Grace C. Madu, Magen N. Lord, Caroline Soares Iizuka, Kevin P. Myers, Emily E. Noble
Summary: Food insecurity is associated with obesity and disordered eating behaviors. Studying a rodent model, researchers found that adolescent food insecurity may increase susceptibility to obesity and altered eating behaviors during adulthood.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
K. Oberman, B. L. van Leeuwen, M. Nabben, J. E. Villafranca, R. G. Schoemaker
Summary: The present study investigated the post-operative complications and therapeutic potential of J147 in male Zucker rats, and found that J147 treatment had positive effects on behavioral and metabolic parameters, but did not affect neuroinflammation. The results suggest that a combination of acute and chronic J147 treatment may be optimal for treatment.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Mathieu Cournoyer, Alice Maldera, Alexandre-Charles Gauthier, Fabien Dal Maso, Marie-Eve Mathieu
Summary: This article provides a comprehensive view of the literature on the effect of different odors on physical activity through a systematic review. It was found that pleasant odors have a positive impact on participants' physical activity. However, better methodological consistency is needed in studies to produce more meaningful results.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Gabriel R. Gilmore, Jeff Dyche
Summary: This study examined sleep, sleep/wake regularity, and cognition in college students diagnosed with depression and using serotonergic antidepressants, comparing them to those without a depression diagnosis. The results showed that students using antidepressants had slightly longer wake after sleep onset and lower sleep efficiency, but these differences were likely not noticed by the participants. There were no differences in sleep regularity or cognition between the two groups.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Erica A. Cross, Kim L. Huhman, H. Elliott Albers
Summary: Social stress plays a significant role in the development of neuropsychiatric disorders and can lead to behavioral deficits such as social withdrawal. This study investigates the impact of social stress on social reward in Syrian hamsters. The results show that subordinate and socially defeated males have reduced motivation for social interactions compared to dominant males. Additionally, winning males exhibit greater activation in the mesolimbic dopamine system compared to losers. In females, there were no differences in social entries between winners and losers, but winning females display more activation in the NAc shell.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Daniel A. R. Cabral, Maria L. M. Rego, Eduardo B. Fontes, Vagner D. O. Tavares
Summary: This study examined the association between body mass index (BMI) and negative emotional states (NES) in men with substance use disorders (SUD) undergoing treatment. The findings showed a positive correlation between BMI and stress, anxiety, and depression. These results suggest that reducing body fat accumulation may contribute to improving mental health in individuals with SUD during recovery.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Elizabeth Agbor Epse Muluh, Jessica C. McCormack, Yunfan Mo, Michael Garratt, Mei Peng
Summary: This PROSPERO pre-registered systematic review and meta-analysis evaluated the olfactory and gustatory changes in pregnant individuals. The meta-analysis revealed that pregnant individuals performed poorer in odour identification, rated olfactory stimuli to be more intense during the second and third trimester, and had increased pleasantness for sweet taste in the first trimester. No major difference was observed in terms of gustatory functions between pregnant and non-pregnant subjects.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Renee Spiteri Douglas, Mackenzie R. Hartley, J. Renee Yang, Tamara B. Franklin
Summary: The expression of Hdac2 in the hippocampus is associated with social status, while the expression of closely related genes Hdac1 and HDAC2 protein is not associated with social rank in the hippocampus.
PHYSIOLOGY & BEHAVIOR
(2024)