期刊
PHYSIOLOGY & BEHAVIOR
卷 101, 期 1, 页码 1-12出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2010.04.025
关键词
Active zone; Structure components; Functional regulation; Synaptic proteins; Aging; Learning memory
资金
- Fifth Clinical College of Anhui Medical University (People's Hospital of Lu'an City)
- Natural Science Foundation of Anhui, China [03043708]
- Natural Science Foundation of the Education Department, Anhui, China [2003kj191]
Neurotransmitter release during synaptic transmission is mediated by the presynaptic active zone. Multiple protein components at the active zone region interact to regulate docking, priming and fusion of the synaptic vesicles with the presynaptic membrane to maintain normal neurotransmitter release. This review discusses research progress in questions of protein transcript and expression pattern changes at the synaptic active zone related to aging and whether these changes have the effects on learning and memory. We will specifically address normal synaptic structure and proteins; active zone structure and components; active zone functional regulation and age-related changes in active zone proteins. (C) 2010 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据