期刊
PHYSIOLOGY & BEHAVIOR
卷 101, 期 4, 页码 462-468出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2010.07.014
关键词
Swine; Obesity; Eating rate; Gastric emptying; Insulin resistance; Feeding behavior; Heart rate variability
资金
- CRITT Sante Bretagne
The aim of our study was to investigate whether the altered eating behavior observed in the context of a diet-induced metabolic syndrome is related to changes of the gastric emptying and autonomic balance Eight adult male Gottingen minipigs were subjected during 5 months to ad libitum Western diet (WD) Several factors were compared between the lean (before WD) and obese conditions general activity and eating behavior gastric emptying adiposity glycemia and insulinemia during IVGTT and heart rate variability (HRV) In our model obesity did not alter the gastric emptying (258 +/- 26 vs 256 +/- 14 min P>0 10) but induced insulin resistance increased basal insulinemia (12 6 +/- 08 to 366 +/- 61 mU/l P<0 02) and reduced insulin sensitivity (4 5E-4 +/- 0 7E-4 to 2 5E-4 0 +/- 2E-4 min(-1) per min(-1) of insulin P<0 05) The HRV and sympathovagal balance were not significantly modified (P>0 10) Fed ad libitum with WD animals overate durably (P<0 001) During a 30-min meal test though the ingestion speed the food ingested (1076 +/- 48 vs 520 +/- 52 g) and energy intake decreased in the obese condition (P<0 05) which can be explained by the fragmentation of the daily caloric intake These data suggest that the slower eating rate and increased number of meals observed in obese minims without neuropathy is independent to gastric emptying The explanation may be sought rather in central modifications induced by obesity that might modify the food perception and/or motivation (C) 2010 Elsevier Inc All rights reserved
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