Article
Cardiac & Cardiovascular Systems
Anuradha Kalyanasundaram, Ning Li, Miranda L. Gardner, Esthela J. Artiga, Brian J. Hansen, Amy Webb, Michael A. Freitas, Maciej Pietrzak, Bryan A. Whitson, Nahush A. Mokadam, Paul M. L. Janssen, Peter J. Mohler, Vadim V. Fedorov
Summary: This study found increased fibrosis and presence of myofibroblasts in the sinoatrial node (SAN) pacemaker complex of heart failure (HF) patients, with unique differences in gene and protein regulation compared to non-HF patients. Additionally, RNA sequencing and proteomic analyses identified distinctive profiles between SAN fibroblasts from HF and non-HF hearts, providing a comprehensive framework for further research on the role of SAN-specific fibrosis in cardiac rhythm regulation and arrhythmias.
Article
Biochemical Research Methods
Philip Gerlee, Philipp M. Altrock, Adam Malik, Cecilia Krona, Sven Nelander
Summary: This article studies the Allee effect in cancer using an individual-based model. The study finds that autocrine signaling plays a crucial role in the generation of the Allee effect, where low cell densities can lead to reduced or negative growth rate. The results of the model are consistent with experimental observations and have important implications for understanding and treating cancer dynamics.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Biology
Stephen P. Ellner, Nicolas Buchon, Tobias Dorr, Brian P. Lazzaro
Summary: The mutual negative feedbacks between pathogens and host immune response could lead to different infection outcomes even in similar hosts, potentially resulting in life-or-death differences. Further research on pathogen modifications may provide new, testable predictions regarding bimodal infection outcomes.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Tom Kretzschmar, Jasmine M. F. Wu, P. Christian Schulze
Summary: Heart failure remains the most common cause of death in the industrialized world, and despite new therapeutic interventions, complete prevention of its development and progression is still not possible, highlighting the need for further research to understand the underlying mechanisms. This review provides a detailed overview of the contribution of impaired mitochondrial dynamics and energy homeostasis during heart failure progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biology
Christina Schenkl, Estelle Heyne, Torsten Doenst, Paul Christian Schulze, Tien Dung Nguyen
Summary: Despite advances in treating cardiac disorders, heart failure (HF) continues to increase globally and poses a medical and economic burden. HF is characterized by metabolic remodeling in the mitochondria, affecting energy homeostasis, calcium handling, oxidative stress, and inflammation. This study focuses on highlighting mitochondrial metabolic alterations and their impact on the pathophysiology of HF, as well as discussing potential metabolic approaches to improve cardiac function.
Article
Medicine, General & Internal
Denise Zaffalon, Efstathios Papatheodorou, Ahmed Merghani, Harshil Dhutia, Eleonora Moccia, Aneil Malhotra, Christopher J. Miles, Virginia Attard, Tessa Homfray, Rajan Sharma, Marta Gigli, Matteo Dal Ferro, Marco Merlo, Michael Papadakis, Gianfranco Sinagra, Sanjay Sharma, Gherardo Finocchiaro
Summary: This study investigated the role of electrocardiogram (ECG) in differentiating between physiological and pathological cardiac remodeling. The ECG was abnormal in a high percentage of patients with dilated cardiomyopathy (DCM), while it was usually normal in athletes with significant cardiac remodeling.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cardiac & Cardiovascular Systems
William D. Watson, Peregrine G. Green, Andrew J. M. Lewis, Per Arvidsson, Giovanni Luigi De Maria, Hakan Arheden, Einar Heiberg, William T. Clarke, Christopher T. Rodgers, Ladislav Valkovic, Stefan Neubauer, Neil Herring, Oliver J. Rider
Summary: The study shows that even in nonischemic heart failure patients with severely impaired systolic function, the heart retains significant metabolic flexibility, including the ability to change substrate use to match arterial supply and workload changes. Increasing the uptake and oxidation of long-chain fatty acids is associated with improved myocardial energetics and contractility.
Review
Biochemistry & Molecular Biology
Xin He, Tailai Du, Tianxin Long, Xinxue Liao, Yugang Dong, Zhan-Peng Huang
Summary: Chronic heart failure is a severe cardiac disease that poses a heavy burden on health. Significant progress has been made in understanding the complexity of the mechanism of chronic heart failure in the past few decades, providing new insights for future therapeutic targets. With the advancement of modern biological techniques, emerging therapeutic strategies such as gene therapy, gene editing techniques, cell therapy, and xenotransplantation offer hope for the treatment of chronic heart failure.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Marine & Freshwater Biology
Karina Kitazawa, Bruna R. Debastiani, Maria Soledad Lopez, Rafael C. Duarte, Gustavo M. Dias
Summary: This study investigates how larval availability, recruitment, predation, and physical parameters affect the diversity and distribution of sessile species along a gradient in a diverse coastal bay threatened by port expansion in the Southwestern Atlantic Ocean. It was found that the sessile community at the mouth of the bay was more diverse with colonial filter-feeding organisms, while the middle of the bay had higher turbidity and mainly consisted of serpulid worms and oysters. The results suggest that the relative importance of regional oceanic and local processes changes along the ocean-land gradient in critical transition zones.
ESTUARINE COASTAL AND SHELF SCIENCE
(2021)
Article
Astronomy & Astrophysics
Martin G. H. Krause, Martin J. Hardcastle
Summary: Research using the ARCADE 2 balloon bolometer, along with other instruments, has detected a radio synchrotron background at frequencies below 3 GHz. This finding cannot be explained by known extragalactic radio sources or diffuse Galactic emission. The predicted spectral index of the modeled radio emission is found to be roughly consistent with the observed radio background.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2021)
Review
Pharmacology & Pharmacy
Fabiana Passaro, Carlo Gabriele Tocchetti, Gaia Spinetti, Francesca Paudice, Luigi Ambrosone, Ciro Costagliola, Francesco Cacciatore, Pasquale Abete, Gianluca Testa
Summary: Heart failure is a clinical syndrome caused by cardiac structural and/or functional abnormalities, leading to reduced cardiac output and/or elevated intracardiac pressures. Nanoparticles can be used for targeted drug delivery to identify, prevent, and treat cardiac fibrosis.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Cardiac & Cardiovascular Systems
John C. Dykes, David N. Rosenthal, Daniel Bernstein, Doff B. McElhinney, Maryanne R. K. Chrisant, Kevin P. Daly, Rebecca K. Ameduri, Kenneth Knecht, Marc E. Richmond, Kimberly Y. Lin, Simon Urschel, Jacob Simmonds, Kathleen E. Simpson, Erin L. Albers, Asma Khan, Kurt Schumacher, Christopher S. Almond, Sharon Chen
Summary: This study aimed to describe the clinical and hemodynamic characteristics of Fontan failure in children listed for heart transplant. The results showed that elevated Fontan pressure is more common than low cardiac output in pediatric failing Fontan patients, and there are subtle hemodynamic differences between the various phenotypes of Fontan failure in children. Additionally, waitlist and post-transplant mortality risks differ by phenotype.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Multidisciplinary Sciences
Catherine E. Finkenbiner, Stephen P. Good, J. Renee Brooks, Scott T. Allen, Salini Sasidharan
Summary: Soil physics simulations indicate that water isotope ratios can differ among different storage types due to transport processes, but these effects are smaller than field data suggests, indicating the presence of unrepresented processes in ecohydrologic separation. Field measurements show varying levels of geochemical separation in subsurface pore waters. Conventional soil physics alone cannot explain the isotopic differences between preferential flow and tightly-bound water. Further research is needed to understand and explain these separations.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Mariona Guitart-Mampel, Pedro Urquiza, Jordana I. Borges, Anastasios Lymperopoulos, Maria E. Solesio
Summary: Aldosterone plays a dual role in regulating electrolyte and blood volume homeostasis, while also adversely affecting the structure and function of the heart in chronic heart failure. By activating the mineralocorticoid receptor, aldosterone promotes inflammation, fibrosis, oxidative stress, and mitochondrial dysfunction in the failing myocardium. MR antagonist drugs are used to reduce the negative effects of aldosterone, and the impact on cardiac adrenergic receptors is significant in chronic heart failure.
Article
Cardiac & Cardiovascular Systems
Alexandra Fabian, Adrienn Ujvari, Marton Tokodi, Balint Karoly Lakatos, Orsolya Kiss, Mate Babity, Mark Zamodics, Nora Sydo, Emese Csulak, Hajnalka Vago, Liliana Szabo, Anna Reka Kiss, Andrea Szucs, Bela Merkely, Attila Kovacs
Summary: This study used three-dimensional echocardiography to investigate the biventricular morphology and function of elite athletes. The results showed that both the left ventricle and right ventricle undergo adaptive changes in response to exercise, with the right ventricle experiencing larger changes. Additionally, the end-diastolic volume of the right ventricle was found to be the strongest independent predictor of exercise capacity.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Review
Toxicology
Yow Keat Tham, Bianca C. Bernardo, Jenny Y. Y. Ooi, Kate L. Weeks, Julie R. McMullen
ARCHIVES OF TOXICOLOGY
(2015)
Editorial Material
Chemistry, Medicinal
Bianca C. Bernardo, Kate L. Weeks, Natalie L. Patterson, Julie R. McMullen
FUTURE MEDICINAL CHEMISTRY
(2016)
Article
Pharmacology & Pharmacy
Sarah-Lena Puhl, Kate L. Weeks, Antonella Ranieri, Metin Avkiran
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2016)
Article
Cardiac & Cardiovascular Systems
Kate L. Weeks, Antonella Ranieri, Agnieszka Karas, Bianca C. Bernardo, Alexandra S. Ashcroft, Chris Molenaar, Julie R. McMullen, Metin Avkiran
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2017)
Review
Cardiac & Cardiovascular Systems
Sebastian Bass-Stringer, Bianca C. Bernardo, Clive N. May, Colleen J. Thomas, Kate L. Weeks, Julie R. McMullen
HEART LUNG AND CIRCULATION
(2018)
Article
Hematology
Ruby C. Y. Lin, Kate L. Weeks, Xiao-Ming Gao, Rohan B. H. Williams, Bianca C. Bernardo, Helen Kiriazis, Vance B. Matthews, Elizabeth A. Woodcock, Russell D. Bouwman, Janelle P. Mollica, Helen J. Speirs, Ian W. Dawes, Roger J. Daly, Tetsuo Shioi, Seigo Izumo, Mark A. Febbraio, Xiao-Jun Du, Julie R. McMullen
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2010)
Article
Cardiac & Cardiovascular Systems
Kate L. Weeks, Xiaoming Gao, Xiao-Jun Du, Esther J. H. Boey, Aya Matsumoto, Bianca C. Bernardo, Helen Kiriazis, Nelly Cemerlang, Joon Win Tan, Yow Keat Tham, Thomas F. Franke, Hongwei Qian, Marie A. Bogoyevitch, Elizabeth A. Woodcock, Mark A. Febbraio, Paul Gregorevic, Julie R. McMullen
CIRCULATION-HEART FAILURE
(2012)
Review
Medicine, Research & Experimental
Kate L. Owen, Lynette Pretorius, Julie R. McMullen
Article
Biochemistry & Molecular Biology
Lynette Pretorius, Kate L. Owen, Julie R. McMullen
FRONTIERS IN BIOSCIENCE-LANDMARK
(2009)
Article
Cell Biology
Catherine E. Winbanks, Kate L. Weeks, Rachel E. Thomson, Patricio V. Sepulveda, Claudia Beyer, Hongwei Qian, Justin L. Chen, James M. Allen, Graeme I. Lancaster, Mark A. Febbraio, Craig A. Harrison, Julie R. McMullen, Jeffrey S. Chamberlain, Paul Gregorevic
JOURNAL OF CELL BIOLOGY
(2012)
Editorial Material
Cardiac & Cardiovascular Systems
Kate L. Weeks, Metin Avkiran
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2014)
Review
Neurosciences
Kate L. Weeks, Metin Avkiran
JOURNAL OF PHYSIOLOGY-LONDON
(2015)
Review
Pharmacology & Pharmacy
Bianca C. Bernardo, Kate L. Weeks, Lynette Pretorius, Julie R. McMullen
PHARMACOLOGY & THERAPEUTICS
(2010)
Article
Medicine, Research & Experimental
Darnel Prakoso, Miles J. De Blasio, Chengxue Qin, Sarah Rosli, Helen Kiriazis, Hongwei Qian, Xiao-Jun Du, Kate L. Weeks, Paul Gregorevic, Julie R. McMullen, Rebecca H. Ritchie
