Calcium Signaling Through CatSper Channels in Mammalian Fertilization

The molecular mechanisms underlying Ca2+ entry into sperm are now much more well defined thanks to direct recordings of mature sperm cells. This article reviews the function of a sperm-specific ion channel, CatSper. CatSpers have a clearly defined function in sperm's hyperactivated motility and are essential for male fertility. We propose that physiological stimuli such as zona pellucida and cyclic nucleotides induce Ca2+ entry through CatSper channels instead of acting on Ca-V and CNG channels as previously thought.