Review
Biochemistry & Molecular Biology
Antonietta Fazio, Camilla Evangelisti, Alessandra Cappellini, Sara Mongiorgi, Foteini-Dionysia Koufi, Irene Neri, Maria Vittoria Marvi, Michele Russo, Alessandra Ghigo, Lucia Manzoli, Roberta Fiume, Stefano Ratti
Summary: Phospholipase C (PLC) enzymes play a crucial role in the plasma membrane of mammalian cells, specifically in the cardiac sarcolemmal (SL) membrane of cardiomyocytes. They are responsible for hydrolyzing phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) into 1,2-diacylglycerol (DAG) and inositol (1,4,5) trisphosphate (Ins(1,4,5)P3), which are important lipid mediators. This review highlights the significance of PLC, particularly PLCβ isoforms, in the cardiovascular system, in both physiological and pathological conditions. Understanding the mechanisms of PLCβ activation and regulation holds promise for the development of therapeutic strategies for cardiac disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Abhipsha Dey, Martin Flajshans, Martin Psenicka, Ievgeniia Gazo
Summary: Embryogenesis is a crucial stage in an organism's life, but externally fertilizing species like fish are particularly vulnerable to DNA damage from environmental factors. While DNA repair pathways have been extensively studied in some fish species, there is a lack of knowledge about these processes in non-model aquaculture fish. This review aims to summarize the features of different DNA repair pathways during fish embryo development, including their regulation, roles in organogenesis, and response to genotoxic stress, to establish a connection between genotoxic stress and embryo phenotype.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Hugo Sato, Maria Laura Leonardi, Sabrina Lorena Roberti, Alicia Jawerbaum, Romina Higa
Summary: Maternal diabetes affects heart development and alters the activation of FOXO1 and expression of target genes involved in cardiovascular formation during embryonic heart development. This leads to increased oxidative stress and pro-inflammatory cardiac development, as well as altered expression of proteolytic enzymes that regulate cardiac function.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Neurosciences
Sung Jin Park, Kirk D. Haan, Yoshikazu Nakamura, Kiyoko Fukami, Thomas E. Fisher
Summary: The study revealed that the PLC delta 1 isoform plays a crucial role in the activation of Delta N-TRPV1 channels and osmosensory transduction in MNCs, with its absence leading to impaired MNC function. This research advances our understanding of the molecular mechanisms of osmoregulation in mammals.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Genetics & Heredity
Hao Li, Peter Hohenstein, Satu Kuure
Summary: The adult mammalian kidney lacks stem cells for regeneration, unlike the embryonic kidney which contains lineage-specific stem cells giving rise to various kidney components; current research focuses on these embryonic progenitor cells which can shed light on the formation of Wilms tumor, a pediatric renal cancer.
Article
Fisheries
Mohammad Ashaf-Ud-Doulah, S. M. Majharul Islam, Md Mahiuddin Zahangir, Md Sadiqul Islam, Christopher Brown, Md Shahjahan
Summary: The study found that temperature has a significant impact on the development of rohu carp embryos and larvae, with the optimal temperature range being 30-32 degrees Celsius or lower. Higher temperatures disrupt embryonic metabolism and physiology, resulting in aberrant and unsuccessful early development.
AQUACULTURE INTERNATIONAL
(2021)
Article
Engineering, Environmental
Shaochen Pang, Yue Gao, Yanwu Wang, Xinglei Yao, Mengxi Cao, Yong Liang, Maoyong Song, Guibin Jiang
Summary: TBBPA exposure disrupts early embryonic development, perturbing cell fate decisions along the DV axis and leading to impaired organogenesis. This highlights the potential ecological and health risks associated with TBBPA.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Mariana Cooke, Marcelo G. Kazanietz
Summary: Diacylglycerol (DAG) is a key lipid messenger that plays critical roles in cell functions, tumor development, and immune surveillance. Imbalances in DAG pathways can lead to tumor initiation and progression.
Article
Physiology
Yun Long, Yi-cheng Wang, Dong-zhi Yuan, Xin-hua Dai, Lin-chuan Liao, Xue-qin Zhang, Li-xue Zhang, Yong-dan Ma, Yi Lei, Zhi-hui Cui, Jin-hu Zhang, Li Nie, Li-min Yue
Summary: GLUT4 is expressed in the mouse uterus during pregnancy, especially increasing on day 4. Estrogen and progesterone promote GLUT4 expression in the endometrial epithelium. GLUT4 regulates glucose transport in endometrial epithelial cells and affects embryo development by altering glucose concentration in the uterine fluid.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Wataru Nomura, Su-Ping Ng, Terunao Takahara, Tatsuya Maeda, Teruo Kawada, Tsuyoshi Goto, Yoshiharu Inoue
Summary: This study found that methylglyoxal (MG) activates the TORC2-Ypk1/2 and TORC2-Pkc1 signaling pathways, and that phosphatidylserine plays a role in their activation. The Rho family GTPase Cdc42 and phosphatidylinositol-specific phospholipase C, Plc1, were also found to contribute to the activation of these signaling pathways.
JOURNAL OF CELL SCIENCE
(2022)
Article
Cell Biology
Michaela Dohnalkova, Kyrylo Krasnykov, Mateusz Mendel, Lingyun Li, Olesya Panasenko, Fabienne Fleury-Olela, Cathrine Broberg Vagbo, David Homolka, Ramesh S. Pillai
Summary: Eukaryotic RNA pol II transcripts are capped at the 50 end by the methylated guanosine (m7G) moiety. CMTR1 and CMTR2 catalyze cap-proximal ribose methylations on the first (cap1) and second (cap2) nucleotides, marking RNAs as self to block the innate immune response pathway. Loss of Cmtr1 or Cmtr2 in mice leads to embryonic lethality and misregulation of specific transcripts, while Cmtr1 mutant adult mouse livers exhibit chronic activation of the interferon pathway. Conditional deletion of Cmtr1 in the germline causes infertility, but global translation is unaffected. These findings reveal essential roles of cap1 and cap2 modifications in gene regulation and immune response evasion.
Review
Anatomy & Morphology
Natalia Moracho, Ana I. R. Learte, Emma Munoz-Saez, Miguel A. Marchena, Maria A. Cid, Alicia G. Arroyo, Cristina Sanchez-Camacho
Summary: MT-MMPs play a role in various processes during embryonic morphogenesis, such as cell migration, proliferation, epithelial-mesenchymal transition, cell polarity and branching, axon growth and navigation, synapse formation, and angiogenesis.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Endocrinology & Metabolism
Erin R. Okawa, Manoj K. Gupta, Sevim Kahraman, Praneeth Goli, Masaji Sakaguchi, Jiang Hu, Kaiti Duan, Brittany Slipp, Jochen K. Lennerz, Rohit N. Kulkarni
Summary: Insulin and insulin-like growth factor-1 receptors are crucial for maintaining pluripotency and normal lineage development of stem cells. Dysregulation in the function and signaling of these receptors leads to upregulation of compensatory pathways to maintain pluripotency, while causing abnormalities in directed differentiation toward the three lineages.
MOLECULAR METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Yi Tian, Ying Zhan, Qin Jiang, Weisi Lu, Xuri Li
Summary: PDGF-C is a relatively new member of the PDGF family, expressed in most organs and cell types, and has demonstrated critical roles in various biological, physiological and pathological processes over the past 20 years.
Article
Cell Biology
Manuela D. Mitsogiannis, Anna Pancho, Tania Aerts, Sonja M. Sachse, Ria Vanlaer, Lut Noterdaeme, Dietmar Schmucker, Eve Seuntjens
Summary: DSCAMs are involved in various neurodevelopmental processes, and their malfunction can lead to disorders such as Fragile X syndrome, intellectual disability, autism, and bipolar disorder. While Dscam and Dscaml1 knockout did not significantly affect developmental events in mice, gain of function experiments showed negative impacts on neural migration processes important for cortical development. This highlights the importance of genes encoding adhesive cues in neuronal migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Dermatology
Kaori Kanemaru, Ayano Matsuyuki, Yoshikazu Nakamura, Kiyoko Fukami
EXPERIMENTAL DERMATOLOGY
(2015)
Review
Biochemistry & Molecular Biology
Yoshikazu Nakamura, Kiyoko Fukami
JOURNAL OF BIOCHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Zen Kouchi, Takahiro Igarashi, Nami Shibayama, Shunichi Inanobe, Kazuyuki Sakurai, Hideki Yamaguchi, Toshifumi Fukuda, Shigeru Yanagi, Yoshikazu Nakamura, Kiyoko Fukami
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Cell Biology
Hideki Yamaguchi, Shuhei Yoshida, Emi Muroi, Nachi Yoshida, Masahiro Kawamura, Zen Kouchi, Yoshikazu Nakamura, Ryuichi Sakai, Kiyoko Fukami
JOURNAL OF CELL BIOLOGY
(2011)
Article
Neurosciences
Kim A. Staats, Lawrence Van Helleputte, Ashley R. Jones, Andre Bento-Abreu, Annelies Van Hoecke, Aleksey Shatunov, Claire L. Simpson, Robin Lemmens, Tom Jaspers, Kiyoko Fukami, Yoshikazu Nakamura, Robert H. Brown, Philip Van Damme, Adrian Liston, Wim Robberecht, Ammar Al-Chalabi, Ludo Van Den Bosch
NEUROBIOLOGY OF DISEASE
(2013)
Article
Cell Biology
Y. Nakamura, K. Kanemaru, R. Kojima, Y. Hashimoto, T. Marunouchi, N. Oka, T. Ogura, K. Tanonaka, K. Fukami
CELL DEATH & DISEASE
(2014)
Article
Multidisciplinary Sciences
Kaori Kanemaru, Yoshikazu Nakamura, Kojiro Sato, Ryota Kojima, Saori Takahashi, Mami Yamaguchi, Manabu Ichinohe, Hiroshi Kiyonari, Go Shioi, Kenji Kabashima, Kyoko Nakahigashi, Masataka Asagiri, Colin Jamora, Hideki Yamaguchi, Kiyoko Fukami
NATURE COMMUNICATIONS
(2012)
Article
Biochemistry & Molecular Biology
Kanako Shiratori, Kaori Kanemaru, Takahiro Ogura, Aya Nakajima, Yuko Sugizaki, Takatsugu Fukuyama, Yoichiro Iwakura, Yoshikazu Nakamura, Kiyoko Fukami
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Dermatology
Takatsugu Fukuyama, Yoshikazu Nakamura, Kaori Kanemaru, Chiho Toyoda, Hyun-Jun Jang, Pann-Ghill Suh, Kiyoko Fukami
EXPERIMENTAL DERMATOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Atsuko Yoneda, Kaori Kanemaru, Ai Matsubara, Erika Takai, Makoto Shimozawa, Reiko Satow, Hideki Yamaguchi, Yoshikazu Nakamura, Kiyoko Fukami
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Yoshikazu Nakamura, Kaori Kanemaru, Madoka Shoji, Kengo Totoki, Karen Nakamura, Hidemasa Nakaminami, Keisuke Nakase, Norihisa Noguchi, Kiyoko Fukami
SCIENTIFIC REPORTS
(2020)
Article
Neurosciences
Sung Jin Park, Kirk D. Haan, Yoshikazu Nakamura, Kiyoko Fukami, Thomas E. Fisher
Summary: The study revealed that the PLC delta 1 isoform plays a crucial role in the activation of Delta N-TRPV1 channels and osmosensory transduction in MNCs, with its absence leading to impaired MNC function. This research advances our understanding of the molecular mechanisms of osmoregulation in mammals.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Kazuya Tsujita, Reiko Satow, Shinobu Asada, Yoshikazu Nakamura, Luis Arnes, Keisuke Sako, Yasuyuki Fujita, Kiyoko Fukami, Toshiki Itoh
Summary: Changes in cell mechanics contribute to cancer cell dissemination. High plasma membrane (PM) tension inhibits cancer dissemination by counteracting mechanosensitive BAR family protein assembly, while restoration of PM tension phenotypically convert malignant cells into a non-motile epithelial cell state.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Kaori Kanemaru, Makoto Shimozawa, Manabu Kitamata, Rikuto Furuishi, Hinako Kayano, Yui Sukawa, Yuuki Chiba, Takatsugu Fukuyama, Junya Hasegawa, Hiroki Nakanishi, Takuma Kishimoto, Kazuya Tsujita, Kazuma Tanaka, Toshiki Itoh, Junko Sasaki, Takehiko Sasaki, Kiyoko Fukami, Yoshikazu Nakamura
Summary: This study reveals the critical role of phospholipid phosphatidylinositol (4,5)-bisphosphate in maintaining the characteristics of epithelial cells.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Kaori Kanemaru, Yoshikazu Nakamura, Kengo Totoki, Takatsugu Fukuyama, Madoka Shoji, Hisae Kaneko, Kanako Shiratori, Atsuko Yoneda, Takafumi Inoue, Yoichiro Iwakura, Kenji Kabashima, Kiyoko Fukami
CELL DEATH AND DIFFERENTIATION
(2017)
